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PHLDA1 deficiency limits microglia activation and protects dopaminergic neurons through attenuating auto-ubiquitination of TRAF6

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中国药理学与毒理学杂志 2018年第9期32卷 693-694页

作者： HAN chao-jun ZHEN Xue-chu Department of Pharmacology College of Pharmaceutical Sciences Soochow University Suzhou 215123 China

OBJECTIVE Pleckstrin homologylike domain family A member 1(PHLDA1),also known as TDAG51,was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell *** research showed that PHILDA1 plays crucial roles in cell proliferation and apoptosis,PHLDA1 deficiency caused several phenotypic changes in macrophages that increased cytoprotection against oxidative and endoplasmic reticulum(ER) ***,little is known about the critical role of PHLDA1 in the neuroinflammation and neuronal *** Mouse Parkinson disease(PD) model was induced by intraperitoneal injection(ip) of MPTP for 7 *** staining was used to observe TH,Iba-1 and PHLDA1 in brain *** microglia and BV2 microglial cell lines were exposed to lipopolysacchrides(LPS) at different time points to determine PHLDA1 mRNA and protein level in ***2 cells with PHLDA1 knockdown using lentivirus experessing shRNA were exposed to LPS for the detection of proinflammatory genes expression by q-PCR or Western *** NF-κB and MAPK pathways were detected to reveal the underlying mechanisms of PHLDA1 regulate microglia ***,to determine the effect of PHLDA1 deletion in the substantia nigra(SN) on motor dysfunction,the mice were previously infected with AAV-GFP(control) or AAV-shP HLDA1 in the SN in PD model,then were administered with behavior *** PHLDA1 was expressed in ***1 was increased in primary microglia or BV2 microglia cell lines by LPS treatment,acted as a positive regulator of TLR4 ***1 deficiency suppressed LPS-induced microglia *** underlying mechanisms of PHLDA1 might be through directly interacting with TRAF6 to promote its auto-ubiquitination consequently enhanced *** PD model,PHLDA1 deletion in the SN limits microglial activation and protects dopaminergic ***1 deficiency mic

关键词： PHLDA1 TRAF6 microglia inflammation Parkinson disease

A data-driven approach to RUL prediction of tools

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Advances in Manufacturing 2024年第1期12卷 6-18页

作者： Wei Li Liang-Chi Zhang chu-Han Wu Yan Wang Zhen-Xiang Cui chao Niu Department of Mechanical Engineering University College LondonLondonWC1E 7JEUK Shenzhen Key Laboratory of Cross-Scale Manufacturing Mechanics Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China SUSTech Institute for Manufacturing Innovation Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China School of Mechanical and Manufacturing Engineering The University of New South WalesKensingtonNSW2052Australia Baoshan Iron&Steel Co. Ltd.Shanghai200941People’s Republic of China

An effective and reliable prediction of the remaining useful life(RUL)of a tool is important to a metal forming process because it can significantly reduce unexpected maintenance,avoid machine shutdowns and increase system *** study proposes a new data-driven approach to the RUL prediction for metal forming processes under multiple contact sliding *** data-driven approach took advantage of bidirectional long short-term memory(BLSTM)and convolutional neural networks(CNN).A pre-trained lightweight CNN-based network,WearNet,was re-trained to classify the wear states of workpiece surfaces with a high accuracy,then the classification results were passed into a BLSTM-based regression model as inputs for RUL *** experimental results demonstrated that this approach was able to predict the RUL values with a small error(below 5%)and a low root mean square error(RMSE)(around 1.5),which was more superior and robust than the other state-of-the-art methods.

关键词： Remaining useful life(RUL) Bidirectional long short-term memory(BLSTM) Data-driven approach Metal forming

Denaturation behavior of inclusions in industrial pure iron by calcium treatment

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Journal of Iron and Steel Research International 2023年第2期30卷 249-258页

作者： Xin Liu Yan-ping Bao Cheng-jian Hua Jian-hua chu chao Gu Min Wang State Key Lab of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China

Only a few Chinese enterprises can produce high-quality industrial pure iron,and studies on the smelting process of industrial pure iron were *** inclusions in a melting process were characterized by means of electron microscopy and an automatic inclusion analysis system,and the evolution mechanism of inclusion was studied using thermodynamic calculation to optimize the calcium alloy addition in liquid *** results show that during the smelting process,inclusions mainly composed of Al_(2)O_(3)and spinel are formed before calcium *** calcium treatment,they continuously react with[Ca],[S]and[Ti],grow up,and are removed during refining and tundish *** the end,there are more small-sized inclusions containing CaS,and the contents of Al_(2)O_(3)and spinel are *** to thermodynamic calculations,the appropriate calcium treatment liquid window for the molten steel composition is(10-38)×10^(-6).Calcium treatment has changed the main types of inclusions in industrial pure iron from Al_(2)O_(3)to small-sized inclusions containing CaS and effectively reduces the influence of Al_(2)O_(3)inclusions on the quality of industrial pure iron.

关键词： Industrial pure iron Calcium treatment Inclusion Thermodynamic CaS

Temperature Compensation Algorithm for Hydraulic System Pressure Control

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Journal of Beijing Institute of Technology 2018年第4期27卷 556-563页

作者： Huien Gao Liang chu Jianhua guo Dianbo Zhang State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022China Jilin Provincial Institute of Standards Changchun 130022China

In this paper the control mechanism of solenoid valve is analyzed,which shows the solenoid valve control is actually the control of coil *** response characteristic of coil current is related to coil inductance and *** coil resistance is influenced greatly by the ambient temperature and the self-heating of coil,which affects the control precision of coil ***,considering the heat dissipation mode of coil,the coil temperature model is established from the perspective of heat conduction,and a temperature compensation algorithm for hydraulic system pressure control is put *** the hardware-in-the-loop testbed is set up by using the dSPACE platform,carrying out wheel cylinder pressurization tests with inlet valve fully opened at-40℃ and 20℃,and testing the actual pressure of wheel cylinder with the target pressures at-40℃ and 6 000 kPa/s(pressurization rate).The results show that the pressure control temperature compensation algorithm proposed in this paper accurately corrects the influence of resistance temperature drift on the response accuracy of wheel cylinder *** the correction,the pressure difference is less than 500 kPa,which can meet the control accuracy requirements of solenoid valve,enriching the linear control characteristic of solenoid valve.

关键词： braking energy recovery heat conduction temperature compensation linear pressure control rapid control prototype

Design and Strategy of Series-Parallel Hybrid System Based on BSFC

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Journal of Beijing Institute of Technology 2018年第4期27卷 564-574页

In this paper,a drive control strategy is developed based on the characteristics of series-parallel plug-in hybrid *** management strategies in various modes are established with the basis on the minimum brake specific fuel consumption(BSFC)curve of *** control strategy,which is based on rules and system efficiency,is adopted to determine the entry/exit mechanisms of various modes according to battery state of charge(SOC),required power and required *** vehicle test results verify that the proposed control strategy can improve vehicle economy efficiently and makes a good effect on engine control.

关键词： series-parallel plug-in hybrid electric vehicle(PHEV) based on rules based on system efficiency

Characteristics of Ce-Mn film on 6061 alloys and its improved performance

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Rare Metals 2019年第10期38卷 971-978页

作者： Xue-Long Hao Wen Ma chu Luo Shi-chao Yang Hong Ji Kai Zhang GRIM AT Engineering Institute Co. Ltd.Beijing 101407China National Center of Analysis and Testing for Nonferrous Metals and Electronic Materials General Research Institute for Nonferrous MetalsBeijing 100088China China United Testing&Certification Co. Ltd.Beijing 101407China guobiao(Beijing)Testing&Certification Co. Ltd..Beijing 101407China GRINM Bohan(Beijing)Publisher Co. LtdBeijing 101407China Guangdong Zhuhai Supervision Testing Institute of Quality and Metrology Zhuhai 519000China Guangdong Provincial Academy of Building Research Guangzhou 510500China

HF2- was applied to accelerate the Ce-Mn film formation on 6061A1 alloy in the Ce3+-*** process of film formation,the composition and structure of the film were analyzed by scanning electron microscopy(SEM) equipped with energy-dispersive spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS)and X-ray diffractometer(XRD).The film formation process includes three *** the initial stage,a threedimensional(3D) skeleton was formed quickly,and then the skeleton was fully filled with cerium oxide and manganese oxide,resulting in a dense ***,a new skeleton was formed and also ***,Ce,O and Mn were detected in the *** existed mainly in the form of Ce4+(89%).The film existed in an amorphous form and was composed of ceria(cerium hydroxide),manganese dioxide and aluminum *** electrostatically spraying fluorocarbon powder,the resultant products satisfied the required mechanical performance and exhibited almost non-filament corrosion compared with commercially available chromium-free conversion *** corrosion resistant time to acetate spray can reach 2000 h,which is consistent with that of fluorocarbon *** results showed that Ce-Mn film can offer an attractive prospect to eliminate volatile organic compounds(VOC) problem arisen by using fluorocarbon paint in the process of industrial production.

关键词： Aluminumalloy Ce-Mn film Process of filmformation Amorphous

Perturbation Analysis of the Attached Water Mass Effect on Offshore Platform Dynamic Response

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China Ocean Engineering 1993年第4期8卷 369-382页

作者： chu, Liangcheng Qu, Naisi guo, Yonggang Lu, Min Dalian Univ of Technology Dalian China

Theoretically speaking, it is impossible to make the differential equation of motion uncoupled for the natural modes of a system in consideration of the attached water. The hydro-elastic structure is equal to the non-proportional damping system. In this paper a perturbation analysis method is put forward. The structure motion equation is strictly solved mathematically, and the non-proportional damping problem is transformed into a series of proportional damping ones in the superposition form. The paper also presents the calculation formula of the dynamic response of the structure being subjected to harmonic and arbitrary load. The convergence of the proposed method is also studied in this paper, and the corresponding convergence conditions are given. Finally, the proposed method is used to analyze the displacement response of a real offshore platform. The calculation results show that this method has the characteristics of high accuracy and fast convergence.

关键词： Convergence of numerical methods Damping Dynamic response Equations of motion Mathematical models Perturbation techniques Structural analysis Structural loads Water

Re-Os isotopic constraint to the age of in komatiites in the Neoarchean Guyang greenstone belt,North China Craton

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Chinese Science Bulletin 2010年第27期55卷 3197-3204页

作者： MA XuDong guo JingHui CHEN Liang chu ZhuYin State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China State Key Laboratory of Continental Dynamics Department of Geology Northwest University Xi'an 710069 China

The 2.5 Ga Guyang greenstone belt is a major lithological unit in the northwestern part of the North China *** have recently been identified to occur within the lower part of the meta-volcanic sedimentary sequence of the greenstone *** biggest komatiite near Guyang has been mapped out,which is 500 m long and 50 m wide lenticular ***-Os isotopic compositions of 9 samples were analyzed to date the *** Os contents are from 0.88 to 2.63 ppb,identical with typical komatiites,and slightly lower than the normal *** 187Os/188Os ratios are from 0.1115 to 0.1197,which are lower enough to exclude the origin of Phanerozoic magma as widely developed in adjacent *** calculated Re depletion model ages(TRD) are from 1346 to 2454 Ma,among them the oldest age of 2454 Ma gives the minimum evaluation for the formation age of the Guyang ***,the komatiites are a part of the Guyang greenstone belt,indicating high degree melting of mantle during～2.5 Ga crustal growth event.

关键词：科马提岩中国西北部同位素组成形成年龄固阳县绿岩带克拉通新太古代

A Facile Synthesis of Benzo[h]quinolines via Silica-TsOH-P2O5 Promoted Condensation of 1-Naphthylamines with 1,3-Diketones under Solvent Free Conditions

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Chinese Journal of Chemistry 2017年第10期35卷 1595-1600页

作者： chuanlei Zhu Ruiqiang guo Zhe Sheng Yanzhe Li Changhu chu School of Pharmacy Shanghai Key Laboratory of New Drug Design East China University of Science and Technology Shanghai 200237 China

A facile synthesis of benzo[h]quinolines has been developed via improved Combes reaction. A combination of silica gel, p-toluenesulfonic acid and phosphorus pentoxide was utilized to promote the condensation of 1-naphthylamines with 1,3-diketones under solvent free conditions. In this case, silica gel was used as reaction media, p-toluenesulfonic acid and phosphorus pentoxide were acted as catalyst and dehydrating agent, respectively.

关键词： silica-TsOH-P2O5 benzo[h]quinoline catalysis synthesis solvent free