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Chinese Physics Letters 2024年第7期41卷 47-52页

作者：王珊宋博乐窦鑫河乔飞鸿李响王锦波吕志国 School of Physical Science and Technology Key Laboratory of Semiconductor Photovoltaic Technology of Inner Mongolia Autonomous RegionInner Mongolia UniversityHohhot 010021China

In comparison to bright pulses, better stability that is not susceptible to loss makes dark pulses accessible for applications in such fields as signal processing, optics sensing, and quantum communication. Here we investigate the dual-wavelength domain-wall dark pulse generation in a graded-index multimode fiber(GIMF) based anomalous dispersion single-mode fiber(SMF) laser. By optimizing intra-cavity nonlinearity and pulse polarization, the mode-locked states can evolve each other between bright pulses, dark pulses, and bright-dark pulse pairs. The evolution mechanism among them may be relevant to the coherent mode superposition, spectral filtering, and mode selection in SMF-GIMF-SMF hybrid-fiber modulation devices that affect the pulse formation and evolution in temporal, frequency, and space domains. These results provide a valuable reference for promoting further development of nonlinear optics and ultrafast optics, in which ultrafast photonic devices, with low cost, simple manufacture as well as wide adaptability, as novel pulsed generation technique, play a vital role.

关键词： fiber polarization optics

RNA结合蛋白ZFP36在心肌细胞缺氧/复氧损伤中的作用及调控机制

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西安交通大学学报（医学版） 2024年第2期45卷 219-227页

作者：吕果孙超峰张皓李红军王芳汉中市中心医院心内科陕西汉中723000 西安交通大学第一附属医院心血管内科陕西西安710061 汉中市疾控中心慢病科陕西汉中723000

目的探讨RNA结合锌指蛋白36(ZFP36)在缺氧/复氧(H/R)诱导的心肌细胞损伤和自噬中的作用及分子调控机制。方法H9C2大鼠心肌细胞感染ZFP36过表达慢病毒(OE-ZFP36)或其阴性对照慢病毒(OE-ZFP36 NC)构建稳转细胞株;转染ATG4D过表达质粒(OE-A... 详细信息

目的探讨RNA结合锌指蛋白36(ZFP36)在缺氧/复氧(H/R)诱导的心肌细胞损伤和自噬中的作用及分子调控机制。方法H9C2大鼠心肌细胞感染ZFP36过表达慢病毒(OE-ZFP36)或其阴性对照慢病毒(OE-ZFP36 NC)构建稳转细胞株;转染ATG4D过表达质粒(OE-ATG4D)提高ATG4D表达。H/R处理诱导心肌细胞损伤;将H9C2细胞分为对照组、H/R组、OE-ZFP36 NC+H/R组、OE-ZFP36+H/R组、OE-ATG4D NC+H/R组、OE-ATG4D+H/R组、OE-ZFP36+OE-ATG4D NC+H/R组和OE-ZFP36+OE-ATG4D+H/R组。各组细胞应用Western blotting检测ATG4D、Beclin1、LC3和ZFP36蛋白表达;实时荧光定量PCR(qPCR)检测ZFP36和ATG4D mRNA表达;CCK-8检测细胞活性;酶联免疫吸附法(ELISA)检测白介素6(IL-6)和肿瘤坏死因子(TNF-α)水平;DCFH-DA法检测活性氧(ROS)水平;SOD试剂盒检测SOD水平;流式细胞术检测细胞凋亡;细胞免疫荧光检测LC3自噬体;双荧光素酶报告基因实验检测ZFP36和ATG4D mRNA的结合。结果与对照组比较,H/R组中细胞活性降低,IL-6和TNF-α水平提高,ROS水平升高而SOD水平降低,细胞凋亡增加;ATG4D、Beclin1蛋白表达上调,同时LC3Ⅱ/LC3Ⅰ比值也显著增加;且ZFP36表达上调(P<0.05)。与OE-ZFP36 NC+H/R组比较,OE-ZFP36+H/R组中细胞活性提高,IL-6和TNF-α水平降低,ROS水平下降而SOD水平升高,细胞凋亡减少,且ATG4D、Beclin1蛋白表达下调,LC3Ⅱ/LC3Ⅰ比值也显著下调(P<0.05)。与感染OE-ZFP36 NC慢病毒比较,感染OE-ZFP36慢病毒降低ATG4D 3′-UTR报告基因的荧光素酶活性,降低ATG4D mRNA稳定性,下调H/R诱导的ATG4D mRNA表达(P<0.05)。与OE-ATG4D NC+H/R组相比,OE-ATG4D+H/R组中的ATG4D mRNA和蛋白表达显著上调,且细胞活性降低,IL-6和TNF-α水平增高,ROS水平升高而SOD水平降低,细胞凋亡增加(P<0.05)。与OE-ZFP36+OE-ATG4D NC+H/R组比较,OE-ZFP36+OE-ATG4D+H/R组中细胞活性降低,IL-6和TNF-α水平增高,ROS水平升高而SOD水平降低,细胞凋亡增加(P<0.05)。结论ZFP36在H/R诱导的心肌细胞损伤中表达上调,过表达ZFP36抑制了H/R诱导的心肌细胞损伤,并通过调控ATG4D抑制自噬,进而抵抗心肌细胞H/R损伤,证明ZFP36是抵抗心肌缺血再灌注损伤的重要调控分子。

关键词：心肌缺血再灌注损伤(MI/RI) 锌指蛋白36(ZFP36) 自噬转录后调控自噬相关蛋白4D(ATG4D)

基于Clo-YOLO的交通标志检测算法研究

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计算机应用文摘 2024年第18期40卷 176-178,182页

作者：杨宵吕国河北建筑工程学院河北张家口075000

交通标志是确保道路安全的重要措施,对其检测是智能交通系统中的关键环节。文章引入YOLOv8网络模型对道路两旁的交通标志进行检测,并提出了一种基于Clo-YOLO的交通标志检测算法。在融合深层特征和浅层特征的过程中,引入了CloFormer模块... 详细信息

交通标志是确保道路安全的重要措施,对其检测是智能交通系统中的关键环节。文章引入YOLOv8网络模型对道路两旁的交通标志进行检测,并提出了一种基于Clo-YOLO的交通标志检测算法。在融合深层特征和浅层特征的过程中,引入了CloFormer模块,以增强目标的特征表达能力,并提高在目标被遮挡时的检测能力。与原模型的检测结果相比,Clo-YOLO模型在检测道路旁交通标志的任务中表现更为出色。

关键词：深度学习目标检测 YOLOv8 CloFormer

Kinetics of indium dissolution from marmatite with high indium content in pressure acid leaching

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Rare Metals 2017年第1期36卷 69-76页

作者： Lei Tian Yan Liu Ting-An Zhang guo-Zhi lv Shuang Zhou guo-Quan Zhang Key Laboratory for Ecological Utilization of Multimetallic Mineral Ministry of Education Northeastern UniversityShenyang 110819 China

The kinetics of oxygen pressure acid leaching marmatite with high indium content was studied. The effects of particle size, agitation rate, temperature, HSOconcentration, and oxygen partial pressure on leaching rate of indium were investigated. The results show that when the agitation rate is above 600 r-min, its influence on indium leaching rate is insignificant. It is determined that the leaching rates increase with the increase in sulfuric acid concentration, temperature, partial oxygen pressure, and the decrease in particle size. Moreover, the results demonstrate that the process of indium leaching is controlled by interface chemical reaction, with apparent activation energy of 65.7 k J-mol. The apparent reaction orders of sulfuric acid and oxygen partial pressure are determined to be 0.749 and 1.260, respectively. The leaching reaction process follows shrinking unreacted core model. And finally, the kinetics model equation is established for indium.

关键词： Marmatite Indium Oxygen pressure acid leaching Kinetics Activation energy Reaction order

基于TESS数据的早型食双星HD190967、HD35921、HD228854和HD100213轨道周期变化的分析研究

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天文学报 2024年第4期65卷 135-147页

作者：张玉豪刘进忠刘荷蕾吕国梁张余新疆大学物理科学与技术学院乌鲁木齐830046 中国科学院新疆天文台乌鲁木齐830011

HD190967、HD35921、HD228854和HD100213都是O型或B型的早型双星,轨道周期分别为6.519 d、4.0024 d、1.8855 d和1.3872 d,它们都属于长周期双星.这类双星数目少,且难以获得完整的光变曲线.TESS(Transiting Exoplanet Survey Satellite)空间望远镜的长时标、短曝光和高精度光度测量为这4颗源提供了优质的数据.利用从TESS获取的光极小时刻和历史数据,对这4颗早型双星的轨道周期进行了分析研究.研究表明4颗源的轨道周期都有长期增加的趋势,HD228854和HD100213的轨道周期除了长期增加外还叠加了正弦变化.分析发现HD190967、HD228854和HD100213这3颗恒星轨道周期增加的原因是伴星与主星间的物质交流造成的,HD35921轨道周期增加的原因是主星星风损失.目前HD228854和HD100213的轨道周期正弦变化比较合理的解释是由于第三天体影响导致的光时轨道效应.

关键词：双星:掩食技术:测光恒星:早型星方法:数据分析

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Pressure leaching of converter vanadium slag with waste titanium dioxide

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Rare Metals 2016年第7期35卷 576-580页

作者： guo-Quan Zhang Ting-An Zhang Ying Zhang guo-Zhi lv Yan Liu Zhuo-Lin Liu Key Laboratory of Ecological Utilization of Multi-Metal Intergrown Ores of Ministry of Education School of Materials and MetallurgyNortheastern University

The process of pressure leaching the converter vanadium slag with waste titanium dioxide without roasting was studied. Mineralogy analysis indicates that the con- verter vanadium slag contains mainly three mineral phases： magnetite, titanium magnetite, and silicate phase. Vana- dium is in combination with iron, titanium, manganese, aluminum, and silicon. The impacts of leaching tempera- ture, leaching time, stirring speed, liquid-to-solid ratio, and initial leaching agent concentration were investigated on the waste titanium dioxide leaching process. The results indi- cate that under the optimal conditions, the vanadium and the iron leaching rates are 96.85 % and 93.50 %, respectively, and the content of titanium is 12.6 % in the residue. The main mineral phases for the residues under the optimal operation conditions are quartz, ilmenite, anatase, and sili- cate phase, and the residues can be reused as the extraction of titanium raw materials for titanium dioxide production technology by the sulfate method.

关键词： Vanadium Waste titanium dioxide Pressure leaching Resource utilization

叶面喷施寡糖对花生根区固氮菌群落结构及产量的影响

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中国土壤与肥料 2024年第6期 178-185页

作者：龚民钱远超杜连涛何久兴孔梦吕国华中国农业科学院农业环境与可持续发展研究所北京100081 山东省烟台市农业技术推广中心山东烟台264001

研究施用壳寡糖和纤维寡糖对花生根区土壤固氮菌群落结构及产量的影响。通过田间试验,以清水处理作为对照(CK),叶面喷施浓度为50 mg/L的壳寡糖(CSOS)和纤维寡糖(COS),利用高通量测序技术,研究土壤中固氮菌群落结构组成及多样性分布特征... 详细信息

研究施用壳寡糖和纤维寡糖对花生根区土壤固氮菌群落结构及产量的影响。通过田间试验,以清水处理作为对照(CK),叶面喷施浓度为50 mg/L的壳寡糖(CSOS)和纤维寡糖(COS),利用高通量测序技术,研究土壤中固氮菌群落结构组成及多样性分布特征,分析2种寡糖对土壤理化性质和花生产量指标的影响。(1)与CK相比,CSOS处理慢生根瘤菌属(Bradyrhizobium)、透明颤菌属(Vitreoscilla)、固氮氢自养单胞菌属(Azohydromonas)、固氮螺菌属(Azospirillum)、假单胞菌属(Pseudomonas)、眉藻属(Calothrix)和弗兰克氏菌属(Frankia),相对丰度显著增加分别为10.99%、45.63%、29.88%、23.24%、181.13%、27.75%和36.61%。COS处理固氮螺菌属(Azospirillum)、中华根瘤菌属(Sinorhizobium)和眉藻属(Calothrix)相对丰度显著增加分别为86.12%、664.41%和277.97%。(2)与CK相比,CSOS处理显著提高土壤中全氮和铵态氮含量,平均增幅分别为15.50%和20.19%。COS处理显著增加土壤中全氮、硝态氮和铵态氮,分别为17.05%、18.68%和27.58%;此外,CSOS和COS处理相较于CK,土壤p H均显著下降,分别下降了0.08和0.06。(3)CSOS和COS处理均显著增加花生产量,分别为19.3%和22.0%。因此,叶面喷施壳寡糖和纤维寡糖,可以调节花生根区土壤不同固氮菌属的相对丰度和影响土壤的理化因子(全氮、硝态氮和铵态氮),最终均显著提高花生产量。

关键词：壳寡糖纤维寡糖固氮菌花生产量

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Conversion therapy in liver transplantation for hepatocellular carcinoma:What's new in the era of molecular and immune therapy?

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 7-13页

作者： Chao Jiang Xiao-Dong Sun Wei Qiu Yu-guo Chen Da-Wei Sun guo-Yue lv General Surgery Center Department of Hepatobiliary and Pancreatic Surgerythe First Hospital of Jilin UniversityChangchun 130021China

Background:Hepatocellular carcinoma(HCC)is the sixth most common cancer globally,with limited therapies and unsatisfactory prognosis once in the advanced *** promising advances in locoregional and systematic treatments,fast development of targeted drugs,the success of immunotherapy,as well as the emergence of the therapeutic alliance,conversion therapy has recently become more well developed and an effective therapeutic *** article aimed to review recent developments in conversion therapy in liver transplantation(LT)for *** sources:We searched for relevant publications on Pub Med before September 2022,using the terms“HCC”,“liver transplantation”,“downstaging”,“bridging treatment”and“conversion therapy.”Results:Conversion therapy was frequently represented as a combination of multiple treatment modalities to downstage HCC and make patients eligible for *** combining various local and systematic treatments in conversion therapy is still controversial,growing evidence has suggested that multimodal combined treatment strategies downstage HCC in a shorter time,which ultimately increases the opportunities for ***,the recent breakthrough of immunotherapy and targeted therapy for HCC also benefit patients with advanced-stage ***:In the era of targeted therapy and immunotherapy,applying the thinking of transplant oncology to benefit HCC patients receiving LT is a new topic that has shed light on advanced-stage *** the expansion of conversion therapy concepts,further investigation and research is required to realize the full potential of conversion treatment strategies,including accurately selecting candidates,determining the timing of surgery,improving the conversion rate,and guaranteeing the safety and long-term efficacy of treatment.

关键词： Liver transplantation Hepatocellular carcinoma Conversion therapy Targeted therapy Immunotherapy Combination therapy

Details determining the success in establishing a mouse orthotopic liver transplantation model

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World Journal of Gastroenterology 2020年第27期26卷 3889-3898页

作者： Ting Li Zheng Hu Lei Wang guo-Yue lv Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina National-Local Joint Engineering Laboratory of Animal Models for Human Diseases Changchun 130061Jilin ProvinceChina Department of Gastrointestinal Surgery The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Liver transplantation(LT)is currently the only effective treatment option for endstage liver *** importance of animal models in transplantation is widely recognized among *** of the well-characterized mouse genome and the greater diversity and availability of both genetically modified animals and research reagents,mouse orthotopic LT(MOLT)has become an ideal model for the investigation of liver biology,tissue injury,regulation of alloimmunity and tolerance induction,and the pathogenesis of specific liver ***,due to its complicated and technically demanding procedure,the model has merely been used by only a few research groups in the world for *** a new learner,training lasting at least a couple of months or even years is *** of the investigators have emphasized the importance of elaborate techniques and dedicated instruments in establishing a MOLT model,but some details are often *** nontechnical details are also significant,especially for researchers who have little experience in mouse ***,we review and summarize the crucial technical and nontechnical details in establishing the model of MOLT based on scientific articles and our experience in six aspects:animal selection,anesthesia,perioperative management,organ procurement,back-table preparation,and implantation *** aim to enable research groups to shorten the learning curve and implement the mouse LT procedure with high technical success.

关键词： Mouse orthotopic liver transplantation Animal selection Anesthesia Perioperative management Organ procurement Back-table preparation Implantation surgery

Gastroretentive drug delivery systems for the treatment of Helicobacter pylori

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World Journal of Gastroenterology 2014年第28期20卷 9321-9329页

作者： Shan Zhao Yan lv Jian-Bin Zhang Bing Wang guo-Jun lv Xiao-Jun Ma Laboratory of Biomedical Material Engineering Dalian Institute of Chemical PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences

Helicobacter pylori (H. pylori) is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world’s population. It is the primary known cause of gastritis, gastroduodenal ulcer disease and gastric cancer. However, combined drug therapy as the general treatment in the clinic, the rise of antibiotic-resistant bacteria, adverse reactions and poor patient compliance are major obstacles to the eradication of H. pylori. Oral site-specific drug delivery systems that could increase the longevity of the treatment agent at the target site might improve the therapeutic effect and avoid side effects. Gastroretentive drug delivery systems potentially prolong the gastric retention time and controlled/sustained release of a drug, thereby increasing the concentration of the drug at the application site, potentially improving its bioavailability and reducing the necessary dosage. Recommended gastroretentive drug delivery systems for enhancing local drug delivery include floating systems, bioadhesive systems and expandable systems. In this review, we summarize the important physiological parameters of the gastrointestinal tract that affect the gastric residence time. We then focus on various aspects useful in the development of gastroretentive drug delivery systems, including current trends and the progress of novel forms, especially with respect to their application for the treatment of H. pylori infections.

关键词： Helicobacter pylori Gastroretentive systems Floating systems Bioadhesive systems Expandable systems