检索结果-南通市图书馆

Analysis of the History and Current Situation of the Development of General Practice Teaching Clinics in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Preventive Medicine 2024年第2期14卷 29-38页

作者： Xiaotong huo Yajun Lian Graduate School Changzhi Medical College Changzhi China Department of Family Medicine Peace Hospital Changzhi Medical College Changzhi China

A summary of the exploration of the teaching mode of the general practice teaching clinic, a summary of the deficiencies of the teaching clinic and a summary of the significance of the establishment of the general practice teaching clinic are presented with a view to promoting the development of general practice and cultivating more excellent successors in general practice.

关键词： General Practice Teaching Clinic Teaching Models Teaching Deficiencies in the Clinic Significance of the Teaching Clinic

Mulberry leaf supplementation inhibits skatole deposition by regulating gut microbiota and upregulating liver cytochrome P4501A1 expression in finishing pigs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2024年第1期16卷 34-44页

作者： Yuqing Sun Xiaoming Men Tianbao Lin Bo Deng Shi Zhong Jinxi huo Kaipeng Qin Zhiqiang Lv Ziwei Xu Yougui Li Institute of Sericulture and Tea Zhejiang Academy of Agricultural Sciences298 Deshengzhong RoadShangchengHangzhou 310021China Institute of Animal Husbandry and Veterinary Science Zhejiang Academy of Agricultural Sciences298 Deshengzhong RoadShangchengHangzhou 310021China

Skatole,a strong fecal odor substance,is generated through microbial degradation of tryptophan in the animal *** easily accumulates in adipose tissue and affects meat *** this study,the effect of mulberry leaf supplementation on skatole in finishing pigs was *** a 35-day trial,20 finishing pigs(barrows and gilts)were fed with a basal diet or basal diet with 6%mulberry *** performance of the pigs(n=10)was automatically recorded by a performance-testing feeder system and 8 pigs in each treatment were slaughtered and sampled for the remaining *** and short-chain fatty acids were detected using HPLC and gas chromatography,*** microbiota were analyzed using 16S r RNA gene *** metabolomics analysis of feces and serum was performed with UHPLC-MS/*** major cytochrome P450(CYP)enzymes that catalyze skatole degradation in the liver were tested by using RT-PCR and Western *** of major bioactive compounds in mulberry leaves on the CYP genes were verified in the hepatic cell line Hep G2 in an in vitro test(n=3).In finishing pigs,mulberry leaf supplementation had no significant effect on the average daily gain,average daily feed intake,and feed conversion ratio(P>0.05),but reduced skatole levels in feces,serum,and backfat(P<0.05),and increased acetic acid levels in feces(P=0.027).Mulberry leaf supplementation decreased the relative abundance of the skatole-producing bacteria Megasphaera and Olsenella(P<0.05).Indole-3acetic acid,the intermediate that is essential for skatole production,was significantly reduced in feces by mulberry leaf supplementation(P<0.05)and was positively correlated with skatole content in feces(P=0.004).In pigs treated with mulberry leaves,liver CYP1A1 expression was increased(P<0.05)and was negatively correlated with skatole content in backfat(P=0.045).The in vitro test demonstrated that mulberry leaf polyphenols and polysaccharides could directly stimulate CYP1A1 expression in

关键词： Pig Skatole Mulberry leaf Microbiota Cytochrome P450

Current collapse suppressed GaN diodes with 38 Watts high RF power rectifier capability

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第2期67卷 335-336页

作者： Kui DANG Zhilin QIU Shudong huo Peng ZHAN Huining LIU Yachao ZHANG Jing NING Hong ZHOU Jincheng ZHANG Key Lab of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian University Guangzhou Wide Bandgap Semiconductor Innovation Center Guangzhou Institute of TechnologyXidian University

Microwave power transmission(MPT) could realize the point-to-point long-distance transfer of energy without any wires, which makes it attractive for solar-powered satellites,drones, and implantable medical devices, and has aroused enormous attention [1]. Microwave rectifiers could convert RF(radio frequency) energy into DC(direct current) power,

关键词：

Linear shallow neural network to accelerate transmitter dispersion eye closure quaternary(TDECQ) assessment

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第4期67卷 337-338页

作者： Junjiang XIANG Zejun CHEN Yijun CHENG Hailin YANG Xuancheng huo Meng XIANG Gai ZHOU Yuwen QIN Songnian FU Institute of Advanced Photonics Technology School of Information EngineeringGuangdong University of Technology School of Optical and Electronic Information Huazhong University of Science and Technology Key Laboratory of Photonic Technology for Integrated Sensing and Communication Ministry of Education of ChinaGuangdong University of Technology Guangdong Provincial Key Laboratory of Information Photonics Technology Guangdong University of Technology

To support the ever-emerging capacity requirement of datacenter interconnection(DCI) applications, transmitter dispersion eye closure quaternary(TDECQ) has been proposed by IEEE802.3 standard [1], which is specifically employed for the four-level pulse amplitude modulation(PAM-4) signals. However, the traditional scheme of TDECQ assessment needs several iterative operations,

关键词： IEEE Standards

Incorporating metal nanoparticles in porous materials via selective heating effect using microwave

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 3175-3179页

作者： Yingyu Zhou Jiacheng Liu Fuyuan Sun Junchen Ouyang Ruifa Su Fanchen Meng Yongqi Luo Cheng Xu Weina Zhang Suoying Zhang Fengwei huo Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China

Metal nanoparticle@porous material composites have attracted increasing attention due to their excellent synergistic catalytic ***,it is a challenge to introduce metal nanoparticles into cavities of porous materials without agglomeration on the *** the progress achieved,a universal approach that can integrate different kinds of metal nanoparticles and porous materials is still highly *** we report a facile and general approach to fabricating metal nanoparticle@porous materials by microwave-triggered selective *** microwave can pass through the non-polar solvent and act on the polar solvent in the porous materials,causing the polar solvent to be heated,vaporized,and away from the pores of porous *** local void produced by the escape of polar solvent facilitates non-polar solvent containing metallic precursor to be dragged into the narrow pores,followed by further reduction,resulting in the complete encapsulation of nanoparticles.A series of metal nanoparticles@porous materials,ranging from metal-organic frameworks(MOFs)to zeolites,are successfully prepared by this method and show excellent size selectivity in catalytic reactions.

关键词： porous material nanoparticle encapsulation microwave synthesis selective heating effect selective catalysis

Flexible UV detectors based on in-situ hydrogen doped amorphous Ga_(2)O_(3) with high photo-to-dark current ratio

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Materials Futures 2024年第1期3卷 181-189页

作者： Yanxin Sui Huili Liang Wenxing huo Xiaozhi Zhan Tao Zhu Zengxia Mei Songshan Lake Materials Laboratory DongguanGuangdong 523808People’s Republic of China Institute of Physics Chinese Academy of SciencesBeijing 100190People’s Republic of China Department of Biomedical Engineering Tianjin University92 Weijin RoadTianjin 300072People’s Republic of China China Spallation Neutron Source DongguanGuangdong 523803People’s Republic of China

Amorphous Ga_(2)O_(3)(a-Ga_(2)O_(3))has been attracting more and more attention due to its unique merits such as wide bandgap(∼4.9 eV),low growth temperature,large-scale uniformity,low cost and energy efficient,making it a powerful competitor in flexible deep ultraviolet(UV)*** the responsivity of the ever-reported a-Ga_(2)O_(3)UV photodetectors(PDs)is usually in the level of hundreds of A/W,it is often accompanied by a large dark current due to the presence of abundant oxygen vacancy(VO)defects,which severely limits the possibility to detect weak signals and achieve versatile *** this work,the VO defects in a-Ga_(2)O_(3)thin films are successfully passivated by in-situ hydrogen doping during the magnetron sputtering *** a result,the dark current of a-Ga_(2)O_(3)UV PD is remarkably suppressed to 5.17×10^(-11) A at a bias of 5 ***,the photocurrent of the corresponding device is still as high as 1.37×10^(-3)A,leading to a high photo-to-dark current ratio of 2.65×107 and the capability to detect the UV light with the intensity below 10 nW cm^(-2).Moreover,the H-doped a-Ga_(2)O_(3)thin films have also been deposited on polyethylene naphtholate substrates to construct flexible UV PDs,which exhibit no great degradation in bending states and fatigue *** results demonstrate that hydrogen doping can effectively improve the performance of a-Ga_(2)O_(3)UV PDs,further promoting its practical application in various areas.

关键词： Ga_(2)O_(3) hydrogen doping ultraviolet photodetector photo-to-dark current ratio neutron reflection

Grain Yield,Biomass Accumulation,and Leaf Photosynthetic Characteristics of Rice under Combined Salinity-Drought Stress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rice science 2024年第1期31卷 118-128,I0023页

作者： WEI Huanhe GENG Xiaoyu ZHANG Xiang ZHU Wang ZHANG Xubin CHEN Yinglong huo Zhongyang ZHOU Guisheng MENG Tianyao DAI Qigen Jiangsu Key Laboratory of Crop Cultivation and Physiology/Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops/Key Laboratory of Saline-Alkali Soil Reclamation and Utilization in Coastal Areas the Ministry of Agriculture and Rural Affairs of China/Research Institute of Rice Industrial Engineering TechnologyYangzhou UniversityYangzhou 225009China Institute of Agricultural Science and Technology Development/Joint International Research Laboratory of Agriculture and Agri-Product Safety the Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China

Simultaneous stresses of salinity and drought often coincide during rice-growing seasons in saline lands,primarily due to insufficient water resources and inadequate irrigation ***,combined salinity-drought stress poses a major threat to rice *** this study,two salinity levels(NS,non-salinity;HS,high salinity)along with three drought treatments(CC,control condition;DJ,drought stress imposed at jointing;DH,drought stress imposed at heading)were performed to investigate their combined influences on leaf photosynthetic characteristics,biomass accumulation,and rice yield ***,drought,and their combination led to a shortened growth period from heading to maturity,resulting in a reduced overall growth *** yield was reduced under both salinity and drought stress,with a more substantial reduction under the combined salinity-drought *** combined stress imposed at heading caused greater yield losses in rice compared with the stress imposed at ***,the combined salinity-drought stress induced greater decreases in shoot biomass accumulation from heading to maturity,as well as in shoot biomass and nonstructural carbohydrate(NSC)content in the stem at heading and ***,it increased the harvest index and NSC remobilization *** and drought reduced the leaf area index and SPAD value of flag leaves and weakened the leaf photosynthetic characteristics as indicated by lower photosynthetic rates,transpiration rates,and stomatal *** reductions were more pronounced under the combined ***,drought,and especially their combination,decreased the activities of ascorbate peroxidase,catalase,and superoxide dismutase,while increasing the contents of malondialdehyde,hydrogen peroxide,and superoxide *** results indicated a more significant yield loss in rice when subjected to combined salinity-drought *** individual and combined stresses of salinity and dro

关键词： antioxidant defense system combined salinity-drought stress drought stress photosynthetic characteristics rice salinity stress

在线全文

学校读者我要写书评

暂无评论

“赛马制”科技项目全生命周期评估体系研究

科学学研究 2024年第9期42卷 1917-1927页

作者：郭琳娜闫冬霍竹科技部科技评估中心北京100081

“赛马制”是我国新型科研项目组织形式,国家和地方政府近年来不断实践,各方关注持续增加。然而,其正处于初期发展阶段,内涵、适用范围和评估方法等尚不明晰。通过分析国内外“赛马”实践案例,提出了政府资助“赛马制”项目内涵。通过... 详细信息

“赛马制”是我国新型科研项目组织形式,国家和地方政府近年来不断实践,各方关注持续增加。然而,其正处于初期发展阶段,内涵、适用范围和评估方法等尚不明晰。通过分析国内外“赛马”实践案例,提出了政府资助“赛马制”项目内涵。通过深入分析各类科技项目特点,对“赛马制”进行了分类并阐述了其在创新链上的适用范围。基于项目生命周期理论,阐明“赛马制”项目选题、立项、实施、成果转化与退出各阶段成功关键因素与管理要点。在上述研究的基础上,提出了项目各阶段对应的评估环节,构建了符合“赛马制”项目特点的评估框架体系。研究结果既可以指导管理者开展“赛马制”项目评估,也可以作为项目团队自查的工具。

关键词：赛马制项目生命周期指南评估里程碑考核绩效评估

Timosaponin AⅢ induces drug-metabolizing enzymes by activating constitutive androstane receptor (CAR) via dephosphorylation of the EGFR signaling pathway

在线全文

学校读者我要写书评

暂无评论

Journal of Biomedical Research 2024年第4期38卷 382-396页

作者： Muhammad Zubair Hafiz Jie Pan Zhiwei Gao Ying huo Haobin Wang Wei Liu Jian Yang Department of Pharmacology Nanjing Medical UniversityNanjingJiangsu 211166China

The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ)on drug-metabolizing enzymes during anticancer *** in vivo experiments were conducted on nude and ICR *** a 24-day administration of T-AⅢ,the nude mice exhibited an induction of CYP2B10,MDR1,and CYP3A11 expression in the liver *** the ICR mice,the expression levels of CYP2B10 and MDR1 increased after a three-day T-AⅢ *** in vitro assessments with HepG2 cells revealed that T-AⅢ induced the expression of CYP2B6,MDR1,and CYP3A4,along with constitutive androstane receptor(CAR)*** with CAR siRNA reversed the T-AⅢ-induced increases in CYP2B6 and CYP3A4 ***,other CAR target genes also showed a significant increase in the *** up-regulation of murine CAR was observed in the liver tissues of both nude and ICR *** findings demonstrated that T-AⅢ activated CAR by inhibiting ERK1/2 phosphorylation,with this effect being partially reversed by the ERK activator *** of the ERK1/2 signaling pathway was also observed in ***,T-AⅢ inhibited the phosphorylation of EGFR at Tyr1173 and Tyr845,and suppressed EGF-induced phosphorylation of EGFR,ERK,and *** the nude mice,T-AⅢ also inhibited EGFR *** results collectively indicate that T-AⅢ is a novel CAR activator through inhibition of the EGFR pathway.

关键词： timosaponin AⅢ CAR metabolism enzyme ERK1/2 signaling pathway EGFR signaling pathway