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Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice

Acta Pharmaceutica Sinica B 2021年第12期11卷 3779-3790页

作者： gundala venkata naveen kumar Keito Hoshitsuki Sanjay Rathod Manda J.Ramsey Lauren Kokai Erin E.Kershaw Wen Xie Christian A.Fernandez Department of Pharmaceutical Sciences and Center for Pharmacogenetics University of Pittsburgh School of PharmacyPittsburghPA 15261USA Division of General Internal Medicine University of Pittsburgh School of MedicinePittsburghPA 15261USA Department of Plastic Surgery University of Pittsburgh and the McGowan Institute for Regenerative MedicinePittsburghPA 15261USA University of Pittsburgh Division of EndocrinologyDepartment of MedicinePittsburghPA 15261USA

PEGylated-L-asparaginase(PEG-ASNase)is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia(ALL).Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis,with obesity and older age considered risk factors of the *** study aims to elucidate the mechanism of PEG-ASNase-induced liver *** received 1500 U/kg of PEG-ASNase and were sacrificed 1,3,5,and 7 days after drug *** triglycerides were quantified,and plasma bilirubin,ALT,AST,and non-esterified fatty acids(NEFA)were *** mRNA and protein levels of genes involved in hepatic fatty acid synthesis,β-oxidation,very low-density lipoprotein(VLDL)secretion,and white adipose tissue(WAT)lipolysis were *** developed hepatic steatosis after PEG-ASNase,which associated with increases in bilirubin,ALT,and *** hepatic genes Ppara,Lcad/Mcad,Hadhb,Apob100,and Mttp were upregulated,and Srebp-1 c and Fas were downregulated after *** plasma NEFA,WAT loss,and adipose tissue lipolysis were also observed after ***,we found that PEG-ASNase-induced liver injury was exacerbated in obese and aged mice,consistent with clinical studies of ASNase-induced liver *** data suggest that PEG-ASNase-induced liver injury is due to drug-induced lipolysis and lipid redistribution to the liver.

关键词： Liver injury Leukemia Asparaginase Lipolysis Adverse drug reaction Adipose tissue Hepatic steatosis Amino acid response

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Cool white light and tunable multicolor emission from Tb^(3+)/Dy^(3+)co-activated glasses under different excitations for WLEDs

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Journal of Rare Earths 2024年第1期42卷 46-56,I0002页

作者： L.Vijayalakshmi K.naveen kumar Jong Dae Baek Department of Automotive Engineering Yeungnam UniversityGyeongsanGyeongbuk38541Republic of Korea Department of Mechanical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

A set of co-doped(Tb^(3+)/Dy^(3+))lithium zinc borate(LZB)glasses were developed by melt *** structural evaluation was performed for synthesized glassy *** Dy^(3+)and Tb^(3+)individually doped glasses exhibit intense yellow and green luminescence bands at 575 nm(^(4)F_(9/2)→^(6)H_(13/2))and543 nm(^(5)D_(4)→^(7)F_(5)),*** sensitization effect of Dy^(3+)on Tb^(3+)was analyzed by increasing the Tb^(3+)content with respect to the optimum Dy^(3+)content(0.5 mol%)in Dy^(3+)/Tb^(3+).The spectral overlay of Dy^(3+)luminescence and Tb^(3+)absorption profiles,Dy^(3+)/Tb^(3+)PL spectra under different excitations 352,362,376,and 385 nm,shortening decay lifetimes of Dy^(3+)in Dy^(3+)/Tb^(3+)co-activated glasses,energy transfer(ET)parameters,chromaticity coordinates and their corresponding correlated temperatures all help to explain ET from Dy^(3+)to Tb^(3+).At 385 nm of Dy^(3+)excitation,the optimized co-activated(0.5Dy^(3+)+1.0Tb^(3+)):LZB glass displays cool white light *** non-radiative ET from Dy^(3+)to Tb^(3+)is dominated by electric dipole-dipole interaction and its ET efficiency was calculated to be 63%.At the same time,reverse ET from Tb^(3+)to Dy^(3+)was also *** shift in color coordinates from dominant yellow to greenish-yellow,green and white light emission suggests that Dy^(3+)/Tb^(3+)coactivated LZB glasses can be a potential candidate for UV converted multicolor and white light emitting devices.

关键词： Rare earths Photoluminescence Energy transfer Spectral overlap Decay lifetime Multicolor emitting LEDs

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Advancing orthopaedic trauma care through WhatsApp:An analysis of clinical and non-clinical applications,challenges,and future directions

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World Journal of Orthopedics 2024年第6期15卷 529-538页

作者： Ravi Saini Madhan Jeyaraman naveen Jeyaraman Vijay kumar Jain Swaminathan Ramasubramanian Karthikeyan P Iyengar Department of Orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr Ram Manohar Lohia HospitalNew Delhi 110001India Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Trauma and Orthopaedics Southport and Ormskirk HospitalsMersey and West Lancashire Teaching NHS TrustSouthport PR86PNUnited Kingdom

The integration of WhatsApp,a widely-used instant messaging application(IMA),into the realm of orthopaedics and trauma surgery has emerged as a significant development in recent *** paper explores the multifaceted role of WhatsApp in orthopaedics,focusing on its clinical and non-clinical applications,advantages,disadvantages,and future *** study synthesizes findings from various research papers,emphasizing the growing reliance on mobile technology in ***’s role in orthopaedics is notable for its ease of use,real-time communication,and ***,it facilitates triage,teleconsultation,diagnosis,treatment,patient advice,and post-operative ***-clinically,it supports telemedicine,teleradiology,virtual frac-ture clinics,research,and education in orthopaedic *** application has proven beneficial in enhancing communication among healthcare teams,providing quick responses,and motivating junior *** use in educational settings has been shown to improve learner’s understanding and patient ***,the use of WhatsApp in orthopaedics is not without *** include the potential spread of misleading information,privacy concerns,and issues with image quality affecting diagnosis and treatment *** paper acknowledges the importance of maintaining professional boundaries and the need for oversight measures to ensure content *** forward,the potential of WhatsApp and similar IMAs in orthopaedics lies in their ability to streamline data collection and retrieval,improve doctor-patient communication,and address challenges like bureaucratic red tape and limited *** paper suggests that future orthopaedic practice,particularly in emergency departments,will increasingly rely on such technologies for efficient patient *** shift,however,must be approached with an understanding of the ethical,legal,and practical implications of integrating social media and mobile

关键词： Social media WhatsApp Orthopaedics Trauma Research

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Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman naveen Jeyaraman Tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan Saurabh kumar Jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United *** Both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and B *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

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Linear and nonlinear propagation characteristics of multi-Gaussian laser beams

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Chinese Physics B 2020年第11期29卷 370-379页

作者： naveen Gupta Sandeep kumar Lovely Professional University PhagwaraIndia

Theoretical investigation on the propagation characteristics of a new class of laser beams known as multi Gaussian(M.G)laser beams has been *** investigate the linear characteristics,propagation of the laser beam in vacuum has been ***,the nonlinear characteristics have been investigated in *** nonlinearity of the plasma has been modeled by relativistic mass nonlinearity of the plasma electrons in the field of laser *** is based on finding the semi analytical solution of the wave equation for the slowly varying envelope of the laser ***,the dynamical evolutions of the beam width and longitudinal phase of the laser beam have been investigated in detail.

关键词： self-focusing multi Gaussian self phase modulation self-channeling

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Strategy and Future Prospects to Develop Room-Temperature-Recoverable NO2 Gas Sensor Based on Two-Dimensional Molybdenum Disulfide

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Nano-Micro Letters 2021年第2期13卷 305-362页

作者： Abhay V.Agrawal naveen kumar Mukesh kumar Functional and Renewable Energy Materials Laboratory Indian Institute of Technology RoparRupnagarPunjab 140001India

Nitrogen dioxide(NO2),a hazardous gas with acidic nature,is continuously being liberated in the atmosphere due to human *** NO2 sensors based on traditional materials have limitations of high-temperature requirements,slow recovery,and performance degradation under harsh environmental *** limitations of traditional materials are forcing the scientific community to discover future alternative NO2 sensitive *** disulfide(MoS2)has emerged as a potential candidate for developing next-generation NO2 gas ***2 has a large surface area for NO2 molecules adsorption with controllable morphologies,facile integration with other materials and compatibility with internet of things(IoT)*** aim of this review is to provide a detailed overview of the fabrication of MoS2 chemiresistance sensors in terms of devices(resistor and transistor),layer thickness,morphology control,defect tailoring,heterostructure,metal nanoparticle doping,and through light ***,the experimental and theoretical aspects used in designing MoS2-based NO2 sensors are also discussed ***,the review concludes the challenges and future perspectives to further enhance the gas-sensing performance of *** and addressing these issues are expected to yield the development of highly reliable and industry standard chemiresistance NO2 gas sensors for environmental monitoring.

关键词： MoS2 NO2 gas sensors Light illumination Heterojunction

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Current understanding of the impact of COVID-19 on gastrointestinal disease:Challenges and openings

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World Journal of Gastroenterology 2021年第6期27卷 449-469页

作者： Tarun Sahu Arundhati Mehta Yashwant kumar Ratre Akriti Jaiswal naveen kumar Vishvakarma Lakkakula venkata Kameswara Subrahmanya Bhaskar Henu kumar Verma Department of Physiology All India Institute of Medical ScienceRaipur 492001ChhattisgarhIndia Department of Biotechnology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia Department of Zoology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia Developmental and Stem Cell Biology Lab Institute of Experimental Endocrinology and Oncology CNRNaplesCampania 80131Italy

The novel coronavirus disease-2019(COVID-19)is caused by a positive-sense single-stranded RNA virus which belongs to the Coronaviridae *** March 2019 the World Health Organization declared that COVID-19 was a ***-19 patients typically have a fever,dry cough,dyspnea,fatigue,and *** patients also report gastrointestinal(GI)symptoms,including diarrhea,nausea,vomiting,and abdominal pain,as well as liver enzyme ***,many studies have found severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral RNA in rectal swabs and stool specimens of asymptomatic COVID-19 *** addition,viral receptor angiotensin-converting enzyme 2 and transmembrane protease serine-type 2,were also found to be highly expressed in gastrointestinal epithelial cells of the intestinal ***,SARS-CoV-2 can dynamically infect and replicate in both GI and liver *** together these results indicate that the GI tract is a potential target of ***,the present review summarizes the vital information available to date on COVID-19 and its impact on GI aspects.

关键词： SARS-CoV-2 COVID-19 Gastrointestinal symptoms Recommendation Diagnosis Therapeutics

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Effect of different geometrical non-uniformities on nonlinear vibration of porous functionally graded skew plates: A finite element study

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Defence Technology（防务技术） 2022年第6期18卷 918-936页

作者： H.S.naveen kumar Subhaschandra Kattimani Department of Mechanical Engineering National Institute of Technology KarnatakaSurathkal575025India

This article presents the investigation of nonlinear vibration analysis of tapered porous functionally graded skew(TPFGS)plate considering the effects of geometrical non-uniformities to optimize the thickness in the structural *** TPFGS plate is analyzed considering linearly,bi-linearly,and exponentially varying *** plate’s effective material properties are tailor-made using a modified power-law distribution in which gradation varies along the thickness direction of the TPFGS *** the non-linear finite element formulation to develop the kinematic equation’s displacement model for the TPFGS plate is based on the first-order shear deformation theory(FSDT)in conjunction with von Karman’s *** nonlinear governing equations are established by Hamilton’s *** direct iterative method is adopted to solve the nonlinear mathematical relations to obtain the nonlinear *** influence of the porosity distributions and porosity parameter indices on the nonlinear frequency responses of the TPFGS plate for different skew angles and variable thicknesses are studied for various geometrical *** influence of taper ratio,variable thickness,skewness,porosity distributions,gradation,and boundary conditions on the plate’s nonlinear vibration is *** nonlinear frequency analysis reveals that the geometrical nonuniformities and porosities significantly influence the porous functionally graded plates with varying thickness than the uniform ***,exponentially and linearly variable thicknesses can be considered for the thickness optimizations of TPFGS plates in the structural design.

关键词： Functionally graded material Shear deformation theory Porosity distributions Variable thickness Geometrical skewness Nonlinear free vibration

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Power system reconfiguration and loss minimization for a distribution systems using ＂Catfish PSO＂ algorithm

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Frontiers in Energy 2014年第4期8卷 434-442页

作者： K Sathish kumar S naveen School of Electrical Engineering VIT University Vellore 632014 India

One of the very important ways to save electrical energy in the distribution system is network reconfiguration for loss reduction. Distribution networks are built as interconnected mesh networks; however, they are arranged to be radial in operation. The distribution feeder reconfiguration is to find a radial operating structure that optimizes network performance while satisfying operating constraints. The change in network configuration is performed by opening sectionalizing （normally closed） and closing tie （normally opened） switches of the network. These switches are changed in such a way that the radial structure of networks is maintained, all of the loads are energized, power loss is reduced, power quality is enhanced, and system security is increased. Distribution feeder reconfiguration is a complex nonlinear combinator- ial problem since the status of the switches is non- differentiable. This paper proposes a new evolutionary algorithm （EA） for solving the distribution feeder reconfiguration （DFR） problem for a 33-bus and a 16- bus sample network, which effectively ensures the loss minimization.

关键词： distribution system reconfiguration (DFR),power loss reduction catfish particle swarm optimization(catfish PSO) radial structure

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Security Attacks in Named Data Networking: A Review and Research Directions

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Journal of Computer Science & Technology 2019年第6期34卷 1319-1350页

作者： naveen kumar Ashutosh kumar Singh Abdul Aleem Shashank Srivastava Department of Computer Science and Engineering Motilal Nehru National Institute of Technology Allahabad Prayagraj 211004India

Contents such as audios,videos,and images,contribute most of the Internet traffic in the current *** content sharing is a tedious *** existing security solutions do not secure data but secure the communicating *** data networking(NDN)secures the data by enforcing the data publisher to sign the *** user can verify the data by using the public key of the *** is resilient to most of the probable security attacks in the TCP/IP model due to its new ***,new types of attacks are possible in *** article surveys the most significant security attacks in NDN such as interest flooding attacks,cache privacy attacks,cache pollution attacks,and content poisoning *** attack is classified according to their behavior and discussed for their detection techniques,countermeasures,and the affected *** article is an attempt to help new researchers in this area to gather the domain knowledge of *** article also provides open research issues that could be addressed by researchers.

关键词： named data networking(NDN) interest flooding attack cache privacy attack cache pollution attack content poisoning attack

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