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Follow-up strategy for early detection of delayed pseudoaneurysms in patients with blunt traumatic spleen injury: A single-center retrospective study

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3163-3170页

作者： Sung Hoon Cho gun woo kim Suyeong Hwang Kyoung Hoon Lim Department of Surgery Trauma CenterKyungpook National University HospitalSchool of MedicineKyungpook National UniversityDaegu 41944South Korea

BACKGROUND The spleen is the most commonly injured solid organ in blunt abdominal trauma,and splenic pseudoaneurysm rupture is associated with a high risk of *** management has become the standard treatment for hemodynam-ically stable patients with splenic *** the other hand,delayed splenic pseudoaneurysms can develop in any patient,and at present,there are no known risk factors that may reliably predict their ***,there is a lack of consensus regarding the most appropriate strategies for monitoring and mana-ging splenic injuries,especially lower-grade(I-III).AIM To determine the predictors of pseudo-aneurysm formation following splenic injury and develop follow-up strategies for early detection of *** We retrospectively analyzed patients who visited the Level I Trauma Center bet-ween January 2013 and December 2022 and were diagnosed with spleen injuries after blunt abdominal *** Using the American Association for the Surgery of Trauma spleen injury scale,the splenic injuries were categorized into the following order based on severity:Grade I(n=57,17.6%),grade II(n=114,35.3%),grade III(n=89,27.6%),grade IV(n=50,15.5%),and grade V(n=13,4.0%).Of a total of 323 patients,35 underwent splenectomy and 126 underwent angioembolization.19 underwent delayed angioembolization,and 5 under-went both initial and delayed *** 14 patients who had undergone delayed angioembolization,no extravasation or pseudoaneurysm was observed on the initial computed tomography *** are no particular patient-related risk factors for the formation of a delayed splenic pseudoaneurysm,which can occur even in a grade I spleen injury or even 21 days after the *** mean detection time for a delayed pseudoaneurysm was 6.26±5.4(1-21,median:6,inter-quartile range:2-9)*** We recommend regular follow-up computed tomography scans,including an arterial and portal venous phase,at least 1 week an

关键词： Blunt trauma Spleen injury Delayed pseudoaneurysm Angioembolization Nonoperative management

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Ultrasound-triggered three dimensional hyaluronic acid hydrogel promotes in vitro and in vivo reprogramming into induced pluripotent stem cells

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Bioactive Materials 2024年第8期38卷 331-345页

作者： Deogil kim Min-Ju Lee Yoshie Arai Jinsung Ahn gun woo Lee Soo-Hong Lee Department of Biomedical Engineering Dongguk University-Seoul04620SeoulSouth Korea

Cellular reprogramming technologies have been developed with different physicochemical factors to improve the reprogramming efficiencies of induced pluripotent stem cells(iPSCs).Ultrasound is a clinically applied noncontact biophysical factor known for regulating various cellular behaviors but remains uninvestigated for cellular ***,we present a new reprogramming strategy using low-intensity ultrasound(LIUS)to improve cellular reprogramming of iPSCs in vitro and in *** 3D microenvironment conditions,increased LIUS stimulation shows enhanced cellular reprogramming of the *** cellular reprogramming process facilitated by LIUS is accompanied by increased mesenchymal to epithelial transition and histone *** stimulation transiently modulates the cytoskeletal rearrangement,along with increased membrane fluidity and mobility to increase HA/CD44 ***,LIUS stimulation with HA hydrogel can be utilized in application of both human cells and in vivo environment,for enhanced reprogrammed cells into ***,LIUS stimulation with a combinatorial 3D microenvironment system can improve cellular reprogramming in vitro and in vivo environments,which can be applied in various biomedical fields.

关键词： Induced pluripotent stem cell Cellular reprogramming Low-intensity ultrasound Biophysical stimulation Cytoskeletal rearrangement

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Real-time and label-free biosensing using moiré pattern generated by bioresponsive hydrogel

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Bioactive Materials 2023年第5期23卷 383-393页

作者： Semin kim Geehong kim Yong woo Ji Chae-Eun Moon Yuna Jung Hyung Keun Lee JaeJong Lee Won-gun Koh Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul120-749Republic of Korea Korea Institute of Machinery&Materials Nano-Convergence Mechanical Systems Research Division156 Gajeongbuk-roYuseong-guDaejeon34103Republic of Korea Department of Ophthalmology Yongin Severance HospitalYonsei University College of Medicine363Dongbaekjukjeon-daeroGiheung-guYongin-siGyeonggi-do16995Republic of Korea Institute of Vision Research Department of OphthalmologyYonsei University College of Medicine50-1 Yonsei-roSeodaemun-guSeoul120-749Republic of Korea Department of Ophthalmology Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineRepublic of Korea College of Pharmacy Yonsei University85 Songdo Hwawak-roYeonsu-guIncheon26426Republic of Korea Department of Ophthalmology Gangnam Severance HospitalYonsei University College of Medicine211 Eonju-roGangnam-guSeoul06273Republic of Korea Department of Nanomechatronics University of Science and Technology217Gajeong-roYuseong-guDaejeon 34113Republic of Korea

Bioresponsive hydrogels are smart materials that respond to various external stimuli and exhibit great potential as biosensors owing to their capability of real-time and label-free ***,we propose a sensing platform based on bioresponsive hydrogels,employing the concept of moiré *** sets of line patterns with different pitch sizes are prepared;a hydrogel grating whose pitch size changes according to external stimuli and a reference grating with constant pitch *** volume changes of the hydrogel caused by external stimuli changes the pitch size of the hydrogel grating,and subsequently,the pitch sizes of the moiré patterns(moiré signal),whose values can be obtained in a real-time and label-free manner through customized moiré microscopy and signal *** confirming that the pH-induced swelling of hydrogel could be monitored using moiré patterns,we performed moiré pattern-based detection of specific proteins using protein-responsive hydrogel that underwent shrinking via interaction with target ***-derived neurotrophic factor and platelet-derived growth factor were selected as the model proteins,and our proposed system successfully detected both proteins at nanomolar *** both cases,the pitch size change of hydrogel grating was monitored much more sensitively using moiré patterns than through direct *** changes in the moiré signals caused by target proteins were detected in ex-vivo environments using a custom-made intraocular lens incorporating the hydrogel grating,demonstrating the capability of the proposed system to detect various markers in intraocular aqueous humor,when implanted in the eye.

关键词： Bioresponsive hydrogel Moirépattern Biosensing Intraocular lens Aqueous humor

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Extracellular vesicles for neural regeneration after spinal cord injury

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Neural Regeneration Research 2024年第3期19卷 491-492页

作者： Young-Ju Lim wook-Tae Park gun woo Lee Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaeguKorea

What is spinal cord injury:Spinal cord injury(SCI)is the damage to the structure of the bundles of cells and nerves that communicate signals from the brain to the body and *** pathology of SCI includes both primary and secondary injuries(Morales et al.,2016).Physical forces such as compression,shearing,contusion,and tearing are major causes of primary injury in *** are two main processes in primary injury:acute and *** acute phase includes traumatic disruption of axons and hemorrhage of the blood vessels around the spinal *** injury to the vessels can lead to increased edema within the neural and cord tissues,susceptibility to infiltration by microglia and astrocytes,excitotoxicity,and ***,disruption of the blood-spinal cord barrier results in the release of inflammatory cytokines from specific cells and vessels.

关键词： acute injuries nerves

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Antioxidant and anticancer activity of Artemisia princeps *** extract in HepG2 and Hep3B hepatocellular carcinoma cells

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Chinese Journal of Cancer Research 2013年第5期25卷 536-543页

作者： Eun-Jeong Choi gun-Hee kim Plant Resources Research Institute Duksung Women's University

Objective：The aim of the present study was to investigate antioxidant and the anticancerigen activity of a methanol extract from Artemisia princeps *** （APME）,a well-known traditional herbal medicine in Asia,in hepatocellular cancer ***：To evaluate the antioxidant activity of APME,reactive oxygen species （ROS） and the antioxidant enzymes,superoxide dismutase （SOD） and catalase were investigated in HepG2 cells exposed to APME （5,100,and 200 μg/mL） for 72 ***,to evaluate the anticancer activity of APME,we investigated the proliferation and apoptosis induction of HepG2 and Hep3B cells exposed to APME （1-200 μg/mL） for 24,48,and 72 ***：APME dose-dependently reduced the generation of ROS in the presence of H2O2 compared with control ***,it increased catalase and SOD ***,APME inhibited cell proliferation in a dose-and time-dependcnt manner,but at concentrations lower than 100 μg/mL,the inhibition was less dose-dependent than ***2 and Hep3B cells exposed to 5,100,and 200 μg/mL APME for 72 h underwent cell cycle arrest and *** to APME resulted in a significant increase in the number of cells in G1 phase and a decrease in the G2/M phase cell *** addition,APME induced P53 expression of HepG2 cells in a dose-dependent manner,and played a role in the downregulation of Bcl-2 and upregulation of Bax in both HepG2 and Hep3B ***：These results indicate the potential role of APME as an antioxidant and anticancerigen agent in hepatocarcinoma cell lines.

关键词： Artemisia princeps var.orientalis antioxidant anticancer hepatocellular carcinoma

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Contrast evaluation methods for natural color images in display systems: within- and cross-content evaluations

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第11期12卷 897-909页

作者： Choon-woo kim School of Information and Communication Engineering Inha University

Contrast evaluation can be used as a criterion to evaluate performance of contrast enhancement algorithms and to compare contrast capability of display systems. This paper deals with contrast evaluation models for natural color images. Two separate models are defined for within- and cross-content evaluations. The former is to differentiate the perceived contrast of the images with the same content. The latter is to discriminate the differences in contrast among the images with different contents. Perception mechanisms are quite different for within- and cross-content evaluations. Local contrast plays an important role in within-content evaluation. In contrast, global contrast dominates the contrast perception for cross-content evaluation. Results of human visual experiments show that the proposed evaluation models outperform previous methods for both within- and cross-content evaluations.

关键词： Contrast evaluation Global contrast Local contrast Within content Cross content Statistical significance

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The Characteristics of CLHS Driving for High Luminance Efficiency in AC PDP

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Plasma Science and Technology 2016年第11期18卷 1116-1122页

作者： gun-Su kim Chi-Hyung AHN Seok-Hyun LEE Department of Electrical and Electronic Engineering Youngsan UniversityYangsanGyeongnam 50510Korea Korea Railroad Research Institute Uiwang Gyeonggi 16105Korea School of Electrical Engineering Inha UniversityIncheon 22212Korea

This paper proposes a CLHS （Capacitor Less Half Sustain） driving method that is applied to a long gap panel to reduce the power consumption. In order to reduce the power consumption in moving images, the luminous efficiency should be improved at the low discharge load （〈25%）. The weight of reactive power consumption tends to increase as the low discharge load decreases. Thus, it is very important to improve the luminous efficiency at low discharge load. It is well known that a long gap panel improves the luminance and the luminous efficiency but it is very difficult to drive the panel due to high driving voltage. It is confirmed that the main factors which cause a long gap panel to increase the minimum driving voltages are not only a long discharge gap but also self-erasing discharge. Self-erasing discharge is generated between the address and sustain electrodes in a sustain period. The CLHS driving method can reduce the reactive power consumption in a sustain period because energy recovery capacitors were removed in the sustain circuit. The CLHS driving method can reduce the minimum driving voltage of the long gap panel because the self-erasing discharge was prevented. When the CLHS driving method was applied to the panel with an ITO gap of 100 μm, Vs and VA minimum voltages are reduced by about 9 V and 12 V compared with those of the normal driving method. The luminance and the luminous efficiency also increased by about 24.3% and 33.3% at the discharge load of 4% compared with those at the normal condition.

关键词： PDP plasma long gap CLHS

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Effect of change of sand properties on travel distance of ricocheted debris

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Defence Technology（防务技术） 2021年第4期17卷 1486-1495页

作者： Yoon Keon kim woo Chun Choi Department of Mechanical Engineering Korea University145 Anam-roSeongbuk-guSeoul02841Republic of Korea

The debris from exploded buildings can ricochet after colliding with the ground,thus increasing the debris travel distance and danger from any associated impacts or *** reduce this danger,the travel distance of ricocheted debris must be accurately *** study analyzed the change in the travel distance of ricocheted concrete debris relative to changes in the properties of a sand *** shear tests were conducted to measure the change in internal friction angle as a function of temperature and water content of the *** element analysis(FEA)was then applied to these variables to predict the speed and angle of the debris after *** FEA results were compared with results of low-speed ricochet experiments,which employed variable temperature and water *** travel distance of the debris was calculated using MATLAB,via trajectory equations considering the drag *** the internal friction angle decreased,the shear stress decreased,leading to deeper penetration of the debris into the *** the loss of kinetic energy increased,the velocity and travel distance of the ricocheted debris *** in the ricochet velocity and travel distance of the debris,according to changes in the internal friction angle,indicated that the debris was affected by the environment.

关键词： Ricochet Exploded debirs Environmental change Sand Temperature Water content Internal friction angle Travel distance

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Characteristics of machined surface controlled by cutting tools and conditions in machining of brittle material

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中国有色金属学会会刊：英文版 2009年第B9期19卷 194-201页

作者： Yong-woo kim Soo-Chang CHOI Jeung-woo PARK Deug-woo LEE Department of Nano Fusion Technology Pusan National University Department of Mechanical Design Engineering Chosun University Department of Nanosystem and Nanoprocess Engineering Pusan National University

One of the ultra-precision machining methods was adapted for brittle material as well as soft material by using multi-arrayed diamond tips and high speed spindle. Conventional machining method is too hard to control surface roughness and surface texture against brittle material because the particles of grinding tools are irregular size and material can be fragile. Therefore, we were able to design tool paths and machine controlled pattern on surface by multi-arrayed diamond tips with uniform size made in MEMS fabrication and high speed spindle, and the maximum speed was about 3×105 r/min. We defined several parameters that can affect the machining surface. Those were multi-array of diamond tips (n×n), speed of air spindle and feeding rate. The surface roughness and surface texture can be controlled by those parameters for micro machining.

关键词：加工表面脆性材料条件控制刀具路径表面粗糙度特征高速主轴加工方法

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Parasitic Robot System for Waypoint Navigation of Turtle

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Journal of Bionic Engineering 2017年第2期14卷 327-335页

作者： Dae-gun kim Serin Lee Cheol-Hu kim Sungho Jo Phill-Seung Lee Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) 373-1 Guseong-dong Yuseong-gu Daejeon 34141 Republic of Korea Institute for Infocomm Research 1 Fusionopolis Way #21-01 Connexis Singapore Department of Computer Science Korea Advanced Institute of Science and Technology (KAIST) 373-1 Guseong-dong Yuseong-gu Daejeon 34141 Republic of Korea

In research on small mobile robots and biomimetic robots, locomotion ability remains a major issue despite many advances in technology. However, evolution has led to there being many real animals capable of exceUent locomotion. This paper presents a ＂parasitic robot system＂ whereby locomotion abilities of an animal are applied to a robot task. We chose a turtle as our first host animal and designed a parasitic robot that can perform ＂operant conditioning＂. The parasitic robot, which is attached to the turtle, can induce object-tracking behavior of the turtle toward a Light Emitting Diode （LED） and positively reinforce the behavior through repeated stimulus-response interaction. After training sessions over five weeks, the robot could successfully control the direction of movement of the trained turtles in the waypoint navigation task. This hybrid animal-robot interaction system could provide an alternative solution to some of the limitations of conventional mobile robot systems in various fields, and could also act as a useful interaction system for the behavioral sciences.

关键词： parasitic robot operant conditioning waypoint navigation red-eared slider trachemys scripta elegans

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