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Differences in parents of pediatric liver transplantation and chronic liver disease patients

World Journal of Clinical Cases 2020年第11期8卷 2162-2172页

作者： Sami Akbulut gulsen gunes Hasan Saritas Bahar Aslan Yunus Karipkiz Khaled Demyati Sukru Gungor Sezai Yilmaz Department of Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey Department of Public Health Inonu University Faculty of MedicineMalatya 44280Turkey Department of Surgical Nursing Inonu University Faculty of Nursing'sMalatya 44280Turkey Department of Nursing Care Inonu University Faculty of Medicine Malatya 44280Turkey Department of Surgery An-Najah National University HospitalAn-Najah National UniversityNablus 11941Palestin Department of Pediatric Gastroenterology Inonu University Faculty of MedicineMalatya 44280Turkey

BACKGROUND With advancements in the treatment of chronic liver disease(CLD),including liver transplantation(LT),quality of life and satisfaction after LT have become an important issue for pediatric patients and their *** evidence-based information is needed to describe and assess the impact of pediatric CLD on parents and the satisfaction of parents with treatment to better understand their *** To assess the satisfaction of parents of pediatric LT patients and that of parents of pediatric CLD patients METHODS During this survey,data were collected from parents of pediatric patients who underwent LT between January 2010 and April 2017(LT group;n=91)and parents of pediatric patients with chronic liver disease(CLD group;n=94).Group comparisons were made based on the pediatric health-related quality of life(PedsQL)health care parent satisfaction scale,impact on family scale(IFS)and demographic *** PedsQL was administered to parents during a phone interview and the results were used to assess the health carerelated satisfaction of *** IFS was used to assess the impact of the child’s CLD status on the *** variables such as education level(elementary vs middle vs high vs university),monthly income(low vs middle vs high),and place of residence(village vs town vs city)were compared between CLD and LT parent ***,PedsQL and IFS results were also analyzed according to demographic *** A total of 185 parents aged 19 to 65 years were *** were statistically significant differences between the LT and CLD groups in terms of career(P<0.001),monthly income(P=0.016),and education level(P=0.041).According to the PedsQL results,family inclusion,communication,technical skills,emotional needs,and overall satisfaction were significantly different between the groups;the LT group had consistently higher scores(P<0.001).Additionally,scores for the IFS parameters of financial impact,familial-social impact,

关键词： Liver transplantation Pediatric liver transplantation Chronic liver disease Parent satisfaction Health-related quality of life health care parent satisfaction scale Impact on family scale

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Transfer of single dose of intravitreal injection of ranibizumab and bevacizumab into milk of sheep

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1069-1075页

作者： Tugba Cakmak Argun Ozlem Yalcin Tok Levent Tok gulsen Yilmaz Fatma Meric Yilmaz Alime gunes Mehmet Argun Osman Butuner Department of Ophthalmology Hatay Dortyol State Hospital Faculty of Medicine Ophthalmology Suleyman Demirel University Ministry of Health Ankara HospitalBiochemistry Biochemistry Department Faculty of MedicineYildirim Beyazit University The Management of Veterinary Service

AIM： To investigate whether single-dose intravitreal injections of bevacizumab and ranibizumab transfer into milk. METHODS： This study included lactating 12 sheep and a single 3-month old suckling lamb of each sheep. Two groups consisting of 6 sheep and their lambs were constituted; the ranibizumab group and the bevacizumab group before the administration of intravitreal injections, blood and milk samples were obtained from all sheep and, following the injections, blood and milk samples of all sheep and blood samples of all lambs were collected at regular time points. Serum and milk concentrations of bevacizumab and ranibizumab were measured using an enzyme-linked immunosorbent assay（ELISA） kit. The limit of determination was 0.9 ng/m L for bevacizumab and 0.62 ng/m L for ***： At 6h after intravitreal injections, bevacizumab concentration was above the limit of determination in the blood of all sheep. At 3wk, when the study was terminated, bevacizumab concentrations were high in 4 sheep. Even though bevacizumab concentrations in milk showed fluctuations, the drug transferred into the milk of all sheep at detectable concentrations. Ranibizumab drug concentrations in the blood and milk of sheep and those in the blood of lambs were below the limit of determination by the ELISA ***： This sheep model study demonstrate that intravitreal injection of ranibizumab, which did not transfer into the milk of sheep and suckling lambs, is safer than bevacizumab during lactation period.

关键词： bevacizumab ranibizumab lactation milk vascular endothelial growth factor

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