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Blockade of Syk modulates neutrophil immune-responses via the mTOR/RUBCNL-dependent autophagy pathway to alleviate intestinal inflammation in ulcerative colitis

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Precision Clinical Medicine 2023年第4期6卷 213-225页

作者： Fengqin Zhu Dehuai jing Huihui Zhou Zongjing Hu Yan Wang guiyuan jin Yonghong Yang Guangxi Zhou Department of Gastroenterology Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China Medical Research Center Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China

Background:Ulcerative colitis(UC)is a progressive chronic inflammatory *** play a critical role in regulating in-testinal mucosal homeostasis in *** tyrosine kinase(Syk)is involved in several inflammatory ***,we evaluated the effects and underlying mechanisms of Syk on neutrophil immune-responses in ***:Syk expression in the colonic tissues of patients with UC was determined using quantitative reverse transcription-polymerase chain reaction(qRT-PCR),western blotting,and *** biopsies from patients with UC were obtained for single-cell *** isolated from peripheral blood were pre-treated with R788(a Syk inhibitor)and gene differences were determined using RNA *** functions were analyzed using qRT-PCR,flow cytometry,and Transwell assay.R788 was administered daily to mice with dextran sulfate sodium(DSS)-induced colitis to verify the effects of Syk on intestinal ***:Syk expression was increased in inflamed mucosa and neutrophils of patients with UC and positively correlated with dis-ease *** inhibition of Syk in neutrophils decreased the production of pro-inflammatory cytokines,chemokines,neutrophil extracellular traps,reactive oxygen species,and *** and migration of neutrophils were sup-pressed by Syk *** blockade ameliorated mucosal inflammation in DSS-induced murine colitis by inhibiting neutrophil-associated immune ***,Syk regulated neutrophil immune-responses via the mammalian target of rapamycin kinase/rubicon-like autophagy enhancer-dependent autophagy ***:Our findings indicate that Syk facilitates specific neutrophil functional responses to mucosal inflammation in UC,and its inhibition ameliorates mucosal inflammation in DSS-induced murine colitis,suggesting its potential as a novel therapeutic target for UC treatment.

关键词： Syk UC neutrophils autophagy

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TNFAIP8L1 Accelerates Atherogenesis by promoting ECs Dysfunction

TNFAIP8L1 Accelerates Atherogenesis by promoting ECs Dysfunc...

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第十二届全国免疫学学术大会

作者： Shao Jie Li Yan Geng Minghong jin guiyuan Zhang Lei Gao Chengjiang Chen Youhai Liu Suxia Department of Immunology Shandong University School of Medicine Departmentof Pathology and Laboratory Medicine University of Pennsylvania

Background:Atherosclerosis is a chronic inflammation disease of the artery walls that originates from the interaction between endothelial cells and immune ***8L-1 is a newly protein of TNFAIP8 family expressed in wide... 详细信息

关键词： TNFAIP8L1(TIPE1) Atherogenesis Apoptosis Endothelial dysfunction

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国资结构和布局调整研究——上海国资调整的途径和方式

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上海市经济管理干部学院学报 2007年第1期5卷 1-13页

作者：金桂苑余长国朱林兴上海市经济管理干部学院

“十一五”期间,上海的国资调整任务十分重要和艰巨。为完成此项任务,必须提高对国资规律性的认识,规范国资委职能和国资运作体系,科学制定国资调整策略,合理选择国资调整方式,深化国资干部管理体制改革,完善国资调整配套体制,并健全国... 详细信息

“十一五”期间,上海的国资调整任务十分重要和艰巨。为完成此项任务,必须提高对国资规律性的认识,规范国资委职能和国资运作体系,科学制定国资调整策略,合理选择国资调整方式,深化国资干部管理体制改革,完善国资调整配套体制,并健全国资法律体系。

关键词：国资调整途径方式

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TIPE3上调P-gp表达降低乳腺癌细胞对阿霉素的敏感性

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山东大学学报（医学版） 2017年第5期55卷 36-42页

作者：廉开礼李炎张娜靳桂媛刘素侠山东大学基础医学院免疫学系山东济南250012

目的探讨新的促癌分子肿瘤坏死因子-α诱导蛋白8样蛋白3(TIPE3)是否影响乳腺癌细胞MCF-7对阿霉素的敏感性及其机制。方法以0、0.5、1.0、1.5μg/m L阿霉素作用于TIPE3表达质粒转染的MCF-7细胞,分别采用细胞活性检测试剂盒(CCK-8)、流式... 详细信息

目的探讨新的促癌分子肿瘤坏死因子-α诱导蛋白8样蛋白3(TIPE3)是否影响乳腺癌细胞MCF-7对阿霉素的敏感性及其机制。方法以0、0.5、1.0、1.5μg/m L阿霉素作用于TIPE3表达质粒转染的MCF-7细胞,分别采用细胞活性检测试剂盒(CCK-8)、流式细胞术分析TIPE3对阿霉素作用的MCF-7细胞相对活性及细胞周期分布的影响;采用Annexin V/PI染色流式细胞术检测分析TIPE3对阿霉素作用的MCF-7细胞凋亡的影响;采用实时荧光定量PCR(qRT-PCR)法和蛋白印记(Western blotting)法检测核因子-kappa B(NF-κB)信号通路活化情况、多药耐药基因1(MDR 1)及多药耐药蛋白P-糖蛋白(P-gp)的表达。结果过表达TIPE3增加了阿霉素处理MCF-7细胞的相对存活率和G2/M期细胞数,降低细胞凋亡率;NF-κB信号通路活化水平增加,多药耐药基因MDR1及其表达蛋白P-gp的表达水平升高。结论 TIPE3通过活化NF-κB信号通路上调P-gp的表达进而降低MCF-7细胞对阿霉素的敏感性。

关键词：肿瘤坏死因子-α诱导蛋白8样蛋白3 乳腺癌 P-糖蛋白核因子-kappa B 阿霉素

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青浦卫生系统新一轮学科人才建设的实践与发展思考

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中华医学科研管理杂志 2016年第2期29卷 120-124页

作者：徐春余谢建芳金贵元程忆文上海市青浦区卫生和计划生育委员会 201700 复旦大学附属中山医院青浦分院

为进一步深化公立医院改革，推进青浦卫生学科人才队伍建设，提升青浦卫生事业发展和医学整体水平的提高，青浦区卫生计生委于2011年10月全面启动了新一轮学科建设与人才培养工程，给予建设经费保障，并经全过程的跟踪和考核评估显示，... 详细信息

为进一步深化公立医院改革，推进青浦卫生学科人才队伍建设，提升青浦卫生事业发展和医学整体水平的提高，青浦区卫生计生委于2011年10月全面启动了新一轮学科建设与人才培养工程，给予建设经费保障，并经全过程的跟踪和考核评估显示，学科人才培养者科研水平得到进一步提高，学术成果明显增加，医疗技术水平稳步提高，学科人才培养者学术氛围逐渐浓厚，同时对学科人才培养者提出了愿景展望。

关键词：卫生人才培养愿景展望

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2型糖尿病下肢动脉硬化病变部位和程度与血小板膜糖蛋白表达的相关性研究

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中国临床医学 2007年第4期14卷 591-592页

作者：邵明哲符伟国范隆华金贵元徐欣全彩娟杨珏刘敏陈英复旦大学附属中山医院血管外科上海200032 复旦大学附属中山医院青浦分院上海201700

目的:探讨血小板膜糖蛋白在2型糖尿病下肢动脉硬化闭塞症(ASO)患者不同部位和不同严重程度的表达及其相关性。方法:80例2型糖尿病合并下肢动脉硬化闭塞症患者,分别检测血小板膜糖蛋白CD62p、CD63、CD61、CD41a、CD42b、纤维蛋白原及血... 详细信息

目的:探讨血小板膜糖蛋白在2型糖尿病下肢动脉硬化闭塞症(ASO)患者不同部位和不同严重程度的表达及其相关性。方法:80例2型糖尿病合并下肢动脉硬化闭塞症患者,分别检测血小板膜糖蛋白CD62p、CD63、CD61、CD41a、CD42b、纤维蛋白原及血小板黏附、聚集试验,根据影像学资料和临床踝肱指数(ABI)检查区分不同部位和严重程度,并比较其差异。结果:2型糖尿病ASO患者髂股动脉端狭窄闭塞患者的血小板膜糖蛋白CD62p、CD63较腘动脉以下闭塞患者明显升高,CD62p、CD63与ABI无相关性。结论:检测血小板膜糖蛋白对于判断2型糖尿病病变部位有一定临床意义。

关键词：动脉硬化闭塞糖尿病血小板膜糖蛋白

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ETS-1在炎症性肠病及结肠炎相关性结直肠癌中的研究进展

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中华炎性肠病杂志（中英文） 2024年第2期8卷 164-168页

作者：孙绪凡靳桂媛马翠梅王岩周慧慧周广玺济宁医学院临床医学院济宁272067 济宁医学院附属医院医学研究中心济宁272029 济宁医学院附属医院消化内科济宁272029

ETS原癌基因1(ETS-1)是ETS转录因子家族的成员之一,在肿瘤和炎症等方面发挥重要作用。在炎症性肠病(IBD)和结肠炎相关性结直肠癌(CAC)中,ETS-1通过诱导炎症反应、破坏肠上皮细胞屏障和增强癌细胞侵袭性等加快疾病的进展。为探索IBD及CA... 详细信息

ETS原癌基因1(ETS-1)是ETS转录因子家族的成员之一,在肿瘤和炎症等方面发挥重要作用。在炎症性肠病(IBD)和结肠炎相关性结直肠癌(CAC)中,ETS-1通过诱导炎症反应、破坏肠上皮细胞屏障和增强癌细胞侵袭性等加快疾病的进展。为探索IBD及CAC的发病机制及潜在治疗靶点,本文就ETS-1在IBD及CAC中的研究进展作一综述。

关键词：炎症性肠病结肠炎相关性结直肠癌 ETS原癌基因1 肠上皮细胞屏障免疫调控

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The fate of carbon resulting from pore water exchange in a mangrove and Spartina alterniflora ecozone

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Acta Oceanologica Sinica 2023年第8期42卷 61-76页

作者： Weizhen Jiang Guizhi Wang Qing Li Manab Kumar Dutta Shilei jin guiyuan Dai Yi Xu State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361102China College of Ocean and Earth Sciences Xiamen UniversityXiamen 361102China Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies Xiamen UniversityXiamen 361102China National Observation and Research Station for the Taiwan Strait Marine Ecosystem Xiamen UniversityZhangzhou 363000China Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310000China

Mangrove and salt-marsh wetlands are important coastal carbon *** order to quantify carbon export via pore water exchange and to evaluate subsequent fate of the exported carbon,we carried out continuous observations in a mangrove-Spartina alterniflora ecozone in the Zhangjiang River Estuary,*** carbon fluxes via pore water exchange were estimated using^(222)Rn and^(228)Ra as tracers to be(2.15±0.63)mol/(m^(2)∙d)for dissolved inorganic carbon(DIC)and(-0.008±0.07)mol/(m^(2)∙d)for dissolved organic carbon(DOC)in the wet season and(3.02±0.65)mol/(m^(2)∙d)for DIC and(-0.15±0.007)mol/(m^(2)∙d)for DOC in the dry season in the mangrove-dominated creek(M-creek),while(2.52±0.82)mol/(m^(2)∙d)for DIC and(0.02±0.09)mol/(m^(2)∙d)for DOC in the dry season in the ***-dominated creek(SA-creek).The negative value means that pore water was a sink of DOC in the *** total carbon via pore water exchange in the tidal creeks in the mangroves accounted for 41%-55%of the net carbon fixed by mangrove vegetation and was 3-4 times as much as the soil carbon accretion in the *** exported carbon in the form of DIC contributed all of the carbon outwelling from the M-creek and 79%of the carbon outwelling from the SA-creek,implying effective fixation of carbon by the wetland ***,it resulted in 54%in the dry season,75%in the wet season of the carbon dioxide released from the M-creek to the atmosphere,and 84%of the release from the ***,quantification of pore water exchange and related soil carbon loss is essential to trace the fate of carbon fixed in intertidal wetlands.

关键词： mangrove salt-marsh carbon dioxide carbon accretion carbon outwelling pore water exchange

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YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells

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Oncology Research 2023年第4期31卷 615-630页

作者： JUNYU HE FENG ZENG XI jin LIN LIANG MENGXIANG GAO WENTAO LI guiyuan LI YANHONG ZHOU NHC Key Laboratory of Carcinogenesis Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha410013China Cancer Research Institute Basic School of MedicineCentral South UniversityChangsha410078China Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha410013China

Fos-related antigen 1(Fra-1)is a nuclear transcription factor that regulates cell growth,differentiation,and *** is involved in the proliferation,invasion,apoptosis and epithelial mesenchymal transformation of malignant tumor ***-1 is highly expressed in gastric cancer(GC),affects the cycle distribution and apoptosis of GC cells,and participates in GC occurrence and ***,the detailed mechanism of Fra-1 in GC is unclear,such as the identification of Fra-1-interacting proteins and their role in GC *** this study,we identified tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta(YWHAH)as a Fra-1-interacting protein in GC cells using co-immunoprecipitation combined with liquid chromatography-tandem mass *** showed that YWHAH positively regulated Fra-1 mRNA and protein expression,and affected GC cell *** proteome analysis showed that Fra-1 affected the activity of the high mobility group AT-hook 1(HMGA1)/phosphatidylinositol-4,5-bisphosphate 3-kinase(PI3K)/protein kinase B(AKT)/mechanistic target of rapamycin(mTOR)signaling pathway in GC *** blotting and flow cytometry confirmed that YWHAH activated HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect GC cell *** results will help to discover new molecular targets for the early diagnosis,treatment,and prognosis prediction of GC.

关键词： Gastric cancer Fra-1 YWHAH Signal transduction pathway Cell proliferation

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Three-dimensionally ordered macroporous CeO_2/Al_2O_3-supported Au nanoparticle catalysts: Effects of CeO_2 nanolayers on catalytic activity in soot oxidation

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Chinese Journal of Catalysis 2017年第9期38卷 1629-1641页

作者： Baofang jin Yuechang Wei Zhen Zhao Jian Liu Yazhao Li Renjie Li Aijun Duan guiyuan Jiang State Key Laboratory of Heavy Oil Processing China University of Petroleum Beijing 102249 China Institute of Catalysis for Energy and Environment Shenyang Normal University Shenyang 110034 Liaoning China

A series of catalysts consisting of three‐dimensionally ordered macroporous(3DOM)x‐CeO2/Al2O3‐supported Au nanoparticles(x=2,10,20,and40wt%)were successfully synthesized using a reduction‐deposition *** catalysts were characterized using scanning electron microscopy,the Brunauer‐Emmett‐Teller method,X‐ray diffraction,transmission electron microscopy,ultraviolet‐visible spectroscopy,and temperature‐programmed reduction by *** nanoparticles of mean particle size5nm were well dispersed and supported on the inner walls of uniform ***3DOM structure improved the contact efficiency between soot and the *** Al‐Ce‐O solid solution was formed in the multilayer support,i.e.,x‐CeO2/Al2O3,by the incorporation of Al3+ions into the CeO2lattice,which resulted in the creation of extrinsic oxygen *** interactions between the metal(Au)and the support(Ce)increased the amount of active oxygen species,and this promoted soot *** catalytic performance in soot combustion was evaluated using a temperature‐programmed oxidation *** presence of CeO2nanolayers in the3DOM Au/x‐CeO2/Al2O3catalysts clearly improved the catalytic activities in soot *** the prepared catalysts,3DOM Au/20%CeO2/Al2O3showed high catalytic activity and stability in diesel soot oxidation.

关键词： Three‐dimensionally ordered macroporous material Gold nanoparticle Multilayer support CeO2 nanolayer Soot combustion

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