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Role of polyphenols in epilepsy: from the perspective of gut microbiota

Food Science and Human Wellness 2024年

作者： Xiaoxue Xu Jian Shi Yinsi Tang guiyang cai Chao Ma Wuyang Wang Rui Feng Tomasz Boczek Zhenwei He Feng Guo Department of Pharmaceutical Toxicology， School of Pharmacy， China Medical University Shenyang Department of Neurology， the First Hospital of China Medical University Department of Pharmacy， the Fourth Affiliated Hospital of China Medical University Department of Gastroenterology， the Fourth Affiliated Hospital of China Medical University Department of Obstetrics and Gynecology， Shengjing Hospital of China Medical University Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education， School of Pharmaceutical Engineering， Shenyang Pharmaceutical University Jiangsu Province Key Laboratory of Anesthesiology， Xuzhou Medical University Department of Molecular Neurochemistry， Medical University of Lodz Department of Neurology， the Fourth Affiliated Hospital of China Medical University

Epilepsy is a devastating neurological condition that affects over 70 million people worldwide. Apart from idiopathic epilepsy， numerous diseases have been reported to cause secondary epilepsy. Polyphenols， ubiquitously existing in fruits and vegetables， has become a promising neuroprotective candidate against multiple neurological abnormalities due to its interplay with gut microbiome composed of the bacterial population in gastrointestinal system. This bioactive compound is also being tested for the management of epileptogenesis. However， there is still insufficient evidence from mechanistic studies to demonstrate the causal relationship between anti-epileptic effect of polyphenols and microbial alteration. In this review， we provide the brief overview of epilepsy， polyphenols and gut microbiota. We then analysis the association of polyphenols and gut microbiota particularly in the epilepsy and symptomatic seizures-induced by epilepsy-related disorders. We also discuss the possibility for the combined application with probiotics to improve the bioavailability and bioaccessibility of polyphenols for expanding its anti-epileptic function. We finally summarize the therapeutic potential of anti-seizure polyphenols through affecting gut microbiome， and propose that the anti-epileptic effect of polyphenols may be tightly relevant to intestinal bacterial flora for overcoming epilepsy and its comorbidities simultaneously. Therefore， the dietary polyphenols targeting specific bacteria may achieve the outcome of ‘one stone， two birds’.

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Study on the evolution of solid–liquid–gas in multi-scale pore methane in tectonic coal

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Chinese Journal of Chemical Engineering 2024年第7期71卷 122-131页

作者： Junjie cai Xijian Li Hao Sui Honggao Xie College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China Mining College Guizhou UniversityGuiyang 550025China

The rich accumulation of methane(CH_(4))in tectonic coal layers poses a significant obstacle to the safe and efficient extraction of coal seams and coalbed *** coal samples from three geologically complex regions were selected,and the main results obtained by using a variety of research tools,such as physical tests,theoretical analyses,and numerical simulations,are as follows:22.4–62.5 nm is the joint segment of pore volume,and 26.7–100.7 nm is the joint segment of pore specific surface *** the dynamic gas production process of tectonic coal pore structure,the adsorption method of methane molecules is“solid–liquid adsorption is the mainstay,and solid–gas adsorption coexists”.Methane stored in micropores with a pore size smaller than the jointed range is defined as solid-state *** within the jointed range,which transition from micropore filling to surface adsorption,are defined as gaseous *** outside the jointed range,where solid–liquid adsorption occurs,are defined as liquid *** evolution of pore structure affects the methane adsorption mode,which provides basic theoretical guidance for the development of coal seam resources.

关键词： Tectonic coal Multiscale pore structure Methane adsorption Micropore filling Monolayer Molecular simulation

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N-Heterocyclic carbene-catalyzed enantioselective(dynamic) kinetic resolutions and desymmetrizations

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Science China Chemistry 2024年第2期67卷 482-511页

作者： Yi Zhang Hui cai Xiuhai Gan Zhichao Jin National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang550025China

N-heterocyclic carbene-catalyzed enantioselective kinetic resolutions,dynamic kinetic resolutions,and desymmetrization reactions are systematically *** content is organized according to the activation modes involved i... 详细信息

关键词： N-heterocyclic carbene kinetic resolution dynamic kinetic resolution desymmetrization organocatalysis

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Superior piezoelectricity in lead-free barium titanate piezoceramics

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Journal of Materiomics 2024年第3期10卷 694-706页

作者： Enpei cai Shiqiang Peng Qibin Liu School of Materials and Metallurgy Guizhou UniversityGuiyang550025China Key Laboratory of Advanced Manufacturing Technology of the Ministry of Education Guiyang550025China

Since the 21st century,increasing environmental protection and human health concern have been the driving force to develop lead-free piezoelectric materials with enhanced performances,and phase en-gineering strategy has been validated to be a viable method in numerous ***,we gained a superb d_(33)~(637±30)pC/N in lead-free(1-x)(Ba_(0.93)Ca_(0.07))(Sn_(0.08)Ti_(0.92))O_(3-x)(Sb_(0.5)Li_(0.5))TiO_(3)[abbreviated as(1-x)BCST-xSLT,0≤x≤0.4%(in mole)]piezoelectrics utilizing chemical *** illustrate the relationship among composition-structure-performance,microstructure characterization,electrical properties measurement,first-principles calculation,and phase-field simulations were ***-resolved polarization mapping of z-contrast imaging manifests the ferroelectric three phases(ReOeT)coexist at the nanoscale with nanoscale polarization switching among *** calculations and simulations confirm that the high-density nano-domain boundary bridges the poly-phase coexisting nano-domains,which makes the polarization reversal easy,thus significantly reducing the energy barrier and polarization anisotropy among different phases.

关键词： Chemical doping Relaxor ferroelectrics Phase-field simulations Phase engineering strategy First-principles calculations

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Diffusion of nanochannel-confined knot along a tensioned polymer

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Communications in Theoretical Physics 2024年第4期76卷 158-166页

作者： Guobing cai Yong Li Yuyu Feng Zhouhui Deng Yanhui Liu College of Physics Guizhou UniversityGuiyang 550025China Kechuang Industrial Development Company Limited Guian New AreaGuiyang 550025China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang 550025China

The knots frequently occur in biopolymer and their diffusion plays an active role in the gene *** this work,Langevin dynamics simulations were carried out to detect the diffusion behaviours of a knot along a tensioned polymer in different spatial *** polymer accommodating a knot was tethered to two macrospheres to block the unravelling of the *** a result,the curves for the diffusion coefficients of the knot with different bending stiffness as a function of the tension in different spatial constraints were *** the space without constraints or with weak constraints,the corresponding curves for the knot with relatively large bending stiffness exhibited two turnover *** the contrary,for the knot with relatively small bending stiffness,the diffusion coefficients were monotonically reduced with increasing ***,in a space with strong constraints,all the curves showed one turnover behaviour regardless of the bending *** turnover behaviours divided the curves into different regimes,and the dominant diffusion mechanisms in the regimes,namely,knot-region breathing,self-reptation,and internal friction,were clearly *** effective friction coefficientsξof the knots with 3_(1),4_(1),5_(1) and 5_(2) types as a function of the knot size N at a fixed tension were well fitted by the relationξ∝*** effective friction coefficients of the knots at relatively large tension f>3 sharply increased with the knot complexity,which is not dependent on the spatial *** contrast,the values of these coefficients at relatively small tension f≤3 were remarkably dependent on the spatial *** work not only provides valuable simulation results to assist the understanding of the diffusion of DNA knot,but also highlights the single-molecule design for the manipulation of DNA knots in future.

关键词： knot langevin dynamics simulations diffusion coefficient self-reptation knot-region breathing internal friction

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Sedimentary Environment and Mineralization of the Black Shale Polymetallic Layer in the Early Cambrian,SW China:Constraints from in situ LA-ICP-MS Analysis of Pyrite

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 416-429页

作者： YANG Zhen FU Yong LI Chao cai Xi GUO Chuan College of Eco-Environmental Engineering Guizhou Minzu UniversityGuiyang 550025China College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China Key Laboratory of Karst Georesources and the Environment Ministry of EducationGuizhou UniversityGuiyang 500025China National Research Center for Geoanalysis Chinese Academy of Geological SciencesBeijing 100037China

A polymetallic layer is usually developed at the bottom of the early Cambrian black shale in Guizhou *** mineral that makes up the polymetallic layer is related to the sedimentary *** analyze the differentiation mechanism between polymetallic deposits(Ni-Mo and V),the Zhijin Gezhongwu profile located in the outer shelf and the Sansui Haishan V deposit located in the lower slope are selected to study the in situ sulfur isotopes and trace elements of *** results show that δ^(34)S values of pyrite vary widely from−7.8‰to 28‰in the Gezhongwu profile,while the δ^(34)S values are relatively uniform(from 27.8‰to 38.4‰)in the Haishan *** isotopic S composition is consistent with the transition that occurs in the sedimentary phase from the shelf to the deep sea on the transgressive Yangtze platform;this indicates that the δ^(34)SO_(4)^(2−)values in seawater must be differently distributed in depositional *** sulfur in the Ni-Mo layer is produced after the mixing of seawater and hydrothermal fluid,while the V layer mainly originates from ***,the Ni-Mo and V deposits have been differentiated primarily on the basis of the combined effect of continental weathering and hydrothermal fluid.

关键词： sedimentary environment black shale polymetallic layer pyrite early Cambrian

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Exploring the impact of anti-shadowing effect on unintegrated gluon distributions in the MD-BFKL equation

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Chinese Physics C 2024年第9期48卷 126-132页

作者： Xiaopeng Wang Yanbing cai Xurong Chen Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guizhou Key Laboratory in Physics and Related Areas Guizhou University of Finance and EconomicsGuiyang 550025China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

This paper presents a comprehensive analysis of the MD-BFKL equation,considering both shadowing and anti-shadowing effects in gluon recombination *** deriving analytical expressions for unintegrated gluon distributions through the solution of the MD-BFKL equation,with and without the incorporation of the antishadowing effect,we offer new insights into the influence of these effects on the behavior of unintegrated gluon *** results,when compared to those from the CT18NLO gluon distribution function,demonstrate that the anti-shadowing effect has a notably stronger impact on the characteristics of unintegrated gluon distributions,particularly in regions of high rapidity and *** work significantly contributes to the understanding of gluon recombination mechanisms and their implications in high energy physics.

关键词： MD-BFKL equation analytic solution anti-shadowing effect

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Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

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Research 2024年第3期2024卷 715-721页

作者： Yuanlin cai Ya Lv Liangzhen Shu Zhichao Jin Yonggui Robin Chi Tingting Li National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore.

An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.

关键词： chemistry. aldehydes chiral

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LD-pumped acousto-optic 2-switched Pr:YLF pulsed laser at 604 nm

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Chinese Optics Letters 2024年第8期22卷 77-81页

作者： Wei Yuan Canlin Jiang Huiying Xu Zhiping cai School of Electronic Science and Engineering Xiamen UniversityXiamen 361005China Center for Modern Educational Technology Guizhou Normal UniversityGuiyang 550001China Fujian Key Laboratory of Ultrafast Laser Technology and Applications Xiamen UniversityXiamen 361005China

We demonstrated an actively acousto-optic Q-switched pulsed laser based on Pr:YLF at 604 nm.A 604 nm continuous-wave(CW)laser with a maximum output power of 3.84 W was achieved for the first time,to the best of our *** Q-switched laser with a maximum average output power of 0.384 W,a narrowest pulse duration of 44.5 ns,a maximum single pulse energy of~64.1μJ,and a maximum peak power of~1.44 kW was obtained at a repetition rate of 6 *** far as we know,this was the first report of such a narrow pulse duration,high-power,and high-energy Q-switched pulsed laser at604 *** beam quality factors M_x~2and M_y~2were measured to be 2.87 and 2.40,*** results show that acousto-optic Q-switching is a promising method for obtaining pulsed lasers.

关键词： 604 nm acousto-optics Q-switching pulsed laser Pr:YLF crystal

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High-power Pr^(3+):YLF continuous wave lasers at 691.7 nm,701.4 nm,705.0 nm,and 708.7 nm

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Chinese Optics Letters 2024年第8期22卷 82-86页

作者： Run Fang Rongbin Dai Huiying Xu Zhiping cai Department of Electronic Engineering Xiamen UniversityXiamen 361005China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Fujian Key Laboratory of Ultrafast Laser Technology and Applications Xiamen UniversityXiamen 361005China

Lasers from^(1)I_(6)to^(3)F_(4)transitions were first demonstrated in a Pr^(3+):YLF crystal by inserting a birefringent *** powers up to 2.44 W,2.10 W,2.01 W,and 2.42 W were obtained at 691.7 nm,701.4 nm,705.0 nm,and 708.7 nm,*** slope efficiencies were 19.8%,16.5%,15.8%,and 19.4%,*** M_(x)^(2)and M_(y)^(2)factors were measured to be 2.29and 2.03 at 691.7 nm,2.23 and 1.86 at 701.4 nm,2.31 and 2.08 at 705.0 nm,and 2.41 and 2.04 at 708.7 nm,with corresponding power fluctuations of less than 5.3%,5.6%,5.8%,and 2.9%.

关键词： Pr^(3+):YLF laser high power laser Pr^(3+):YLF crystal

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