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Visible light cross-linking and bioactive peptides loaded integrated hydrogel with sequential release to accelerate wound healing complicated by bacterial infection

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Nano Research 2024年第3期17卷 1737-1747页

作者： guiyan wang Ning Yuan Jun Zhang Man Qin Suwei Dong Yuguang wang Department of Pediatric Dentistry Peking University School and Hospital of StomatologyBeijing 100081China State Key Laboratory of Natural and Biomimetic Drugs Chemical Biology Centerand School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing 100081China

The effective management of bacterial infections that are resistant to multiple drugs remains a substantial clinical *** eradication of drug-resistant bacteria and subsequent promotion of angiogenesis are imperative for the regeneration of the infected ***,a novel and facile peptide containing injectable hydrogel with sustained antibacterial and angiogenic capabilities is *** antibacterial peptide that consists of 11 residues(CM11,WKLFKKILKVL)is loaded onto acrylate-modified gelatin through charge interactions.A vascular endothelial growth factor mimetic peptide KLT(KLTWQELYQLKYKGI)with a GCG(Gly-Cys-Gly)modification at the N-terminal is covalently coupled through a visible light-induced thiol-ene *** this reaction,the acrylate gelatin undergoes cross-linkage within *** on the physical/chemical double crosslinking strategy,the bioactive peptides achieve sustained and sequential *** results show that the hydrogel significantly inhibits methicillin-resistant Staphylococcus aureus(MRSA)growth through the rapid release of CM11 peptides at early stage;it forms obvious growth inhibition zones against pathogenic bacterial ***,cell counting kit-8 assay and scratch test confirm that the CM11/KLT-functionalized hydrogels promote cell proliferation and migration through the later release of KLT *** a mouse skin wound infected with self-luminous MRSA,the CM11/KLT-functionalized hydrogels enhance wound healing,with rapidly bacterial infection reduction,lower expression of inflammatory factors,and neovascularization *** results suggest that the rationally designed,sustained and sequential release CM11/KLT-functionalized hydrogels have huge potential in promoting the healing of multi-drug resistant bacterial infected wounds.

关键词： antimicrobial peptide vascular endothelial growth factor(VEGF)mimetic peptide sequential release visible-light crosslinking hydrogel wound therapy

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A preliminary study of the effects of plastic film-mulched raised beds on soil temperature and crop performance of early-sown short-season spring maize(Zea mays L.) in the North China Plain

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The Crop Journal 2016年第4期4卷 331-337页

作者： Jing Dang Weili Liang guiyan wang Pengfei Shi Dan Wu Faculty of Agronomy Agricultural University of Hebei

To identify a strategy for earlier sowing and harvesting of spring maize(Zea mays L.) in an alternative maize–maize double cropping system, a 2-year field experiment was performed at Quzhou experimental station of China Agricultural University in 2014 and 2015. A short-season cultivar, Demeiya number 1(KX7349), was used in the experiment. Soil temperature to 5 cm depth in the early crop growth stage, crop growth, crop yield, and water use of different treatments(plastic film-mulched raised bed(RF) and flat field without plastic film mulching(CK) in 2014; RF, plastic film-mulched flat field(FF), and CK in 2015)were measured or calculated and compared. Soil temperature in the film-mulched treatments was consistently higher than that in CK(1.6–3.5 °C in average) during the early growth stage. Crops in plastic film-mulched treatments used 214 fewer growing-degree days(GDDs) in 2014 and 262 fewer GDDs in 2015. In 2014, the RF treatment yielded 32.7%higher biomass than CK, although its 9.4% higher grain yield was not statistically significant. Also, RF used 17.9% less water and showed 33.1% higher water use efficiency(WUE) than CK. In 2015, RF and FF showed 56.2% and 49.5% higher yield, 15.0% and 4.5%lower water use(ET), and 63.4% and 75.7% higher WUE, respectively, than CK. RF markedly increased soil temperature in the early crop season, accelerated crop growth, reduced ET,and greatly increased crop yield and WUE. Compared with FF, RF had no obvious effect on crop growth rate, although soil temperature during the period between sowing and stem elongation was slightly increased. However, RF resulted in lower ET and higher WUE than FF. Effects of RF on soil water dynamics as well as its cost-effectiveness remain topics for further study.

关键词： Raised bed Film mulch Spring Short-season Maize North China Plain

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固态发光碳纳米粒子的制备及在潜指纹成像中的应用

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高等学校化学学报 2019年第12期40卷 2583-2589页

作者：王桂萍张平王桂燕沈阳理工大学装备工程学院沈阳 110159 沈阳药科大学制药工程学院沈阳 110016

采用热分解法,以柠檬酸钠和尿素为前驱体,通过控制反应温度制备了不需要结合任何固体分散基质即可呈现明亮固态发光的碳纳米粒子(CNPs).利用X射线衍射(XRD),透射电子显微镜(TEM),X射线光电子能谱(XPS)、紫外-可见吸收光谱(UV-Vis)和光... 详细信息

采用热分解法,以柠檬酸钠和尿素为前驱体,通过控制反应温度制备了不需要结合任何固体分散基质即可呈现明亮固态发光的碳纳米粒子(CNPs).利用X射线衍射(XRD),透射电子显微镜(TEM),X射线光电子能谱(XPS)、紫外-可见吸收光谱(UV-Vis)和光致发光光谱(PL)等对CNPs的物相、形貌和粒径、表面基团及光学特性进行了表征.结果表明,该CNPs为无定形碳结构,准球形形貌,粒径分布在5~15 nm范围,其表面存在C=O,C=N和O=C-N等基团.CNPs的水溶液和固体粉末在365 nm紫外光辐射下,均呈现明亮的蓝绿色发光.将该CNPs粉末用作荧光试剂可直接显现不同非渗透性客体表面的潜指纹(LFPs).在365 nm紫外光激发下,CNPs粉末刷显后的LFPs细节特征清晰可辨,强荧光背景客体表面的LFPs获得了高对比度的显现效果.同时,老化30 d的LFPs利用CNPs粉末也能够显现出可识别的指纹细节.CNPs发光粉末作为指纹试剂在刑侦领域具有潜在的应用前景.

关键词：碳纳米粒子固态发光潜指纹成像

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Combined action of C-reactive protein and lipid profiles on risk of hypertension and prehypertension in Mongolian adults in Inner Mongolia, China

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Chinese Medical Journal 2014年第11期127卷 2016-2020页

作者： Zhang Shihui Xu Tian Peng Yanbo Peng Hao wang Aili wang guiyan wang Dali Zhang Yonghong Department of Epidemiology School of Public Health Medical College of Soochow University Suzhou Jiangsu 215123 China Department of Food Sanitation Suzhou Food and Drug Administration Suzhou Jiangsu 215007 China Department of Neurology Affiliated Hospital of Hebei United UniversityTangshan Hebei 063000 China Department of Health Care Xiamen Maternal and Child Care Hospital Xiamen Fujian 361003 China

Background Many studies have suggested that C-reactive protein （CRP） and blood lipids are associated with hypertension and cardiovascular disease （CVD）.However,few studies discussed the combined action of CRP and blood lipids on the risk of hypertension and *** study aimed to investigate the combined action of CRP and lipid profiles on the risk of hypertension and prehypertension in Mongolian adults from Inner Mongolia,*** The systolic and diastolic blood pressure,height,weight and waist circumference were measured and factors such as smoking,alcohol intake,family history of hypertension,etc.,were investigated and CRP,low-density lipoprotein cholesterol （LDL-C）,triglycerides （TG） were tested for 2 534 Mongolian adults aged ≥20 *** subjects were divided into four subgroups,namely CRP 〈median and LDL-C （TG）〈median subgroup,CRP 〈median and LDL-C （TG）〉median subgroup,CRP 〉median and LDL-C （TG）〈median subgroup and CRP 〉median and LDL-C （TG）〉median *** ORs （95% C/s） of hypertension and prehypertension for the subgroups were calculated by univariate and multivariate *** The multivariate adjusted ORs （95%CIs） of hypertension/prehypertension were 1.389 （0.979-1.970）/1.1 51（0.865-1.531）,1.666 （1.159-2.394）/1.431 （1.060-1.930）,1.756 （1.242-2.484）/ 1.770 （1.321-2.372）,for CRP 〈median and LDL-C 〉median subgroup,CRP 〉median and LDL-C 〈median subgroup,and CRP 〉median and LDL-C 〉median subgroup,respectively,compared with CRP 〈median and LDL-C 〈median ***,the multivariate adjusted ORs （95% CIs） of hypertension/prehypertension were 2.032 （1.394-2.963）/1.442 （1.047-1.988）,1.412 （0.960-2.079）/1.596 （1.166-2.184）,and 2.197 （1.595-3.027）/1.730 （1.321-2.266） for CRP 〈median and TG 〉median subgroup,CRP 〉median and TG 〈median subgroup,and CRP 〉median and TG 〉median subgroup,respectively,compared with CRP 〈median and TG 〈median *** risks of hypertension and prehypertension were the highest in the CRP 〉median a

关键词： hypertension prehypertension C-reactive protein blood lipid

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正义、公正、公平辨析

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南开学报（哲学社会科学版） 2006年第2期 134-140页

作者：王桂艳天津师范大学马克思主义学院天津300384

正义、公正、公平等范畴既存在着相同,也存在着不同,因此,不能把复杂的正义问题简单地归结为公正或公平问题。对于正义问题应从理念、制度以及日常生活等三个层面进行考察。相应地,对正义、公正、公平等范畴的辨析也需要从这三个层面来... 详细信息

正义、公正、公平等范畴既存在着相同,也存在着不同,因此,不能把复杂的正义问题简单地归结为公正或公平问题。对于正义问题应从理念、制度以及日常生活等三个层面进行考察。相应地,对正义、公正、公平等范畴的辨析也需要从这三个层面来展开。正义包含着一切美好的事物和信念,体现着真、善、美的全部内涵,更具有理念色彩;公正是一种社会普遍认同的并与一定的制度性因素相联系的正义;公平主要关乎的是人们日常生活操作层面的事情,它只需遵循同一标准规则的相同对待。

关键词：正义公正公平

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法律移植与本土资源关系的理性思考

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现代财经（天津财经大学学报） 2005年第12期25卷 66-69页

作者：王桂艳天津师范大学马克思主义学院天津300384

强调法律全球化、构建社会主义和谐社会,必须关注法律移植问题。但是法律移植必须与本土资源有机结合才能真正地推进中国法制现代化的发展。目前国内对这一问题的思考大多是围绕着具体问题而展开的,采取的也多是单一视角和单向度的思维... 详细信息

强调法律全球化、构建社会主义和谐社会,必须关注法律移植问题。但是法律移植必须与本土资源有机结合才能真正地推进中国法制现代化的发展。目前国内对这一问题的思考大多是围绕着具体问题而展开的,采取的也多是单一视角和单向度的思维方式,缺乏一种从社会实践中去考察这一关系问题的多维视角。因此,在哲学方法论视野下进一步阐明法律移植与法律本土化的关系问题很有必要。

关键词：法律移植本土化实践

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SI of Interaction energy prediction of organic molecules using Deep Tensor Neural Network

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Chinese Journal of Chemical Physics 2021年第1期34卷 I0001-I0010页

作者： Yuan Qi Hong Ren Hong Li Dinglin Zhang Hongqiang Cui Junben Weng Guohui Li guiyan wang Yan Li Dalian Institute of Chemical Physics State Key Laboratory of Molecular Reaction DynamicsDalian116023China Aerospace Center Hospital Department of OphthalmologyBeijing100049China Dalian Naval Academy Department of Basic SciencesDalian116018China Harbin Engineering University College of Intelligent Systems Science and EngineeringHarbin150001China

The support informations of DTNN architecture and prediction results of six testing cases in K-fold are listed here.

关键词： Deep prediction listed

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市场经济运行中的效率与公平及分配正义辨正

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现代财经（天津财经大学学报） 2007年第7期27卷 8-12页

作者：王桂艳天津师范大学马克思主义学院天津300387

要建立一个真正意义上的和谐社会,必须以实现分配正义为前提。而仅靠市场经济的分配模式尚不能实现合理、公正的分配,解决社会不公问题。政府介入是经济运行的必要调控手段,政府介入到市场经济的运行中来,必然会面临如何处理公平与效率... 详细信息

要建立一个真正意义上的和谐社会,必须以实现分配正义为前提。而仅靠市场经济的分配模式尚不能实现合理、公正的分配,解决社会不公问题。政府介入是经济运行的必要调控手段,政府介入到市场经济的运行中来,必然会面临如何处理公平与效率的关系问题。只有理顺这一关系才能使社会财富的分配走向更加合理化,才能创造一个和谐的制度环境,从而实现和谐社会构建。

关键词：效率公平分配正义

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Effects of Straw Utilization Methods on Dry Matter Production and Yield of Japonica Rice in Northern China

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Asian Agricultural Research 2020年第1期12卷 44-49,52页

作者： Yuefeng CUI Tiegang LU Guocai SUN guiyan wang Jian wang Wenjia HUANG Liaoning Tieling Academy of Agricultural Sciences Tieling 112616China

To study the effects of straw utilization methods on dry matter production and yield of japonica rice in northern China,taking the super japonica rice Shennong 265 as the test material,using the planting method of seedling transplanting,setting four treatments,namely,the conventional production,directly returning straws to field(6 t/ha),returning straws to field at low amount of biochar(2 t/ha)and returning straws to field at high amount of biochar(40 t/ha),this paper analyzed the changes in production and yield of super japonica rice *** to the experimental results,compared with the conventional production,after the straws were directly returned to the field,the dry matter accumulation of japonica rice was insufficient,and the leaf output rate and contribution rate were significantly reduced by 41.19%and 34.69%,respectively;the number of filled grains per panicle,1000-grain weight,and panicles per plant showed negative effect,leading to a decline in the yield;under the condition of returning straws to field at high amount of biochar,the dry matter accumulation showed a decline trend,both the leaf and stem sheath significantly reduced by 21.41%and 17.43%,and the number of filled grains per panicle also declined;under the condition of returning straws to field at low amount of biochar,the dry matter accumulation increased,and the leaf contribution rate increased by 11.68%,the number of filled grains per panicle,1000-grain weight,and panicles per plant showed positive effect,showing the potential of yield *** conclusion,returning suitable straw biochar to field(2 t/ha)is favorable for promoting the japonica rice production in northern China.

关键词： Straw Biochar Japonica rice Dry matter production

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Cu_2O微晶的可控制备及可见光催化亚甲基蓝降解性能

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高等学校化学学报 2015年第7期36卷 1351-1357页

作者：李锋王桂燕张岩李洪仁沈阳大学师范学院化学系沈阳110044 沈阳药科大学制药工程学院沈阳110016

以醋酸铜为铜源,柠檬酸钠为形貌导向剂,乙二醇和水为溶剂,采用溶剂热法制备了立方状形貌的Cu2O微晶.利用X射线衍射（XRD）、X射线光电子能谱（XPS）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）和紫外-可见漫反射光谱（UV-Vis DRS... 详细信息

以醋酸铜为铜源,柠檬酸钠为形貌导向剂,乙二醇和水为溶剂,采用溶剂热法制备了立方状形貌的Cu2O微晶.利用X射线衍射（XRD）、X射线光电子能谱（XPS）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）和紫外-可见漫反射光谱（UV-Vis DRS）等对Cu2O微晶进行了表征.结果表明,在柠檬酸钠与醋酸铜摩尔比为1.0时,于180℃反应5 h可以制备出尺寸分布在0.6~1.5μm间的均一立方状形貌Cu2O微晶.研究了该微晶对亚甲基蓝（MB）在可见光下降解反应的光催化性能.结果表明,在H2O2存在下,Cu2O微晶（0.3 g/L）在100 min内对30 mg/L MB溶液的降解率可以达到98%.该催化剂经过8次循环使用对MB的降解率仍保持在96%以上,展现了较高的催化活性及良好的稳定性.通过活性物种的分析对催化体系的光催化机理进行了推测.

关键词：氧化亚铜溶剂热法光催化亚甲基蓝

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