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Twenty years of Gendicine?rAd-p53 cancer gene therapy:The first-in-class human cancer gene therapy in the era of personalized oncology

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Genes & Diseases 2024年第4期11卷 234-245页

作者： li Qi guiqing li Peipei li Hongwei Wang Xiaolong Fang Tongchuan He Jingjing li Affiliated Hospital of Weifang Medical University School of Clinical MedicineWeifang Medical UniversityWeifangShandong 262700China Jinming Yu Academician Workstation of Oncology Affiliated Hospital of Weifang Medical UniversityWeifangShandong 262700China Decording Therapeutics Corp Shangha 200000China Yangkun Biogroup Co. LtdNanjingJiangsu 210002China The University of Chicago ChicagoIL 60290USA

Genetic mutations in TP53 contribute to human malignancies through various *** date,there have been a variety of therapeutic strategies targeting p53,including gene therapy to restore normal p53 function,mutant p53 rescue,inhibiting the MDM2-p53 interaction,p53-based vaccines,and a number of other *** review focuses on the functions of TP53 and discusses the aberrant roles of mutant p53 in various types of *** human p53 adenovirus,trademarked as Gendicine,which is the first anti-tumor gene therapy drug,has made tremendous progress in cancer gene *** herein discuss the biological mechanisms by which Gendicine exerts its effects and describe the clinical re-sponses reported in clinical ***,the clinical studies suggest that the combination of Gendicine with chemotherapy and/or radiotherapy may produce more pronounced efficacy in slowing tumor growth and progression than gene therapy/chemotherapy ***,we summarize the methods of administration of recombinant human p53 adenovirus for different cancer types to provide a reference for future clinical trials.

关键词： Gendicine Gene therapy p53 mutation Recombinant p53 adenovirus TP53

伪时空图卷积网络修复姿态引导的Transformer行人视频修复方法

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计算机辅助设计与图形学学报 2024年第4期36卷 552-564页

作者：唐福梅聂勇伟余嘉祺张青李桂清华南理工大学计算机科学与工程学院广州510006 中山大学计算机学院广州510006

为解决监控视频中被遮挡行人的修复问题,提出了一种基于人体姿态的行人视频修复方法,即先修复视频中残缺的行人姿态序列,然后在修补后的姿势序列的引导下修复视频帧中人体的缺失部分.该方法采用OpenPose从视频中提取被遮挡的人体姿态序... 详细信息

为解决监控视频中被遮挡行人的修复问题,提出了一种基于人体姿态的行人视频修复方法,即先修复视频中残缺的行人姿态序列,然后在修补后的姿势序列的引导下修复视频帧中人体的缺失部分.该方法采用OpenPose从视频中提取被遮挡的人体姿态序列,针对其因存在遮挡情况导致未识别出和未准确识别部分关节点的问题,提出了一种伪时空图卷积网络模型对缺失姿态进行修复,得到一个相对准确的姿态序列;基于修复后的姿态,提出了基于姿态序列引导的Transformer行人视频修复模型.在Human3.6M数据集上进行了测试,所提出的方法在4个指标PSNR,RMSE,SSIM,LPIPS上均比对比方法有提升,特别是RMSE指标提升了9.50%,LPIPS指标提升了21.67%.

关键词：深度学习图卷积神经网络 Transformer 人体姿态补全视频修复

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艺术体操专项灵敏素质训练方法探究

当代体育科技 2024年第20期14卷 34-37页

作者：苗雨李贵庆武汉体育学院湖北武汉430079

艺术体操是一项身体动作和器械动作紧密结合的运动项目,运动员在高质量地完成成套动作的整个过程中,对身体和器械运动的方位、角度有着严格的要求。在进行不同项目训练时,对灵敏素质要求不同,从而导致训练方法不同。以高校艺术体操专项... 详细信息

艺术体操是一项身体动作和器械动作紧密结合的运动项目,运动员在高质量地完成成套动作的整个过程中,对身体和器械运动的方位、角度有着严格的要求。在进行不同项目训练时,对灵敏素质要求不同,从而导致训练方法不同。以高校艺术体操专项组训练为研究对象,对运动灵敏素质训练主要体现和训练方法进行探讨分析,在了解现有训练方法的基础上为艺术体操训练提供更有效的灵敏素质训练方法。调动训练者训练的积极性和主动性,从而使艺术体操灵敏训练趋于多样性与科学化。

关键词：艺术体操灵敏素质训练方法身体感知

State space representation and phase analysis of gradient descent optimizers

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Science China(Information Sciences) 2023年第4期66卷 140-154页

作者： Biyuan YAO guiqing li Wei WU School of Computer Science and Engineering South China University of Technology School of Computer Wuhan University

Deep learning has achieved good results in the field of image recognition due to the key role of the optimizer in a deep learning network. In this work, the optimizers of dynamical system models are established,and the influence of parameter adjustments on the dynamic performance of the system is proposed. This is a useful supplement to the theoretical control models of optimizers. First, the system control model is derived based on the iterative formula of the optimizer, the optimizer model is expressed by differential equations, and the control equation of the optimizer is established. Second, based on the system control model of the optimizer, the phase trajectory process of the optimizer model and the influence of different hyperparameters on the system performance of the learning model are analyzed. Finally, controllers with different optimizers and different hyperparameters are used to classify the MNIST and CIFAR-10 datasets to verify the effects of different optimizers on the model learning performance and compare them with related methods. Experimental results show that selecting appropriate optimizers can accelerate the convergence speed of the model and improve the accuracy of model recognition. Furthermore, the convergence speed and performance of the stochastic gradient descent(SGD) optimizer are better than those of the stochastic gradient descent-momentum(SGD-M) and Nesterov accelerated gradient(NAG) optimizers.

关键词： optimizer control model phase trajectory parameter adjustment classification dynamic performance

Feature-preserving color pencil drawings from photographs

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Computational Visual Media 2023年第4期9卷 807-825页

作者： Dong Wang guiqing li Chengying Gao Shengwu Fu Yun liang College of Mathematics and Informatics South China Agricultural UniversityGuangzhouChina School of Computer Science&Engineering South China University of TechnologyGuangzhouChina School of Data and Computer Science Sun Yat-sen UniversityGuangzhouChina

Color pencil drawing is well-loved due to its rich *** paper proposes an approach for generating feature-preserving color pencil drawings from *** mimic the tonal style of color pencil drawings,which are much lighter and have relatively lower saturation than photographs,we devise a lightness enhancement mapping and a saturation reduction *** lightness mapping is a monotonically decreasing derivative function,which not only increases lightness but also preserves input photograph *** saturation is usually related to lightness,so we suppress the saturation dependent on lightness to yield a harmonious ***,two extremum operators are provided to generate a foreground-aware outline map in which the colors of the generated contours and the foreground object are *** experiments show that color pencil drawings generated by our method surpass existing methods in tone capture and feature preservation.

关键词： non-photorealistic rendering pencil drawings image editing feature preservation

肿瘤坏死因子超家族成员14对小鼠银屑病样皮炎中角质形成细胞铁死亡的作用

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中国皮肤性病学杂志 2024年第8期38卷 849-859页

作者：龙胜杰郑权友李桂清许桂莲高小玲西南大学医学研究院重庆400715 陆军军医大学基础医学院免疫学教研室重庆400038 陆军军医大学第一附属医院第九五八医院肾病泌尿科重庆400020 重庆市第九人民医院肾内科重庆400799

目的探讨肿瘤坏死因子超家族成员14(tumornecrosis factorsuperfamily 14,TNFSF14)/liGHT对小鼠银屑病样皮炎中角质形成细胞铁死亡的作用及机制。方法动物实验中,将liGHT^(+/+)小鼠(C57BL/6背景)和liGHT^(-/-)小鼠(C57BL/6背景)分为4组(每组5只):liGHT^(+/+)小鼠凡士林(vaseline)组;liGHT^(+/+)小鼠咪喹莫特(imiquimod,IMQ)组;liGHT^(-/-)小鼠凡士林组;liGHT^(-/-)小鼠咪喹莫特组。凡士林或咪喹莫特涂抹背部皮肤,1次/d,连续5 d后收集皮损组织样本。qRT-PCr检测酰基辅酶a合成酶长链家族成员4(ACSL4)、胱氨酸谷氨酸反向转运体(xCT)和谷胱甘肽过氧化物酶4(GPX4)等铁死亡指标以及IL-23/IL-17轴等炎症因子指标的表达;免疫组织化学检测ACSL4、xCT、GPX4及角蛋白(KrT6)的表达。体外细胞实验中,将人永生化角质细胞系HaCaT细胞做以下处理:培养基(Medium)对照组、重组人liGHT因子(recombinant human liGHT,rhliGHT)处理组、rhliGHT+PTL[(-)-Parthenolide,欧苷菊,NF-κB活化抑制剂]处理组。在处理2 d和2.5 d后收集细胞,分别提取总rNA和蛋白。qRT-PCr检测细胞中ACSL4、xCT、GPX4和IL-23/IL-17轴相关炎症因子以及KrT6的表达;Western blot或细胞免疫荧光检测ACSL4、xCT、GPX4、P65、P-p65和KrT6的表达。结果动物实验结果显示,在IMQ诱导的小鼠银屑病样皮炎模型中,TNFSF14/liGHT基因敲除后细胞铁死亡水平下降、IL-23/IL-17轴等相关炎症因子释放均显著减少。体外细胞实验结果显示,加入rhliGHT刺激HaCaT细胞后,细胞铁死亡水平上升、IL-23/IL-17轴等炎症因子的表达均显著上调,NF-κB通路被激活;加入NF-κB活化抑制剂PTL后,可部分逆转rhliGHT对HaCaT细胞的上述效应。结论TNFSF14/liGHT可能通过激活NF-κB通路促进角质形成细胞铁死亡,参与银屑病样皮炎的病理发生过程。

关键词： TNFSF14/liGHT NF-κB IL-23/IL-17轴铁死亡银屑病小鼠

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龙塘大坝枢纽改造工程鱼道设计研究

水利水电工程设计 2024年第2期43卷 14-17,27页

作者：杨振冰菅宇翔李桂青中水北方勘测设计研究有限责任公司天津300222

为了减缓龙塘大坝枢纽改造工程对南渡江鱼类洄游的不利影响,通过建设龙塘大坝鱼道,有效减缓龙塘大坝工程对南渡江上下游的阻隔影响,提升南渡江河流连通性。现对海口市南渡江龙塘大坝枢纽改造工程鱼道设计进行研究,介绍龙塘大坝鱼道的设... 详细信息

为了减缓龙塘大坝枢纽改造工程对南渡江鱼类洄游的不利影响,通过建设龙塘大坝鱼道,有效减缓龙塘大坝工程对南渡江上下游的阻隔影响,提升南渡江河流连通性。现对海口市南渡江龙塘大坝枢纽改造工程鱼道设计进行研究,介绍龙塘大坝鱼道的设计及试验过程,内容主要包括南渡江龙塘大坝枢纽主要过鱼种类的游泳能力试验、游泳能力指标在鱼道设计中的应用、鱼道局部数学模型、鱼道局部物理模型、优化设计及放鱼试验等6个方面,可供其他过鱼设施设计参考。

关键词：鱼道游泳试验南渡江龙塘大坝

基于FLOW⁃3D数值模拟和物理模型试验的水闸水流条件研究

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水利水电工程设计 2024年第2期43卷 63-68页

作者：刘德宇武帅曹阳李桂青中水北方勘测设计研究有限责任公司天津300222 水利部水利水电规划设计总院北京100120

介绍FLOW-3D数值模拟和物理模型试验在海口市龙塘大坝枢纽改造工程水流条件研究的应用,通过各工况的数值模拟与物理模型试验,对水闸水流流态、流速和沿程水面线等水力特性进行计算与观测。经对比分析,各工况下FLOW-3D数值模拟和物理模... 详细信息

介绍FLOW-3D数值模拟和物理模型试验在海口市龙塘大坝枢纽改造工程水流条件研究的应用,通过各工况的数值模拟与物理模型试验,对水闸水流流态、流速和沿程水面线等水力特性进行计算与观测。经对比分析,各工况下FLOW-3D数值模拟和物理模型试验所得的流态、水面线、流速变化及分布规律基本一致,为研究泄水建筑物布置及体型设计的可行性及合理性,泄水建筑物设计及运行管理提供了科学依据。

关键词： FLOW-3D 数值模拟物理模型试验水流条件

Added Benefit of the Early-Morning-Orbit Satellite Fengyun-3E on the Global Microwave Sounding of the Three-Orbit Constellation

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Advances in Atmospheric Sciences 2024年第1期41卷 39-52页

作者： Juan li Zhengkun QIN guiqing liU Jing HUANG CMA Earth System Modeling and Prediction Centre Beijing 100081China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Joint Center for Data Assimilation Research and Applications School of Atmospheric SciencesNanjing University of Information Science&TechnologyNanjing 210044China

The three-orbit constellation can comprehensively increase the spatial coverage of polar-orbiting satellites,but the polar-orbiting satellites currently in operation are only mid-morning-orbit and afternoon-orbit ***-3E(FY-3E)was launched successfully on 5 July 2021 in *** an early-morning-orbit satellite,FY-3E can help form a complete three-orbit observation system together with the mid-morning and afternoon satellites in the current mainstream operational *** this study,we investigate the added benefit of FY-3E microwave sounding observations to the midmorning-orbit Meteorological Operational satellite-B(Met Op-B)and afternoon-orbit Fengyun-3D(FY-3D)microwave observations in the Chinese Meteorological Administration global forecast system(CMA-GFS).The results show that the additional FY-3E microwave temperature sounder-3(MWTS-3)and microwave humidity sounder-2(MWHS-2)data can increase the global coverage of microwave temperature and humidity sounding data by 14.8% and 10.6%,*** enables the CMA-GFS to achieve nearly 100% global coverage of microwave-sounding observations at each analysis ***,after effective quality control and bias correction,the global biases and standard deviations of the differences between observations and model simulations are also *** on the Advanced Microwave Sounding Unit A and the Microwave Humidity Sounder onboard Met Op-B,and the MWTS-2 and MWHS-2 onboard FY-3D,adding the microwave sounding data of FY-3E can further reduce the errors of analysis results and improve the global prediction skills of CMA-GFS,especially for the southern-hemisphere forecasts within 96 hours,all of which are significant at the 95% confidence level.

关键词： data assimilation microwave temperature sounder MWTS-3