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Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions

World Journal of Clinical Cases 2018年第15期6卷 922-930页

作者： Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha cabrera-Palma guillermo cabrera-álvarez Liver Research Unit Medica Sur Clinic and Foundation Department of Gastroenterology Hospital "Juárez" of México Department of Molecular Biology in Me-dicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" Department of Internal Medicine "Christus Muguerza "Super Specialty" Hospital" Monterrey Department of Gas-troenterology "University Hospital "Jose Eleuterio González" Monterrey Department of Gastroenterology "General Hospital of Mexico "Dr.Eduardo Liceaga" Department of Gastroenterology "Central Military Hospital" Faculty of Medicine and Nutrition Juárez University of the State of Durango Liver Clinic Regional General Hospital IMSS 1

AIM To investigate the main current etiologies of cirrhosis in *** We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico.

关键词： Alcoholic liver disease Hepatitis C virus Nonalcoholic steatohepatitis Liver cirrhosis

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Nodal user’s demand response based on incentive based programs

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Journal of Modern Power Systems and Clean Energy 2017年第1期5卷 79-90页

作者： Nestor GONZáLEZ-cabrera guillermo GUTIéRREZ-ALCARAZ Instituto Tecnolo´gico Superior de Irapuato Irapuato 36620Mexico Instituto Tecnolo´gico de Morelia Morelia 58120Me´xico

This paper describes a practical approach to identify nodal price compensation payment for nodal consumers willing to reduce their energy consumption(consumers’ demand response). The implementation of a nodal reliability service pricing is based on contingency assessment of N-2 order for transmission lines. A representative annualized demand curve is used to reflect the system’s operation condition by seasons. Such curve is used to access the nodal reliability impact trough a whole year in order to determine back-payments(incentive payment) to users for service interruption. The IEEE_RTS 24 nodes system is used to implement the proposed approach.

关键词： Nodal demand response Demand side management Reliability assessment Incentive based programs(IBP)

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Autoimmune hepatitis:Towards a personalized treatment

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World Journal of Hepatology 2024年第11期16卷 1225-1242页

作者： Alejandro Costaguta guillermo Costaguta FernandoÁlvarez Department of Hepatology and Liver Transplant Unit Sanatorio de Niños de RosarioRosario 2000Santa FeArgentina Department of Gastroenterology Hepatologyand NutritionCHU Sainte-JustineMontreal H3T 1C5QuebecCanada of Pediatrics CHU Sainte-JustineMontreal H3T 1C5QuebecCanada

Autoimmune hepatitis is an uncommon condition that affects both adults and children and is characterized by chronic and recurrent inflammatory activity in the *** inflammation is accompanied by elevated IgG and autoantibody ***,treatment consists of steroids with the addition of azathioprine,which results in remission in approximately 80%of *** significant advancements in our understanding of the immune system over the past two decades,few modifications have been made to treatment algorithms,which have remained largely unchanged since they were first proposed more than 40 years *** review summarized the various treatment options currently available as well as our experiences using *** steroids are the standard treatment for induction therapy,other medications may be *** A,a calcineurin inhibitor that decreases T cell activation,has proven effective for induction of remission,but its long-term side effects limit its appeal for ***,a drug belonging to the same family,has been used in patients with refractory diseases with fewer side *** and everolimus have interesting effects on regulatory T cell populations and may become viable options in the *** mofetil is not effective for induction but is a valid alternative for patients who are intolerant to azathioprine.B celldepleting drugs,such as rituximab and belimumab,have been successfully used in refractory cases and are useful in both the short and long *** promising treatments include anti-tumor necrosis factors,Janus kinases inhibitors,and chimeric antigen receptor T cell *** growing armamentarium allows us to imagine a more tailored approach to the treatment of autoimmune hepatitis in the near future.

关键词： Novel therapies Immunosuppressors Treatment tailoring Personalization Special populations

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Precision silviculture:use of UAVs and comparison of deep learning models for the identification and segmentation of tree crowns in pine crops

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International Journal of Digital Earth 2022年第1期15卷 2223-2238页

作者： Manuel Ignacio Perez Bruno Karelovic Roberto Molina Rodrigo Saavedra Pierluigi Cerulo guillermo cabrera Department of Computer Sciences Universidad de Concepcion Biblioteca CentralConcepcionChile Celulosa Arauco y Constitucion SA I&DSantiagoChile

The monitoring of trees is crucial for the management of large areas of forest cultivations,but this process may be ***,remotely sensed data offers a solution to automate this *** this work,we used two neural network methods named You Only Look Once(YOLO)and Mask R-CNN to overcome the challenging tasks of counting,detecting,and segmenting high dimensional Red–Green–Blue(RGB)images taken from unmanned aerial vehicles(UAVs).We present a processing framework,which is suitable to generate accurate predictions for the aforementioned tasks using a reasonable amount of labeled *** compared our method using forest stands of different ages and *** counting,YOLO overestimates 8.5%of the detected trees on average,whereas Mask R-CNN overestimates a 4.7%of the *** the detection task,YOLO obtains a precision of 0.72 and a recall of 0.68 on average,while Mask R-CNN obtains a precision of 0.82 and a recall of *** segmentation,YOLO overestimates a 13.5%of the predicted area on average,whereas Mask R-CNN overestimates a 9.2%.The proposed methods present a cost-effective solution for forest monitoring using RGB images and have been successfully used to monitor∼146,500 acres of pine cultivations.

关键词： Artificial intelligence tree identification forestry remote sensing

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Insights into the role of major bioactive dietary nutrients in lamb meat quality:a review

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Journal of Animal Science and Biotechnology 2022年第4期13卷 951-966页

作者： JavierÁlvarez-Rodríguez Olaia Urrutia Sandra Lobón guillermo Ripoll Juan Ramón Bertolín Margalida Joy Departament de Ciència Animal Universitat de Lleida25198 LleidaSpain Departamento de Agronomía Biotecnología y AlimentaciónIS-FOOD InstituteEscuela Técnica Superior de Ingeniería Agronómica y BiocienciasUniversidad Pública de NavarraPamplonaSpain Centro de Investigación y Tecnología Agroalimentaria de Aragón(CITA) Avda.Montañana 93050059 ZaragozaSpain Instituto Agroalimentario de Aragón–IA2(CITA-Universidad de Zaragoza) Avda.Miguel Servet17750013 ZaragozaSpain.

Feed supplementation withα-linolenic acid(ALA)and linoleic acid(LA)increases their content in muscle,ALA increases n-3 polyunsaturated fatty acids and decrease n-6/n-3 ratio in muscle,and LA increases rumenic ***,high LA supplementation may have negative effects on lambs’lipid oxidative stability of *** the sources of ALA and LA are fed as fresh forage,the negative effects are counterbalanced by the presence of other bioactive compounds,as vitamin E(mainlyα-tocopherol)and polyphenols,which delay the lipid oxidation in *** is a wide consensus on the capability of vitamin E delaying lipid oxidation on lamb meat,and its feed content should be adjusted to the length of supplementation.A high dietary inclusion of proanthocyanidins,phenolic compounds and terpenes reduce the lipid oxidation in muscle and may improve the shelf life of meat,probably as a result of a combined effect with dietary vitamin ***,the recommended dietary inclusion levels depend on the polyphenol type and concentration and antioxidant capacity of the feedstuffs,which cannot be compared easily because no routine analytical grading methods are yet *** phenolic compounds content in dietary ingredients/supplements for lambs are reported,no specific association with animal physiology responses may be established.

关键词： Fatty acid Forage Oilseed Polyphenol Vitamin E

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US children with special health care needs and ethnic discrimination: results from multivariate modeling

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World Journal of Pediatrics 2019年第2期15卷 182-189页

作者： guillermo Montes St.John Fisher College Alesi 106C3690 East Ave.RochesterNY 14618USA Children's Institute Inc. RochesterNYUSA

Background To determine the prevalence of parent-reported ethnic/racial discrimination,and to determine if children with special health care needs are more likely to experience ethnic discrimination than other children who have similar family income,age,sex,race,parental education and Hispanic *** Using the National Survey of Children's Health 2011-2012 (n =95,677),ethnic discrimination was measured by two questions that asked 'was child ever treated or judged unfairly because of his/her race or ethnic group?' and if so,how often it occurred in the last 12 months prior to the *** An estimated 3 million US children aged 0-17 years have experienced parent-reported ethnic discrimination (1.4% White,9.1% Black,9.9% other race,4.7% Hispanic).The likelihood to experience ethnic discrimination is much higher for Black and other race children,compared to White *** with special health care needs were two times more likely to experience ethnic discrimination frequently in the 12 months prior to the survey than comparable children in terms of age,sex,race,family income,parental education,and social *** family income did not prevent the exposure to ethnic discrimination but was associated with fewer *** Theoretical frameworks,such as social determinants of health,must account for the bidirectional nature of the relationship between health and ethnic *** care must assess if ethnic discrimination has occurred and whether trauma-informed approaches are needed.

关键词： Children with special health care needs Ethnic discrimination United States

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A thick-disk galaxy model and simulations of equal-mass galaxy pair collisions

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Research in Astronomy and Astrophysics 2020年第11期20卷 333-353页

作者： guillermo Arreaga-Garcıa Departamento de Investigacion en Fsica Universidad de Sonora.Apdo.Postal 14740C.P.83000HermosilloSonoraMexico

We implement a numerical model reported in the literature to simulate the evolution of a galaxy composed of four matter components,such as:a dark-matter halo;a rotating disk of stars;a spherical bulge of stars and a ring of molecular *** show that the evolution of this galaxy model is stable at least for 10 Gyr(Gyr=109 years).We characterize the resulting configuration of this galaxy model by figures of the circular velocity and angular momentum distribution;the tangential and radial components of the velocity;the peak density evolution and the radial density ***,we calculate several models of equal-mass galaxy binary collisions,such as:(i)frontal and(ii)oblique(with an impact parameter),(iii)two models with initial conditions taken from a 2-body orbit and(iv)a very close *** allow comparison with the galaxy model,we characterize the dynamics of the collision models in an analogous ***,we determine the de Vaucouleurs fitting curves of the radial density profile,on a radial scale of 0–100 kpc,for all the collision models irrespective of the pre-collision *** study the radial mass density and radial surface density profiles at a smaller radial scale,0–20 kpc,we use a four-parameter fitting curve.

关键词： galaxies kinematics and dynamics galaxies interaction methods numerical

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Empirical formulae to describe some physical properties of small groups of protogalaxies with multiplicity

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Research in Astronomy and Astrophysics 2021年第8期21卷 141-158页

作者： guillermo Arreaga-Garcia Departamento de Investigacion en Fisica Universidad de Sonora Apdo.Postal 14740C.P.83000HermosilloSonoraMexico

By means of identical cubic elements,we generate a partition of a volume in which a particle-based cosmological simulation is carried *** each cubic element,we determine the gas particles with a normalized density greater than an arbitrarily chosen density *** using a proximity parameter,we calculate the neighboring cubic elements and generate a list of *** imposing dynamic conditions on the gas particles,we identify gas clumps and their neighbors,so that we calculate and fit some properties of the groups so identified,including the mass,size and velocity dispersion,in terms of their multiplicity(here defined simply as the number of member galaxies).Finally,we report the value of the ratio of kinetic energy to gravitational energy of such dense gas clumps,which will be useful as initial conditions in simulations of gravitational collapse of gas clouds and clusters of gas clouds.

关键词： galaxies:kinematics and dynamics hydrodynamics methods:numerical

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Over 9% efficiency achieved for all-polymer solar cells processed by a green solvent

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Science China Chemistry 2017年第8期60卷 1109-1110页

作者： guillermo C.Bazan Departments of Chemistry ＆ Biochemistry and Materials University of California Santa Barbara CA 93106 USA

Bulk-heterojunction polymer solar cells （PSCs） have at- tracted considerable attention owning to their potential for fabricating flexible, light-weight and large area solar cell panels via high-throughput roll-to-roll technologies. Compared with conventional PSCs comprising small mol- ecule acceptors, such as fullerenes, all-polymer solar cells （all-PSCs） containing blends of p-type/n-type polymers in the photoactive layer provide advantages including easily tunable absorption band, enhanced absorption coefficient,

关键词： PSCs on in is for efficiency achieved for all-polymer solar cells processed by a green solvent Over 9 by

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Modified Maximum Likelihood Estimation in Autoregressive Processes with Generalized Exponential Innovations

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Open Journal of Statistics 2014年第8期4卷 620-629页

作者： Bernardo Lagos-álvarez guillermo Ferreira Emilio Porcu Department of Statistics Universidad de Concepción Concepción Chile Department of Mathematics University Federico Santa María Valparaíso Chile

We consider a time series following a simple linear regression with first-order autoregressive errors belonging to the class of heavy-tailed distributions. The proposed model provides a useful generalization of the symmetrical linear regression models with independent error, since the error distribution covers both correlated innovations following a Generalized Exponential distribution. Furthermore, we derive the modified maximum likelihood (MML) estimators as an efficient alternative for estimating model parameters. Finally, we investigate the asymptotic properties of the proposed estimators. Our findings are also illustrated through a simulation study.

关键词： Autoregressive Time Series Model Maximum Likelihood Modified Maximum Likelihood Least Squares Generalized Exponential

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