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World Journal of Gastroenterology 2018年第23期24卷 2427-2440页

作者： Esteban Juan Fiore Luciana María Domínguez Juan bayo Mariana Gabriela García guillermo Daniel Mazzolini Laboratory of Gene Therapy Instituto de Investigaciones en Medicina TraslacionalCONICET-Universidad Austral

Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells(MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise,it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles(EVs). EVs contain proteins,lipids and nucleic acids(DNA,m RNA,mi RNA,lnc RNA) from the cell of origin,allowing for intercellular communication. Recently,different studies have demonstrated that MSC-derived EVs could reproduce,at least in part,the biological effects obtained by MSCbased therapies. Moreover,due to EVs' stability for long periods of time and easy isolation methods they have become a therapeutic option to MSCs treatments. This review summarizes the latest results achieved in clinical trials using MSCs as cell therapy for liver regeneration,the role of EVs in liver physiopathology and the potential of MSC-derived EVs as intercellular mediators and therapeutic tools in liver diseases.

关键词： Mesenchymal stem cells Extracellular vesicles Cirrhosis Liver Acute damage Regeneration

Improving the knowledge of plant potential biodiversity-ecosystem services links using maps at the regional level in Southern Patagonia

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Ecological Processes 2021年第1期10卷 709-734页

作者： Yamina Micaela Rosas Pablo L.Peri María Vanessa Lencinas Romina Lasagno guillermo J.Martínez Pastur Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas(CADIC)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 2009410 UshuaiaTierra del FuegoArgentina. Instituto Nacional de Tecnología Agropecuaria(INTA) Universidad Nacional de la Patagonia Austral(UNPA)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)CC 3329400 Río GallegosSanta CruzArgentina. Instituto Nacional de Tecnología Agropecuaria(INTA) CC 3329400 Río GallegosSanta CruzArgentina.

background:Biodiversity supports multiple ecosystem services,whereas species loss endangers the provision of many services and affects ecosystem resilience and resistance *** increase of remote sensing techniques allows to estimate biodiversity and ecosystem services supply at the landscape level in areas with low available data(*** Patagonia).This paper evaluates the potential biodiversity and how it links with ecosystem services,based on vascular plant species across eight ecological *** also evaluated the habitat plant requirements and their relation with natural gradients.A total of 977 plots were used to develop habitat suitability maps based on an environmental niche factor analysis of 15 more important indicator species for each ecological area(n=53 species)using 40 explanatory ***,these maps were combined into a single potential biodiversity map,which was linked with environmental variables and ecosystem services *** comparisons,data were extracted and compared through analyses of ***:The plant habitat requirements varied greatly among the different ecological areas,and it was possible to define groups according to its specialization and marginality *** potential biodiversity map allowed us to detect coldspots in the western mountains and hotspots in southern and eastern *** biodiversity was associated to higher temperatures and normalized difference vegetation index,while lower biodiversity was related to elevation and *** biodiversity was closely associated with supporting and provisioning ecosystem services in shrublands and grasslands in the humid steppe,while the lowest values were related to cultural ecosystem services in Nothofagus ***:The present study showed that plant species present remarkable differences in spatial distributions and ecological requirements,being a useful proxy for potential biodiversity *** biodiversity values

关键词： Habitat suitability Environmental variables Ecosystem functions Conservation management Ecosystem services Landscape modelling

Flowering and seeding patterns in pure and mixed Nothofagus forests in Southern Patagonia

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Ecological Processes 2016年第1期5卷 261-272页

作者： Monica Toro Manriquez Luciana Mestre Maria Vanessa Lencinas Alvaro Promis guillermo Martinez Pastur Rosina Soler National Scientific and Technical Research Council(CONICET) Austral Center for Scientific Research(CADIC-CONICET)Houssay 2009410 UshuaiaTierra del FuegoArgentina department of Silviculture and Nature Conservation University of ChileAv.Santa Rosa 113159206 SantiagoLa PintanaChile

Introduction:Variation in reproductive phenology among species is an important mechanism for maintaining species *** mixed forests,the impact of limiting(biotic and abiotic)factors on tree reproductive success regulates the maintenance of species in balanced proportions or the conversion towards monospecific *** study offer a significant first approach to the reproductive phenology of mixed forests,assessing flowering,seeding and loss factors on reproductive success in three forest types(pure deciduous Nothofagus pumilio(Np),evergreen Nothofagus betuloides(Nb)and mixed(M)forests),comparing also between two geographical locations(coast and mountain),during one growing ***:Flowering falling started early in *** fall occurred first and more concentrated in Np,while in Nb,it was progressive during *** in M combined both patterns,but with better reproductive performance of both *** production was greater in Nb(42,900,000 ha^(−1))than in Np(710,000 ha^(−1)),while M presented intermediate values(31,900,000 ha^(−1)).Abortion was greatest in Np(19% of female flowers and 10% of immature fruits),while fruit predation was low(7-9%)in all forest *** seed was the main loss factor,but with low net values for each species in *** geographical location,sea proximity generated a quick starting of the growing season in coast compared to mountain ***,we detected forest types×location interactions in flowering and seeding patterns(*** male flower production and in empty and viable seeds),with differences in species response according to ***:Both deciduous and evergreen species have reproductive advantages in mixed compared to pure ***,mixed were more similar to pure evergreen forests in their reproductive traits and the incidence of the limiting *** study of only one growing season does not allow us to conclude whether mixed forests are stable communities,but we cont

关键词： Broadleaved Mixed forest Geographical location Leaf habit Reproductive phenology Seed quality

The ILux^(®) compared to the mechanical meibomian gland expression for the treatment of moderate and severe meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1042-1048页

作者： María Ximena Núñez Andrea Acosta-Ortega guillermo Raul Vera-Duarte Catalina Gómez-Duarte Unit of Cornea Cataract and Refractive SurgeryVision Sana Research GroupClínica de Oftalmología de CaliFaculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia department of Ophthalmology Faculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia department of Ophthalmology Hospital de ClínicasNational University of AsunciónAsunción 111421Paraguay

AIM:To compare the safety and effectiveness of eyelid treatment with the ILux®-MGD Treatment System in one session versus five sessions of mechanical meibomian gland expression(MMGE)in patients with moderate to severe meibomian gland dysfunction(MGD).METHODS:A prospective,randomized,open-label,and controlled clinical trial that compared one session of the ILux®MGD Treatment System versus five sessions of MMGE in both eyes of 130 patients aged≥18y with Ocular Surface Disease Index(OSDI)scores≥13,total meibomian gland scores(MGS)ofdel for repeated means to determine the treatment relationship with total MGS,NIBUT,and *** was a significant difference between ILux®and MMGE(Pderate to severe MGD for one year without adverse events.

关键词： meibomian gland dysfunction ILux® ocular surface dry eye

3D cellular-resolution imaging in arteries using few-mode interferometry

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Light(Science & Applications) 2019年第1期8卷 183-191页

作者： Biwei Yin Zhonglie Piao Kensuke Nishimiya Chulho Hyun Joseph A.Gardecki Adam Mauskapf Farouc A.Jaffer guillermo J.Tearney Wellman Center for Photomedicine Harvard Medical School and Massachusetts General HospitalBostonMA 02114USA Cardiovascular Research Center and Cardiology Division Harvard Medical School and Massachusetts General HospitalBostonMA 02114USA department of Pathology Harvard Medical School and Massachusetts General HospitalBostonMA 02114USA Harvard-MIT Division of Health Sciences and Technology CambridgeMA 02139USA

Cross-sectional visualisation of the cellular and subcellular structures of human atherosclerosis in vivo is significant,as this disease is fundamentally caused by abnormal processes that occur at this scale in a depth-dependent ***,due to the inherent resolution-depth of focus tradeoff of conventional focusing optics,today’s highestresolution intravascular imaging technique,namely,optical coherence tomography(OCT),is unable to provide crosssectional images at this resolution through a coronary ***,we introduce an intravascular imaging system and catheter based on few-mode interferometry,which overcomes the depth of focus limitation of conventional highnumerical-aperture objectives and enables three-dimensional cellular-resolution intravascular imaging in vivo by a submillimetre diameter,flexible *** of diseased cadaver human coronary arteries and living rabbit arteries were acquired with this device,showing clearly resolved cellular and subcellular structures within the artery wall,such as individual crystals,smooth muscle cells,and inflammatory *** capability of this technology to enable cellularresolution,cross-sectional intravascular imaging will make it possible to study and diagnose human coronary disease with much greater precision in the future.

关键词： arteries rabbit resolution

Insights into the role of major bioactive dietary nutrients in lamb meat quality:a review

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Journal of Animal Science and Biotechnology 2022年第4期13卷 951-966页

作者： JavierÁlvarez-Rodríguez Olaia Urrutia Sandra Lobón guillermo Ripoll Juan Ramón Bertolín Margalida Joy departament de Ciència Animal Universitat de Lleida25198 LleidaSpain departamento de Agronomía Biotecnología y AlimentaciónIS-FOOD InstituteEscuela Técnica Superior de Ingeniería Agronómica y BiocienciasUniversidad Pública de NavarraPamplonaSpain Centro de Investigación y Tecnología Agroalimentaria de Aragón(CITA) Avda.Montañana 93050059 ZaragozaSpain Instituto Agroalimentario de Aragón–IA2(CITA-Universidad de Zaragoza) Avda.Miguel Servet17750013 ZaragozaSpain.

Feed supplementation withα-linolenic acid(ALA)and linoleic acid(LA)increases their content in muscle,ALA increases n-3 polyunsaturated fatty acids and decrease n-6/n-3 ratio in muscle,and LA increases rumenic ***,high LA supplementation may have negative effects on lambs’lipid oxidative stability of *** the sources of ALA and LA are fed as fresh forage,the negative effects are counterbalanced by the presence of other bioactive compounds,as vitamin E(mainlyα-tocopherol)and polyphenols,which delay the lipid oxidation in *** is a wide consensus on the capability of vitamin E delaying lipid oxidation on lamb meat,and its feed content should be adjusted to the length of supplementation.A high dietary inclusion of proanthocyanidins,phenolic compounds and terpenes reduce the lipid oxidation in muscle and may improve the shelf life of meat,probably as a result of a combined effect with dietary vitamin ***,the recommended dietary inclusion levels depend on the polyphenol type and concentration and antioxidant capacity of the feedstuffs,which cannot be compared easily because no routine analytical grading methods are yet *** phenolic compounds content in dietary ingredients/supplements for lambs are reported,no specific association with animal physiology responses may be established.

关键词： Fatty acid Forage Oilseed Polyphenol Vitamin E

Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography

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Light(Science & Applications) 2018年第1期7卷 511-523页

作者： Rongrong Liu James A.Winkelmann Graham Spicer Yunxiao Zhu Aya Eid guillermo A.Ameer Vadim backman Ji Yi department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA department of Chemical and Biological Engineering Northwestern UniversityEvanstonIL 60208USA department of Medicine Boston University School of MedicineBostonMA 02118USA

Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor a microvascular niche and better understand crucial biological ***,capillary oximetry and pericapillary ultrastructure are challenging to measure in *** we demonstrate a novel optical imaging system,dual-band dual-scan inverse spectroscopic optical coherence tomography(D2-ISOCT),that,for the first time,can simultaneously obtain the following metrics in vivo using endogenous contrast:(1)capillary-level oxygen saturation and arteriolar-level blood flow rates,oxygen delivery rates,and oxygen metabolic rates;(2)spatial characteristics of tissue structures at length scales down to 30 nm;and(3)morphological images up to 2mm in *** illustrate the capabilities of D2-ISOCT,we monitored alterations to capillaries and the surrounding pericapillary tissue(tissue between the capillaries)in the healing response of a mouse ear wound *** obtained microvascular and ultrastructural metrics corroborated well with each other,showing the promise of D2-ISOCT for becoming a powerful new non-invasive imaging tool.

关键词： optical capillary inverse

Diversity and seasonal variation of ground and understory spiders from a tropical mountain cloud forest

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Insect Science 2020年第4期27卷 826-844页

作者： Emmanuel F.Campuzano guillermo Ibarra-Nunez Salima Machkour-M Rabet Alejandro Moron-Rios Maria Luisa Jimenez Colegio de la Frontera Sur(ECOSUR) Unidad TapachulaTapachulaChiapasMexico ECOSUR Unidad ChetumalChetumalQuintana RooMexico ECOSUR Unidad CampecheCampecheCampecheMexico Centro de Investigaciones Biologicas del Noroeste(CIBNOR) La PazBaja California SurMexico

We made intensive samplings to study the seasonal response of spiders across different forest strata(ground and understory)in a tropical mountain cloud forest from *** sampled spiders from ten plots in six sampling events during the dry and rainy season,to analyze their abundance,structure(distribution of abundance among species),diversity and the response of the five dominant species at each *** demonstrated that seasonal patterns of spider communities differed among strata,revealing a complex spatiotemporal ***,structure,diversity of ground spiders,as well as the responses of four dominant species at this stratum,showed low seasonal *** contrast,a strong seasonal variation was observed for the understory assemblage,with lowest abundance and highest diversity in the rainy season,and different assemblage structures for each *** patterns of each assemblage seem linked to the responses of their dominant *** found high co-occurrence among most of the ground dominant species with similar habitat use and with multivoltine patterns,contrasting with low co-occurrence among most of the understory dominant species with similar habitat use and univoltine *** results showed that the spiders’assemblages of tropical mountain cloud forest(opposed to what is found in temperate and boreal forests)increase their species richness with the height,and that their responses to seasonal change differ between *** programs of these habitats should consider the spatial and temporal variations found here,as a better understanding of their ecological dynamics is required to support their sustainable management.

关键词： community structure El Triunfo Biosphere Reserve interspecific competition Mexico temporal change vertical stratification

An alternative to MINFLUX that enables nanometer resolution in a confocal microscope

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Light(Science & Applications) 2022年第9期11卷 2077-2085页

作者： LUCIANO A.MASULLO ALAN M.SZALAI LUCIA F.LOPEZ MAURICIO PILO-PAIS guillermo P.ACUNA Fernando D.Stefani Centro de Investigaciones en Bionanociencias(CIBION) Consejo Nacionallde Investigaciones Cientificas y Técnicas(CONICET)Godoy Cruz 2390C1425FQD Ciudad Autónoma de Buenos AiresBuenos AiresArgentina departamento de Fisica Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresGuiraldes 2620C1428EHA Ciudad Autónoma de Buenos AiresBuenos AiresArgentina department of Physics University of FribourgChemin du Musee 3Fribourg CH-1700Switzerland

Localization of single fluorescent emitters is key for physicochemical and biophysical measurements at the nanoscale and beyond ensemble *** include single-molecule tracking and super-resolution imaging by single-molecule localization *** the numerous localization methods available,MINFLUX outstands for achieving a~10-fold improvement in resolution over wide-field camera-based approaches,reaching the molecular scale at moderate photon *** application of MINFLUX and related methods has been hindered by the technical complexity of the ***,we present RASTMIN,a single-molecule localization method based on raster scanning a light pattern comprising a minimum of *** delivers~1-2nm localization precision with usual fluorophores and is easily implementable on a standard confocal microscope with few *** demonstrate the performance of RASTMIN in localization of single molecules and super-resolution imaging of DNA origami structures.

关键词： resolution pattern enable

design and development of a New Control System for Improving Energy Efficiency and demand Response

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Journal of Construction Research 2020年第1期2卷 37-49页

作者： guillermo Escrivá-Escrivá Institute for Energy Engineering Universitat Politècnica de ValènciaCamino de Veras/nedificio 8Eescalera F2ªplanta46022 ValenciaSpain

One of the best strategies for improving energy efficiency in any system is using the energy resources in the facilities *** energy systems only when they are absolutely necessary is one of the best cost-benefit ratio strategies,*** best energy saving strategy is,not using *** aim of this paper resides on introducing a new Energy Management and Control System(EMCS),developed by the authors,which has been installed at the Universitat Politècnica de Valè*** the paper,the architecture,the components and the installation cost analysis of the EMCS,as well as management actions implemented in the university and the obtained results are ***,this innovative system has been designed to improve demand response in energy systems by providing consumers with a tool for responding actively to energy demands,and also to provide all the different electrical market agents with a communication and business platform for exchanging information.

关键词： Energy efficiency demand response Control systems Web interface Energy saving