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Design and Implementation of a Rehabilitation Upper-limb Exoskeleton Robot Controlled by Cognitive and Physical Interfaces

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Journal of Bionic Engineering 2022年第5期19卷 1374-1391页

作者： Arturo Gonzalez‑Mendoza Ivett Quinones‑Uriostegui Sergio Salazar‑Cruz Alberto‑Isaac perez‑Sanpablo Ricardo Lopez‑Gutierrez Rogelio Lozano LAFMIA UMI Center for Research and AdvancedStudies of National Polytechnic InstituteAv.Instituto Politecnico Nacional No.250807360 Mexico CityMexico Motion Analysis Lab National Institute of Rehabilitation Luis Guillermo Ibarra IbarraCalz.Mexico Xochimilco No.28914389 Mexico CityMexico CONACYT-CINVESTAV Av.Instituto Politecnico Nacional 250807360 Mexico CityMexico UTC-CNRS UMR Sorbonne UniversitesUTC-CNRS UMR7253 HeudiasycCompiegneFrance

This paper presents an upper limb exoskeleton that allows cognitive(through electromyography signals)and physical user interaction(through load cells sensors)for passive and active exercises that can activate neuroplasticity in the rehabilitation process of people who suffer from a neurological *** the exoskeleton to be easily accepted by patients who suffer from a neurological injury,we used the ISO9241-210:2010 as a methodology design *** the first steps of the design process,design requirements were collected from previous usability tests and ***,as a second step,a technological solution is proposed,and as a third step,the system was evaluated through performance and user *** part of the technological solution and to allow patient participation during the rehabilitation process,we have proposed a hybrid admittance control whose input is load cell or electromyography *** hybrid admittance control is intended for active therapy exercises,is easily implemented,and does not need musculoskeletal modeling to ***,electromyography signals classification models and features were evaluated to identify the best settings for the cognitive human–robot interaction.

关键词： Human Robot interaction Hybrid admittance control Surface electromyography Upper-limb exoskeletal robot

Antenatal use of bosentan and/or sildenafil attenuates pulmonary features in rats with congenital diaphragmatic hernia

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World Journal of Pediatrics 2014年第4期10卷 354-359页

作者： María de Lourdes Lemus-Varela Amed Soliz Belinda Claudia Gómez-Meda Ana Lourdes Zamora-perez José Manuel Ornelas-Aguirre Valery Melnikov Blanca Miriam Torres-Mendoza guillermo Moisés Zúñiga-González Division of Neonatology High Specialty Medical UnitPediatric HospitalWestern National Medical CenterMexican Social Security InstituteGuadalajaraJaliscoMéxico Neonatal Intensive Care Unit Division of NeonatologyMiami Children's HospitalMiami FLDUSA Molecular Biology in Medicine Institute Molecular Biology and Genomic DepartmentHealth Sciences University CenterUniversity of GuadalajaraGuadalajaraJaliscoMéxico Odontology Research Institute Integrated Odontology Clinic DepartmentHealth Sciences University CenterUniversity of GuadalajaraGuadalajaraJaliscoMéxico Pathology Department High Specialty Medical UnitNorth-western National Medical CenterMexican Social Security InstituteCiudad ObregónSonoraMéxico School of Medicine University of ColimaColimaMéxico Division of Neurosciences Western Biomedical Research CenterMexican Social Security Institute and Department of ClinicsHealth Sciences University CenterUniversity of GuadalajaraGuadalajaraJaliscoMéxico Mutagenesis Laboratory Western Biomedical Research CenterMexican Social Security InstituteGuadalajaraJaliscoMéxico

Background:Lung hypoplasia,pulmonary persistent hypertension of the newborn and its morphological changes are the main features in congenital diaphragmatic hernia(CDH).This study was undertaken to investigate if antenatal use of sildenafil and/or bosentan attenuates vascular remodeling,promotes branching,and improves alveolarization in experimental nitrofeninduced ***:Nitrofen(100 mg)was gavage-fed to pregnant rats at post conception day(PCD)9 to induce *** rats were randomized to 5 groups:1)control;2)nitrofen;3)nitrofen+sildenafil 100 mg/kg per day at PCD 16-20;4)nitrofen+bosentan 30 mg/kg per day,at PCD 16-20,and 5)nitrofen+bosentan+sildenafil,same doses and administration *** cesarean delivery,the offsprings were sacrifi *** diaphragmatic defect and pulmonary hypoplasia were identified,and the lungs were *** wall thickness,bronchiolar density and alveolarization were ***:The offsprings with CDH were characterized by severe pulmonary hypoplasia(lung weight-to-body weight ratio:0.0263[95%confidence interval(CI)0.0242-0.0278)]in the nitrofen group versus 0.0385(95%CI 0.0355-0.0424)in the control group(P=0.0001).Pulmonary arterial wall thickness was decreased to 3.0(95%CI 2.8-3.7)μm in the nitrofen+sildenafil group versus 5.0(95%CI 4.1-4.9)μm in the nitrofen group(P=0.02).Terminal bronchioles increased to 13.7(95%CI 10.7-15.2)μm in the nitrofen+bosentan group in contrast to 8.7(95%CI 7.2-9.4)μm in the nitrofen group(P=0.002).More significant differences(P=0.0001)were seen in terminal bronchioles in the nitrofen+sildenafil+bosentan group than in the nitrofen group[14.0(95%CI 12.5-15.4)μm versus 8.5(95%CI 7.1-9.3)μm].Pulmonary arterial wall thickness was also decreased in the former ***:In this rat model,antenatal treatment with sildenafil attenuates vascular *** promotes the development of terminal bronchioles in nitrofen-induced CDH.

关键词： antenatal treatment bosentan congenital diaphragmatic hernia pulmonary hypoplasia sildenafil

不同种族幽门螺杆菌菌株CagA蛋白羧基端结构和生物学功能的差异

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胃肠病学和肝病学杂志 2010年第9期19卷 834-837页

作者：陈明红力超彭孝纬潘秀珍 guillermo perez-perez 福建省立医院福建省胃肠病研究所福建福州350001 福建省肿瘤医院美国纽约大学医学院微生物研究所

目的比较不同种族***菌株CagA蛋白羧基端结构以及诱导AGS细胞延伸、分泌IL-8能力的差异。方法 PCR扩增CagA3′端可变区DNA序列并进行测序,获得CagA3′端可变区氨基酸序列。以不同***菌株与AGS细胞孵育,观察AGS延伸细胞的百分数,测定细... 详细信息

目的比较不同种族***菌株CagA蛋白羧基端结构以及诱导AGS细胞延伸、分泌IL-8能力的差异。方法 PCR扩增CagA3′端可变区DNA序列并进行测序,获得CagA3′端可变区氨基酸序列。以不同***菌株与AGS细胞孵育,观察AGS延伸细胞的百分数,测定细胞培养上清IL-8含量。结果美籍亚裔和美籍非裔菌株的CagA羧基端氨基酸第3个EPIYA前后的氨基酸序列存在明显差异。不同种族cag PAI+***导致AGS细胞延伸、分泌IL-8能力无明显差异。cag PAI+***诱导细胞延伸AGS细胞、分泌IL-8的能力明显大于cag ***。结论不同种族***菌株CagA蛋白羧基端结构存在差异。***-lori菌株诱导AGS细胞延伸、分泌IL-8的能力与cag PAI有关。

关键词：幽门螺杆菌细胞毒素相关基因致病岛 EPIYA

Determination of Epibionts of the Marine Turtle Lepidochelys Ofivacea （Eschscholtz, 1829） Nesting in Ceuta Beach, Sinaloa, Mexico

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Journal of Agricultural Science and Technology(B) 2012年第11期2卷 1190-1194页

作者： Ingmar Sosa-Comejo Dulce Italivi Montano-Valdez Marcos Bucio-Pacheco Fernando Enciso-Saracho Jorge guillermo Sanchez-Zazueta Estela Fierros-perez Escuela de Biologla Universidad Autdenoma de Sinaloa Culiacfn Rosales Sinaloa CP 80030 Mexico Facultad de Ciencias del Mar Universidad Autenoma de Sinaloa. Mazatl6n Sinaloa Mexico

Epibionts are floristic and faunistic benthonic organisms living attached to the skin of another animal; this phenomenon is well known as epibiosis and has been documented for all species of marine turtles. The interaction between the turtle and epibiotic organisms is to provide substrate for the epibionts communities, their presence are based mainly in the shell and in other anatomical structures in lower intensity. It has been registered that some epibionts affect growth, and can cause diverse damage in anatomical structures like the eyes, mouth, and limbs. They are usually vectors of disease. For such reasons the objective of the present work is to determinate the epibionts species associated with the marine turtle Lepidochelys olivacea in Ceuta beach, Sinaloa, Mexico. During the nesting season May-December of 2008-2009, the female turtles nesting and strandings were monitored and epibionts were collected. Eleven species distributed in the following taxa were obtained： fishes of the family Echeneidae, Hirudineos （Ozobranchus branchiatus, Ozobranchus margoi）, Arthropods （Chelonibia testudinaria, Lepas sp., Conchoderma virgatum） and the first registry of Stephanolepas muricata for Lepidochelys olivacea. According to the records from Ceuta Beach the species of epibionts are still being registered with the exception of Ozobranchus margoi, and Stephanolepas muricata, thus, suggesting further research on epibiont organisms.

关键词： Epibiont Ceuta Lepidochelys olivacea turtles.

Management of cancer patients during COVID-19 pandemic at developing countries

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World Journal of Clinical Cases 2020年第16期8卷 3390-3404页

作者： Jaime González-Montero guillermo Valenzuela Mónica Ahumada Olga Barajas Luis Villanueva Department Faculty of MedicineUniversity of ChileSantiago 70058Chile Department Hospital Clinico Universidad de Chile and Clínica DávilaChile Department Hospital Clinico Universidad de Chile and Fundación Arturo López-PérezChile Department Hospital Clínico Universidad de Chile and Fundación Arturo López-PerezChile

Cancer patient care requires a multi-disciplinary approach and multiple medical and ethical *** care during a pandemic health crisis requires prioritising the use of resources for patients with a greater chance of survival,especially in developing *** coronavirus disease 2019 crisis has generated new challenges given that cancer patients are normally not prioritised for admission in critical care ***,the development of new cancer drugs and novel adjuvant/neoadjuvant protocols has dramatically improved the prognosis of cancer patients,resulting in a more complex decision-making when prioritising intensive care in pandemic *** this context,it is essential to establish an effective and transparent communication between the oncology team,critical care,and emergency units to make the best decisions,considering the principles of justice and ***,cancer treatment protocols must be adapted to prioritise according to oncologic response and *** technologies are powerful tools to optimise cancer care during pandemics,and we must adapt quickly to this new scenario of clinical care and *** this new challenging pandemic scenario,multi-disciplinary work and effective communication between clinics,technology,science,and ethics is the key to optimising clinical care of cancer patients.

关键词： Cancer Oncology Pandemic COVID-19 SARS-CoV-2

Foliar Analysis as an Estimate on the Nutritional State of Conilon Coffee Plantations on Cambisoils

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Journal of Life Sciences 2014年第2期8卷 181-187页

作者： Alberto perez Diaz Emesto Castaneda Hidalgo Salvador Lozano Trejo Carlos Alberto Bustamante Gonzailez Ramon Antonio Rivera Espinosa Geraldo Rodriguez Ortiz Gloria Martha Martin Alonso Cerelino Roblesperez guillermo Acosta Coutin Alberto Fernandez Turro Centro de Estudios de Cafe y Cacao Universidad de Guantanamo Guantanamo 95300 Cuba Instituto Tecnologico del Valle de Oaxaca Ex Hacienda de Nazareno Xoxocotlan 712320 Mexico Instituto de Investigaciones Agroforestales UCTB-Tercer Frente Santiago de Cuba 92700 Cuba Instituto Nacional de Ciencias Agricolas San Jose de las Lajas Mayabeque 32700 Cuba Universidad de Ciencias Pedagogicas "Raul Gomez Garcla " Guantanamo 95100 Cuba

The objective of this paper relies on the establishment of the sampling moment and the nutritional state of the species Conilon coffee （Coffea canephora） cultivated in Cambisoils. The effect of different rates of nitrogen fertilization was also studied in the leaves concentrations of N, at randomized complete block designs （N0= 0; N1 = 50; N2 = 100; N3 = 150 and N4 = 200 ***^-1 of N） in presence of P （40 ***^-1 of P2O5） and K （160 ***^-1 of K2O）, with four replicates. The samples were carried out in the months of March （flower blossoming stage）, June （fruits growing stage）, September （grain development） and December （maturation） in all treatments. Foliar analysis carried out in the month of June （fruits growing stage） for the purpose of establishing critical nutrient range values for N, settling down approaches of interpretation of the same one for the Conilon coffee plantations on Cambisoils. The biggest percentages in the yields are obtained with leaves containing N between 2.80% and 3.10%, a value below 2.80% N which they associated with indicative percentages of stable maximum yield that did not surpass the limits of the adequate nutrients supply.

关键词： Nitrogen fertilization critical nitrogen range Conilon coffee leaves concentrations of N.

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EL CAMARIN迷你公寓

现代装饰 2019年第2期 28-35页

作者： Luciano Intile Enrico Cavaglià Fermínlndavere Esteban Basili guillermo Mirochnic Rodrigo perez de Pedro Cecile Elbel Sabine Uldry TommasoPolli Fernando Schapochnik 彭佳 IR arquitectura

这间公寓由阿根廷IR arquitectura建筑设计事务所所设计,是上世纪50年代Chacarita社区房产的一部分。它位于建筑二层的一个角落,可以俯瞰下面的街道。设计师利用空间的特点,打造了一间明亮而又灵活的迷你公寓。

关键词：世纪空间建筑设计利用角落设计师设计事务所公寓

Pseudopemphigoid as caused by topical drugs and pemphigus disease

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World Journal of Ophthalmology 2015年第1期5卷 1-15页

作者： Laura C Huang James R Wong Javier Alonso-Llamazares Carlos H Nousari Victor L perez guillermo Amescua Carol L Karp Anat Galor Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiamiFL 33136United States Department of Dermatology and Cutaneous Surgery Miami Veterans Administration Medical CenterMiamiFL 33136United States Institute for Immunofluorescence Pompano BeachFL 33069United States Ameripath/Quest South Florida Pompano BeachFL 33069United States Department of Dermatology and Cutaneous Surgery University of Miami Miller School of MedicineMiamiFL 33136United States Department of Ophthalmology Miami Veterans Administration Medical CenterMiamiFL 33136United States

Pseudopemphigoid can cause a chronic cicatricial conjunctivitis that is clinically identical to the manifestations seen in mucous membrane pemphigoid, a disorder with a common clinical phenotype and multiple autoimmune links. For the purpose of this review, we will describe pseudopemphigoid as caused by topical drugs, the most common etiology with ocular manifestations, and as caused by the pemphigus disease, a more rare etiology. Specifically, we will discuss the ophthalmological features of drug-induced cicatricial conjunctivitis, pemphigus vulgaris, and paraneoplastic pemphigus. Other etiologies of pseudopemphigoid exist that will not be described in this review including autoimmune or inflammatory conditions such as lichen planus, sarcoidosis, granulomatosis with polyangiitis(Wegener's granulomatosis), erythema multiforme(minor, major, and Stevens-Johnson syndrome), bullous pemphigoid, skin-dominated linear IgA bullous dermatosis, and skin-dominated epidermolysis bullosa acquisita. Prompt diagnosis of the underlying etiology in pseudopemphigoid is paramount to the patient's outcome as certain diseases are associated with a more severe clinical course, increased ocular involvement, and differential response to treatment. A completehistory and ocular examination may find early cicatricial changes in the conjunctiva that are important to note and evaluate to avoid progression to more severe disease manifestations. When such cicatricial changes are noted, proper diagnostic techniques are needed to help elucidate a diagnosis. Lastly, collaboration between ophthalmologists and subspecialists such as dermatologists, pathologists, immunologists, and others involved in the care of the patient is needed to ensure optimal management of disease.

关键词： Pseudopemphigoid Mucous membrane pemphigoid Cicatricial conjunctivitis Pemphigus vulgaris Paraneoplastic pemphigus Drug-induced conjunctival cicatrization