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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 890-892页

作者： guillermo daniel mazzolini Eda Kaya Ali Canbay Gene Therapy Laboratory Instituto de Investigaciones en Medicina Traslacional(IIMT)Universidad Austral-CONICETBuenos AiresArgentina Liver Unit Hospital Universitario AustralUniversidad AustralBuenos AiresArgentina Section of Gastroenterology and Hepatology University Hospital Knappschaftskrankenhaus BochumRuhr University BochumBochumGermany Department of Medicine University Hospital Knappschaftskrankenhaus BochumRuhr University BochumBochumGermany

Hepatocellular carcinoma(HCC)is the sixth most common cancer and the second leading cause of cancer-related death worldwide(1).Unfortunately,the incidence and mortality of HCC are increasing steadily in formerly low-risk countries(2).Although the contribution of patients infected with hepatitis B virus(HBV)and hepatitis C virus(HCV)has dramatically decreased due to the use of highly effective antiviral agents,increasing epidemiologic evidence indicates a link between non-alcoholic fatty liver disease(NAFLD)and the risk of HCC(1).It is important to highlight that the prevalence of NAFLD has increased in parallel with the obesity,metabolic syndrome,and type 2 diabetes mellitus *** patients with NAFLD,the incidence of HCC is around 0.44 per 1,000 person-years(3).

关键词： NAFLD hepatitis mortality

Taking advantage of the potential of mesenchymal stromal cells in liver regeneration:Cells and extracellular vesicles as therapeutic strategies

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World Journal of Gastroenterology 2018年第23期24卷 2427-2440页

作者： Esteban Juan Fiore Luciana María Domínguez Juan Bayo Mariana Gabriela García guillermo daniel mazzolini Laboratory of Gene Therapy Instituto de Investigaciones en Medicina TraslacionalCONICET-Universidad Austral

Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells(MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise,it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles(EVs). EVs contain proteins,lipids and nucleic acids(DNA,m RNA,mi RNA,lnc RNA) from the cell of origin,allowing for intercellular communication. Recently,different studies have demonstrated that MSC-derived EVs could reproduce,at least in part,the biological effects obtained by MSCbased therapies. Moreover,due to EVs' stability for long periods of time and easy isolation methods they have become a therapeutic option to MSCs treatments. This review summarizes the latest results achieved in clinical trials using MSCs as cell therapy for liver regeneration,the role of EVs in liver physiopathology and the potential of MSC-derived EVs as intercellular mediators and therapeutic tools in liver diseases.

关键词： Mesenchymal stem cells Extracellular vesicles Cirrhosis Liver Acute damage Regeneration

Physiological dormancy broken by endozoochory:Austral parakeets(Enicognathus ferrugineus)as legitimate dispersers of calafate(Berberis microphylla)in the Patagonian Andes

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Journal of Plant Ecology 2020年第5期13卷 538-544页

作者： Carolina Bravo daniel Chamorro Fernando Hiraldo Karina Speziale Sergio A.Lambertucci JoséL.Tella guillermo Blanco Department of Evolutionary Ecology Museo Nacional de Ciencias NaturalesCSICJoséGutiérrez Abascal 228006 MadridSpain Centre d’Etudes Biologiques de Chizé UMR 7372CNRS and La Rochelle UniversitéF-79360 Beauvoir-sur-NiortFrance Departamento de Ciencias Ambientales Universidad de Castilla-La ManchaAv.Carlos III s/n45071 ToledoSpain Department of Conservation Biology Estación Biológica de DoñanaCSICAmérico Vespucio 2641092 SevillaSpain Grupo de Investigaciones en Biología de la Conservación Departamento de EcologíaINIBIOMA(CONICET-National University of Comahue)Pasaje Gutiérrez 11258400 BarilocheArgentina

Aims Seed dispersal by endozoochory is an important process in plant regeneration and the establishment of new *** with dormancy may especially benefit after disperser gut ***,the ways in which gut passage affect the germination of plant species with physiological dormancy remain ***,we experimentally assessed the mutualistic interaction between the Austral parakeet(Enicognathus ferrugineus)as a disperser of calafate(Berberis microphylla),a thorny bush inhabiting the understory of the Austral temperate forests of South America with seeds that are characterized by deep physiological *** Germination success and viability of calafate seeds obtained from faeces and from intact fruits were tested under four treatments:(i)digested seeds,(ii)digested seeds with faecal extract,(iii)intact seeds from fruit and(iv)intact seeds from fruit with *** Findings About 65%of the Austral parakeet droppings contained calafate *** of seeds did not differ between ***,germination was significantly higher in digested seeds than in intact seeds from fruits,while no difference was found between faecal and pulp *** faecal matter nor fruit pulp provided seeds with any ecological advantages derived from enhancing germinability,but did confer some disadvantage in germination *** matter is expected to be completely lacking around seeds after several months under snow before germinating in the following spring,given intense washing due to persistent rain and the spring thaw in the Patagonian *** higher germinability along with faster germination of digested seeds supports the hypothesis of a legitimate mutualistic interaction between Austral parakeets and *** hypothesized that the passage through the disperser digestive tract might break physiological dormancy as differences in germinability between ingested and non-ingested *** results highlight the relevant role of endoz

关键词： seed dispersal Austral forest mutualism gut passage viability germination success germinability

The architecture of the(post)studio:Jackson Pollock’s barn and Andy Warhol’s Silver Factory

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Frontiers of Architectural Research 2023年第2期12卷 266-276页

作者： guillermo Lockhart Milan Departamento de Proyectos Arquitecto´nicos Escuela Te´cnica Superior de ArquitecturaUniversidad Polite´cnica de MadridMadrid 28040Spain

This article will discuss a false dichotomy between two models,the modern art studio and the post-studio,which oppose the private and the public,the individual and the collective,hiding and the *** will begin by analysing daniel Buren’s position in his canonical text“Fonction de l’Atelier”and his practice,where the artist defines the foundations of post-studio *** the text also describes a New York studio type that must be left behind,we will analyse Jackson Pollock’s and Andy Warhol’s workspaces through drawing reconstructions to demonstrate that these meet the defining characteristics of both *** will be shown that the artists have used design strategies to retain certain aspects of studio culture while exploring others of the *** turning point reveals that the current belief about the obsolescence of the studio in a global era defined by communication,networking and mobility ignores its emerging post-studio *** work aims to acknowledge this shift,obtaining a critical vision that will allow us to design contemporary workspaces avoiding stereotypical and reductionist approaches.

关键词： Andy Warhol daniel Buren Function of the studio Jackson Pollock Post-studio Studio

Electric memory effects in styrene-butadiene rubber, containing electric inclusions of highly aromatic oil

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Journal of Advanced Dielectrics 2018年第3期8卷 44-57页

作者： Ricardo Raúl Mocellini Federico guillermo Bonifacich Fernando daniel Lambri Mariel Antonella Lambri Griselda Irene Zelada Osvaldo Agustín Lambri CONICET-UNR Laboratorio de MaterialesEscuela de Ingeniería Electrica Centro de Tecnología e Investigacion Electrica Facultad de Ciencias ExactasIngeniería y Agrimensura Avda.Pellegrini 250Rosario 2000Argentina

It was determined that samples of styrene-butadiene rubber(SBR),containing highly aromatic oil,exhibit memory effects giving rise to dynamic elastic modulus,damping and internal stresses degree which can be tailored depending on the applied electric field *** capability and stability of the interaction process between aligned neighbor dipoles for exhibiting a memory effect,once the aligning electric field was removed are *** is determined that depending on the spatial arrangement and the amount of electric charge of the dipoles,this interaction is able to promote a memory effect which keeps the alignment between *** electrostatic interaction plays the role of a counteracting effect for keeping the alignment,which was called *** results from the developed model were applied successfully to SBR composite samples for explaining the memory effects recorded from dynamic mechanical analysis(DMA)measurements under electric *** addition,the model of the electric inclusion based on the inclusion theory for continuous media,was applied to determine the degree of internal stresses in the dielectric composite material due to the external applied electric *** addition,from the coupling between the model developed here and simple issues related to the mechanical properties of composite materials,a procedure for determining the maximum possible gap between the electric dipoles in composite dielectric materials is also shown.

关键词： Modeling memory effect dynamic mechanical analysis electric interaction polymer matrix composite with electric inclusions

Evaluation of curcumin and copper acetate against Salmonella Typhimurium infection,intestinal permeability,and cecal microbiota composition in broiler chickens

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1019-1030页

作者： Anaisa ALeyva-Diaz daniel Hernandez-Patlan Bruno Solis-Cruz Bishnu Adhikari Young Min Kwon Juan D.Latorre Xochitl Hernandez-Velasco Benjamin Fuente-Martinez Billy M.Hargis Raquel Lopez-Arellano guillermo Tellez-Isaias Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y ZootecniaUNAM04510 Ciudad de MexicoMexico Laboratorio 5:LEDEFAR Unidad de Investigacion MultidisciplinariaFacultad de Estudios Superiores(FES)CuautitlanUniversidad Nacional Autonoma de Mexico(UNAM)54714 Cuautitlan IzcalliMexico Department of Poultry Science Center of Excellence for Poultry ScienceUniversity of Arkansas1260 W.MaplePOSC 0-114FayettevilleAR 72704USA Centro de Ensenanza Investigacion y Extension en Produccion AvicolaFacultad de Medicina Veterinaria y ZootecniaUNAMCiudad de MexicoMexico

Background:Interest in the use of natural feed additives as an alternative to antimicrobials in the poultry industry has increased in recent years because of the risk of bacterial *** of the most studied groups are polyphenolic compounds,given their advantages over other types of additives and their easy potentiation of effects when complexes are formed with metal ***,the objective of the present study was to evaluate the impact of dietary supplementation of copper acetate(CA),curcumin(CR),and their combination(CA-CR)against Salmonella Typhimurium colonization,intestinal permeability,and cecal microbiota composition in broiler chickens through a laboratory Salmonella infection *** recovery was determined on day 10 post-challenge by isolating Salmonella in homogenates of the right cecal tonsil(12 chickens per group)on Xylose Lysine Tergitol-4(XLT-4)with novobiocin and nalidixic *** integrity was indirectly determined by the fluorometric measurement of fluorescein isothiocyanate dextran(FITC-d)in serum samples from blood obtained on d 10 *** ***,microbiota analysis was performed using the content of the left caecal tonsil of 5 chickens per group by sequencing V4 region of 16S rRNA ***:The results showed that in two independent studies,all experimental treatments were able to significantly reduce the *** colonization in cecal tonsils(CT,P<0.0001)compared to the positive control(PC)***,only CA-CR was the most effective treatment in reducing *** counts in both independent ***,the serum fluorescein isothiocyanate dextran(FITC-d)concentration in chickens treated with CR was significantly lower when compared to PC(P=0.0084),which is related to a decrease in intestinal permeability and therefore intestinal *** effect of dietary treatments in reducing Salmonella was further supported by the analysis of 16S rRNA gene sequences using Li

关键词： Broiler chickens Copper acetate Curcumin Intestinal permeability Microbiota composition Salmonella Typhimurium

The Genome of Cucurbita argyrosperma (Silver- Seed Gourd) Reveals Faster Rates of Protein- Coding Gene and Long Noncoding RNA Turnover and Neofunctionalization within Cucurbita

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Molecular Plant 2019年第4期12卷 506-520页

作者： Josue Barrera-Red on do Enrique Ibarra-Laclette Alejandra Vazquez-Lobo Yocelyn T. Gutierrez-Guerrero guillermo Sanchez de la Vega daniel Pinero Salvador Montes-Hernandez Rafael Lira-Saade Luis E. Eguiarte Departamento de Ecologia Evolutiva Instituto de Ecologia Universidad Nacional Aut6noma de Mexico Circuito Exterior s/n Anexo al Jardin Bot合nico 04510 Ciudad de Mexico Mexico Departamento de Estudios Moleculares Avanzados Instituto de Ecologia A.C. Carretera Antigua a Coatepec No. 351 Col. El Haya. C.P. Xalapa Veracruz 91070 Mexico Centro de Investigaciones en Biodiversidad y Conservacion Universidad Autdnoma del Estado de Morelos Av. Universidad 1001 Col. Chamilpa Cuernavaca Morelos 62209 Mexico Campo Experimental Bajio Instituto Nacional de In vestigaciones Forestales Agricolas y Pecuarias (INIFAP) Km 6.5 Carretera Celaya-San Miguel de Allen de Celaya Guanajuato 38110 Mexico UBIPRO Facultad de Estudios Superiores Iztacala Universidad Nacional Autdnoma de Mexico Av. de los Barrios #1 Col. Los Reyes Iztacala Tlanepantla Edo. de Mex 54090 Mexico

Whole-genome duplications are an important source of evolutionary novelties that change the mode and tempo at which genetic elements evolve within a genome. The Cucurbita genus experienced a wholegenome duplication around 30 million years ago, although the evolutionary dynamics of the coding and noncoding genes in this genus have not yet been scrutinized. Here, we analyzed the genomes of four Cucurbita species, in eluding a newly assembled genome of Cucurbita argyrosperma, and compared the gene con tents of these species with those of five other members of the Cucurbitaceae family to assess the evolutionary dynamics of protein-coding and long intergenic noncoding RNA (lincRNA) genes after the genome duplication. We report that Cucurbita genomes have a higher protein-coding gene birth-death rate compared with the genomes of the other members of the Cucurbitaceae family. C. argyrosperma gene families associated with pollination and transmembrane transport had significantly faster evolutionary rates. lincRNA families showed high levels of gene turnover throughout the phylogeny, and 67.7% of the lincRNA families in Cucurbita showed evidence of birth from the neofunctionalization of previously existing protein-coding genes. Collectively, our results suggest that the whole-genome duplication in Cucurbita resulted in faster rates of gene family evolution through the neofunctionalization of duplicated genes.

关键词： Cucurbita argyrosperma, comparative genomics molecular evolution neofunctionalization long noncoding RNA whole-genome duplication

Presence of the deep-bodied pipefish, <i>Leptonotus blainvilleanus </i>(Eydoux &Gervais, 1837) [Syngnathiformes: Syngnathidae], in San Jorge Gulf, Patagonia, Argentina

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Open Journal of Ecology 2012年第2期2卷 58-59页

作者： guillermo M. Caille Ariana Apezteguia daniel Vaquero Pablo Cochia Ciencias Naturales Universidad Nacional de la Patagonia Trelew Argentina Fundación Patagonia Natural Puerto Madryn Argentina

This short report communicates the finding of a Deep-bodied pipefish, Leptonotus blainvilleanus, (Eydoux & Gervais, 1837) [Syngnathiformes, Syngnathidae] in shallow waters of the San Jorge Gulf, Patagonia Argentina, in August 2010. It’s a new record for its known distribution range in the coast of South America. Photos and videos are available.

关键词： Syngnathidae Leptonotus balainvilleanus San Jorge Gulf Coastal Cold-Temperate Waters Patagonia Argentina

Description of interhemispheric disconnection syndrome in a patient with Marchiafava-Bignami disease

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World Journal of Neuroscience 2013年第3期3卷 190-197页

作者： daniel Gustavo Politis Romina Mara Tirigay Pablo guillermo Gómez María Eugenia Tabernero Cognitive Impairment Laboratory Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Neurology Service Inter-Zone Acute Hospital “Eva Perón” San Martín Provincia de Buenos Aires Argentina

Interhemispheric disconnection syndrome (IDS), described by Sperry, Gazzaniga and Bogen, is characterized by the presence of visual and tactile anomia, absence of interhemispheric transference of unilateral somatosensory stimulation of both hands, hemialexia and unilateral left-side apraxia. Subsequently, changes were also observed in the sensory interhemispheric transfer and in tests of crossed motor control. In Marchiafava-Bignami disease (MBD) there have been descriptions of partial IDS. The aim is to describe the dissociations in IDS that are presented in a patient with MBD, using a specialized assessment methodology. Patient and Method: A 54-year-old patient, righthanded, with 11 years of schooling, presented with antecedent chronic alcoholism. Neuropsychological tests were administered for general assessment along with specific tests of interhemispheric transference. Results: Borderline changes were found in visual memory, visual-constructive abilities and attention and executive functioning. In tasks of interhemispheric transference the patient showed changes in: the imitation of hand poses;inter-manual pressure point localization (tactile stimulation);reading aloud of words by visual hemifield;and movement control. Conclusion: Our patient showed a wide lesion of the Corpus Callosum (CC) with relative preservation of the splenium, accompanied by partial disconnection syndrome in the context of a global cognitive deterioration from his chronic alcoholism.

关键词： Split-Brain Marchiafava-Bignami Disease Hemispheric Specialization Tachioscopic Assessment Interhemispheric Disconnection Syndrome

Arylated analogues of cypronazole: fungicidal effect and activity on human fibroblasts. Docking analysis and molecular dynamics simulations

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Natural Products and Bioprospecting 2022年第1期12卷 107-120页

作者： Natividad Herrera Cano Sebastian A.Andujar Cristina Theoduloz daniel A.Wunderlin Ana N.Santiago guillermo Schmeda-Hirschmann Ricardo D.Enriz Gabriela E.Feresin Instituto de Biotecnología Facultad de IngenieríaUniversidad Nacional de San JuanCONICET-CCT San JuanAv.Libertador General San Martín1109(O)5400 San JuanArgentina Facultad de Química Bioquímica y Farmacia-IMIBIO-SL(CONICET)Universidad Nacional de San LuisChacabuco 9155700 San LuisArgentina Laboratorio de Cultivo Celular Facultad de Ciencias de la SaludUniversidad de TalcaCasilla 7473460000 TalcaChile ICYTAC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamentoQuímica OrgánicaCiudad UniversitariaBv.Juan Filloy s/n5000 CórdobaArgentina INFIQC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamento Química OrgánicaCiudad UniversitariaHaya de La Torre S/N5000 CórdobaArgentina Laboratorio de Química de Productos Naturales Instituto de Química de Recursos NaturalesUniversidad de TalcaCasilla 7473460000 TalcaChile

Triadimefon(TDM)and cyproconazole(CPZ)are two triazoles widely used as *** azoles were synthe-sised starting from commercial TDM and *** compounds were evaluated against phytopathogenic filamentous fungi,including Aspergillus fumigatus(AF),***(AN),***(AU),***(AJ),***(AT),Fusarium oxyspo-rum and Botrytis cinerea isolated from grapevine in the province of San Juan,*** of the synthesised compounds(1-(Biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one,1;2-(Biphenyl-4-yl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,3;3-Cyclopropyl-2-(4’-fluorobiphenyl-4-yl)-1-(1H-1,2,4-triazol1-yl)butan-2-ol,4)presented remarkable in vitro fungicidal properties,with better effects than TDM and CPZ on some of the target *** was assessed using human lung fibroblasts *** 1,with IC50 values of 389.4μM,was less toxic towards MRC-5 human lung fibroblasts than commercial TDM(248.5μM)and CPZ(267.4μM).Docking analysis and molecular dynamics simulations suggest that the compounds present the same interaction in the binding pocket of the CYP51B enzyme and with the same amino acids as *** derivatives investigated could be considered broad-spectrum but with some selectivity towards imperfect fungi.

关键词： Azoles Antifungal cytotoxicity Conformational and electronic analysis