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Monitoring stress and recovery states: Structural and external stages of the short version of the RESTQ sport in elite swimmers before championships

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Journal of Sport and Health Science 2019年第1期8卷 77-88页

作者： Michel Nicolas Philippe Vacher guillaume Martinent Laurent Mourot Laboratory of Socio Psychology and Management of Sport (SPMS EA 4180) University of Burgundy Laboratory of Vulnerabilities and Innovation in Sport (L-ViS EA 7428) Univ Lyon University of Claude Bernard Lyon 1 University of Franche Comt-Prognostic Markers and Regulatory Factors of Heart and Vascular Diseases and Exercise Performance Health Innovation Platform

Background: Psychological stress and recovery monitoring is a key issue for increasing athletes' health, well-being, and performance. This multistudy report examined changes and the doseàresponse relationships between recoveryàstress psychological states, training load(TL), heart rate(HR), heart rate recovery(HRR), and heart rate variability(HRV) while providing evidence for the factorial validity of a short French version of the RecoveryàStress Questionnaire for Athletes(RESTQ-36-R-Sport).Methods: Four hundred and seventy-three university athletes(Study 1), 72 full expert swimmers(Study 2), and 11 national to international swimmers(Study 3) participated in the study. Data were analyzed through confirmatory factor analyses(Study 1), repeated ANOVAs and correlational analyses(Study 2), t tests and correlational analyses(Study 3).Results: Multiple-group confirmatory factor analyses showed that the RESTQ-36-R-Sport scores were partially invariant across gender, type of sport, and practice level(Study 1). A doseàresponse relationship was performed between TL and RESTQ-36-R-Sport scores during an ecological training program(Study 2). Finally, relationships were found between physiological(HRR) and psychological(RESTQ-36-R-Sport) states during an ecological tapering period leading to a national championship(Study 3).Conclusion: As a whole, these findings provided evidence for the usefulness of the short version of the RESTQ-36-R-Sport for regular monitoring to prevent potential maladaptation due to intensive competitive sport practice.

关键词： Adaptation Confirmatory factor analysis Heart rate variability Monitoring Recovery Stress

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Inflammatory bowel disease registries for collection of patient iron parameters in Europe

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World Journal of Gastroenterology 2018年第10期24卷 1063-1071页

作者： Jonas Halfvarson Fraser Cummings Olof Grip guillaume Savoye Department of Gastroenterology Faculty of Medicine and HealthOebro UniversityObro SE 70182Sweden Department of Gastroenterology Southampton University Hospital NHS Foundation TrustSouthamptonHampshire SO16 6YDUnited Kingdom Department of Gastroenterology Skae University HospitalMalmo-20502Sweden Service d'heato-gastroenteologie CHU de Rouen-Hoital Charles NicolleRouen 76031France

Iron deficiency without anemia and iron deficiency anemia are common and frequently overlooked complications of inflammatory bowel disease. Despite the frequency and impact of iron deficiency in inflammatory bowel disease, there are gaps in our understanding about its incidence, prevalence and natural history and, consequently, patients may be undertreated. Medical registries have a key role in collecting data on the disease's natural history, the safety and effectiveness of drugs in routine clinical practice, and the quality of care delivered by healthcare services. Even though iron deficiency impacts inflammatory bowel disease patients and healthcare systems substantially, none of the established European inflammatory bowel disease registries systematically collects information on iron parameters and related outcomes. Collection of robust iron parameter data from patient registries is one way to heighten awareness about the importance of iron deficiency in this disease and to generate data to improve the quality of patient care, patient outcomes, and thus quality of life. This objective could be achieved through collection of specific laboratory, clinical, and patientreported measurements that could be incorporated into existing registries. This review describes the status of current European inflammatory bowel disease registries and the data they generate, in order to highlight their potential role in collecting iron data, to discuss how such information gathering could contribute to our understanding of iron deficiency anemia, and to provide practical information in regard to the incorporation of accumulated iron parameter data into registries.

关键词： Anemia Iron deficiency Registries Inflammatory bowel disease Patient care

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m^(6)A Profile Dynamics Indicates Regulation of Oyster Development by m^(6)A-RNA Epitranscriptomes

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 742-755页

作者： Lorane Le Franc Bruno Petton Pascal Favrel guillaume Rivière Laboratoire de Biologie des Organismes et des Ecosyste`mes Aquatiques(BOREA) Muséum d’Histoire NaturelleSorbonne UniversitéUniversitéde Caen NormandieUniversitédes AntillesCNRS UMR 8067IRD14032 CaenFrance Ifremer Laboratoire des Sciences de l’Environnement MarinUMR 6539 CNRS/UBO/IRD/IfremerCentre Bretagne29280 PlouzanéFrance

The N6-methylation of RNA adenosines(N6-methyladenosine,m^(6)A)is an important regulator of gene expression with critical implications in vertebrate and insect ***,the developmental significance of epitranscriptomes in lophotrochozoan organisms remains *** methylated RNA immunoprecipitation sequencing(MeRIP-seq),we generated transcriptome-wide m^(6)A-RNA methylomes covering the entire development of the oyster from oocytes to *** RNA classes display specific m^(6)A signatures,with messenger RNAs(mRNAs)and long non-coding RNAs(lncRNAs)exhibiting distinct profiles and being highly methylated compared to transposable element(TE)*** are dynamic and correspond to the chronological steps of development(cleavage,gastrulation,organogenesis,and metamorphosis),with minimal mRNA and lncRNA methylation at the morula stage followed by a global *** m^(6)A levels are correlated with transcript levels,and shifts in methylation profiles correspond to expression *** methylated transcripts cluster according to embryo-larval stages and bear the corresponding developmental functions(cell division,signal transduction,morphogenesis,and cell differentiation).The m^(6)A level of TE transcripts is also regulated and peaks during the *** demonstrate that m^(6)A-RNA methylomes are dynamic and associated with gene expression regulation during oyster *** putative epitranscriptome implication in the cleavage,maternal-to-zygotic transition,and cell differentiation in a lophotrochozoan model brings new insights into the control and evolution of developmental processes.

关键词： RNA methylation Transcription Embryo Metamorphosis Evo-devo

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Hemostasis testing in patients with liver dysfunction: Advantages and caveats

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World Journal of Gastroenterology 2021年第42期27卷 7285-7298页

作者： guillaume Nguyen Manon Lejeune Benjamin Crichi Corinne Frere Department of Hematology Trousseau HospitalAssistance Publique Hôpitaux de ParisParis 75012France Department of Hematology Pitié-Salpêtrière HospitalAssistance Publique Hôpitaux de ParisParis 75013France Department of Internal Medicine Saint-Louis HospitalAssistance Publique Hôpitaux de ParisParis 75010France Inserm UMRS_1166 Institute of Cardiometabolism and NutritionSorbonne UniversitéParis 75013France

Due to concomitant changes in pro-and anti-coagulant mechanisms,patients with liver dysfunction have a“rebalanced hemostasis”,which can easily be tipped toward either a hypo-or a hypercoagulable *** are often faced with the question whether patients with chronic liver disease undergoing invasive procedures or surgery and those having active bleeding require correction of the hemostasis *** coagulation screening tests,such as the prothrombin time/international normalized ratio and the activated partial thromboplastin time have been demonstrated to have numerous limitations in these patients and do not predict the risk of bleeding prior to high-risk *** introduction of global coagulation assays,such as viscoelastic testing(VET),has been an important step forward in the assessment of the overall hemostasis profile.A growing body of evidence now suggests that the use of VET might be of significant clinical utility to prevent unnecessary infusion of blood products and to improve outcomes in numerous *** present review discusses the advantages and caveats of both conventional and global coagulation assays to assess the risk of bleeding in patients with chronic liver disease as well as the current role of transfusion and hemostatic agents to prevent or manage bleeding.

关键词： Hemostasis Bleeding risk Conventional tests Thrombin generation Viscoelastic tests Hemostatic agents

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Oxidative dehydrogenation of propane under steady-state and transient regimes over alumina-supported catalysts prepared from mixed V_2W_4O_(19)^(4-) hexametalate precursors

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Journal of Natural Gas Chemistry 2010年第2期19卷 123-133页

作者： Sébastien Paul Elise Berrier Marcia Cristina Kaezer Frana Jean-guillaume Eon Univ Lille Nord de France F-59000 LilleFrance ECLille UCCSF-59650 Villeneuve d'AscqFrance CNRS UMR 8181F-59650 Villeneuve d'AscqFrance USTL UCCSF-59650 Villeneuve d'AscqFrance Instituto de Quimíca Universidade Federal do Rio de Janeiro-Cidade UniversitáriaIlha do Fundo21945-970 Rio de JaneiroBrazil

An integrated approach combining the development of an innovative catalyst and the research of a set of adequate operating conditions for the propane oxidative dehydrogenation （ODH） is *** experimental set-up,specially designed for steady-state and transient studies is *** preparation method,the characterization and the performances in steady-state and transient regimes of catalysts based on V2W4O194-Lindqvist isopolyanion used as a precursor and supported on alumina are *** influence of the preparation method of the catalyst and the role of water in the feed gas are more particularly discussed.

关键词： propane oxidative dehydrogenation (ODH) transient regime pulsed reactor Lindqvist isopolyanion in-situ Raman

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Iron-catalyzed reductive cyclization of nitroarenes: Synthesis of aza-heterocycles and DFT calculations

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Chinese Chemical Letters 2023年第3期34卷 337-341页

作者： Christine Tran Aicha Abdallah Valentin Duchemann guillaume Lefevre Abdallah Hamze CNRS BioCISUniversitéParis-SaclayChatenay-Malabry 92290France Chimie ParisTech CNRSInstitute of Chemistry for Life and Health SciencesPSL UniversityCSB2DParis 75005France

Research into environmentally friendly strategies for hydrogen transfer reduction is increasing, along with the need for more elaborate heterocyclic platforms. Within this context, we develop a new approach for substituted dihydrobenzo[c]carbazoles and indoles. These compounds were synthesized through an iron-catalyzed hydrogen transfer reduction of nitroarenes, followed by intramolecular cyclization. This transformation involves using a Kn?lker-type catalyst, Cs_(2)CO_(3) as the base, and benzyl alcohol as the nonexpensive and low volatile hydrogen donor. We synthesize 30 examples of aza-heterocycles with moderate to excellent yields by applying this strategy. Additionally, DFT calculations demonstrated that the pathway reaction could follow an anionic mechanism.

关键词： Iron Cyclization Nitroarenes Dihydrobenzo[c]carbazoles Indoles

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A Specific Class of Short Treadmilling Microtubules Enhances Cortical Microtubule Alignment

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Molecular Plant 2016年第8期9卷 1214-1216页

作者： guillaume Chomicki Raymond Wightman Simon R. Turner Faculty of Life Sciences University of Manchester Oxford Road Manchester M13 9PT UK

Dear Editor Anisotropic cell expansion is a property of plant cells that is dependent upon the formation of a highly ordered cortical micro- tubule （MT） array. The orientation of cortical microtubules is crit- ical for guiding cellulose synthase complexes in the plasma mem- brane and thereby determining the direction of the cell expansion （Paredez et al., 2006）.

关键词： dependent thereby direction

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Intra-operative peritoneal lavage for colorectal cancer

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World Journal of Gastroenterology 2014年第8期20卷 1935-1939页

作者： guillaume Passot Kayvan Mohkam Eddy Cotte Olivier Glehen Departement of General and Surgical Oncology Hospices Civils de Lyon69495 Pierre BéniteFrance EMR 3738 Université Lyon 1F-69364 LyonFrance

Free cancer cells can be detected in peritoneal fluid at the time of colorectal surgery. Peritoneal lavage in colorectal surgery for cancer is not used in routine, and the prognostic significance of intraperitoneal free cancer cells (IPCC) remains unclear. Data concerning the technique of peritoneal lavage to detect IPCC and its timing regarding colorectal resection are scarce. However, positive IPCC might be the first step of peritoneal spread in colorectal cancers, which could lead to early specific treatments. Because of the important heterogeneity of IPCC determination in reported studies, no treatment have been proposed to patients with positive IPCC. Herein, we provide an overview of IPCC detection and its impact on recurrence and survival, and we suggest further multi-institutional studies to evaluate new treatment strategies.

关键词： Peritoneal carcinomatosis Colorectal cancer Free intraperitoneal cells Immunocytochemistry

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Targeting natural killer cells in solid tumors

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Cellular & Molecular Immunology 2019年第5期16卷 415-422页

作者： guillaume Habif Adeline Crinier Pascale Andre Eric Vivier Emilie Narni-Mancinelli Innate Pharma MarseilleFrance Aix Marseille Universite INSERMCNRSCentre d’Immunologie de Marseille-LuminyMarseilleFrance Service d’Immunologie Marseille ImmunopoleHopital de la TimoneAssistance Publique-Hopitaux de MarseilleMarseilleFrance

Natural killer(NK)cells are innate lymphoid cells endowed with cytolytic activity and a capacity to secrete cytokines and *** lines of evidence suggest that NK cells play an important role in anti-tumor *** therapies against hematological malignacies make use of the immune properties of NK cells,such as their ability to kill residual leukemic blasts efficiently after conditioning during haploidentical hematopoietic stem cell ***,knowledge on NK cell infiltration and the status of NK cell responsiveness in solid tumors is limited so *** pro-angiogenic role of the recently described NK cell-like type 1 innate lymphoid cells(ILC1s)and their phenotypic resemblance to NK cells are confounding factors that add a level of complexity,at least in ***,we review the current knowledge on the presence and function of NK cells in solid tumors as well as the immunotherapeutic approaches designed to harness NK cell functions in these conditions,including those that aim to reinforce conventional anti-tumor therapies to increase the chances of successful treatment.

关键词： killer tumors lymphoid

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Color retargeting:Interactive time-varying color image composition from time-lapse sequences

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Computational Visual Media 2015年第4期1卷 321-330页

作者： Shao-Ping Lu guillaume Dauphin Gauthier Lafruit Adrian Munteanu Department of Electronics and Informatics(ETRO) Vrije Universiteit Brussel (VUB) and iMinds Department of LISA unit ImageUniversité Libre de Bruxelles(ULB)

In this paper,we present an interactive static image composition approach,namely color retargeting,to flexibly represent time-varying color editing effect based on time-lapse video *** of performing precise image matting or blending techniques,our approach treats the color composition as a pixel-level resampling problem. In order to both satisfy the user's editing requirements and avoid visual artifacts,we construct a globally optimized interpolation field. This field defines from which input video frames the output pixels should be *** proposed resampling solution ensures that(i) the global color transition in the output image is as smooth as possible,(ii) the desired colors/objects specified by the user from different video frames are well preserved,and(iii) additional local color transition directions in the image space assigned by the user are also *** examples have been shown to demonstrate that our efficient solution enables the user to easily create time-varying color image composition results.

关键词： time-lapse sequence image composition color retargeting time-varying transition optimized interpolation field

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