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Review of anticancer mechanisms of isoquercitin

世界临床肿瘤学杂志：英文版 2016年第2期7卷 189-199页

作者： guilherme di Camillo Orfali Ana Carolina Duarte Vivien Bonadio Natalia Peres Martinez Maria Elisa Melo Branco de Araújo Fernanda Bruschi Marinho Priviero Patricia Oliveira Carvalho Denise Gon?alves Priolli Scientific Initiation Program Sao Francisco University Medical School Postgraduate Program in Health Science Sao Francisco University Medical School

This review was based on a literature search of PubM ed and Scielo databases using the keywords "quercetin,rutin,isoquercitrin,isoquercitin(IQ),quercetin-3-glucoside,bioavailability,flavonols and favonoids,and cancer" and combinations of all the *** collected relevant scientific publications from 1990 to 2015 about the absorption,bioavailability,chemoprevention activity,and treatment effects as well as the underlying anticancer mechanisms of *** are a group of polyphenolic compounds widely distributed throughout the plant *** subclass of flavonols receives special attention owing to their health *** main components of this class are quercetin,rutin,and IQ,which is a flavonoid and although mostly found as a glycoside,is an aglycone(lacks a glycoside side chain).This compound presents similar therapeutic profiles to quercetin but with superior bioavailability,resulting in increased efficacy compared to the aglycone *** has therapeutic applications owing to its wide range of pharmacological effects including antioxidant,antiproliferative,anti-inflammatory,anti-hypertensive,and *** protective effects of IQ in cancer may be due to actions on lipid *** addition,the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway,mixed-lineage protein kinase 3,mitogen-activated protein kinase,apoptotic pathways,as well proinflammatory protein *** review contributed to clarifying the mechanisms of absorption,metabolism,and actions of IQ and isoquercitrin in cancer.

关键词： Drug screening assays Antitumor Cancer Flavonoids Flavonols Antioxidants Neoplasms

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Duodenal adenoma surveillance in patients with familial adenomatous polyposis

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World Journal of Gastrointestinal Endoscopy 2015年第10期7卷 950-959页

作者： Fábio guilherme Campos Marianny Sulbaran Adriana Vaz Safatle-Ribeiro Carlos Augusto Real Martinez Gastroenterology Department Hospital das Clínicas University of Sao Paulo Medical School Gastroenterology Department University of Sao Paulo Medical School Colorectal Division State University of Campinas (UNICAMP Sao Paulo) Postgraduate Program in Health Sciences at San Francisco University

Familial adenomatous polyposis(FAP) is a hereditary disorder caused by Adenomatous Polyposis Gene mutations that lead to the development of colorectal polyps with great malignant risk throughout life. Moreover, numerous extracolonic manifestations incorporate different clinical features to produce varied individual phenotypes. Among them, the occurrence of duodenal adenomatous polyps is considered an almost inevitable event, and their incidence rates increase as a patient's age advances. Although the majority of patients exhibit different grades of duodenal adenomatosis as they age, only a small proportion(1%-5%) of patients will ultimately develop duodenal carcinoma. Within this context, the aim of the present study was to review the data regarding the epidemiology, classification, genetic features, endoscopic features, carcinogenesis, surveillance and management of duodenal polyps in patients with FAP.

关键词： Familial adenomatous polyposis Adenoma Duodenum Surveillance Endoscopy Digestive system

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