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Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice

World Journal of Gastroenterology 2008年第4期14卷 574-581页

作者： Malgorzata Sidorkiewicz Jean-Philippe Jais guilherme tralhao Serban Morosan Carlo Giannini Nicolas Brezillon Patrick Soussan Oona Delpuech Dina Kremsdorf Inserm U845Paris 75015France Pasteur InstituteDepartment of VirologyParisFrance University of Paris-DescartesCHU NeckerParisFrance Department of Medical BiochemistryMedical University of LodzLodzPoland Université Paris Descartes CHU NeckerService of Biostatistics and Medical InformaticsParisFrance Inserm U845Paris 75015France Pasteur InstituteDepartment of VirologyParisFrance University of Paris-DescartesCHU NeckerParisFrance Inserm U845Paris 75015France Pasteur InstituteDepartment of VirologyParisFrance University of Paris-DescartesCHU NeckerParisFrance Department of Internal MedicineUniversity of FlorenceFlorenceItaly

AIM： To analyze the modulation of gene expression profile associated with inhibition of liver regeneration in hepatitis B X （HBx）-expressing transgenic mice. METHODS： Microarray technology was performed on liver tissue obtained from 4 control （LacZ） and 4 transgenic mice （HBx-LacZ）, 48 h after partial hepatectomy. The significance of the normalized logratios was assessed for each gene, using robust t-tests under an empirical Bayes approach. Microarray hybridization data was verified on selected genes by quantitative PCR. RESULTS： The comparison of gene expression patterns showed a consistent modulation of the expression of 26 genes, most of which are implicated in liver regeneration. Up-regulated genes included DNA repair proteins （Rad-52, MSH6） and transmembrane proteins （syndecan 4, tetraspanin）, while down-regulated genes were connected to the regulation of transcription （histone deacetylase, Zfp90, MyoDl） and were involved in the cholesterol metabolic pathway and isoprenoidbiosynthesis （farnesyl diphosphate synthase, Cyp7b1, geranylgeranyl diphosphate synthase, SAA3）. CONCLUSION： Our results provide a novel insight into the biological activities of HBx, implicated in the inhibition of liver regeneration,

关键词： Hepatitis B virus Hepatitis BX (HBx) protein Liver regeneration Microarray analysis Cholesterol Isoprenoid

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The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

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Animal Models and Experimental Medicine 2020年第1期3卷 1-8页

作者： Rui C.Oliveira Ana Margarida Abrantes Joseguilherme tralhao Maria Filomena Botelho Biophysics Unit Faculty of MedicineUniversity of CoimbraCoimbraPortugal Pathology Department University Hospital(CHUC)CoimbraPortugal Centre of Investigation on Environment Genetics and Oncobiology(CIMAGO)CoimbraPortugal Surgery A Department Faculty of MedicineUniversity Hospital(CHUC)CoimbraPortugal

Colorectal cancer is a worldwide health burden,with high incidence and mortality,especially in the advanced stages of the *** models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic *** order to accomplish that,the animal models must replicate the clinical evolution of the disease in all of its *** this article,we review the existent mouse models,with their strengths and weaknesses in the replication of human cancer disease progression,with major focus on orthotopic models.

关键词： colorectal cancer mouse model orthotopic model

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