The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

作     者：Rui C.Oliveira Ana Margarida Abrantes JoseGuilherme Tralhao Maria Filomena Botelho Rui C. Oliveira;Ana Margarida Abrantes;José Guilherme Tralh?o;Maria Filomena Botelho

作者机构：Biophysics UnitFaculty of MedicineUniversity of CoimbraCoimbraPortugal Pathology DepartmentUniversity Hospital(CHUC)CoimbraPortugal Centre of Investigation on EnvironmentGenetics and Oncobiology(CIMAGO)CoimbraPortugal Surgery A DepartmentFaculty of MedicineUniversity Hospital(CHUC)CoimbraPortugal 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2020年第3卷第1期

页      面：1-8页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：colorectal cancer mouse model orthotopic model 

摘      要：Colorectal cancer is a worldwide health burden,with high incidence and mortality,especially in the advanced stages of the *** models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic *** order to accomplish that,the animal models must replicate the clinical evolution of the disease in all of its *** this article,we review the existent mouse models,with their strengths and weaknesses in the replication of human cancer disease progression,with major focus on orthotopic models.