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Colorectal cancer in young adults: A difficult challenge

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World Journal of Gastroenterology 2017年第28期23卷 5041-5044页

作者： Fábio guilherme Campos division of colorectal surgery department of gastroenterologyhospital das clínicasuniversity of sao paulo

Sporadic colorectal cancer(CRC) is traditionally diagnosed after the sixth decade of life,and current recommendations for surveillance include only patients older than 50 years of age. However,an increasing incidence of CRC in patients less than 40 years of age has been reported. This occurrence has been attributed to different molecular features and low suspicion of CRC in young symptomatic individuals. When confronting young-onset CRC with older patients,issues such as biological aggressiveness,stage at diagnosis and clinical outcomes seem to differ in many aspects. In the future,the identification of the molecular profile underlying the early development of sporadic CRC will help to plan tailored screening recommendations and improve management. Besides that,differential diagnosis with CRC linked with hereditary syndromes is necessary to provide adequate patient treatment and family screening. Until we find the answers to some of these doubts,doctors should raise suspicion when evaluating an young adult and be aware of this risk and consequences of a late diagnosis.

关键词： Colorectal cancer Young age Hereditary Prognosis

Is more evidence needed for thrombectomy in basilar artery occlusion? The BASICS and BEST meta- analytical approaches

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Stroke & Vascular Neurology 2021年第4期6卷 671-672,I0094-I0096页

作者： Davi J Fontoura Solla Felipe Coelho Argolo Karol P Budohoski Angelos G Kolias Joséguilherme M P Caldas Jamary oliveira-Filho Division of Neurosurgery Department of NeurologyUniversity of Sao PauloSao PauloBrazil NIHR Global Health Research Group on Neurotrauma Cambridge UniversityCambridgeUK Machine Learning for Mental Health Lab King's College LondonLondonUK Division of Neurosurgery Department of Clinical NeurosciencesAddenbrooke's HospitalCambridge UniversityCambridgeUK Radiology University of Sao PauloSao PauloBrazil Postgraduate Program in Health Sciences Federal University of BahiaSalvadorBahiaBrazil

INTRODUCTION The benefit of mechanical thrombectomy for stroke associated with anterior circulation large vessel occlusion(LVO)is well established and among the most effective treatments in medicine.1 Stroke associated with basilar artery occlusion(BAO)was not included in the seminal thrombectomy randomised clin-ical trials(RCTs).BAO accounts for 1%of the ischaemic strokes and 5%-10%of the LVO,but 70%-80%of BAO victims evolve to death or full dependence.23 The terminal nature of the brainstem and thalamic circulations may predispose to such dismal *** two RCT designed to assess the efficacy of early(<6-8 hours since symptoms onset)thrombectomy for BAO treatment,the BEST and BASICS trials.24 Given the prior evidence for thrombectomy benefit for anterior circu-lation stroke is well settled;BAO stroke shares a similar physiopathology with very poor prog-nosis.

关键词： throm occlusion basilar

Crohn's disease in one mixed-race population in Brazil

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World Journal of Gastroenterology 2007年第33期13卷 4489-4492页

作者： Genoile oliveira Santana Luiz guilherme Costa Lyra Tamara Celi Almeida Santana Lidiane Bianca dos Reis Jorge Carvalho Guedes Maria Betania Toralles André Castro Lyra Gastrohepatology Unit Federal University of Bahia Brazil Gastrohepatology Unit Hospital San Rafael BahiaBrazil Gastrohepatology Unit Federal University of Bahia Brazil Department of Medicine Federal University of Bahia Brazil Gastrohepatology Unit Hospital San Rafael BahiaBrazil Department of Medicine Federal University of Bahia Brazil Gastrohepatology Unit Federal University of Bahia Brazil Department of Medicine Federal University of Bahia Brazil Genetic Unit Federal University of Bahia Brazil

AIM： To evaluate the classification and severity of Crohn＇s disease in different racial groups. METHODS： Patients with Crohn＇s disease from the outpatient clinic of the University Hospital Prof. Edgard Santos were enrolled in the study. This hospital is a reference centre for inflammatory bowel disease. Race was determined using self-identification. The Vienna＇s classification was applied for all subjects. The severity of Crohn＇s disease was determined according to the number of surgical procedures, hospital admissions in the last year and treatment with steroids and immunosuppressors. Statistical analysis was calculated using t test for means,χ^2 or F for proportions. A P value 〈 0.05 was considered to be significant. RESULTS： Sixty-five patients were enrolled. Non-white patients were more frequently diagnosed with Crohn＇s disease in the age less than 40 years than white patients. The behaviour of disease was similar in both groups with a high frequency of the penetrating form. There was a tendency for non-white patients to have a greater frequency of hospital admissions in the last year compared to white subjects. Non-whites also had a higher rate of colonic and upper gastrointestinal involvement, and were also more frequently on treatment with immunossupressors than white patients although this difference was not statistically significant. CONCLUSION： Non-white patients with Crohn＇s disease had an earlier diagnosis and appeared to have had a more severe disease Dresentation than white patients.

关键词： Racial group Brazil Race Inflammatory bowel disease Crohn's disease

Cerium alleviates drought-induced stress in Phaseolus vulgaris

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Journal of Rare Earths 2020年第3期38卷 324-331页

作者： Olívia Graziela Gelioli Salgado Jéssica Cristina Teodoro Joyce Pereira Alvarenga Cynthia de oliveira Teotonio Soares de Carvalho Débora Domiciano Paulo Eduardo Ribeiro Marchiori Luiz Roberto Guimaraes guilherme Department of Soil Science Federal University of LavrasCP 3037Campus UFLALavras37200-000Brazil Department of Biology Federal University of LavrasCP 3037Campus UFLALavras37200-000Brazil

Extreme drought events are expected to be one of the main challenges for tropical agriculture and,consequently,for global food *** this reason,it is urgent to develop strategies to increase water use efficiency,as well as to increase crops’ ability to cope with *** rare earth elements(REEs) are known to alleviate damages in plants under abiotic stresses,we hypothesized that addition of Ce^3+to nutrient solution would promote the growth of common bean,especially under simulated drought *** test this hypothesis,we conducted an experiment evaluating the effect of six Ce^3+concentrations on the development and physiological traits of common bean grown in nutrient solution under normal condition and under induced drought stress,caused by the addition of polyethylene glycol6000 to the nutrient *** results show that Ce^3+alleviates water stress in common bean plants,increasing their survival rate and *** addition,Ce^3+application increases photosynthesis rate,chlorophyll content and water use efficiency under water ***,we observe no significant effect of Ce^3+on plants growing under normal ***,Ce3+seems to be a promising attenuator of drought stress for common bean.

关键词： Water stress Polyethylene glycol Rare earth elements Cerium nitrate Mitigation Common bean

Discontinuation of antiviral therapy in chronic hepatitis B patients

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World Journal of Clinical Cases 2021年第24期9卷 6979-6986页

作者： Renato Medas Rodrigo Liberal guilherme Macedo Department of Gastroenterology and Hepatology Centro Hospitalar Universitario de São JoãoPorto 4200-319Portugal

Nucleos(t)ide analogs(NUC)are the first-line therapy for patients with chronic hepatitis B(CHB)recommended by most current *** therapy decreases progression of liver disease,reduces the risk of liver-related complications,and improves the quality of life of patients with *** indefinite or long-term NUC therapy is usually recommended,this strategy raises several concerns,such as side-effects,adherence,costs,and patient willingness to stop *** data showed the feasibility,efficacy,and safety of stopping antiviral therapy in carefully selected CHB patients,leading to its incorporation in international *** who discontinue NUC have a higher likelihood of hepatitis B surface antigen(HBsAg)loss compared to patients who continue on *** pertaining endpoints allowing safety discontinuation of NUC therapy differ among international *** hepatitis B e antigen(HBeAg)-positive patients,durable HBeAg seroconversion is considered an acceptable treatment *** HBeAg-negative patients,some guidelines propose undetectability hepatitis B virus DNA for at least 2 or 3 years,while others consider HBsAg loss as the only acceptable *** patients who stop therapy should remain under strict clinical and laboratorial follow-up protocols to detect and manage relapses in a timely *** reliable predictor of relapse has been consistently identified to date,although quantitative HBsAg has been increasingly studied as a reliable biomarker to predict safe NUC discontinuation.

关键词： Chronic hepatitis B Finite therapy Hepatitis B surface antigen loss Relapse Retreatment

Conscience imperative of providing information and knowledge in hepatology:The Portuguese approach

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World Journal of Clinical Cases 2017年第1期5卷 24-26页

作者： guilherme Macedo Marco Silva Department of Gastroenterology the Centro Hospitalar São JoãoWGO Training CenterFaculty of MedicineUniversity of Porto4200-319 PortoPortugal

The last 25 years have been a thrilling time for the Portuguese hepatologists. Our national meetings have been providing the forum for the exchange of scientific ideas and the presentation of clinical research in clinical Hepatology, a growing world of knowledge in medical care. Bridging the gaps between technology and clinical daily practice, the latest development and the almost humble bedside care, has been a challenge for the increasing numbers of doctors devoted to the diagnostic and treatment of liver disease. We have been trying to be very persuasive among the Portuguese medical community in demonstrating that cultural vectors may influence the origin and pattern of liver disease among us. Viral hepatitis and alcoholic liver disease are paradigms of this assumption. Chronic liver disease is responsible for 3% of the deaths in Portugal, which accounts for the top ten causes of death in our country. The recognition by public health authorities of this fact along with the national net of hepatology outpatient consultation in public hospitals, has brought liver diseases under the lights of doctors concerns and an increased public awareness of its dimension.

关键词： Alcohol Cirrhosis Hepatology Liver Public health

Vine pruning waste-based activated carbon for cerium and lanthanum adsorption from water and real leachate

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Journal of Rare Earths 2024年第10期42卷 1960-1968页

作者： Raphael Forgearini Pinheiro Alejandro Grimm Kátia da Boit Martinello Mohammad Rizwan Khan Naushad Ahmad Luis Felipe oliveira Silva Irineu Antônio Schadach De Brum guilherme Luiz Dotto Glaydson Simões dos Reis Research Group on Adsorptive and Catalytic Process Engineering(ENGEPAC) Federal University of Santa MariaAv.Roraima1000-797105900Santa MariaRSBrazi Department of Forest Biomaterials and Technology Biomass Technology CentreSwedish University of Agricultural SciencesUmed SE-90183Sweden Universidad De La Costa Calle 58#55-66080002BarranquillaAtlanticoColombia Department of Chemistry College of ScienceKing Saud UniversityRiyadh11451Kingdom of Saudi Arabia Institute of Chemistry Federal University of Rio Grande do Sul90040-060Porto AlegreBrazil

In this study,vine pruning wastes(VPW)were used as raw material to develop an alternative activated carbon(VPW-AC)for adsorbing and concentrating rare earth elements cerium(Ce(Ⅲ))and lanthanum(La(Ⅲ))from synthetic and real leachate *** Ce and La adsorption studies evaluated the effects of VPW-AC dosage,pH,contact time,rare earth initial concentration,and *** VPW-AC adsorbent was subjected to many physicochemical characterization methods to correlate and understand its adsorptive *** characterization data indicate a carbonaceous adsorbent with a specific surface area of 467 m^(2)/*** potential indicates a material with a negatively charged surface at a pH higher than 3.1,which is extremely beneficial to cations *** both rare earths elements(REEs),the adsorption capacity increases with the increase of the pH,reaching its maximum at pH *** kinetic data are well fitted by Avrami-fractional o rder,while the Liu model agreeably fits equilibrium *** maximum adsorption capacities for Ce(Ⅲ)and La(Ⅲ)are 48.45 and 53.65 mg/g at 298 K,*** thermodynamic studies suggest that the adsorption process is favorable,spontaneous,and exothermic for both *** filling,surface complexation,and ion exchange are the dominant ***,the VPW-AC was subjected to the recovery of REEs from real phosphogypsum leachate,and it is proved that it can be successfully used to recover REEs in a real process.

关键词： Vine pruning wastes Sustainable carbon adsorbent Rare earth elements Phosphogypsum leachate Ion-exchange mechanism

Cooperative Localization and Tracking in Distributed Robot-Sensor Networks

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Tsinghua Science and Technology 2005年第1期10卷 91-101页

作者：张帆 guilherme S.Pereira Vijay Kumar General Robotics Automation Sensing and Perception Laboratory University of Pennsylvania Philadelphia PA USA

This paper addresses the problem of real-time position and orientation estimation of networked mobile robots in two-dimensional Euclidean space with simultaneous tracking of a rigid unknown object based on exteroceptive sensory information extracted from distributed vision systems. The sufficient and necessary conditions for team localization are proposed. A localization and object tracking approach based on statistical operators and graph searching algorithms is presented for a team of robots localized with het- erogeneous sensors. The approach was implemented in an experimental platform consisting of car-like mobile robots equipped with omnidirectional video cameras and IEEE 802.11b wireless networking. The experimental results validate the approach.

关键词： cooperative localization multi-robot formation distributed sensor network sensor data fusion

The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

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Animal Models and Experimental Medicine 2020年第1期3卷 1-8页

作者： Rui C.oliveira Ana Margarida Abrantes Joseguilherme Tralhao Maria Filomena Botelho Biophysics Unit Faculty of MedicineUniversity of CoimbraCoimbraPortugal Pathology Department University Hospital(CHUC)CoimbraPortugal Centre of Investigation on Environment Genetics and Oncobiology(CIMAGO)CoimbraPortugal Surgery A Department Faculty of MedicineUniversity Hospital(CHUC)CoimbraPortugal

Colorectal cancer is a worldwide health burden,with high incidence and mortality,especially in the advanced stages of the *** models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic *** order to accomplish that,the animal models must replicate the clinical evolution of the disease in all of its *** this article,we review the existent mouse models,with their strengths and weaknesses in the replication of human cancer disease progression,with major focus on orthotopic models.

关键词： colorectal cancer mouse model orthotopic model