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Exploring the potential for an evolutionarily conserved role of the taste 1 receptor gene family in gut sensing mechanisms of fish

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Animal Nutrition 2022年第4期11卷 293-308页

作者： Anna Rita Angotzi Esther Leal Sara Puchol José M. Cerdá-Reverter Sofia morais Department of Fish Physiology and Biotechnology Instituto de Acuicultura de Torre de la SalIATS-CSICTorre la Sal s/nRibera de Cabanes12595 CastellonSpain Lucta S.A. Innovation DivisionAnimal Science UnitUAB Research Park08193 BellaterraSpain

In this study,we investigated the transcriptional spatio-temporal dynamics of the taste 1 receptor(T1R)gene family repertoire in seabream(Sparus aurata[sa]),during larval ontogeny and in adult *** early larval development,sa T1R expression arises heterochronously,*** extraoral taste-related perception in the gastrointestinal tract(GIT)anticipates first exogenous feeding(at 9 days post hatching[dph]),followed by the buccal/intraoral perception from 14 dph onwards,supporting the hypothesis that the early onset of the molecular machinery underlying sa T1R expression in the GIT is not induced by food but rather genetically *** adulthood,we characterized the expression patterns of sa T1R within specific tissues(n=4)distributed in oropharingeal,GIT and brain regions substantiating their functional versatility as chemosensory signaling players to a variety of biological functions beyond oral taste ***,we provided for the first time direct evidences in fish for m RNA coexpression of a subset of sa T1R genes(mostly sa T1R3,*** common subunit of the heterodimeric T1R complexes for the detection of“sweet”and“umami”substances),with the selected gut peptides ghrelin(ghr),cholecystokinin(cck),hormone peptide yy(pyy)and proglucagon(pg).Each peptide defines the enteroendocrine cells(ECCs)identity,and establishes on morphological basis,a direct link for T1R chemosensing in the regulation of fish digestive ***,we analyzed the spatial gene expression patterns of 2 taste signaling components functionally homologous to the mammalian G(i)a subunit gustducin,namely sa G(i)a1 and sa G(i)a2,and demonstrated their co-localization with the sa T1R3in EECs,thus validating their direct involvement in taste-like transduction mechanisms of the fish *** conclusion,data provide new insights in the evolutionary conservation of gut sensing in fish suggesting a conserved role for nutrient sensors modulating entero-endocrine secretion.

关键词： Taste 1 receptor Fish larvae Gut nutrient sensing Gut peptides G(i)alpha protein subunits 1 and 2

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A unified electrical model based on experimental data to describe electrical transport in carbon nanotube-based materials

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Nano Research 2020年第6期13卷 1764-1779页

作者： Yoann Dini Jérôme Faure-Vincent Jean Dijon Univ.Grenoble-Alpes CEALITENDTNMF-38000GrenobleFrance Univ.Grenoble-Alpes CEACNRSIRIGSyMMESF-38000GrenobleFrance

Understanding the electrical transport in carbon nanotube(CNT)materials is one key to reach very high electrical *** CNT material resistivity(ρ(T))as function of the temperature are fully apprehended by their reduced activation W(T)=dln(ρ)/dln(T)*** to now,no model accurately fits W(T)curves,thus preventing from precisely describing the CNT material electrical *** present a new electrical transport model that perfectly fits all W(T)curves found in the literature and in our own *** material resistivities are modeled byρ(T)=ρ0(T^−α+M(1+βTγT^2)).Our model has few enough parameters(α,M,β,γ)to relate them to the CNT *** 70 K,we experimentally show that CNT material resistivity follows the Luttinger Liquid theory justifying the T^−αterm in our *** 70 K,the polynomial part becomes dominant and depends on the two different CNT fabrication techniques which lead to two very different yarn *** yarns made from floating catalyst chemical vapor deposition CNTs,the polynomial is explained by the percolation of metallic CNT ***,the polynomial of yarns spun from CNT arrays is explained by the electrical transport in CNT bundles which are the basic building blocks of this type of yarns.

关键词： carbon nanotube carbon-based materials electrical conductivity electrical transport model Luttinger Liquid

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Highly electroactive N–Fe hydrothermal carbons and carbon nanotubes for the oxygen reduction reaction

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Journal of Energy Chemistry 2020年第11期29卷 260-270页

作者： R.G.morais N.Rey-Raap J.L.Figueiredo M.F.R.Pereira Associate Laboratory LSRE-LCM Departamento de Engenharia QuimicaFaculdade de EngenhariaUniversidade do PortoR.Dr.Roberto Frias s/n4200-465PortoPortugal

Glucose-derived carbons were prepared by hydrothermal carbonization of glucose followed by carbonization or activation to obtain carbon materials with different microporosities. These microporous carbons and carbon nanotubes(CNTs) were functionalized with melamine and/or iron(Ⅱ) phthalocyanine(FePc)following three different methodologies:(i) Functionalization with melamine via thermal treatment,(ii)incorporation of the lowest amount of FePc reported in the literature via incipient wetness impregnation followed by thermal treatment and(iii) functionalization with melamine followed by Fe Pc *** chemical and textural characterization of the prepared materials and their electrochemical assessment allowed to understand the role of microporosity in the incorporation of FePc and its effect on the oxygen reduction reaction(ORR). It was observed that FePc was preferentially incorporated inside the porous structure, especially in samples with more developed microporosity. However, functionalization with melamine modified the textural properties and the surface chemistry, favoring the incorporation of FePc on the surface. Regarding the electrochemical performance, the presence of FePc greatly enhanced the electroactivity of the microporous catalysts. An onset potential of 0.88 V and a four-electron pathway were obtained for glucose-derived carbons, whereas the limiting current densities and kinetic current densities rose by 126% and 222%, respectively, in comparison to the base sample. Notwithstanding, the highest electrochemical activity was observed for the sample prepared with CNTs, due to the synergy between the active metal centers and their highly graphitic carbon structure. The electrochemical parameters of CNTFeP csurpass the commercial Pt/C. The half-wave potential is 40 mV higher, the limiting current density increases by 17%, and a negligible production of by-products(< 1%) was observed.

关键词： Iron(Ⅱ)phthalocyanine Hydrothermal carbons Carbon nanotubes Oxygen reduction reaction Electrocatalysis

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Challenges in Implementing DVI Best Practice Guidelines Due to the Brumadinho Disaster

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Forensic medicine and Anatomy Research 2024年第1期12卷 1-12页

作者： Reinaldo Moreira Silva Bruno Diniz Sander morais Carlos Danilo Ruas Silva Elza Cristina Lopes de Oliveira Fernando Pereira Macedo Giovanni Vitral Pinto Guadalupe Dell’Arret Coutinho Higgor Gonçalves Dornelas João Luiz Silva Moreira Laila Evangelista de Almeida Fernandes Marcia Lobão Iannini Patrícia Siqueira Valéria Rosalina Dias e Santos Sordaini Maria Caligiorne Instituto de Criminalística Polícia Civil de Minas Gerais Belo Horizonte Brazil

The broke of a tailings dam from Vale S.A. destroyed a gigantic area killing 270 persons in Brumadinho/Brazil. Organizing activities after a mass disaster is a complex process that requires the involvement of many people and resources in the laboratory. To DNA identification of the victims, a daunting work had to be made by DNA laboratory staff in a collaborative effort with many partners. Efforts to implement good practice guidelines in Disaster Victim Identification (DVI) have revealed several important aspects that need to change in the forensic DNA laboratory. This article highlights the challenges of implementing DVI best practice guidelines in resource-poor settings, but with professionals from different sectors engaged in the same goal of briefly identifying victims and helping families and society.

关键词： Disaster Victim Identification DNA Brumadinho

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Larvicidal efficacy of plant extracts and isolated compounds from Annonaceae and Piperaceae against Aedes aegypti and Aedes albopictus

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Asian Pacific Journal of Tropical medicine 2020年第9期13卷 384-396页

作者： Alzeir M.Rodrigues Victor Emanuel P.Martins Selene M.morais Departamento de Ensino Instituto Federal de EducaçãoCiência e Tecnologia do Ceará(IFCE)Rodovia CE 060km 332Vila Martins63.560-000 AcopiaraCearáBrazil Programa de Pós-Graduação em Biotecnologia RENORBIOUniversidade Estadual do CearáAvenida Doutor Silas Munguba170060741-000 FortalezaCearáBrazil Instituto de Ciências Exatas e da Natureza Universidade da Integração Internacional da Lusofonia Afro-Brasileira(Unilab)Campus das AurorasRua JoséFranco de Oliveira s/n62790-970 RedençãoCearáBrasil Departamento de Química Universidade Estadual do CearáAvenida Doutor Silas Munguba170060741-000 FortalezaCearáBrazil

The Aedes(Ae.)aegypti and *** mosquitoes are vectors of epidemiologically relevant arboviruses in the public health context,such as the dengue,Zika and chikungunya *** the alternatives to synthetic insecticides for the control of these vectors,the use of natural plant products deserves *** review summarizes findings on the larvicidal potential of plant extracts on *** and ***,as well as the potential of isolated compounds from plants of the Annonaceae and Piperaceae families against these *** related to larvicidal activity of plant extracts and isolated compounds in Aedes *** the Web of Science database were used,for plant extracts considering publications between 2000 and 2019.A total of 859 articles were analyzed for plant extracts and estimates of lethal concentration values(LC50 and LC90).In the end,95 articles that presented the larvicidal potential of 150 plant species from 52 families were *** two families most studied for this activity were Fabaceae and Asterace *** plant families with the best LC50 values against mosquitoes were Piperaceae and *** activity of 50 acetogenins has already been identified on ***,and 29 of them presented LC50 below 10μg/mL,as well as the larvicidal activity of 8 compounds isolated from ***,plants of these two families are promising for the development of commercial botanical larvicides in the form of extracts and isolated substances,as well as the production via organic synthesis of the most active compounds.

关键词： Larvicidal activity Plant extracts Acetogenins Aedes

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Early Prosthetic Valve Endocarditis with Mycobacterium Tuberculosis after Mitral Valve Replacement: A Case Report

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World Journal of Cardiovascular Surgery 2024年第3期14卷 33-40页

作者： Papa Amath Diagne Mory Camara Papa Ousmane Ba Momar Sokhna Diop Moussa Samba Abdou Lahad Mbengue Jean Claude Ndiogou Dione Myriam Bizrane Marième Soda Mbaye Moussa Seck Diop Toudiani Malam Kaka Papa Salmane Ba Papa Adama Dieng Amadou Gabriel Ciss Assane Ndiaye Cardiovascular and Thoracic Surgery Department FANN National University Hospital Dakar Senegal

Background: Tuberculous endocarditis is a rare but serious complication of heart valve replacement surgery. We report the case of a 24-year-old patient, who presented with tuberculous endocarditis after mechanical mitral valve replacement, with a favorable clinical course following anti-tuberculosis treatment. Case Presentation: We report a 24-year-old male patient, admitted to the cardiac surgery department of the Fann Hospital (Dakar, Senegal), for the management of severe mixed (rheumatic and endocarditic) mitral insufficiency with associated tricuspid insufficiency. He had a history of recurrent angina and polyarthralgia in childhood, was hospitalized several times for refractory global cardiac decompensation, and for a suspected infective endocarditis a month before his admission. On admission, the clinical examination revealed signs suggestive of mitral and tricuspid insufficiency. Transthoracic echocardiography revealed severe post-endocarditic mitral insufficiency with A3 amputation, highly mobile 15 mm vegetations on the free edge of the large valve, moderate tricuspid insufficiency, and severe pulmonary artery hypertension. mechanical mitral valve replacement and tricuspid valve annuloplasty using autologous pericardial strip were performed via median sternotomy. After ten days, the patient presented with global cardiac decompensation associated with a clinico-biological infectious syndrome, and tans-oesophageal echography revealed an abscess at the sinotubular junction, communicating with the aorta. A thoraco-abdomino-pelvic CT scan was done, which revealed a bilateral alveolar-interstitial syndrome with mediastinal lymphadenopathy. Anti-tuberculosis treatment with RHZE was initiated for 06 months. The clinical course was favorable. Conclusion: Tuberculous endocarditis in prostheses is a serious complication of heart valve replacement surgery, which may evolve favorably under medical treatment.

关键词： Tuberculous Endocarditis Prosthetic Valve Endocarditis Mycobacterium Tuberculosis

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分布式量子计算研究进展

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量子电子学报 2024年第1期41卷 1-25页

作者：王升斌窦猛汉吴玉椿郭国平郭光灿本源量子计算科技(合肥)股份有限公司安徽合肥230088 中国科学技术大学中国科学院量子信息重点实验室安徽合肥230026

量子比特的高效拓展是量子计算获取量子加速优势需要解决的基本问题,分布式量子计算(DQC)因其高度可行性和灵活性,成为解决量子比特拓展问题的关键技术之一。根据芯片间通信方式的不同,分布式量子计算可以分为基于量子隐形传态和基于量... 详细信息

量子比特的高效拓展是量子计算获取量子加速优势需要解决的基本问题,分布式量子计算(DQC)因其高度可行性和灵活性,成为解决量子比特拓展问题的关键技术之一。根据芯片间通信方式的不同,分布式量子计算可以分为基于量子隐形传态和基于量子线路拆分的分布式量子计算两种类型,前者主要面向容错量子计算,而后者被认为可在中等规模含噪声量子(NISQ)时代有效提升量子计算机算力。从长远角度来看,作为量子网络的主要应用之一,分布式量子计算可以更好地整合接入量子网络的海量量子计算机以解决高难度问题。首先介绍了分布式量子计算的来源和类型,在此基础上,给出了两类分布式量子计算的基本原理和发展状况,以及关注度较高的应用算法和编译优化方法。

关键词：量子信息分布式量子计算量子隐形传态量子线路拆分

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Credit granting sorting model for financial organizations

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Financial Innovation 2022年第1期8卷 307-330页

作者： Paulo Cesar Schotten Leydiana de Sousa Pereira Danielle Costa morais CDSID-Center for Decision Systems and Information Development Universidade Federal de PernambucoAv.Acadêmico Hélio Ramoss/n–Cidade UniversitáriaRecifePE CEP 50.740-530Brazil

Considering the environment of risks and influences inherent in the decision-making process for credit-granting operations,it has become a matter of survival for financial organizations to seek to improve how they engage in effective decision-making to ensure that their returns on invested capital will meet the expectations established at the beginning of the process.A credit-granting sorting model for financial organizations is *** model aggregates the perspectives of different decision-makers to support an organization in the process of credit analysis and,consequently,to improve its *** decision-making model is based on the ELECTRE TRI-B multicriteria *** sorts credit-granting proposals into three classes,namely credit approved,technical analysis,and credit *** group decision emerges from the decision rules of the organization’s executive *** new proposed approach to dealing with credit-granting results in the systematization of credit analysis,reduction of doubt among decision-makers,avoidance of the emergence of informal groups,reduction of conflicts within a financial organization,and external interferences.

关键词： Credit granting ELECTRE TRI-B Financial market Group decision-making Multicriteria methods

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Exploring the effects of dietary inulin in rainbow trout fed a high‑starch,100%plant‑based diet

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Journal of Animal Science and Biotechnology 2024年第2期15卷 713-732页

作者： Raphaël Defaix Jep Lokesh Laura Frohn Mickael Le Bechec Thierry Pigot Vincent Veron Anne Surget Sandra Biasutti Frederic Terrier Sandrine Skiba-Cassy Jerome Roy Stephane Panserat Karine Ricaud Universite de Pau Et Des Pays de L’Adour E2S UPPAINRAENUMEASaint‑Pee‑Sur‑NivelleFrance Universite de Pau Et Des Pays de L’Adour E2S UPPACNRSIMT Mines AlesIPREMPauFrance Universite de Pau Et Des Pays de L’Adour E2S UPPAIUT des Pays de l’AdourDepartement Genie BiologiqueMont de MarsanFrance.

Background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and ***,a prebiotic,could have nutritional and metabolic effects,along with anti-inflammatory properties in teleosts,improving growth and *** tested this hypothesis in rainbow trout by feeding them a 100%plant-based diet,which is a viable alternative to fishmeal and fish oil in aquaculture *** a two-factor design,we examined the impact of inulin(2%)as well as the variation in the carbohydrates(CHO)/plant protein ratio on rainbow *** assessed the influence of these factors on zootechnical parameters,plasma metabolites,gut microbiota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liver metabolism,and immune markers in a 12-week feeding *** The use of 2%inulin did not significantly change the fish intestinal microbiota,but interestingly,the high CHO/protein ratio group showed a change in intestinal microbiota and in particular the beta diversity,with 21 bacterial genera affected,including Ralstonia,Bacillus,and 11 lactic-acid producing *** were higher levels of butyric,and valeric acid in groups fed with high CHO/protein diet but not with *** high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b,il8,and tnfa)in liver and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).However,the 2%inulin did not modify the expression of plasma immune ***,inulin induced a negative effect on rainbow trout growth performance irrespective of the dietary *** With a 100%plant-based diet,inclusion of high levels of carbohydrates could be a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improve the use of CHO wh

关键词： Aquaculture Fish nutrition Gut microbiota Immune markers Intermediary metabolism Inulin Prebiotic Rainbow trout Short-chain fatty acids

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Impact loads generated by tandem cavitation bubble on solid wall

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Journal of Hydrodynamics 2022年第3期34卷 467-482页

作者： Nyo me Thet Naing Jaehyun Park Seung-Ho Hyun Rho-Taek Jung School of Naval Architecture and Ocean Engineering University of UlsanUlsanKorea School of Electrical Engineering University of UlsanUlsanKorea Foundation for Industry Cooperation University of UlsanUlsanKorea

Experiments on two cavitation bubbles,which are generated at the same instant,with three different sizes near solid wall are conducted and their impulses on the boundary are registered by polyvinylidene fluoride(PVDF)*** to being near the boundary,bubble interactions and deformed features are in contrast with those in infinite fluid *** this paper,five morphologies of bubble deformation during growth and collapse phases are observed by high-speed *** profiles are strongly influenced by inter-bubble distance(η),stand-off distance from boundary(γ),and bubble size *** of photographs coupled with sensor measurements enabled qualitative investigation of two bubble interactions on the *** sensor data acquisition,it is confirmed that lower bigger bubble with upper smaller bubble configuration produces highest impulses on the boundary compared with other vertical arrangements of the tandem cavitation bubble employed in this study.

关键词： Two bubbles spark-generated bubble impulse polyvinylidene fluoride(PVDF)

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