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An Improved Graphics Processing Unit Acceleration Approach for Three-Dimensional Structural Topology Optimization Using the Element-Free Galerkin Method

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Computer Modeling in Engineering & Sciences 2021年第9期128卷 1151-1178页

作者： Haishan lu Shuguang Gong Jianping Zhang guilan Xie Shuohui Yin School of Mechanical Engineering Xiangtan UniversityXiangtan411105China

We proposed an improved graphics processing unit(GPU)acceleration approach for three-dimensional structural topology optimization using the element-free Galerkin(EFG)method.This method can effectively eliminate the race condition under parallelization.We established a structural topology optimization model by combining the EFG method and the solid isotropic microstructures with penalization model.We explored the GPU parallel algorithm of assembling stiffness matrix,solving discrete equation,analyzing sensitivity,and updating design variables in detail.We also proposed a node pair-wise method for assembling the stiffnessmatrix and a node-wise method for sensitivity analysis to eliminate race conditions during the parallelization.Furthermore,we investigated the effects of the thread block size,the number of degrees of freedom,and the convergence error of preconditioned conjugate gradient(PCG)on GPU computing performance.Finally,the results of the three numerical examples demonstrated the validity of the proposed approach and showed the significant acceleration of structural topology optimization.To save the cost of optimization calculation,we proposed the appropriate thread block size and the convergence error of the PCG method.

关键词： Topology optimization EFG method GPU acceleration race condition preconditioned conjugate gradient

Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2326-2343页

作者： Ting Liu Minglong Chen Jintao Fu Ying Sun Chao lu guilan Quan Xin Pan Chuanbin Wu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 510632China

Proteins and peptides have become a significant therapeutic modality for various diseases because of their high potency and specificity.However,the inherent properties of these drugs,such as large molecular weight,poor stability,and conformational flexibility,make them difficult to be formulated and delivered.Injection is the primary route for clinical administration of protein and peptide drugs,which usually leads to poor patient’s compliance.As a portable,minimally invasive device,microneedles(MNs)can overcome the skin barrier and generate reversible microchannels for effective macromolecule permeation.In this review,we highlighted the recent advances in MNs-mediated transdermal delivery of protein and peptide drugs.Emphasis was given to the latest development in representative MNs design and fabrication.We also summarize the current application status of MNs-mediated transdermal protein and peptide delivery,especially in the field of infectious disease,diabetes,cancer,and other disease therapy.Finally,the current status of clinical translation and a perspective on future development are also provided.

关键词： Microneedles Transdermal drug delivery Proteins Peptides Infectious diseases Diabetes Cancer Clinic

Application of a ddRT-PCR to quantify seasonal influenza virus for viral isolation

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Biosafety and Health 2022年第5期4卷 299-302页

作者： Yimeng Liu Jiachen Zhao Xiaomin Peng Guilan Lu Weixian Shi Zhaomin Feng Hui Xu Shujuan Cui Yang Pan Daitao Zhang Peng Yang Quanyi Wang Institute for Infectious Disease and Endemic Disease Control Beijing Center for Disease Prevention and ControlBeijing 100013China

Viral isolation in cell cultures has been regarded for decades as the“gold standard”for the laboratory diagnosis of influenza viral infections.Not all viral strains could be isolated from clinical samples.This study aimed to quantify the viral load in the samples before isolation to save working time and improve working efficiency.Four hundred samples from patients with influenza-like cases were confirmed pdmH1N1 positive(200 cases)and B Victoria(BV)positive(200 cases)by whole-genome sequencing and analyzed by ddPCR for viral load in samples before isolation,and isolation results were verified by hemagglutination(HA)assay and hemagglutination-inhibition(HI)tests.Probit regression analysis was used to calculate the isolation viral load limit with a 95%probability level by SPSS 19.0 software.The results showed that the isolation limit of viral load was 4.9×10^(4)(95%CI:2.5×10^(4)–9.0×10^(4))copies/mL for pdmH1N1 and 1.9×10^(4)(95%CI:7.8×103–3.6×10^(4))copies/mL for BV.The isolation rate of clinical samples is positively correlated with the viral load in clinical samples,which can be used for viral culture,providing important guidance for daily work.

关键词： Influenza virus ddRT-PCR Viral load Viral isolation

Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma

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Science China(Life Sciences) 2010年第10期53卷 1215-1220页

作者： WANG guilan lu JiRong Department of Pediatrics Zhongshan Boai HospitalZhongshan 528403China Department of Pediatrics First HospitalJilin UniversityChangchun 130021China

This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on airway inflammation and airway responsiveness in asthmatic mice. The retrovirus-mediated delivery of IL-4RA to the airways of mice inhibited elevations of airway responsiveness and the development of allergic inflammation in asthmatic mice, and regulated the Th1/Th2 balance in OVA-sensitized and -challenged mouse models. This suggests that gene therapy is a therapeutic option for treating and controlling chronic airway inflammation and asthma symptoms.

关键词： asthma model retrovirus vector IL-4RA gene transfer

A triple-enhanced chemodynamic approach based on glucosepowered hybrid nanoreactors for effective bacteria killing

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Nano Research 2023年第2期16卷 2682-2694页

作者： Jintao Fu Yixian Zhou Ting Liu Wenhao Wang Yiting Zhao Ying Sun Yiming Zhang Wenxuan Qin Zhongwei Chen Chao lu guilan Quan Chuanbin Wu Xin Pan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 511443China

Rapid evolution of multidrug resistance in bacterial pathogens is outpacing the development of new antibiotics,and chemodynamic therapy(CDT)provides an excellent alternative.However,achieving highly efficient CDT is still a great challenge,since the pH in the infection site is close to neutral and the supply of H_(2)O_(2)is inadequate.We herein constructed the antibacterial nanoreactors.Indocyanine green(ICG)and glucose oxidase(GOx)were incorporated into homologous zeolitic imidazolate framework-8(ZIF-8)nanoparticles coating with metal polyphenol network(MPN)composed by Fe^(3+)and tannic acid(TA).The well-designed nanoreactors could simultaneously break the pH and H_(2)O_(2)limitations,and generate hyperthermia under irradiation,thus realizing a triple-enhanced CDT for high-efficiency sterilization.Furthermore,the nanoreactors could combine CDT with photothermal therapy(PTT)and photodynamic therapy(PDT),which not only improved the bactericidal efficiency and broadened the antibacterial spectrum,but also alleviated the antibiotics resistance issues.Remarkably,the proposed nanoreactors achieved a robust in vitro bacterial killing against Gram-positive methicillin-resistant Staphylococcus aureus(MRSA)and Gram-negative Pseudomonas aeruginosa.The nanoreactors achieved an 99.7%MRSA reduction in an MRSA-induced murine abscess model accompanied with negligible toxicity.Overall,this study provides a promising strategy for multiple-enhanced CDT and multimodal combined therapy for pathogenic infections.

关键词： metal-organic frameworks glucose oxidase photothermal therapy photodynamic therapy localized bacterial infection

Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone

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Chinese Journal of Cancer Research 2014年第1期26卷 112-118页

作者： Yongxiang Yi Yufeng Zhang Qiang Wei Liang Zhao Jianbo Han Yan Song Ying Ding Guilan Lu Junmao Liu Huaiying Ding Feng Dai Xiaojun Tang Department of Hepatobiliary Surgery the Second Affiliated Hospital of Southeast University Department of Medical Imaging the Second Affiliated Hospital of Southeast University

Objective：To compare radiofrequency ablation （RFA） or microwave ablation （MWA） and transcatheter arterial chemoembolization （TACE） with RFA or MWA monotherapy in hepatocellular carcinoma （HCC）.Methods：A prospective,randomized,controlled trial was conducted on 94 patients with HCC ≤7 cm at a single tertiary referral center from June 2008 to June 2010 at the Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Southeast University.The patients were randomly assigned into the TACERFA or TACE-MWA （combined treatment group） and the RFA-alone or MWA-alone groups （control group）.The primary end point was overall survival.The secondary end point was recurrence-free survival,and the tertiary end point was adverse effects.Results：Until the time of censor,17 patients in the TACE-RFA or TACE-MWA group had died.The median follow-up time of the patients who were still alive for the TACE-RFA or TACE-MWA group was 47.5±11.3 months （range,29 to 62 months）.The 1-,3-and 5-year overall survival for the TACE-RFA or TACE-MWA group was 93.6％,68.1％ and 61.7％,respectively.Twenty-five patients in the RFA or MWA group had died.The median follow-up time of the patients who were still alive for the RFA or MWA group was 47.0±12.9 months （range,28 to 62 months）.The 1-,3-and 5-year overall survival for the RFA or MWA group was 85.1％,59.6％ and 44.7％,respectively.The patients in the TACE-RFA or TACE-MWA group had better overall survival than the RFA or MWA group [hazard ratio （HR）,0.526; 95％ confidence interval （95％ CO,0.334-0.823; P=0.002],and showed better recurrence-free survival than the RFA or MWA group （HR,0.582; 95％ CI,0.368-0.895; P=0.008）.Conclusions：RFA or MWA combined with TACE in the treatment of HCC ≤7 cm was superior to RFA or MWA alone in improving survival by reducing arterial and portal blood flow due to TACE with iodized oil before RFA.

关键词： Radiofrequency ablation （RFA） transcatheter arterial chemoembolization （TACE） hepatocellular carcinoma （HCC）

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2609-2644页

作者： Liming Lin Jiaying Chi Yilang Yan Rui luo Xiaoqian Feng Yuwei Zheng Dongyi Xian Xin Li guilan Quan Daojun Liu Chuanbin Wu Chao lu Xin Pan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 511443China Shantou University Medical College Shantou 515041China The Third Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510630China

Membrane-disruptive peptides/peptidomimetics(MDPs)are antimicrobials or anticarcinogens that present a general killing mechanism through the physical disruption of cell membranes,in contrast to conventional chemotherapeutic drugs,which act on precise targets such as DNA or specific enzymes.Owing to their rapid action,broad-spectrum activity,and mechanisms of action that potentially hinder the development of resistance,MDPs have been increasingly considered as future therapeutics in the drug-resistant era.Recently,growing experimental evidence has demonstrated that MDPs can also be utilized as adjuvants to enhance the therapeutic effects of other agents.In this review,we evaluate the literature around the broad-spectrum antimicrobial properties and anticancer activity of MDPs,and summarize the current development and mechanisms of MDPs alone or in combination with other agents.Notably,this review highlights recent advances in the design of various MDP-based drug delivery systems that can improve the therapeutic effect of MDPs,minimize side effects,and promote the codelivery of multiple chemotherapeutics,for more efficient antimicrobial and anticancer therapy.

关键词： Membrane-disruptive peptides/peptidomimetics Drug-resistance Drug delivery systems Combination therapy

桅杆长径比对有限长锥台形捕能柱涡激横向摆动特性的影响

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振动与冲击 2023年第9期42卷 261-267,303页

作者：龚曙光徐凡业谢桂兰卢海山湘潭大学机械工程学院湖南湘潭411105

无叶片风力机是利用捕能柱的风致横向摆动收集风能并将其转换成电能的装置。通过引入桅杆结构并将其与有限长锥台型捕能柱构成一个捕能系统,在建立有限长锥台型捕能系统简化模型的基础上,推导了与捕能系统几何形状相关的无量纲结构系数... 详细信息

无叶片风力机是利用捕能柱的风致横向摆动收集风能并将其转换成电能的装置。通过引入桅杆结构并将其与有限长锥台型捕能柱构成一个捕能系统,在建立有限长锥台型捕能系统简化模型的基础上,推导了与捕能系统几何形状相关的无量纲结构系数计算式,探讨了桅杆长径比对有限长锥台型捕能柱涡激摆动特性及捕能效率的影响。所得结果表明,桅杆结构的引入能有效地提升有限长捕能柱的涡激横向摆幅峰值及捕能效率,且其均随桅杆长径比的增大呈现先增大后减小的趋势。与无限长捕能柱结构相比,在桅杆长径比为6.67时有限长捕能柱的能量收集效率提升了44.8%;增大桅杆的长径比会使锁频区间增宽,但捕能系统的固有频率会减小;对于给定的捕能系统存在一个与其相匹配的最佳桅杆长径比。所得结论对于无叶片风力机的设计与实际工程应用具有重要的指导作用。

关键词：无叶片风力机涡激摆动锥台形捕能柱桅杆有限长长径比

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绿色发展背景下新疆工业生产效率研究

中阿科技论坛（中英文） 2022年第3期 79-83页

作者：芦敏韩桂兰新疆财经大学新疆乌鲁木齐830000

本文利用2010—2019年新疆14个地州的面板数据,运用两种DEA模型分别对新疆各地州工业生产效率进行测算,研究发现:(1)乌鲁木齐市和克拉玛依市工业生产效率长期领先于其他地州,和田地区和喀什地区的工业生产效率情况发展相对于其他地州较... 详细信息

本文利用2010—2019年新疆14个地州的面板数据,运用两种DEA模型分别对新疆各地州工业生产效率进行测算,研究发现:(1)乌鲁木齐市和克拉玛依市工业生产效率长期领先于其他地州,和田地区和喀什地区的工业生产效率情况发展相对于其他地州较差。新疆整体和南北疆工业生产效率发展情况不同,南疆地区差异较大,北疆相对差异较小。(2)新疆工业生产效率的全局Moran's I指数基本保持在-0.2的水平,工业生产效率呈现出空间负相关关系。从整体差异来看,总体的Dagum基尼系数低于0.2。

关键词：工业生产效率 Dagum基尼系数 DEA模型