Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

作     者：Ting Liu Minglong Chen Jintao Fu Ying Sun Chao Lu Guilan Quan Xin Pan Chuanbin Wu Ting Liu;Minglong Chen;Jintao Fu;Ying Sun;Chao Lu;Guilan Quan;Xin Pan;Chuanbin Wu

作者机构：School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China College of PharmacyJinan UniversityGuangzhou 510632China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第8期

页      面：2326-2343页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 100602[医学-中西医结合临床] 

基　　金：funded by the National Natural Science Foundation(Project No.81803466,China) Guangdong Macao joint innovation funding project(Project No.2020A050515009,China) the Research and Development Plan for Key Areas in Guangdong Province(Project No.2019B020204002,China) the Foundation of Traditional Chinese Medicine Bureau of Guangdong Province(Project No.20191057,China) 

主　　题：Microneedles Transdermal drug delivery Proteins Peptides Infectious diseases Diabetes Cancer Clinic 

摘      要：Proteins and peptides have become a significant therapeutic modality for various diseases because of their high potency and specificity.However,the inherent properties of these drugs,such as large molecular weight,poor stability,and conformational flexibility,make them difficult to be formulated and delivered.Injection is the primary route for clinical administration of protein and peptide drugs,which usually leads to poor patient’s compliance.As a portable,minimally invasive device,microneedles(MNs)can overcome the skin barrier and generate reversible microchannels for effective macromolecule permeation.In this review,we highlighted the recent advances in MNs-mediated transdermal delivery of protein and peptide drugs.Emphasis was given to the latest development in representative MNs design and fabrication.We also summarize the current application status of MNs-mediated transdermal protein and peptide delivery,especially in the field of infectious disease,diabetes,cancer,and other disease therapy.Finally,the current status of clinical translation and a perspective on future development are also provided.