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Mutual feedback between algal blooming and global warming

Journal of Oceanology and Limnology 2024年第3期42卷 787-801页

作者： Jianrong MA guijun yanG Xianfu ZHAO Boqiang QIN Kun SHAN Botian ZHOU yan ZENG Jingfu WANG Jingan CHEN Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550002China School of Environment and Ecology Jiangnan UniversityWuxi 214122China Key Laboratory of Ministry of Water Resources for Ecological Impacts of Hydraulic-projects and Restoration of Aquatic Ecosystem Institute of HydroecologyMinistry of Water Resources&Chinese Academy of SciencesWuhan 430079China State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China

Global warming and algal blooms have been two of the most pressing problems faced by the world today.In recent decades,numerous studies indicated that global warming promoted the expansion of algal blooms.However,research on how algal blooms respond to global warming is scant.Global warming coupled with eutrophication promoted the rapid growth of phytoplankton,which resulted in an expansion of algal blooms.Algal blooms are affected by the combined effects of global warming,including increases in temperatures,CO_(2)concentration,and nutrient input to aquatic systems by extreme weather events.Since the growth of phytoplankton requires CO_(2),they appear to act as a carbon sink.Unfortunately,algal blooms will release CH4,CO_(2),and inorganic nitrogen when they die and decompose.As substrate nitrogen increases from decompose algal biomass,more N2O will be released by nitrification and denitrification.In comparison to CO_(2),CH4has 28-fold and N2O has 265-fold greenhouse effect.Moreover,algal blooms in the polar regions may contribute to melting glaciers and sea ice(will release greenhouse gas,which contribute to global warming)by reducing surface albedo,which consequently would accelerate global warming.Thus,algal blooms and global warming could form feedback loops which prevent human survival and development.Future researches shall examine the mechanism,trend,strength,and control strategies involved in this mutual feedback.Additionally,it will promote global projects of environmental protection combining governance greenhouse gas emissions and algal blooms,to form a geoengineering for regulating the cycles of carbon,nitrogen,and phosphorus.

关键词： climate change carbon neutrality eutrophication greenhouse gas glaciers melting geoengineering

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Wheat genotypes tolerant to heat at seedling stage tend to be also tolerant at adult stage:The possibility of early selection for heat tolerance breeding

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The Crop Journal 2022年第4期10卷 1006-1013页

作者： Lu Lu Hui Liu Yu Wu guijun yan UWA School of Agriculture and Environment The University of Western AustraliaPerthWA 6009Australia The UWA Institute of Agriculture The University of Western AustraliaPerthWA 6009Australia Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041SichuanChina

Wheat production is seriously influenced by extreme hot weather,which has attracted increasing attention.It is important to compare wheat responses to heat at seedling and reproductive stages,to explore the potential relationship between the performances at different growing stages and the possibility of early selection to accelerate heat tolerance breeding.In this study,forty wheat genotypes were screened under heat stress at both seedling and adult stages.It was found that root lengths at seedling stage were severely reduced by heat stress with significant variations among wheat genotypes.Heat-tolerant genotypes at seedling stage showed less root length decrease than susceptible ones.Wheat genotypes tolerant at seedling stage showed higher yield at adult stage after heat treatment.The performances of wheat genotypes screened under heat stress at seedling and adult stages were ranked by seedling damage index and adult damage index.A significant positive relationship was found between heat tolerance at seedling stage and at adult stage(r=0.6930),suggesting a similar tolerant/susceptible mechanism at different plant growth stages and the possibility of early selection at seedling stage for breeding heat tolerance.Extremely tolerant and susceptible genotypes with consistent performances at seedling and adult stages were genetically compared and associated SNP markers and linked candidate genes were identified.

关键词： Heat tolerance Seedling stage Adult stage Linear regression Genetic mechanism

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Identification of KASP markers and putative genes for pre-harvest sprouting resistance in common wheat(Triticum aestivum L.)

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The Crop Journal 2023年第2期11卷 549-557页

作者： Guannan Liu Daniel Mullan Aimin Zhang Hui Liu Dongcheng Liu guijun yan UWA School of Agriculture and Environment and The UWA Institute of AgricultureThe University of Western AustraliaPerthWA 6009Australia InterGrain Pty.Ltd. 19 Ambitious Link Bibra LakeWA 6163Australia State Key Laboratory of North China Crop Improvement and Regulation College of AgronomyHebei Agriculture UniversityBaoding 071000HebeiChina

Common wheat(Triticum aestivum L.)is the most important crop in the world and a typical allopolyploid with a large and complex genome.Pre-harvest sprouting(PHS)leads to a significant reduction in grain quality worldwide.PHS is a complex trait with related QTL located on different chromosomes.However,the study of markers and genes related to PHS resistance is limited especially for whitegrained wheat.Four pairs of near isogenic lines(NILs)from a white-grained wheat cross of CharaDM5637B*8 targeting a major QTL for PHS resistance(Qphs.ccsu-3A.1)on wheat chromosme 3AL were genotyped using the 90K SNP Illumina iSelect array.Ten SNPs were identified,with a 75%-100%consistency between genotype and phenotype in the resistant or susceptible isolines.The 10 SNPs were converted to cost-effective kompetitive allele-specific PCR(KASP)markers.Screening of 48 wheat cultivars with different phenotypes of PHS identified four KASP markers with 81.3%-85.4%conformity between genotype and phenotype.Further investigation revealed that the four SNPs(BS00022245_51,Kukri_c49927_151,BS00022884_51 and BS00110550_51)corresponding to the four validated KASP markers are residing in three independent genes(TraesCS3A03G1072800,TraesCS3A03G1072400,TraesCS3A03G1071800)close to each other with a distance of 4.28-4.48 Mb to the targeted QTL.These three annotated genes have potential functions related to PHS resistance.Our study revealed that combined use of NILs and the 90K SNP chip is a powerful approach for developing KASP markers and mining functional genes in wheat.The KASP markers for PHS resistance on chromosome 3AL are useful for high-throughput evaluation and marker-assisted selection,and the three identified genes could lead to a better understanding of the genetic pathways controlling PHS.

关键词： Pre-harvest sprouting(PHS) KASP marker Functional genes Chromosome 3AL 90K SNP assay Near-isogenic lines

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Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2694-2697页

作者： Lu Xu yanjun yang Lingling Zhang guijun yan Shiyuan Li Yifan Li Yali Hu Lijun Ding Bruno Péault Haixiang Sun Center for Reproductive Medicine and Obstetrics and Gynecology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Center for Molecular Reproductive Medicine Nanjing UniversityNanjing 210093China Department of Obstetrics and Gynecology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China NHC Key Lab of Reproduction Regulation Shanghai Institute of Planned Parenthood ResearchPharmacy SchoolFudan UniversityShanghai 200032China Clinical Center for Stem Cell Research the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Orthopedic Hospital Research Center and Broad Stem Cell Center David Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210008China

Dear Editor,Chemotherapy-induced ovarian failure significantly diminishes ovarian blood flow,ovarian size,and follicular development.Angiogenesis plays a vital role in repairing ovarian damage.1 Perivascular stem cells(PSCs),known as mural cells covering the vasculature,are essential for blood vessel formation and postulated as progenitors of mesenchymal stem cells(MSCs).2,3 We previously established umbilical cord artery-derived PSCs(UCA-PSCs)and Wharton’s jelly-derived MSCs(WJ-MSCs)and UCAPSCs display optimal angiogenic capacity in vitro.4 Therefore,we explored the angiogenesis and pro-angiogenesis mechanisms of UCA-PSCs and provided them as an efficient treatment strategy for ovarian failure.

关键词： CD146 treatment artery damage

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子宫内膜上皮细胞类器官在生殖领域的研究进展

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中国临床药理学与治疗学 2024年第5期29卷 576-582页

作者：曹志文颜桂军南京大学医学院附属鼓楼医院生殖医学和妇产医学中心江苏南京210000

近年来,子宫内膜上皮细胞类器官研究在生殖领域取得了显著进展。传统的二维细胞培养模型和动物实验难以准确还原子宫内膜的三维结构和生理功能,从而限制了对子宫内膜上皮细胞正常生理机制和相关疾病机制的深入研究。新兴的类器官技术为... 详细信息

近年来,子宫内膜上皮细胞类器官研究在生殖领域取得了显著进展。传统的二维细胞培养模型和动物实验难以准确还原子宫内膜的三维结构和生理功能,从而限制了对子宫内膜上皮细胞正常生理机制和相关疾病机制的深入研究。新兴的类器官技术为此提供了新途径,子宫内膜上皮细胞类器官通过干细胞或前体细胞在三维培养基中自行组织形成,成功地高度还原了在体子宫内膜腺体的特征。这种类器官模型不仅能够模拟子宫内膜上皮细胞在不同周期阶段的生理变化,还能够模拟囊胚与子宫内膜之间的复杂互动过程。此外,子宫内膜上皮细胞类器官系统为生殖领域的基础研究和临床研究提供了重要工具,包括生殖相关基础研究、疾病机制探索、药物筛选及靶向治疗研究等。这些研究可为深入了解子宫内膜的生物学特性、疾病机制以及相关疾病的治疗策略提供全新的思路和方法。

关键词：子宫内膜上皮细胞类器官药物筛选

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油料作物育种的分子工具和技术创新

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浙江大学学报（农业与生命科学版） 2023年第4期49卷 445-453页

作者：许玲 Hui LIU guijun yan Wallace COWLING 周伟军路战远浙江理工大学生命科学与医药学院浙江杭州310018 西澳大学农业与环境学院/西澳大学农业研究所西澳大利亚州珀斯6009 浙江大学农业与生物技术学院浙江杭州310058 内蒙古自治区农牧业科学院内蒙古呼和浩特010031

油料作物的主要育种目标是提高产量、品质和抗逆性。目前,就产量而言,全球主要油料作物依次为大豆、油菜、向日葵和花生。本文综述了这些主要油料作物育种的分子工具和技术创新,包括基因组选择、基因组编辑、分子设计育种等新技术,指出... 详细信息

油料作物的主要育种目标是提高产量、品质和抗逆性。目前,就产量而言,全球主要油料作物依次为大豆、油菜、向日葵和花生。本文综述了这些主要油料作物育种的分子工具和技术创新,包括基因组选择、基因组编辑、分子设计育种等新技术,指出了当前在遗传研究和育种实践中存在的主要问题,并对技术进展和未来应用前景进行了展望,旨在为油料作物高产、优质、高效育种提供借鉴。

关键词：油料作物育种分子工具技术创新

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河北省非金属露天矿山水平分层式开采探索与实践

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中国矿业 2024年第6期33卷 203-209页

作者：张兆长李岩南贵军河北省地质矿产勘查开发局国土资源勘查中心(河北省矿山和地质灾害应急救援中心) 河北石家庄050081

河北省非金属露天矿山数量多,矿山地质环境问题突出。为了从根本上改善非金属露天矿山生态环境,消除生产过程中和开发利用后的矿山地质灾害隐患,消除安全生产风险,降低修复治理成本,推进砂石资源开发高质量发展,河北省按照政策引领、摸... 详细信息

河北省非金属露天矿山数量多,矿山地质环境问题突出。为了从根本上改善非金属露天矿山生态环境,消除生产过程中和开发利用后的矿山地质灾害隐患,消除安全生产风险,降低修复治理成本,推进砂石资源开发高质量发展,河北省按照政策引领、摸清底数、试点先行、制定规范、全面推行的步骤,首先制定出台了相关政策文件,在此基础上摸清全省露天矿山是否符合水平分层式开采条件,将露天矿山划分为孤山型、半山型、山脊型三种类型,选择符合水平分层式开采的矿山开展试点工作并制定了相应的技术规定,指导并全面推行非金属露天矿山水平分层式开采。通过多次调研和参与全过程实践,总结了非金属露天矿山水平分层式开采的相关政策、基本概念、实施路径,分析并提出了实施过程中可能存在的问题以及相关建议。研究结果表明,非金属露天矿山水平分层式开采可有效解决矿山高陡边坡修复难题,提高矿产资源集约化利用率,同时还可为当地提供大量可利用地,对保障京津冀生态环境支撑区建设具有重要意义。

关键词：露天矿山非金属开采方式开发利用恢复治理

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Pravastatin alleviates lipopolysaccharide-induced placental TLR4 over-activation and promotes uterine arteriole remodeling without impairing rat fetal development

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The Journal of Biomedical Research 2018年第4期32卷 288-297页

作者： Muyi yang Zhenyu Diao Zhiyin Wang guijun yan Guangfeng Zhao Mingming Zheng Anyi Dai Yimin Dai Yali Hu Drum Tower Clinical Medical College Nanjing Medical University Department of Obstetrics and Gynecology Nanjing Drum Tower HospitalNanjing University Medical School

Preeclampsia is associated with over-activation of the innate immune system in the placenta,in which toll-like receptor 4（TLR4） plays an essential part.With their potent anti-inflammatory effects,statins have been suggested as potential prevention or treatment of preeclampsia,although evidence remains inadequate.Herewith,we investigated whether pravastatin could ameliorate preeclampsia-like phenotypes in a previously established lipopolysaccharide（LPS）-induced rat preeclampsia model,through targeting the TLR4/NF-κB pathway.The results showed that pravastatin reduced the blood pressure [maximum decline on gestational day（GD） 12,（101.33±2.49） mmHg vs.（118.3±1.37） mmHg,P〈0.05] and urine protein level [maximum decline on GD9,（3,726.23± 1,572.86） μg vs.（1,991.03 ±609.37）μg,P〈 0.05],which were elevated following LPS administration.Pravastatin also significantly reduced the rate of fetal growth restriction in LPS-treated rats（34.10% vs.8.99%,P〈0.05）.Further pathological analyses suggested a restoration of normal spiral artery remodeling in preeclampsia rats by pravastatin treatment.These effects of pravastatin were associated with decreased TLR4/NF-κB protein levels in the placenta and IL-6/MCP-1 levels in serum.Additionally,no obvious abnormalities in fetal liver,brain,and kidney were found after administration of pravastatin.These results provide supportive evidence for use of pravastatin in preventing preeclampsia.

关键词： preeclampsia arteriole remodeling pravastatin toll-like receptor 4 fetal development

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The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian ageing in mice

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Life Metabolism 2022年第2期1卷 149-160页

作者： Xin-Ying Wang Xin-Ge Zhang Yong-Juan Sang Dan-yang Chong Xiao-Qiang Sheng Hai-Quan Wang Chao-Fan yang guijun yan Hai-Xiang Sun Chao-Jun Li State Key Laboratory of Reproductive Medicine and China International Joint Research Center on Environment and Human Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Center for Reproductive Medicine Department of Obstetrics and GynecologyNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjingJiangsu 210093China Ministry of Education Key Laboratory of Model Animal for Disease Study Model Animal Research Center of Nanjing UniversityNanjingJiangsu 210093China

Adverse nutritional conditions during the perinatal stage are related to early menopause in adulthood;however,the underlying mechanism is still unclear.Herein,we revealed that colostrum-activated ketone body elevation during the postnatal stage regulated primordial follicle reservoir size and then affected ovarian ageing.We found that the expression of the ketogenesis rate-limiting enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2(Hmgcs2)was largely enhanced during primordial follicle pool formation after birth and might be activated in the ovaries by colostrum.Reactive oxygen species(ROS)elevation in the ovaries leads to follicle apoptosis to deplete damaged follicles,while Hmgcs2 deficiency enhances follicle apoptosis and thus decreases the size of the primordial follicle pool and leads to premature ovarian ageing(POA),which might be related to the activation of cellular endogenous antioxidant system.All these defects could be rescued by ketone body administration,which suppressed ROS-activated follicle apoptosis.Our results suggest that the internal metabolic homeostasis of newborn mice is critical for the primordial reservoir and that any intrauterine and perinatal undernutrition could result in POA.

关键词： ketone body primordial follicle pool Hmgcs2 ROS POA

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li yan guijun Qin Xulei Tang Gang Chen Min Xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Tao yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu Yuhong Chen Jieli Lu Weiqing Wang Guang Ning Yu Xu Yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with CKD.We included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life behavior.Using isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD prevalence.Leisure-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working population.In stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long sleepers.More pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active way.The U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical activity.The divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

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