Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling

作     者：Lu Xu Yanjun Yang Lingling Zhang Guijun Yan Shiyuan Li Yifan Li Yali Hu Lijun Ding Bruno Péault Haixiang Sun 

作者机构：Center for Reproductive Medicine and Obstetrics and Gynecologythe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Center for Molecular Reproductive MedicineNanjing UniversityNanjing 210093China Department of Obstetrics and Gynecologythe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China NHC Key Lab of Reproduction RegulationShanghai Institute of Planned Parenthood ResearchPharmacy SchoolFudan UniversityShanghai 200032China Clinical Center for Stem Cell Researchthe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Orthopedic Hospital Research Center and Broad Stem Cell CenterDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA State Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjing 210008China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第8期

页      面：2694-2697页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by grants from the National Key Research and Development Program of China(2018YFC1004701) Nature Science Foundation of China(81871128 and 81571391) Nanjing Medical Science Development Project(ZKX16042) L.D grants from Nature Science Foundation of China(82030040) Jiangsu Province Social Development Project(BE2018602) H.S.For this work,Bruno Péault has been supported by grants from the British Heart Foundation and BIRAX Regenerative Medicine Initiative 

主　　题：CD146 treatment artery damage 

摘      要：Dear Editor,Chemotherapy-induced ovarian failure significantly diminishes ovarian blood flow,ovarian size,and follicular *** plays a vital role in repairing ovarian damage.1 Perivascular stem cells(PSCs),known as mural cells covering the vasculature,are essential for blood vessel formation and postulated as progenitors of mesenchymal stem cells(MSCs).2,3 We previously established umbilical cord artery-derived PSCs(UCA-PSCs)and Wharton’s jelly-derived MSCs(WJ-MSCs)and UCAPSCs display optimal angiogenic capacity in vitro.4 Therefore,we explored the angiogenesis and pro-angiogenesis mechanisms of UCA-PSCs and provided them as an efficient treatment strategy for ovarian failure.