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Evaluation of recombinant endostatin in the treatment of atherosclerotic plaques and neovascularization in rabbits

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 599-607页

作者： Wei MAO Jing KONG Jin DAI Zhao-quan HUANG Dong-zhi WANG gui-bao ni Min-li CHEN Department of Cardiology Zhejiang Traditional Chinese Medical Hospital Hangzhou 310006 China First College of Clinical Medicine Zhejiang Chinese Medical University Hangzhou 310053 China Department of Pathology Zhejiang Traditional Chinese Medical Hospital Hangzhou 310006 China Center of Experimental Animal Zhejiang Chinese Medical University Hangzhou 310053 China

Objective： Atherosclerotic plaques and neovascularization play an important role in the course of coronary atherosclerosis. This study evaluated the effect of recombinant endostatin on experimental atherosclerotic plaques and neovasculanzation in rabbits. Methods： Eighteen healthy male rabbits were divided into three groups： control group, atherosclerotic model group, and recombinant endostatin treated group. The atherosclerotic model was es- tablished via a high-cholesterol diet after balloon catheter injury. The subject weights, serum total cholesterol, creatine kinase-myocardial band fraction （CKMB）, and matrix metalloproteinase-2 （MMP-2） were measured. Six weeks after treatment, the aortic roots were taken for pathological assay. The thickness ratio of the intima to media was measured by hematoxylin and eosin （HE） staining, and the number of neovessels was measured by immunohistochemistry via monoclonal antibody CD31 staining. Results： The weight, plasma total cholesterol, and CKMB were not significantly different between the atherosclerotic model group and the recombinant endostatin treated group, but much higher than those of the control group （P〈0.05）. The thickness ratio of the intima to media in the recombinant endostatin treated group was distinctly less than that in the atherosclerotic model group （P〈0.05）. The number of neovessels decreased dramatically （P〈0.05） and the content of MMP-2 decreased slightly without statistical difference （P〉0.05） in the recombinant endostatin treated group, compared to the atherosclerotic model group. Conclusions： Recombinant en- dostatin is able to inhibit the growth of neovascularization in the atherosclerotic plaque and the development of plaque.

关键词： Recombinant endostatin Atherosclerosis Neovessels

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CaH2-promoted activity of ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-Lin Jiang bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the ni/CaCO3（31.6%） and ni/CaH2-CaO （42.4%） ***,the ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the ni-carbonate interface for ***2could modify the electronic structure of ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride ni catalysts Carbonate Metal-carbonate interface

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Novel aqueous rechargeable nickel//bismuth battery based on highly porous Bi_(2)WO6 and Co_(0.5)ni_(0.5)MoO_(4) microspheres

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Rare Metals 2023年第3期42卷 902-915页

作者： Wei-Wei Kang Ya-Nan Zhao Wen-Qing Zhang Ying Sun Xue-Qin Zhang gui-Yun Yi Guang-Xu Huang bao-Lin Xing Chuan-Xiang Zhang bao-Ping Lin College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo 454003China School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China

Developing high performances aqueous rechargeable batteries is imperative and ***,a novel aqueous rechargeable nickel//bismuth battery is developed based on highly porous Bi_(2)WO_(6) and Co_(0.5)ni_(0.5)MoO_(4) microspheres as electrode active *** Bi_(2)WO6 microspheres assembled from nanosheets as anode active materials can afford a specific capacity of179.2 mAh·g^(-1) at 1 A·g^(-1),rate capability of 74.7%in 1-20 A·g^(-1),and capacity retention of 57.2%for 1500 cycles at 15 A·g^(-1).Owing to the highly porous microsphere with’ribbon’-like and intertwined nanolayers morphology,the screened Co0.5ni0.5MoO4 cathode active materials present an outstanding specific surface area of 293 m^(2)·g^(-1)and excellent electrochemical performance(such as superior specific capacity of 113.2 mAh·g^(-1) at 1 A·g^(-1),high rate performance of 51.8%in 1-15 A·g^(-1),and good capacity retention of 48.5%for 4600 cycles at15 A·g^(-1)).The corresponding aqueous rechargeable nickel//bismuth battery delivers the maximum energy density and power density of 35.8 Wh·kg^(-1) and3238.5 W·kg^(-1),*** present research would offer a worthwhile guidance for the effective construction of electrode active materials for aqueous rechargeable nickel//bismuth batteries.

关键词： Aqueous rechargeable batteries(ARBs) Porous Co_(0.5)ni_(0.5)MoO_(4) Bi_(2)WO microspheres Energy storageandconversion

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Dynamic Test of Hydro Mechanical Composite Transmission for Cotton Picker

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Journal of Beijing Institute of Technology 2020年第3期29卷 366-378页

作者： Xiangdong ni Mingxi bao College of Mechanical and Electrical Engineering Shihezi UniversityShihezi 832003XinjiangChina Key Laboratory of Northwest Agricultural Equipment Ministry of AgricultureShihezi UniversityShihezi 832003XinjiangChina

With a transmission system suitable for a medium or large self-propelled cotton picker as the object of the study,the following work focuses on the influence law of an independently designed hydro-mechanical continuously variable transmission(HMCVT)in the process of changing *** HMCVT simulation model was established using the multibody dynamics Simulation X *** accuracy of the simulation model was verified by comparing the numerical values of the output speed of the HMCVT with model *** HMCVT test bench was built independently using a John Deere 4045HYC11 diesel engine as power *** engine speed,load torque,oil pressure,and flow of speed regulating valve were considered the influencing *** sliding friction power was the response index for the segment change process *** analysed the reasons for the decrease in output speed during the shifting process,and proposed to effectively reduce the stable speed difference before and after the output shaft shifting by shifting the stage ahead(with displacement ratio of-0.96).This study provides a reference value for the smoothness of the HMCVT of the self-propelled cotton picker,and is relevant in promoting the use of the cotton picker.

关键词： transmission scheme shifting process test analysis dynamic characteristics

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A DFT study of the CO adsorption and oxidation at ZnO surfaces and its implication for CO detection

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Chinese Chemical Letters 2020年第6期31卷 1674-1679页

作者： Zibin ni Shenyuan bao Xue-Qing Gong Key Laboratory for Advanced Materials Centre for Computational Chemistry and Research Institute of Industrial CatalysisSchool of Chemistry&Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

Recently,ZnO-based gas sensors have been successfully fabricated and widely studied for their excellent sensitivity and selectivity,especially in CO ***,detailed explorations of their mechanisms are rather ***,aiming at clarifying the sensing mechanism,we carried out density functional theory(DFT)calculations to track down the CO adsorption and oxidation on the ZnO(1010)and(1120)*** calculated results show that the lattice O of ZnO(1010)is more reactive than that of ZnO(1120)for CO *** the calculated energetics and structures,the main reaction product on both surfaces can be determined to be CO2 rather than ***,the surface conductivity changes during the adsorption and reaction processes of CO were also *** both ZnO(1010)and(1120),the conductivity would increase upon CO adsorption and decrease following CO oxidation,in consistence with the reported experimental *** work can help understand the origins of ZnO-based sensors’performances and the development of novel gas sensors with higher sensitivity and selectivity.

关键词： Density functional theory ZnO Gas sensor CO oxidation Surface conductivity

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Simultaneous determination of three 5-nitroimidazoles in foodstuffs by differential pulse voltammetry and chemometrics

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Chinese Chemical Letters 2011年第5期22卷 591-594页

作者： Yi gui Yong nian ni Serge Kokot State Key Laboratory of Food Science and Technology Nanchang University Nanchang 330047 China Department of Chemistry Nanchang University Nanchang 330031 China Chemistry Faculty of Science and Technology Queensland University of Technology Brisbane 4001 Australia

The voltammetric behaviour of three 5-nitroimidazoles,metronidazole,tinidazole and ornidazole,was investigated,and a method was developed for the simultaneous determination of these compounds,based on their reduction at a hanging mercury drop electrode（HMDE） in pH 8.95 buffer with differential pulse voltammetric（DPV） *** defined voltammetric waves with peak potentials of -692,-640 and -652 mV were observed for these compounds,*** is difficult to determine them individually from their mixtures without preseparation,for their voltammetric peaks overlapped seriously,so the chemometrics were used to resolve the overlapped voltammogram and quantify the *** proposed method was successfully applied to the determination of three 5-nitroimidazoles in milk and honey samples.

关键词： nitroimidazoles Metronidazole Tinidazole Ornidazole Chemometrics Differential pulse voltammetry

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-Xin Yang bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co ni-In and ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Evaluation of RDF queries via equivalence

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Frontiers of Computer Science 2013年第1期7卷 20-33页

作者： Weiwei ni Zhihong CHONG Hu SHU Jiajia bao Aoying ZHOU School of Computer Science and Engineering Southeast University Nanjing 210096 China Software School East China Normal University Shanghai 200062 China

Performance and scalability are two issues that are becoming increasingly pressing as the resource descrip- tion framework （RDF） data model is applied to real-world ap- plications. Because neither vertical nor flat structures of RDF storage can handle frequent schema updates and meanwhile avoid possible long-chain joins, there is no clear winner be- tween the two typical structures. In this paper, we propose an alternative open user schema. The open user schema con- sists of flat tables automatically extracted from RDF query streams. A query is divided into two parts and conquered on the fiat tables in the open user schema and on the vertical ta- ble stored in a backend storage. At the core of this divide and conquer architecture with open user schema, an efficient iso- morphic decision algorithm is introduced to guide a query to related flat tables in the open user schema. Our proposal in essence departs from existing methods in that it can accom- modate schema updates without possible long-chain joins. We implement our approach and provide empirical evalua- tions to demonstrate both the efficiency and effectiveness of our approach in evaluating complex RDF queries.

关键词： divide and conquer architecture open user schema RDF query streams

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Numerical simulation on the pressure wave in a 30 mm electrothermal-chemical gun with the discharge rod plasma generator

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Defence Technology（防务技术） 2019年第5期15卷 674-679页

作者： Yan-jie ni Yong Jin Gang Wan bao-ming Li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094JiangsuChina China Academy of Ordnance 100089BeijingChina

An axisymmetric two-dimensional(2D)internal ballistic model including the transient burning rate law is used to simulate the 30mm electrothermal-chemical(ETC)launch with the discharge rod plasma generator(DRPG).The relationship between the pressure wave and the initial parameters,such as input electric power,discharging timing sequence,loading density and propellant web thickness,is researched through the change of initial parameters in the *** the condition of synchronous discharging,the maximum of the pressure wave can be controlled while the ratio of the input electric energy to the propellant chemical energy(electric energy ratio)is less than *** the electric energy ratio is larger than 0.11,the maximum of the pressure wave increases rapidly with the electric energy *** the increasing of the electric energy ratio,the change of the first negative amplitude value can be *** the condition of timing sequence discharging,the allowed input electric energy ratio to control the pressure wave is proportional to the current pulse *** the high electric energy ratio,the maximum of the pressure wave is inverse proportional to the current pulse *** pressure wave increases with the increasing of the loading *** the allowed electric energy ratio to control the pressure wave and the variation trend of the first negative amplitude wave value doesn't *** the discharging of the DRPG,the influence of changing propellant web thickness in ETC launch can be ignored.

关键词： Electrothermal-chemical launch Pressure wave Plasma Solid propellant Electric energy ratio

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