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Trends and frontiers in signal amplification for aptamer-based tumor detection:A bibliometric analysis

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World Journal of Clinical Cases 2024年第21期12卷 4726-4741页

作者： Dan Cai gui-Lin Chen Ting Wang Kun-He Zhang Department of Gastroenterology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Institute of Gastroenterology and Hepatology Nanchang 330006Jiangxi ProvinceChina Department of Anorectal Surgery The 908th Hospital of the Chinese People's Liberation Army Joint Logistics Support ForceNanchang 330000Jiangxi ProvinceChina

BACKGROUND Malignant tumors are one of the leading causes of death worldwide,imposing a substantial economic and social *** detection is the key to improving cure rates and reducing mortality rates,which requires the development of sensitive early detection *** amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from *** To investigate the current research status,developmental trajectories,and hotspots in signal amplification for aptamer-based tumor detection through bibliometric *** English publications pertaining to signal amplification in aptamer-based tumor detection were retrieved from the Web of Science Core Collection *** and CiteSpace software were employed to analyze various information within this field,including countries,institutions,authors,co-cited authors,journals,co-cited journals,cited references,and *** A total of 757 publications were included in this *** accounted for 85.47%of all publications,with Nanjing University(China)emerging as the institution with the highest publication *** most influential authors and journals were Hasanzadeh *** Iran and"Biosensors and Bioelectronics",*** and carcinoembryonic antigen(CEA)stood out as the most researched tumor-related ***,the predominant signal amplification technique,nanomaterial,and signal transduction method were identified as hybridization chain reactions,gold nanoparticles,and electrochemical methods,*** the past 3 years,exosomes,CEA,electrochemical biosensors,and nanosheets have emerged as research hotspots,exhibiting a robust burst of *** This study is the first bibliometric analysis of literature on signal amplification in aptamer-based tumor detection and elucidates the current status,hotspots,and prospective research directions within this ***,i

关键词： Aptamer Signal amplification Tumor Bibliometrics Electrochemistry Nanosheet

Quantifying the natural growth rate of hepatocellular carcinoma:A real-world retrospective study in southwestern China

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World Journal of Hepatology 2024年第5期16卷 800-808页

作者： Li Tu Hong Xie Qi Li Ping-gui Lei Pei-Ling Zhao Fan Yang Chi Gong Yuan-Lin Yao Shi Zhou Department of General Practice The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Clinical Medicine Soochow UniversitySuzhou 215123Jiangsu ProvinceChina Department of Radiology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Clinical Laboratory Center The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Key Laboratory of Biology and Medical Engineering Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Radiology Yanhe Tujia Autonomous County People's HospitalTongren 565300Guizhou ProvinceChina Department of Radiology The Qiandongnan Miao and Dong Autonomous Prefecture People's HospitalKaili 556000Guizhou ProvinceChina Department of Interventional Radiology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

BACKGROUND In recent years,approximately half of the newly diagnosed cases and mortalities attributed to hepatocellular carcinoma(HCC)have been reported in *** the high incidence of HCC,there remains a paucity of data regarding the natural growth pattern and the determination of optimal surveillance intervals specific to the Chinese *** To quantify the natural tumor growth pattern of HCC in regional *** A retrospective analysis was performed on patients from a single institution in Southwest China who had undergone two or more serial dynamic computed tomography or magnetic resonance imaging scans between 2014 and 2020,without having received any anti-cancer *** growth was assessed using tumor volume doubling time(TVDT)and tumor growth rate(TGR),with volumes measured manually by experienced *** univariate linear regression and descriptive analysis were applied to explore associations between growth rates and clinical *** This study identifies the median TVDT for HCC as 163.4 d,interquartile range(IQR)72.1 to 302.3 d,with a daily TGR of 0.42%(IQR 0.206%-0.97%).HCC growth patterns reveal that about one-third of tumors grow indolently with TVDT exceeding 270 d,another one-third of tumors exhibit rapid growth with TVDT under 90 d,and the remaining tumors show intermediate growth rates,with TVDT ranging between 3 to 9 *** The identified TGRs support biannual surveillance and follow-up for HCC patients in certain regions of *** the observed heterogeneity in HCC growth,further investigation is warranted.

关键词： Hepatocellular carcinoma Natural tumor growth pattern Tumor volume doubling time Tumor growth rate Realworld retrospective study

基于多尺度混合注意力与度量融合的小样本行人重识别

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控制与决策 2024年第5期39卷 1441-1449页

作者：陈贵震邹国锋刘月傅桂霞高明亮山东理工大学电气与电子工程学院山东淄博255049

针对行人重识别中可用行人图像不足导致的小样本问题,以双相似网络为基础,提出一种基于多尺度混合注意力与度量融合的小样本行人重识别方法.首先,将多尺度混合注意力机制引入特征嵌入模块,即在不同尺度层内的特征提取中引入空间注意力,... 详细信息

针对行人重识别中可用行人图像不足导致的小样本问题,以双相似网络为基础,提出一种基于多尺度混合注意力与度量融合的小样本行人重识别方法.首先,将多尺度混合注意力机制引入特征嵌入模块,即在不同尺度层内的特征提取中引入空间注意力,在不同尺度层间的特征融合中引入通道注意力,实现更具判别力的小样本行人特征提取;然后,在度量模块,提出欧氏距离与余弦距离融合的双重度量方法,实现行人特征的空间绝对距离和方向差异的综合度量,提升行人相似性度量的可靠性;接着,采用双重度量方式和关系度量方式,分别获得行人特征的相似度得分;最后,通过加权融合获得联合度量得分,构建联合损失实现网络的整体优化和训练.在Marketmini、Duke-mini和MSMT17-mini三个小型数据集上的实验表明,所提出方法在5-way 1-shot和5-way 5-shot两种模式下的平均识别准确率分别达到90.40%和95.69%、86.77%和94.96%、71.08%和82.63%,与其他小样本学习算法相比,识别性能有较大提升.

关键词：行人重识别小样本双相似网络多尺度混合注意力度量融合双重度量

Deep-large faults controlling on the distribution of the venting gas hydrate system in the middle of the Qiongdongnan Basin, South China Sea

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China Geology 2024年第1期7卷 36-50页

作者： Jin-feng Ren Hai-jun Qiu Zeng-gui Kuang Ting-wei Li Yu-lin He Meng-jie Xu Xiao-xue Wang Hong-fei Lai Jin Liang National Engineering Research Center of Gas Hydrate Exploration and Development Guangzhou 511458China Guangzhou Marine Geological Survey China Geological SurveyGuangzhou 511458China China Geological Survey Ministtry of Natural ResourcesBeijing 100037China

Many locations with concentrated hydrates at vents have confirmed the presence of abundant thermogenic gas in the middle of the Qiongdongnan Basin(QDNB).However,the impact of deep structures on gasbearing fluids migration and gas hydrates distribution in tectonically inactive regions is still *** this study,the authors apply high-resolution 3D seismic and logging while drilling(LWD)data from the middle of the QDNB to investigate the influence of deep-large faults on gas chimneys and preferred gasescape *** findings reveal the following:(1)Two significant deep-large faults,F1 and F2,developed on the edge of the Songnan Low Uplift,control the dominant migration of thermogenic hydrocarbons and determine the initial locations of gas chimneys.(2)The formation of gas chimneys is likely related to fault activation and *** chimney 1 is primarily arises from convergent fluid migration resulting from the intersection of the two faults,while the gas chimney 2 benefits from a steeper fault plane and shorter migration distance of fault F2.(3)Most gas-escape pipes are situated near the apex of the two *** reactivations facilitate free gas flow into the GHSZ and contribute to the formation of fracture‐filling hydrates.

关键词： Venting gas hydrates Deep-large faults Gas chimney Gas-escape pipes High-resolution 3D seismic Logging while drilling Qiongdongnan Basin South China Sea

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两种核桃蚜虫危害对核桃光合特征的影响

林业科学研究 2024年第1期37卷 130-139页

作者：张文佳马贵龙高桂珍新疆农业大学林学与风景园林学院新疆乌鲁木齐830052

[目的]明确核桃黑斑蚜和核桃全斑蚜危害对不同生长期核桃叶片光合作用的影响。[方法]在核桃的速生生长期、硬核期和脂化期,利用便携式叶绿素测定仪(SPAD-502plus)和LI-6400便携式光合作用系统测定了核桃不同生长时期受到不同密度的两种... 详细信息

[目的]明确核桃黑斑蚜和核桃全斑蚜危害对不同生长期核桃叶片光合作用的影响。[方法]在核桃的速生生长期、硬核期和脂化期,利用便携式叶绿素测定仪(SPAD-502plus)和LI-6400便携式光合作用系统测定了核桃不同生长时期受到不同密度的两种核桃蚜虫危害不同时长后叶片的SPAD值、光合速率(P_(n))、蒸腾速率(T_(r))等光合特性指标,并测定了受不同核桃蚜虫危害后的核桃果实质量、出仁率等。[结果]在速生生长期受到核桃黑斑蚜或核桃全斑蚜短期危害1~5 d,核桃叶片SPAD值无显著差异,而在硬核期和脂化期受核桃黑斑蚜、核桃全斑蚜和混合蚜虫危害均导致叶片SPAD值呈下降趋势。两种核桃蚜虫危害后核桃叶片的光合速率(P_(n))和蒸腾速率(T_(r))均显著下降,且蚜虫密度不同下降程度不同。受核桃黑斑蚜和核桃全斑蚜危害后核桃单果质量(青皮)和干果质量均呈下降趋势;受不同种类蚜虫危害后的核桃出仁率均出现下降。[结论]蚜虫危害对核桃叶片光合作用产生负面影响,导致核桃果实出仁率下降。因此,对两种核桃蚜虫的防治应该采取紧急措施,以保护核桃产量和质量。

关键词：核桃核桃黑斑蚜核桃全斑蚜 SPAD值光合特征

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敦煌写经“涅槃”作“[七大]”商诂

语言研究 2024年第3期44卷 117-122页

作者：姚权贵贵州师范大学文学院贵阳550025

敦煌写经中“涅槃”的书写特例作“[七大]”,从字形上看,它的写法与“炎”字的草书(如“[七大]”)非常接近,历代写本文献里“炎”的俗写形体与“[七大]”也基本相同。佛教文化如来、众生之机缘既尽,即入于涅槃,故托薪尽火随灭,而称涅槃... 详细信息

敦煌写经中“涅槃”的书写特例作“[七大]”,从字形上看,它的写法与“炎”字的草书(如“[七大]”)非常接近,历代写本文献里“炎”的俗写形体与“[七大]”也基本相同。佛教文化如来、众生之机缘既尽,即入于涅槃,故托薪尽火随灭,而称涅槃为炎,称涅槃经为炎经,称涅槃点为炎点。因此佛典“涅槃”常常别称“炎”,敦煌写经书作“[七大](炎)”来记录佛教术语“涅槃”,有直接的文献证据。

关键词：敦煌写经涅槃 [七大] 炎

A potential giant gallium deposit hosted in the tailing dam of the Fankou Zn-Pb deposit in northern Guangdong Province, South China

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China Geology 2024年第1期7卷 157-160页

作者： Peng-peng Yu Zhao-bin Hu Yi Zheng Lan-xuan Guo Shi-yuan Ouyang gui-qiang Yuan Shang-zhou Chen Cheng-ming Wang Xi Chen School of Earth Sciences and Geological Engineering Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Lab of Geological Process and Mineral Resources Survey Sun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China Zhongjin Lingnan Nonfemet Co. LtdShenzhen 518000China

*** The Fankou giant zinc(Zn)-lead(Pb)deposit in Guangdong Province is well-known for its huge reserves of over 10 Mt(million ton)Zn+Pb metals and high ore-grade with Zn+Pb exceeding 15%(Guangdong Fankou Deposit Investigation Group,1980;Zhu XY et al.,2017).After 60 years of exploration and exploitation,the deposit has accumulated millions of tons of *** interesting question is that what components are hosted in these tailings,and whether some key and critical metals such as gallium and germanium are extremely enriched and worth further comprehensive *** motivated us to conduct an integrated set of field investigation,sampling,major-trace element analyses and reserve assessments about the Fankou *** this contribution,we discover that the tailings contain a variety of metal elements such as zinc,lead and gallium with comprehensive utilization *** data can act as a scientific guidance for further exploration and utilization of the Fankou tailings,and aid to enhance the utilization efficiency of the key mineral resource in *** study also provide demonstration for future green mine construction in China.

关键词： deposit comprehensive Guangdong

Efficacy of Huoxue Qianyang Qutan Recipe on essential hypertension:A randomized,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第4期22卷 484-492页

作者： Jun Xie Yu-long Ma Ming-tai gui Lei Yao Jian-hua Li Ming-zhu Wang Xun-jie Zhou Yi-fan Wang Ming-yi Zhao Hui Cao Bo Lu De-yu Fu Department of Cardiology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai University of Traditional Chinese Medicine Shanghai 200120China

Background:Hypertension,a prevalent disease,is a significant risk factor for coronary heart *** Qianyang Qutan Recipe (HQQR),a traditional Chinese herbal remedy,has been used for treating hypertension over several ***:This study assesses HQQR’s efficacy for controlling blood pressure among patients with hypertension related to blood stasis,yang hyperactivity and ***,setting,participants and interventions:A randomized controlled trial was conducted at the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,from July 2020 to June *** components of HQQR were identified using thin-layer chromatography and high-performance liquid *** aged18–80 years,exhibiting traditional Chinese medicine syndromes of blood stasis,yang hyperactivity or phlegm,along with grades 1 or 2 hypertension,were randomly categorized into two *** intervention group was given HQQR granules alongside conventional hypertension treatment,while the control group was given placebo granules in addition to conventional treatment for 12 *** outcome measures:The primary outcome was clinic blood pressure,whereas secondary outcomes included metabolic indices (e.g.,homeostasis model assessment of insulin resistance[HOMA-IR],total cholesterol[TC],low-density lipoprotein cholesterol and triglyceride),target organ damage indices (left ventricular mass index and urinary albumin creatinine ratio[UACR]) and inflammation indices(interleukin-6[IL-6]and high-sensitivity C-reactive protein[hs-CRP]).Results:HQQR’s primary components were identified as salvianolic acid B,emodin and ferulic *** the 216 participants (108 in each group),compared to the control,the intervention group exhibited significant improvements (P<0.001) in clinic systolic blood pressure ([136.24±7.63]vs[130.06±8.50]mmHg),clinic diastolic blood pressure ([84.34±8.72]vs[80.46±6.05]mmHg),home systol

关键词： Huoxue Qianyang Qutan Recipe Hypertension Target organ damage Glycolipid metabolism Inflammatory Chinese herbal compound

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含能材料通道式制备技术的发展思考

含能材料 2024年第3期32卷 232-234页

作者：范桂娟张祯琦中国工程物理研究院化工材料研究所

通道式制备技术具有高效的混合和传递性能、反应空间小、模块化结构、并行放大,可有效提高反应过程安全性和过程的精准调控,实现连续安全生产等优点,其应用领域正在从精细化工、医药等逐渐拓展至含能材料领域,可有效解决传统间歇反应模... 详细信息

通道式制备技术具有高效的混合和传递性能、反应空间小、模块化结构、并行放大,可有效提高反应过程安全性和过程的精准调控,实现连续安全生产等优点,其应用领域正在从精细化工、医药等逐渐拓展至含能材料领域,可有效解决传统间歇反应模式中所存在的合成过程可控性差、效率低、危险性高、工程放大难等问题。目前,通道式制备技术已实现了多种含能材料的合成、结晶及包覆过程,从而开启了含能材料制备模式的革新时代。

关键词：含能材料通道式模块化结构间歇反应传递性能工程放大可控性反应空间