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普伐他汀对大鼠坐骨神经压碎损伤功能恢复的影响

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中国组织工程研究 2025年第5期29卷 942-950页

作者：刘赞安冉李宝成内蒙古科技大学包头医学院内蒙古自治区包头市014000 内蒙古科技大学包头医学院第一附属医院手足踝外科内蒙古自治区包头市014010

背景:普伐他汀是临床上治疗高胆固醇血症的有效药物,目前发现其在中枢神经损伤的治疗上也能发挥有益作用,然而其机制仍未可知。目的:探究普伐他汀治疗能否加速坐骨神经压碎损伤的功能恢复及其潜在作用机制。方法:将雄性SD大鼠随机分为... 详细信息

背景:普伐他汀是临床上治疗高胆固醇血症的有效药物,目前发现其在中枢神经损伤的治疗上也能发挥有益作用,然而其机制仍未可知。目的:探究普伐他汀治疗能否加速坐骨神经压碎损伤的功能恢复及其潜在作用机制。方法:将雄性SD大鼠随机分为假手术组(坐骨神经暴露但不损伤+生理盐水灌胃)、阴性对照组(坐骨神经压碎损伤+生理盐水灌胃)、普伐他汀组(坐骨神经压碎损伤+普伐他汀灌胃)。普伐他汀组大鼠术后普伐他汀(5 mg/kg)灌胃治疗1周,其余两组大鼠给予等量生理盐水灌胃。术后观察各组大鼠一般情况;术后第2,4,6,8周末测量各组大鼠的坐骨功能指数;术后8周末测量腓肠肌湿质量比;ELISA法检测血清中炎症细胞因子的水平;组织形态计量学分析坐骨神经有髓神经纤维数目、纤维直径、轴突直径、髓鞘厚度;RT-qPCR检测神经生长因子、脑源性神经营养因子的mRNA表达量,Western blot法检测生长相关蛋白43的蛋白表达量。结果与结论:与阴性对照组相比,普伐他汀组坐骨神经功能指数恢复更快(P<0.05),更接近于假手术组水平,血清中炎症细胞因子肿瘤坏死因子α及白细胞介素6表达更低(P<0.05)且接近假手术组,坐骨神经中神经生长因子、脑源性神经营养因子的mRNA相对表达量增加(P<0.05或P<0.01),坐骨神经中生长相关蛋白43的蛋白相对表达量也明显增加(P<0.05),有髓神经纤维数目增加更多,纤维直径、轴突直径及髓鞘厚度数值更大(P<0.01)且与假手术组更接近。结果说明,普伐他汀的治疗加速了坐骨神经压碎损伤的功能恢复,其可能机制是抑制炎症细胞因子肿瘤坏死因子α及白细胞介素6的表达及促进神经营养因子神经生长因子、脑源性神经营养因子的分泌。

关键词：周围神经损伤普伐他汀功能恢复神经营养因子坐骨神经功能指数

Effect of flank angle and friction coefficient on contact stress of turbine rotor

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Journal of Central South University 2013年第7期20卷 1792-1796页

作者： WU Xiao-zan TAO Qing-bin CHEN An-ping XU Hui School of Physics Science and Technology Central South University Changsha 410083 China School of Materials Science and Engineering Central South University Changsha 410083 China

In order to simulate the stress of turbine rotor in aeroengine, based on the ANSYS, the simplification model of the turbine rotor was built up. By applying the simplification model, the contact stress of turbine rotor was computed. The maximum contact stress appears at the chamfer below the flank, which agrees with experiment result. At the same time, the contact stress changing with the flank angle and friction coefficient was calculated, The results show that the contact stress in the flank increases slowly with the increase of flank angle; with the friction coefficient increasing, the contact stress in flank length decreases; the contact stress will not change when the friction coefficient is over 0.25.

关键词： aeroengine contact stress ANSYS optimization design

Research on dual-command operation path optimization based on Flying-V warehouse layout

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High Technology Letters 2023年第4期29卷 388-396页

作者：刘建胜 YUAN bin YANG zan ZHONG RAY Y School of Advanced Manufacturing Nanchang UniversityNanchang 330031P.R.China Department of Industrial and Manufacturing Systems Engineering University of Hong KongHong Kong 999077P.R.China

To enhance the efficiency of warehouse order management,this study investigates a dual-com-mand operation mode in the Flying-V non-traditional warehouse *** dual-command opera-tion strategies are designed,and a dual-command operation path optimization model is established with the shortest path as the optimization ***,a genetic algorithm based on a dynamic decoding strategy is *** results demonstrate that the Flying-V layout warehouse management and access cooperation operation can reduce the operation time by an average of 25%-35%compared with the single access operation path,and by an average of 13%-23%compared with the‘deposit first and then pick’operation *** findings provide evidence for the effec-tiveness of the optimization model and algorithm.

关键词： Flying-V access collaboration path optimization dynamic decoding genetic al-gorithm

Expression analysis,single nucleotide polymorphisms within SIRT4 and SIRT7 genes and their association with body size and meat quality traits in Qinchuan cattle

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Journal of Integrative Agriculture 2016年第12期15卷 2819-2826页

作者： gui Lin-sheng XIN Xiao-ling WANG Jia-li HONG Jie-yun zan Lin-sen College of Animal Science and Technology Northwest A&F University Yangling 712100 P.R.China Institute of Animal Husbandry and Veterinary Medicine Henan Academy of Agricultural Scinece Zhengzhou 450008 P.R.China

Silent information regulator 2 （Sir2） proteins, or sirtuins, are nicotine adenine dinucleotide （NAD）-dependent deacetylases that connect metabolism with longevity in lower organisms. In mammals, there are seven Sir2 homologs, namely, silent information regulators （SIRT1-7）. SIRT4 and SIRT7 genes play a crucial role in regulating lipid metabolism, cellular growth and metabolism. This suggests that they are potential candidate genes for affecting body size and meat quality traits in animals. Hence, this study aimed to detect genetic variations of both SIRT4 and SIRT7 bovine genes in Qinchuan cattle, and to evaluate the effect of these variations on economically important body size and meat quality traits. Expression analysis using quantitative real-time PCR （qPCR） indicated that SIRT4 and SIRT7 were broadly expressed in all thirteen studied tissues. The expression of SIRT4 was higher in liver, muscle, and in subcutaneous fat tissue. In the case of SIRT7, the expression was higher in lung, abomasum, and subcutaneous fat. Using DNAsequencing, a total of three single nucleotide polymorphisms （SNPs） were identified within SIRT4 and SIRT7 genes in 468 Qinchuan cattle. These included one novel SNP within 3＇ untranslated regions （UTR） of SIRT4 （SNP1： g. 13915A〉G） and two novel synonymous substitutions in SIRT7 （SNP2： g.3587C〉T and SNP3： g.3793T〉C）. Statistical analyses indicated that all three SNPs could significantly influence some body size and meat quality traits in Qinchuan cattle. These novel findings will provide a background for application of bovine SIRT4 and SIRT7 genes in the selection program of Chinese cattle.

关键词： SIRT4 SIRT7 single nucleotide polymorphisms (SNPs) beef cattle

Potato/Maize intercropping reduces infestation of potato tuber moth, Phthorimaea operculella(Zeller) by the enhancement of natural enemies

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Journal of Integrative Agriculture 2020年第2期19卷 394-405页

作者： ZHENG Ya-qiang ZHANG Li-min CHEN bin YAN Nai-sheng gui Fu-rong zan Qing-an DU Guang-zu HE Shu-qi LI Zheng-yue GAO Yu-lin XIAO Guan-li State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming 650201P.R.China College of Agriculture&Biology Technology Yunnan Agricultural UniversityKunming 650201P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China

The potato tuber moth(PTM),Phthorimaea operculella(Zeller),is one of the most economically significant insect pests for potato in both field and storage *** evaluate the infestation,reduction of potato yield and the control efficacy for PTM,field tests were conducted in two seasons by intercropping of potato as the host plant with maize as a non-host plant of *** intercropping patterns were tested,which were 2 rows of potatoes with either 2,3,or 4 rows of maize(abbreviated 2 P:2 M,2 P:3 M,and 2 P:4 M),and the monocropped potato as the control,2 rows of potatoes,without maize,(abbreviated 2 P:0 M).Results showed that the population and infestation of PTM in the 2 P:3 M intercropping pattern was significantly lower than those in 2 P:2 M,2 P:4 M and the monocropping pattern of 2 P:0 M,due to the enhancement of natural *** mines and tunneling in potato leaves in 2 P:3 M intercropping were significantly lower than those in 2 P:2 M and 2 P:4 M *** population of parasitoids and the parasitism rate of PTM in intercropping pattern of 2 P:3 M were significantly higher than that in intercropping pattern of 2 P:2 M,2 P:4 M and monocropping pattern of 2 P:0 *** conclude that the potato intercropped with maize reduced the adult and larva populations,and reduced the damage from PTM by enhancing the number of parasitoids and the level of *** greatest population density of parasitoids and parasitism rate were in the intercropping pattern of 2 rows of potatoes with 3 rows of *** data indicate that the host/non-host intercropping patterns can be used as a biological control tactic against PTM by enhancing the density of natural enemies in the agro-ecosystems.

关键词： potato tuber moth Phthorimaea operculella(Zeller) intercrop biological control natural enemies parasitoids

Analysis of Famous TCM Doctor zan Qiang's Experience in the Treatment of Perimenopausal Osteoporosis

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Journal of Clinical and Nursing Research 2021年第3期5卷 125-128页

作者： Zengrui Zhang bin Shao Yanzhao Li Qiang zan Shaanxi University of Traditional Chinese Medicine Xianyang 712046China binzhou Medical University Hospital Binzhou 256603China Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Xianyang 712000China

The purpose of this study was to analyze the clinical experience of zan Qiang,a famous doctor of Traditional Chinese Medicine in Shaanxi province,in the treatment of perimenopausal *** believed that the main etiology and pathogenesis of perimenopausal osteoporosis were "deficiency of kidney essence,decreased marrow and bone",deficiency of liver and kidney"and"stasis caused by deficiency".Although it is a chronic physiological disease,and the pathological process is irreversible,the treatment groups of"tonifying kidney and filling essence","tonifying liver and tonifying kidney"and "tonifying deficiency and promoting blood circulation" can significantly improve the symptoms of patients,slow down the progress of the disease and improve the quality of life of patients.

关键词： zan Qiang Liver and kidney treatment Perimenopausal osteoporosis

Association of body mass index with serum alanine aminotransferase in Chinese adolescents:a school-based cross-sectional study

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Gastroenterology Report 2020年第2期8卷 119-124,I0002页

作者： zan Ding Jing Zhang Chang-Yu Deng Ying-bin You Hua Zhou Institute of Low Carb Medicine Baoan Central Hospital of Shenzhenthe Fifth Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongP.R.China Department of Nursing Baoan Central Hospital of Shenzhenthe Fifth Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongP.R.China Department of Preventive Medicine Shantou University Medical CollegeShantouGuangdongP.R.China

Background:Numerous studies have consistently demonstrated that high body mass index(BMI)is related to elevated serum alanine aminotransferase(ALT)among adults,but little is known about the association regarding adolescents,especially in *** this study,we aimed to investigate the association between BMI and ALT activity among Chinese ***:A school-based cross-sectional study was performed among nine high schools in Shenzhen,China between February 2017 and June 2018.A generalized linear-regression model adjusting for age and gender was conducted,and bivariate correlation analysis between ALT and BMI was also ***:A total of 7,271 adolescents aged from 9 years to 17 years were ***,weight,BMI,and ALT were higher among boys than among girls(all P<0.001).The mean(standard deviation)of serum ALT levels was 14.26(14.77)U/*** the entire BMI range,the BMIALT correlation was stronger for boys(Spearman’s r=0.396,P<0.001)and adolescents of 14 years17 years(r=0.356,P<0.001)than for girls(r=0.203,P<0.001)and adolescents of 9 years13 years(r=0.221,P<0.001),*** ALT increased rapidly and followed a linear pattern from the point of BMI20.5 kg/m^(2),and each increase of 1 kg/m^(2)in BMI range above 20.5 kg/m^(2)was averagely correlated with an increase of 2.71 U/L in ALT levels(P<0.001).Conclusions:We found a significant BMIALT *** at 20.5 kg/m^(2)may be a cut-off for evaluating serum ***27.1 kg/m^(2)for boys and24.9 kg/m^(2)for girls were linked to an elevated ALT activity for Shenzhen adolescents.

关键词： adolescent alanine aminotransferase association body mass index cut-off point

In-Plane Dynamic Crushing Behaviors of a Vertex-Based Hierarchical Auxetic Honeycomb

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Acta Mechanica Solida Sinica 2024年第1期37卷 53-62页

作者： Yichen zan Xiuhui Hou Zichen Deng School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversityXi'an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China

Auxetic metamaterials,which exhibit the negative Poisson’s ratio(NPR)effect,have found wide applications in many engineering ***,their high porosity inevitably weakens their bearing capacity and impact *** improve the energy absorption efficiency of auxetic honeycombs,a novel vertex-based hierarchical star-shaped honeycomb(VSH)is designed by replacing each vertex in the classical star-shaped honeycomb(SSH)with a newly added self-similar *** analytical model is built to investigate the Young’s modulus of VSH,which shows good agreement with experimental results and numerical *** in-plane dynamic crushing behaviors of VSH at three different crushing velocities are investigated,and empirical formulas for the densification strain and plateau stress are *** results reveal more stable deformation modes for VSH,attributed to the addition of self-similar star-shaped ***,compared with SSH under the same relative densities,VSH exhibits better specific energy absorption and higher plateau ***,VSH is verified to be a better candidate for energy absorption while maintaining the auxetic *** study is expected to provide a new design strategy for auxetic honeycombs.

关键词： Vertex-based hierarchical star-shaped honeycomb Auxetic honeycomb Energy absorption Plateau stress Negative Poisson's ratio

BFGS quasi-Newton location algorithm using TDOAs and GROAs

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Journal of Systems Engineering and Electronics 2013年第3期24卷 341-348页

作者： Benjian Hao zan Li State Key Laboratory of Integrated Services Networks Xidian University

With the emergence of location-based applications in various fields, the higher accuracy of positioning is demanded. By utilizing the time differences of arrival （TDOAs） and gain ratios of arrival （GROAs）, an efficient algorithm for estimating the position is proposed, which exploits the Broyden-Fletcher-Goldfarb-Shanno （BFGS） quasi-Newton method to solve nonlinear equations at the source location under the additive measurement error. Although the accuracy of two-step weighted-least-square （WLS） method based on TDOAs and GROAs is very high, this method has a high computational complexity. While the proposed approach can achieve the same accuracy and bias with the lower computational complexity when the signal-to-noise ratio （SNR） is high, especially it can achieve better accuracy and smaller bias at a lower SNR. The proposed algorithm can be applied to the actual environment due to its real-time property and good robust performance. Simulation results show that with a good initial guess to begin with, the proposed estimator converges to the true solution and achieves the Cramer-Rao lower bound （CRLB） accuracy for both near-field and far-field sources.

关键词： time difference of arrival (TDOA) gain ratio of arrival (GROA) source location Broyden-Fletcher-Goldfarb-Shanno (BFGS) quasi-Newton method.