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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第4期11卷 238-248页

作者： Ze-wei TAO long-gui LI zhao-hua GENG Tao DANG Shan-jun ZHU Department of Cardiovascular Diseases Xinqiao Hospital Third Military Medical University Chongqing 40003 7 China

Therapeutically delivered mesenchymal stem cells (MSCs) improve ventricular remodeling. However,the mechanism underlying MSC cardiac remodeling has not been clearly determined. Congestive heart failure (CHF) was induced in rats by cauterization of the left ventricular free wall. MSCs were cultured from autologous bone marrow and injected into the border zone and the remote myocardium 5 d after injury. Ten weeks later,when compared with sham operation,CHF significantly increased nucleus mitotic index,capillary density,and expression of insulin-like growth factor 1,hepatocyte growth factor and vascular endothelial growth factor in the border zone (P<0.01) and decreased each of them in the remote myocardium (P<0.05 or P<0.01). MSC implantation in CHF dramatically elevated ex-pression of these growth factors in the remote myocardium and further elevated their expression in the border zone when compared with CHF without MSC addition (P<0.05 or P<0.01). This was paralleled by a higher nucleus mitotic index and a significantly increased capillary density both in the remote myocardium and in the border zone,and by a lower percentage of area of collagen and a higher percentage of area of myocardium in the border zone (P<0.05 or P<0.01),and cardiac remodeling markedly improved. Autologous MSC implantation promoted expression of growth factors in rat failing myocardium,which might enhance cardiomyogenesis and angiogenesis,and improved cardiac remodeling.

关键词： Mesenchymal stem cells Growth factor Myocardium Cardiac remodeling

Design,synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors

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Chinese Chemical Letters 2011年第10期22卷 1215-1218页

作者： Wen Jing zhao Yong Heng Shi gui long zhao Yu Li Wang Hua Shao Li Da Tang Jian Wu Wang School of Chemistry and Chemical Engineering Shandong University Jinan 250100 China Tianjin Key Laboratory of Molecular Design and Drug Discovery Tianjin Institute of Pharmaceutical Research Tianjin 300193 China School of Pharmacy Tianjin Medical University Tianjin 300070 China

A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors,with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key *** in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test（OGTT）,and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin.

关键词： Synthesis C-Glucoside SGLT2 inhibitor Anti-hyperglycemic activity gem-Dimethyl

A New Approach to Ethyl 1-Aroyl/Aroylmethyl-5-methyl-3- methylthiopyrazole-4-carboxylates: High Regioselectivity in Alkylation and Acylation Reactions between N-1 and N-2 of a Pyrazole Derivative

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Chinese Chemical Letters 2005年第9期16卷 1161-1164页

作者： Li Rong WEN gui long zhao Ming LI Wen Ying QI Xiu Li ZHANG Hua Zheng YANG College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 State Key Laboratory of Elemento-organic Chemistry Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 Ocean Food and Drug Institute Ocean University of China Qingdao 266003

Two series, totalizing twelve, of new compounds, ethyl 1-aroyl/aroylmethyl-5-methyl-3- methylthiopyrazole-4-carboxylates 5/6, have been synthesized via highly regioselective acylation and alkylation of ethyl 3-methyl-5-methylthio-1H- pyrazole-4-carboxylate 2a with aroyl chloride 3 and alpha-tosyloxysubstitutedacetophenones 4. Unexpected structures of the product have been unambiguously determined by both X-ray crystallographic analysis and 2D NMR.

关键词： Pyrazole regioselectivity X-ray crystallographic analysis 2D NMR

Design,synthesis and biological activity of cyclohexane-bearing C-glucoside derivatives as SGLT2 inhibitors

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Chinese Chemical Letters 2013年第5期24卷 429-432页

作者： Shuo Zhang Yu-Li Wang Qun-Chao Wei Wei-Ren Xu Li-Da Tang gui-long zhao Jian-Wu Wang School of Chemistry and Chemical Engineering Shandong University Tianjin Key Laboratory of Molecular Design and Drug Discovery Tianjin Institute of Pharmaceutical Research

Seven cyclohexane-bearing C-glucoside derivatives（7,9,12,13 and 17-19） were designed and synthesized as SGLT2 inhibitors starting from a potent SGLT2 inhibitor we discovered in earlier work, （lS）-1-deoxy-l-[4-methoxy-3-（trans-n-propylcyclohexyl）methylphenyl]-D-glucose（1）.The in vitro and in vivo biological activities were evaluated by hSGLT2/hSGLTl inhibition and urinary glucose excretion （UGE）,*** the synthesized compounds 12,the 6-deoxy derivative of 1 was the most active and selective SGLT2 inhibitor（IC_（50）= 1.4nmol/L against hSGLT2;selectivity = 1576）.Compound 12 was a potent SGLT2 inhibitor,which could induce more urinary glucose than 1 and dapagliflozin in UGE.

关键词： Synthesis C-Glucoside SGLT2 inhibitor Urinary glucose excretion Cyclohexane-bearing

SrCl_2 as an efficient cocatalyst for acidic hydrolysis of methyl glycosides

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Chinese Chemical Letters 2014年第4期25卷 561-566页

作者： Yong-Heng Ya-Fei Xie Yu-Qiang Liu Qun-Chao Wei Li-Da Tang Wei-Ren Xu Li-Da Tang gui-long zhao School of Pharmacy Tianjin Medical University Tianjin Key Laboratory of Molecular Design and Drug Discovery Tianjin Institute of Pharmaceutical Research

SrCl2 was found to be the most efficient cocatalyst for the acidic hydrolysis of methyl glycosides after 26 kinds of most representative metal salts were screened. The SrCl2-cocatalyzed acidic hydrolysis of methyl glycosides is highlighted by short reaction times, less byproducts and high yields. A possible mechanism for the SrCl2-cocatalyzed hydrolysis is also proposed.

关键词： Cocatalyst Hydrolysis Lewis acid Methyl glycoside Strontium chloride

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原油罐底泥的溶剂提取法处理技术

石油大学学报（自然科学版） 2005年第1期29卷 120-122页

作者：李美蓉张建桂召龙石油大学化学化工学院山东东营257061 胜利油田规划设计研究院山东东营257068

对胜利油田郝现联合站的罐底泥进行了分析,针对油泥特点,进行了化学破乳溶剂萃取离心分离的脱油处理技术研究。实验结果表明,室温时在油泥中加入油泥体积2%的破乳剂、80%的提取剂,搅拌均匀,在转速1500r/min时离心15min,脱油率可达91 7%... 详细信息

对胜利油田郝现联合站的罐底泥进行了分析,针对油泥特点,进行了化学破乳溶剂萃取离心分离的脱油处理技术研究。实验结果表明,室温时在油泥中加入油泥体积2%的破乳剂、80%的提取剂,搅拌均匀,在转速1500r/min时离心15min,脱油率可达91 7%,脱水率为25.5%。溶剂可循环利用,脱除的油可回收。该方法经济可行,为油田油泥砂综合利用或无害化处理提供了一条有效途径。

关键词：原油罐罐底脱油联合站破乳剂油田化学破乳底泥油泥处理技术

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埕岛油田注入海水净化处理技术研究

工业水处理 2001年第2期21卷 22-24页

作者：韩霞刘娜宗华桂召龙胜利石油管理局勘察设计研究院化学室山东东营257026

针对埕岛油田海域海水水质特点和注入海水的处理要求 ,研究了注入海水混凝沉降—过滤净化处理工艺技术。并配套研制筛选了混凝剂和絮凝剂 ,降低了后续过滤设备的处理负荷 ,提高了净化效果。

关键词：埕岛油田注水开采海水净化技术混凝剂絮凝剂

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin long Chuanhua Ge Yueyang zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

Extremal Entangled Four-Qubit Pure States with Respect to Multiple Entropy Measures

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Communications in Theoretical Physics 2008年第2期49卷 329-332页

作者： LIU Dan zhao Xin long gui-Lu Department of Physics Tsinghua University Beijing 100084 China Center of Quantum Information Science and Technology Tsinghua University Beijing 100084 China School of Science Dalian Nationalities University Dalian 116600 China Key Laboratory for Atomic and Molecular Nano-Sciences Tsinghua University Beijing 100084 China

Four-qubit entanglement has been investigated using a recent proposed entanglement measure, multiple entropy measures （MEMS）. We have performed optimization for the nine different families of states of four-qubit sy... 详细信息

关键词： four-qubit entanglement multiple entanglement measures

Comprehensive Evidence of Octupole Vibration in ^(158)Gd

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Chinese Physics Letters 1999年第12期16卷 870-872页

作者： long gui-lu JI Hua-ying zhao En-guang Department of Physics Tsinghua UniversityBeijing 100084 Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080 Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion AcceleratorChinese Academy of SciencesLanzhou 730000

Comprehensive evidence of the SU(3) octupole vibration limit in the spdf interacting boson model is found in the spectrum, E2 and El transition rates, and relative intensities in 158Gd. This is a good example of a rot... 详细信息

关键词： rare Vibration limit