咨询与建议

看过本文的还看了

相关文献

该作者的其他文献

文献详情 >Design,synthesis and in vivo a... 收藏

Design,synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors

Design,synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors

作     者:Wen Jing Zhao Yong Heng Shi Gui Long Zhao Yu Li Wang Hua Shao Li Da Tang Jian Wu Wang 

作者机构:School of Chemistry and Chemical Engineering Shandong University Jinan 250100 China Tianjin Key Laboratory of Molecular Design and Drug Discovery Tianjin Institute of Pharmaceutical Research Tianjin 300193 China School of Pharmacy Tianjin Medical University Tianjin 300070 China 

出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期:2011年第22卷第10期

页      面:1215-1218页

核心收录:

学科分类:0832[工学-食品科学与工程(可授工学、农学学位)] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 083203[工学-农产品加工及贮藏工程] 

基  金:Key Projects of Tianjin Science and Technology Support Plan(No. 10ZCKFSH01300) for financial support 

主  题:Synthesis C-Glucoside SGLT2 inhibitor Anti-hyperglycemic activity gem-Dimethyl 

摘      要:A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors,with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key *** in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test(OGTT),and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin.

读者评论 与其他读者分享你的观点

用户名:未登录
我的评分