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Radical cholecystectomy without liver resection for peritoneal side early incidental gallbladder cancer

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World Journal of Gastroenterology 2024年第32期30卷 3739-3742页

作者： Gaetano Piccolo Matteo Barabino guglielmo NiccolòPiozzi Paolo Pietro Bianchi Department of Health Sciences(DISS) University of MilanSan Paolo HospitalMilan 20142LombardyItaly Department of Colorectal Surgery Portsmouth Hospitals University NHS TrustPortsmouthUnited Kingdom

Gallbladder cancer(GBC)is a rare disease with a poor *** cholecystectomy may be an adequate treatment only for very early disease(Tis,T1a),whereas reoperation is recommended for more advanced disease(T1b and T2).Radical cholecystectomy should have two fundamental objectives:To radically resect the liver parenchyma and to achieve adequate clearance of the lymph ***,recent studies have shown that compared with lymph node dissection alone,liver resection does not improve survival *** oncological roles of lymphadenectomy and liver resection is ***,for patients with incidental GBC without liver invasion,hepatic resection is not always mandatory.

关键词： Incidental gallbladder cancer Reoperation Radical cholecystectomy Early stage Liver resection

Robotic complete mesocolic excision for right colon cancer:Learning curve,training,techniques,approach,platforms,and future perspectives

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 53-59页

作者： guglielmo NiccolòPiozzi Sentilnathan Subramaniam Rauand Duhoky Werner Hohenberger Jim S.Khan Department of Colorectal Surgery Portsmouth Hospitals University NHS TrustPortsmouthUK Colorectal Surgery Unit Department of General SurgeryHospital SelayangSelangorMalaysia Faculty of Technology University of PortsmouthPortsmouthUK Department of General Surgery Universitatsklinikum ErlangenErlangenGermany Faculty of Science and Health University of PortsmouthPortsmouthUK

Colon cancer has the fifth highest incidence worldwide and has the sixth highest *** with rectal cancer,colon cancer currently has the worst 5-year overall survival for patients with stage II and III *** mesocolic excision has been developed as a standardized and optimized surgical technique for the excision of colon *** technique has traditionally been performed through an open approach since laparoscopy is generally considered technically *** robotic approach has been slowly implemented for colon cancer,but the newest robotic platforms allow for a safer and optimized approach for right colon *** robotic approaches have been developed and *** expansion of the current robotic platform ecosystem is gradually providing new outputs in the application of the robotic approach to complete mesocolic *** review gains an oversight of existing literature on robotic complete mesocolic excision for right colon cancer(learning curve,training,techniques,approach,platforms,and future perspectives).

关键词： Robotic surgery Complete mesocolic excision Robotic platform Colon cancer Colorectal surgery

Epitopes for a 2019-nCoV vaccine

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Cellular & Molecular Immunology 2020年第5期17卷 539-540页

作者： guglielmo Lucchese Universitätsmedizin Greifswald Department of Neurology17475 GreifswaldGermany

After causing an initial cluster of Pneumonia in Wuhan City,Hubei Province,the 2019-nCoV has quickly spread through South East Asia and within a few weeks to Europe,Africa,and *** estimates suggested a mortality rate of 2%and that~18%of the cases show severe symptoms,although such estimates are still subject to rapid changes(https://***/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-internationalhealth-regulations-(2005)-emergency-committee-regarding-theoutbreak-of-novel-coronavirus-(2019-ncov)).

关键词： statement estimates committee

The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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Current Urology 2024年第2期18卷 128-132页

作者： Francesco Chierigo Rocco Simone Flammia GabrieleSorce Benedikt Hoeh Lukas Hohenhorst Andrea Panunzio Zhe Tian Fred Saad Marcus Graefen Michele Gallucci Alberto Briganti Francesco Montorsi Felix K.H.Chun Shahrokh F.Shariat Alessandro Antonelli Giovanni Guano guglielmo Mantica Marco Borghesi Nazareno Suardi Carlo Terrone Pierre I.Karakiewicz Department of Surgical and Diagnostic Integrated Sciences University of GenovaGenovaItaly IRCCS Ospedale Policlinico San Martino GenovaItaly Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity ofMontréal Health CenterMontréalQuébecCanada Department of Urology IRCCS Policlinico San MartinoGenovaItaly Department of Maternal-Child and Urological Sciences Sapienza Rome UniversityPoliclinico Umberto I HospitalRomeItaly Department of Urology University Hospital FrankfurtFrankfurt am MainGermany Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Department of Urology University of VeronaAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly Division of Experimental Oncology/Unit of Urology URIUrological Research InstituteIRCCS San Raffaele Scientific InstituteMilanItaly Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan

Objectives:This study aimed to test the association between of type and number of D'Amico high-risk criteria(DHRCs)with cancer-specific mortality(CSM)in high-risk prostate cancer patients treated with radical *** and methods:In the Surveillance,Epidemiology,and End Results database(2004–2016),we identified 31,281 radical prostatectomy patients with at least 1 DHRC,namely,prostate-specific antigen(PSA)>20 ng/mL(hrPSA),biopsy Gleason Grade Group(hrGGG)score of 4 and 5,or clinical tumor stage≥T3(hrcT).Multivariable Cox regression models and competing risks regression models(adjusting for other cause mortality)tested the association between DHRCs and 5-year ***:Of 31,281 patients,14,394(67%)exclusively harbored hrGGG,3189(15%)harbored hrPSA,and 1781(8.2%)harbored *** 2132 patients(6.8%)harbored a combination of the 2 DHRCs,and 138(0.6%)had all 3 ***-year CSMrates ranged from 0.9%to 3.0%when any individual DHRC was present(hrcT,hrPSA,and hrGGG,in that order),1.6%to 5.9%when 2 DHRCs were present(hrPSA-hrcT,hrcT-hrGGG,and hrPSA-hrGGG,in that order),and 8.1%when all 3 DHRCs were *** regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSM that was observed in univariable analyses,with hazard ratios from 1.00 to 2.83 for 1 DHRC,2.35 to 5.88 for combinations of 2 DHRCs,and 7.13 for all 3 ***:Within individual DHRCs,hrcT and hrPSA exhibited weaker effects than hrGGG ***,a dose-response effect was identified according to the number of ***,the type and number of DHRCs allow further risk stratification within the high-risk subgroup.

关键词： High risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER

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从剩余价值危机到欧元危机

政治经济学季刊 2024年第1期3卷 151-164页

作者：古列尔莫·卡尔凯迪骆桢(译) 阿姆斯特丹大学经济系四川大学经济学院

本文分析了2008年“次贷危机”以来,欧元区面临的债务危机及其引发的欧元危机背后的根本矛盾。通过介绍欧元的诞生,本文展示了欧元区各国由于产业技术和生产率差异的持续存在,使得统一货币下各国企业的竞争力差异体现为国际收支的分化,... 详细信息

本文分析了2008年“次贷危机”以来,欧元区面临的债务危机及其引发的欧元危机背后的根本矛盾。通过介绍欧元的诞生,本文展示了欧元区各国由于产业技术和生产率差异的持续存在,使得统一货币下各国企业的竞争力差异体现为国际收支的分化,并带来了逆差国财政状况的持续恶化。基于劳动价值论和不平等交换理论的分析表明,逆差国并不能通过退出欧元区实现本币贬值来恢复经济增长。欧元区需要的是体系改革,以提高经济落后国家的技术水平和生产率。然而,国家之间利益分歧和居于领导地位的德国内部不同集团间的利益与路线差异使得欧元区的改革举步维艰,直至危机爆发。

关键词：欧元危机利润率下降剩余价值

A Finite Volume Upwind-Biased Centred Scheme for Hyperbolic Systems of Conservation Laws:Application to Shallow Water Equations

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Communications in Computational Physics 2012年第9期12卷 1183-1214页

作者： guglielmo Stecca Annunziato Siviglia Eleuterio F.Toro Department of Civil and Environmental Engineering University of TrentoVia Mesiano 77I-38100 TrentoItaly Laboratory of AppliedMathematics University of TrentoVia Mesiano 77I-38100 TrentoItaly.

We construct a new first-order central-upwind numerical method for solving systems of hyperbolic equations in conservative *** applies in multidimensional structured and unstructured *** proposed method is an extension of the UFORCEmethod developed by Stecca,Siviglia and Toro[25],in which the upwind bias for the modification of the staggered mesh is evaluated taking into account the smallest and largest wave of the entire Riemann *** proposed first-order method is shown to be identical to the Godunov upwindmethod in applications to a 2×2 linear hyperbolic *** method is then extended to non-linear systems and its performance is assessed by solving the two-dimensional inviscid shallow water *** to second-order accuracy is carried out using an ADER-WENO approach in the finite volume framework on unstructured ***,numerical comparison with current competing numerical methods enables us to identify the salient features of the proposed method.

关键词： Conservative hyperbolic systems centred schemes unstructured meshes numerical fluxes shallow water equations FORCE upwind-biased

Hepatitis B in pregnancy

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World Journal of Gastroenterology 2012年第34期18卷 4677-4683页

作者： guglielmo Borgia Maria Aurora Carleo Giovanni Battista Gaeta Ivan Gentile Department of Public Medicine and Social Security Section of Infectious DiseasesUniversity of Naples "Federico Ⅱ"80131 NaplesItaly Department of Internal Medicine Section of Infectious DiseasesSecond University of Naples80131 NaplesItaly

Chronic hepatitis B virus (HBV) infection affects about 350 million individuals worldwide. Management of HBV infection in pregnancy is difficult because of several peculiar and somewhat controversial aspects. The aim of the present review is to provide a tool that may help physicians to correctly manage HBV infection in pregnancy. This review focuses on (1) the effect of pregnancy on HBV infection and of HBV infection on pregnancy; (2) the potential viral transmission from mother to newborn despite at-birth prophylaxis with immunoglobulin and vaccine; (3) possible prevention of mother-to-child transmission through antiviral drugs, the type of antiviral drug to use considering their efficacy and potential teratogenic effect, and the timing of their administration and discontinuation; and (4) the evidence for the use of elective caesarean section vs vaginal delivery and the possibility of breastfeeding.

关键词： Hepatitis B virus Pregnancy Therapy Te-nofovir Lamivudine Telbivudine Entecavir Breastfeed-ing Elective caesarean section

Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano De Rienzo Paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.M.Salamanca Matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora Marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo M De Reijke Vito Ricapito Pierluca Pellegrini Andrea Minervini Sergio Serni Francesco Sessa Department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Department of Urology San Carlo di Nancy HospitalRomeItaly Department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly Department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly Department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly Department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly Department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland Department of Urology University of CataniaItaly Department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly Department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the Delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia Delphi consensus

Portfolio optimization of credit risky bonds: a semi-Markov process approach

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Financial Innovation 2020年第1期6卷 456-469页

作者： Puneet Pasricha Dharmaraja Selvamuthu guglielmo D’Amico Raimondo Manca Department of Mathematics Indian Institute of Technology DelhiNew Delhi 110016India Department of Pharmacy University G.d’Annunzio of Chieti-Pescara66100 ChietiItaly Department of MEMOTEF University of RomeLa Sapienza00161 RomeItaly

This article presents a semi-Markov process based approach to optimally select a portfolio consisting of credit risky *** criteria to optimize the credit portfolio is based on l_(∞)-norm risk measure and the proposed optimization model is formulated as a linear programming *** input parameters to the optimization model are rate of returns of bonds which are obtained using credit ratings assuming that credit ratings of bonds follow a semi-Markov *** credit ratings by semi-Markov processes has several advantages over Markov chain models,i.e.,it addresses the ageing effect present in the credit rating *** transition probability matrices generated by semi-Markov process and initial credit ratings are used to generate rate of returns of *** empirical performance of the proposed model is analyzed using the real ***,comparison of the proposed approach with the Markov chain approach is performed by obtaining the efficient frontiers for the two models.

关键词： Semi-Markov process Credit ratings Credit risky bonds Portfolio optimization Min-max absolute deviation