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Paternal Zn-deficiency abolishes metabolic effects in offspring induced by diet type

Animal Nutrition 2022年第1期8卷 310-320页

作者： guanya li Zhenglin Dong Shusheng Yue Dan Wan Yulong Yin Key Laboratory of Agro-Ecological Processess in Subtropical Region Hunan Research Center of Livestock&Poultry SciencesSouth-Central Experimental Station of Animal Nutrition and Feed Science in Ministry of AgricultureInstitute of Subtropical AgricultureThe Chinese Academy of SciencesChangshaHunan 410125China Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangshaHunan410081China

Accumulating evidence implicates that offspring are susceptible to paternal alterations in numerous fetal disorders,such as growth and metabolic ***,less study has been conducted to define the relationship between paternal zinc deficiency(ZnD)and energy metabolism of *** the present study,we used a paternal ZnD exposure(Zn at 0.3 mg/g)model to test energy metabolism of male and female offspring with the intervention of diet type(high-fat diet and low-fat diet).Our results demonstrated that paternal ZnD decreased body weight(BW)gain per week(Plism and catabolism of hepatic energy products also exhibited *** attenuated liver glucose but increased lipids content accompanied with elevated adiponectin and reduction in leptin level in serum,which exhibited lipid metabolic disturbance and smaller ratio of liver weight to BW in male but not female *** qRT-PCR and liver energy metabolites analysis revealed that paternal ZnD mainly induced reduction in glucose tolerance and lowered glucose uptaking ability in male offspring and thereby alleviated glycolysis and the tricarboxylic acid cycle(TCA)cycle,which displayed a male ***,we propose that paternal ZnD abolishes metabolic effects in male offspring induced by diet type *** findings reveal a novel link between paternal Zn-D and offspring energy metabolism.

关键词： Zinc-deficiency Paternal Energy metabolism Offspring

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Role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity in a piglet model

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Science China(life Sciences) 2023年第9期66卷 2086-2098页

作者： Zhenglin Dong Shuan liu Qingqing Deng guanya li Yulong Tang Xin Wu Dan Wan Yulong Yin Key Laboratory of Agro-Ecological Processes in Subtropical Region Hunan Research Center of Livestock&Poultry SciencesSouth-Central Experimental Station of Animal Nutrition and Feed Science in Ministry of AgricultureInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China

Iron is an essential trace element for both the host and resident microbes in the gut. In this study, iron was administered orally and parenterally to anemic piglets to investigate the role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity. We found that oral iron administration easily increased the abundance of Proteobacteria and Escherichia-Shigella, and decreased the abundance of Lactobacillus in the ileum. Furthermore, similar bacterial changes, namely an increase in Proteobacteria, Escherichia-Shigella, and Fusobacterium and a reduction in the Christensenellaceae_R-7_group,were observed in the colon of both iron-supplemented groups. Spearman's correlation analysis indicated that the changed Fusobacterium, Fusobacteria and Proteobacteria in the colon were positively correlated with hemoglobin, colon and spleen iron levels. Nevertheless, it was found that activated m TOR1 signaling, improved villous height and crypt depth in the ileum,enhanced immune communication, and increased protein expression of IL-22 and IL-10 in the colon of both iron-supplemented groups. In conclusion, the benefits of improved host iron outweigh the risks of altered gut microbiota for intestinal mucosal growth and immune regulation in treating iron deficiency anemia.

关键词： iron deficiency iron-microbial interactions m TOR signaling immune regulation

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Electroacupuncture reduces posterior cingulate cortex activation and functional connectivity during food cue stimulation in overweight/obese subjects

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Science China(Information Sciences) 2020年第7期63卷 63-65页

作者： Yang HE Karen M.von DENEEN guanya li Mingzhu XU Wenjing ZHANG Xiaoping li Yuanyuan REN Yi ZHANG Center for Brain Imaging School of Life Science and Technology Xidian University Department of Acupuncture and Massage Xi'an Traditional Chinese Medicine HospitalShaanxi University of Chinese Medicine

Dear editor,Obesity is a pervasive public health issue involving excessive adiposity or body fat, and causes metabolic diseases including insulin resistance,type 2 diabetes mellitus, high blood pressure and heart disease [1]. Among the anti-obesity interventions, electroacupuncture (EA) is regarded as the safest and most effective alternative treatment

关键词： overweight/obese electroacupuncture fMRI food-cue reactivity generalized psychophysiological interaction dorsal anterior cingulate cortex posterior cingulate cortex

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Oral administration of dibutyryl adenosine cyclophosphate improved growth performance in weaning piglets by enhancing lipid fatty acids metabolism

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Animal Nutrition 2018年第3期4卷 260-264页

作者： guanya li ling Chang Guanglei Zhang Zehe Song Dan Wan Chunyan Xie Hong Wang Zhiyong Fan Hunan Co-Innovation Center of Safety Animal Production College of Animal Science and Technology and College of Bioscience and Biotechnology Hunan Agricultural University Key Laboratory of Agro-Ecological Processes in Subtropical Region Institute of Subtropical Agriculture The Chinese Academy of Sciences National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production Meiya Hai'an Pharmaceutical Co. Ltd.

Dibutyryl adenosine cyclophosphate(dbc AMP-Ca), an analog of cyclic adenosine monophosphate(c AMP), plays greater roles in regulating physiological activities and energy metabolism than c AMP. The aim of this study was to investigate the effect of oral administration of dbc AMP-Ca on growth performance and fatty acids metabolism in weaning piglets. A total of 14 early weaning piglets(7 ± 1 d of age,3.31 ± 0.09 kg, Landrace ? Large White ? Duroc) were randomly divided into 2 groups: control group and dbc AMP-Ca group, and the piglets received 7 m L of 0.9% Na Cl or 1.5 mg dbc AMP-Ca dissolved in 7 m L of 0.9% Na Cl per day for 10 d, respectively. The results showed that the average daily gain(ADG)increased by 109.17%(P lipoprotein cholesterol(HDLC) concentration(P lipoprotein cholesterol(LDLC) concentration(P liver C18:2 n6 t content significantly increased in dbc AMP-Ca group(P liferator-activated receptor a(PPARa) and hormone sensitive glycerol three lipase(HSL), of which genes are related to lipid metabolism, were also significantly increased(P lism in the liver of weaning piglets.

关键词： Dibutyryl adenosine cyclophosphate Growth performance lipid metabolism Peroxisome proliferator-activated receptor α Hormone sensitive glycerol three lipase Early weaning piglets

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Bariatric surgery induces alterations in effective connectivity between the orbitofrontal cortex and limbic regions in obese patients

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Science China(Information Sciences) 2020年第7期63卷 49-59页

作者： Shijun DUAN Gang JI guanya li Yang HU Wenchao ZHANG Jia WANG Dardo TOMASI Nora D.VOLKOW Yongzhan NIE Guangbin CUI Gene-Jack WANG Yi ZHANG Department of Radiology Tangdu Hospital Fourth Military Medical University State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases Fourth Military Medical University Center for Brain Imaging School of Life Science and Technology Xidian University Laboratory of Neuroimaging National Institute on Alcohol Abuse and Alcoholism

Obese subjects show enhanced brain responses in motivation and reward neurocircuitry encompassing sensory and somatic integration-interception, motivation-reward(striatal), emotion, and memory processes, which attenuate frontal region activation during food cues. Bariatric surgery(BS) is the only reliable treatment for morbid obesity. Unfortunately, it is unknown how BS affects neurocircuitry after weight loss. We aimed to examine effects of BS on the basal activity of brain areas involved in reward and motivation processing, emotion, memory, and gut-brain interaction. We combined resting-state fMRI with amplitude of low-frequency fluctuation(ALFF) and Granger causality analysis(GCA) to assess interactions between regions within the frontal-mesolimbic circuitry in 16 obese subjects(OB) and 22 normal-weight(NW) *** OB group was studied at baseline and 1 month post BS. Comparisons between OB and NW, and preand post BS showed significant differences in ALFF in areas involved in drive(caudate, orbitofrontal cortex(OFC)), arousal(thalamus), and conditioning/memory(amygdala, hippocampus)(P limbic regions(amygdala,hippocampus, and medial thalamus) and the caudate. Post BS, the connectivity of the OFC to limbic regions decreased, whereas the connectivity from the amygdala and hippocampus to the caudate and thalamus was enhanced, particularly in subjects with lower body mass index(BMI). OFC activation in the OB group was associated with BMI prior to surgery, and changes in OFC post surgery were associated with alterations in BMI. Overall, the functional connectivity of the OFC was significantly decreased. As it is important for salience attribution and connected to limbic brain regions involved with emotional reactivity and conditioning after BS, its significant association with BMI changes indicates the contribution of OFC changes to the improved control of eating behavi

关键词： fMRI Granger causality analysis obesity bariatric surgery frontal-mesolimbic

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基于逐级匹配技术的复合多层吸波材料优化设计

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电子元件与材料 2023年第10期42卷 1217-1220,1226页

作者：李冠亚何清婷电子科技大学国家电磁辐射控制材料工程技术研究中心四川成都611731 多频谱吸波材料与结构教育部重点实验室四川成都611731

复合多层吸波材料除具备“薄、轻、宽、强”等要求外,快速有效的设计方法可大大缩短其研发应用时间周期,利于技术迭代升级。本文基于传输线理论和逐级匹配技术,控制复合多层吸波材料界面的电磁传输特性,设计实现满足材料应用指标要求的... 详细信息

复合多层吸波材料除具备“薄、轻、宽、强”等要求外,快速有效的设计方法可大大缩短其研发应用时间周期,利于技术迭代升级。本文基于传输线理论和逐级匹配技术,控制复合多层吸波材料界面的电磁传输特性,设计实现满足材料应用指标要求的复合多层吸波材料。本文方法基于单频点提出,适用于单频及宽带设计要求。通过对实验室制备的多层吸波材料进行测试,得到在目标单频点反射率-30 dB及目标频带内平均反射率-35 dB的实测结果,验证了本文提出方法的正确性和有效性。本方法有望成为快速有效研发复合多层吸波材料的有效手段之一。

关键词：多层吸波材料优化方法传输线理论单频宽带

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合金效应加强水分子在PtRu_n团簇上的吸附作用

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计算物理 2017年第2期34卷 230-236页

作者：李永李海生李冠亚王赵武李国岭左正伟李立本河南科技大学物理工程学院河南洛阳471023

利用第一性原理计算方法,研究合金效应对PtRu_(n-1)(n=2-14)和H_2O-PtRu_(n-1)(n=2-14)体系的几何构型、稳定性及吸附水特性的影响.结果表明:铂原子替代钌原子的能量较低,容易与钌团簇形成合金,铂原子喜欢占据配位数较低位置.相对于纯... 详细信息

利用第一性原理计算方法,研究合金效应对PtRu_(n-1)(n=2-14)和H_2O-PtRu_(n-1)(n=2-14)体系的几何构型、稳定性及吸附水特性的影响.结果表明:铂原子替代钌原子的能量较低,容易与钌团簇形成合金,铂原子喜欢占据配位数较低位置.相对于纯钌团簇,合金效应很大程度上提高了水分子在PtRun团簇上的吸附能.考虑范德瓦尔斯力后,水分子在PtRu_7上的吸附能增大,分解势垒降低,水分子可以在PtRu_7上分解.铂钌合金更适合做分解水制取氢气的催化剂.

关键词：第一性原理计算合金效应吸附能催化剂

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery

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