Oral administration of dibutyryl adenosine cyclophosphate improved growth performance in weaning piglets by enhancing lipid fatty acids metabolism

作     者：Guanya Li Ling Chang Guanglei Zhang Zehe Song Dan Wan Chunyan Xie Hong Wang Zhiyong Fan 

作者机构：Hunan Co-Innovation Center of Safety Animal Production College of Animal Science and Technology and College of Bioscience and Biotechnology Hunan Agricultural University Key Laboratory of Agro-Ecological Processes in Subtropical Region Institute of Subtropical Agriculture The Chinese Academy of Sciences National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production Meiya Hai'an Pharmaceutical Co. Ltd. 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2018年第4卷第3期

页      面：260-264页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：jointly supported by National Key Research and Development Program of China (2016YFD0501209, and 2016YFD0500504) the Earmarked Fund for China Agriculture Research System (CARS-35) the Major Project of Hunan Province (2016NK2124 2015NK1002) 

主　　题：Dibutyryl adenosine cyclophosphate Growth performance Lipid metabolism Peroxisome proliferator-activated receptor α Hormone sensitive glycerol three lipase Early weaning piglets 

摘      要：Dibutyryl adenosine cyclophosphate(dbc AMP-Ca), an analog of cyclic adenosine monophosphate(c AMP), plays greater roles in regulating physiological activities and energy metabolism than c AMP. The aim of this study was to investigate the effect of oral administration of dbc AMP-Ca on growth performance and fatty acids metabolism in weaning piglets. A total of 14 early weaning piglets(7 ± 1 d of age,3.31 ± 0.09 kg, Landrace ? Large White ? Duroc) were randomly divided into 2 groups: control group and dbc AMP-Ca group, and the piglets received 7 m L of 0.9% Na Cl or 1.5 mg dbc AMP-Ca dissolved in 7 m L of 0.9% Na Cl per day for 10 d, respectively. The results showed that the average daily gain(ADG)increased by 109.17%(P 0.05) in the dbc AMP-Ca group compared with the control group. Besides,dbc AMP-Ca significantly decreased blood high density lipoprotein cholesterol(HDLC) concentration(P 0.05) and significantly increased blood low density lipoprotein cholesterol(LDLC) concentration(P 0.05) compared with the control group. Further, liver C18:2 n6 t content significantly increased in dbc AMP-Ca group(P 0.05) compared with the control group. With the increase of C18:2 n6 t content,the m RNA expression levels of peroxisome proliferator-activated receptor a(PPARa) and hormone sensitive glycerol three lipase(HSL), of which genes are related to lipid metabolism, were also significantly increased(P 0.05 or P 0.01). All of the results indicated that dbc AMP-Ca improved the ADG, which was probably done by regulating fatty acids metabolism in the liver of weaning piglets.