检索结果-南通市图书馆

Global Pharmacopoeia Genome Database is an integrated and mineable genomic database for traditional medicines derived from eight international pharmacopoeias

引用

Science China(Life Sciences) 2022年第4期65卷 809-817页

作者： Baosheng Liao Haoyu Hu Shuiming Xiao guanru zhou Wei Sun Yang Chu Xiangxiao Meng Jianhe Wei Han Zhang Jiang Xu Shilin Chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China Institute of Pharmacy Hubei University of Chinese MedicineWuhan430065China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing100193China Pharmacy College Chengdu University of Traditional Chinese MedicineChengdu611137China Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China

Genomic data have demonstrated considerable traction in accelerating contemporary studies in traditional medicine. However,the lack of a uniform format and dispersed storage limits the full potential of herb genomic data. In this study, we developed a Global Pharmacopoeia Genome Database(GPGD). The database contains 34,346 records for 903 herb species from eight global pharmacopoeias(Brazilian, Egyptian, European, Indian, Japanese, Korean, the Pharmacopoeia of the People’s Republic of China, and U.S. Pharmacopoeia’s Herbal Medicines Compendium). In particular, the GPGD contains 21,872 DNA barcodes from 867 species, 2,203 organelle genomes from 674 species, 55 whole genomes from 49 species, 534 genomic sequencing datasets from 366 species, and 9,682 transcriptome datasets from 350 species. Among the organelle genomes, 534 genomes from 366 species were newly generated in this study. Whole genomes, organelle genomes, genomic fragments, transcriptomes, and DNA barcodes were uniformly formatted and arranged by species. The GPGD is publicly accessible at http://*** and serves as an essential resource for species identification, decomposition of biosynthetic pathways, and molecular-assisted breeding analysis. Thus, the database is an invaluable resource for future studies on herbal medicine safety, drug discovery, and the protection and rational use of herbal resources.

关键词： Global Pharmacopoeia Genome Database herb traditional medicine genomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pure quantum gradient descent algorithm and full quantum variational eigensolver

引用

Frontiers of physics 2024年第2期19卷 221-234页

作者： Ronghang Chen zhou Guang Cong Guo guanru Feng Shi-Yao Hou College of Physics and Electronic Engineering Center for Computational SciencesSichuan Normal UniversityChengdu 610068China Shenzhen SpinQ Technology Co. Ltd.Shenzhen 518045China DEEPROUTE.AI

Optimization problems are prevalent in various fields,and the gradient-based gradient descent algorithm is a widely adopted optimization ***,in classical computing,computing the numerical gradient for a function with variables necessitates at least d+1 function evaluations,resulting in a computational complexity of O(d).As the number of variables increases,the classical gradient estimation methods require substantial resources,ultimately surpassing the capabilities of classical ***,leveraging the principles of superposition and entanglement in quantum mechanics,quantum computers can achieve genuine parallel computing,leading to exponential acceleration over classical algorithms in some *** this paper,we propose a novel quantum-based gradient calculation method that requires only a single oracle calculation to obtain the numerical gradient result for a multivariate *** complexity of this algorithm is just O(1).Building upon this approach,we successfully implemented the quantum gradient descent algorithm and applied it to the variational quantum eigensolver(VQE),creating a pure quantum variational optimization *** with classical gradient-based optimization algorithm,this quantum optimization algorithm has remarkable complexity advantages,providing an efficient solution to optimization *** proposed quantum-based method shows promise in enhancing the performance of optimization algorithms,highlighting the potential of quantum computing in this field.

关键词： quantum algorithm gradient descent variational quantum algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

体外培育牛黄对人冠状病毒肺炎湿毒疫模型的机制研究

引用

中国药物警戒 2021年第12期18卷 1117-1122页

作者：赵荣华郭姗姗孙静时宇静包蕾耿子涵鲍岩岩周冠儒高英杰崔晓兰王道涵无中国中医科学院中药研究所生物安全实验室北京100700 武汉健民大鹏药业有限公司武汉430000 北京中医药大学东方医院儿科北京100078

目的观察体外培育牛黄对人冠状病毒肺炎湿热疫毒袭肺证小鼠模型的治疗作用。方法通过体外培育牛黄(0.128、0.064、0.032 g/kg)对小鼠肺指数和肺指数抑制率、肺组织病毒载量、肺组织炎性因子白细胞介素(IL)-1β,白细胞分化抗原(cluster o... 详细信息

目的观察体外培育牛黄对人冠状病毒肺炎湿热疫毒袭肺证小鼠模型的治疗作用。方法通过体外培育牛黄(0.128、0.064、0.032 g/kg)对小鼠肺指数和肺指数抑制率、肺组织病毒载量、肺组织炎性因子白细胞介素(IL)-1β,白细胞分化抗原(cluster of differentiation,CD14),氧化应激因子丙二醛(MDA)及超氧化物歧化酶(SOD)含量、下丘脑环磷酸腺苷(cAMP)及前列腺素(prostaglandin,PG)E2含量、外周血CD4^(+)T淋巴细胞,CD8^(+)T淋巴细胞及B淋巴细胞百分比的影响评价药物对模型的治疗作用。结果人冠状病毒肺炎湿热疫毒袭肺证小鼠病证结合模型小鼠体重减轻,摄食及饮水量下降明显,扎堆不动,反应迟缓,皮毛干枯不泽,大便粘腻,小便量少色黄,体外培育牛黄可明显改善模型小鼠上述状态。体外培育牛黄可降低模型小鼠肺指数;明显降低模型小鼠肺组织病毒核酸表达量;显著降低模型小鼠肺组织炎性因子CD14、MDA含量,显著升高SOD含量;显著降低模型小鼠c AMP含量,对PGE2含量无显著变化;显著升高模型小鼠CD4^(+)T细胞、CD8^(+)T细胞的百分比。结论体外培育牛黄对人冠状病毒肺炎湿热疫毒袭肺证小鼠病证结合模型具有显著的治疗作用,可通过降低模型小鼠肺指数、调节下丘脑CAMP及PGE2的含量、调节免疫机能和抑制炎性因子释放等作用环节进行治疗,为临床用药提供实验室依据。

关键词：冠状病毒肺炎体外培育牛黄中医病机湿热疫毒袭肺免疫机能炎性因子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry

引用

Signal Transduction and Targeted Therapy 2023年第1期8卷 13-37页

作者： Wenzhe Yi Ping Xiao Xiaochen Liu Zitong Zhao Xiangshi Sun Jue Wang Lei zhou guanru Wang Haiqiang Cao Dangge Wang Yaping Li State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264000China

Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological *** metabolic engineering,bioorthogonal groups can be tagged onto cell membranes,which selectively attach to cargos with paired groups via bioorthogonal *** to its simplicity,high efficiency,and specificity,bioorthogonal chemistry has demonstrated great application potential in drug *** the one hand,bioorthogonal reactions improve therapeutic agent delivery to target sites,overcoming off-target *** the other hand,nanoparticles and biomolecules can be linked to cell membranes by bioorthogonal reactions,providing approaches to developing multi-functional drug delivery systems(DDSs).In this review,we first describe the principle of labeling cells or pathogenic microorganisms with bioorthogonal *** then highlight recent breakthroughs in developing active targeting DDSs to tumors,immune systems,or bacteria by bioorthogonal chemistry,as well as applications of bioorthogonal chemistry in developing functional bio-inspired DDSs(biomimetic DDSs,cell-based DDSs,bacteria-based and phage-based DDSs)and ***,we discuss the difficulties and prospective direction of bioorthogonal chemistry in drug *** expect this review will help us understand the latest advances in the development of active targeting and multi-functional DDSs using bioorthogonal chemistry and inspire innovative applications of bioorthogonal chemistry in developing smart DDSs for disease treatment.

关键词： functional orthogonal breakthrough

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

circPVT1 promotes silica-induced epithelial-mesenchymal transition by modulating the miR-497-5p/TCF3 axis

引用

Journal of Biomedical Research 2024年第2期38卷 163-174,I0011-I0015页

作者： Siyun zhou Yan Li Wenqing Sun Dongyu Ma Yi Liu Demin Cheng guanru Li Chunhui Ni Department of Occupational Medical and Environmental Health Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Biomedical Publications Center Nanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversityNanjingJiangsu 211166China

Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary ***,whether circRNA is involved in the process remains *** present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying *** found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial *** isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the *** immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to ***,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3(TCF3),an E-cadherin transcriptional repressor,in the silica-treated epithelial ***,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3 axis in the silica-induced EMT process in lung epithelial *** validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.

关键词： silicosis epithelial-mesenchymal transition circPVT1 miR-497-5p TCF3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatoprotective ability of tetramethylpyrazine produced by Bacillus amyloliquefaciens

引用

Systems Microbiology and Biomanufacturing 2021年第2期1卷 223-233页

作者： Wenqing Zhang guanru Si Zhiming Rao Shuai Zong Jinglei Li Xian Zhang Chuanqiang Gao zhou Ping Ming Ye School of Food and Biological Engineering Hefei University of Technology230009 HefeiChina Research Institute of Jiangnan Small Pit Brewing Technology Xuancheng 242000China The Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122JiangsuChina College of Food Science and Engineering Yangzhou UniversityYangzhou 225127JiangsuChina

Tetramethylpyrazine(TTMP),an important aroma compound,was produced by Bacillus amyloliquefaciens XJB-104 with distillers’grains as raw *** yield of TTMP under optimized fermentation procedure was 3176.52 mg/*** in the fermentation broth was purified and the purity(>99%)was measured by gas chromatography-mass ***,the hepatoprotective activity of TTMP in ethanol-water system was evaluated by biochemical indicators of liver injury,parameters of antioxidant defense system and inflammatory response,and liver histopathological assessment in *** treatment increased serum levels of alanine aminotransferase,aspartate aminotransferase,alkaline phos-phatase and lactate dehydrogenase,suggesting liver *** high and low dose of TTMP significantly decreased levels of these ***,the reduction in the activities or concentrations of superoxide dismutase,catalase,reduced glutathione and malondialdehyde in liver tissue caused by ethanol was significantly alleviated by *** inflammatory cytokines including transcription factor,tumor necrosis factor,interleukin-1beta,interleukin,macrophage chemoattractant protein,inducible nitric oxide synthase and cyclooxygenase were also suppressed by TTMP *** is concluded that TTMP in ethanol-water system has potential liver-protective activity,especially when ethanol is consumed at low doses for short periods of time.

关键词： Tetramethylpyrazine Bacillus amyloliquefaciens Hepatoprotective effect Distillers’grains Ethanol-water system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effectiveness of flesh-moistening paste in psoriasis vulgaris patients with symptom pattern of blood stasis:a randomized and parallel-controlled trial

引用

Journal of Traditional Chinese Medicine 2020年第6期40卷 1018-1025页

作者： Guo Xinwei Lang Na Li guanru Li Ping Qu Jianhua zhou Dongmei Wang Ping Cang Zhang Deng BingXu Lou Weihai Xu Jingna Lan Haibing Liu Yumin Zhang Weishu Sun Liyun Dermatology Department Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Beijing Institute of Traditional Chinese Medicine Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Dermatology Department China Academy of Chinese Medical Sciences Xiyuan HospitalBeijing 100091China Dermatology Department Beijing Hospital of Traditional Chinese MedicineShunyi BranchBeijing 101300China Dermatology Department Gulou Hospital of Traditional Chinese Medicine of BeijingBeijing 100009China

OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on both the left and right side of the same patients with psoriasis vulgaris,diagnosed via TCM as blood stasis pattern,were selected as the targeted skin lesions.A randomized,double-blind,parallel-controlled,multicenter controlled trial was *** targeted skin lesions were categorized into either the treatment or control *** treatment group used the flesh-moistening paste;the control group used a *** the paste and the placebo were topically applied twice daily for eight *** patients were examined biweekly to evaluate the *** two groups were compared in terms of the psoriasis area and severity index(PASI)of the targeted skin lesions,which is scored according to erythema,desquamation,infiltration,area,pruritus,and improvement of skin barrier *** events were recorded during the study *** 21.0 was used to analyze the ***:Fifty-six patients were enrolled between February 2016 and October *** were complicated by cardio-cerebrovascular disease and were excluded;thus,54 outpatients were finally enrolled in the *** dropped out during the study period:three failed to complete their follow-up visits for unknown reasons,and one exited due to an adverse *** final trial comprised 50 of the 56 originally selected patients,with a 92.6%completion *** 8 weeks of treatment,the targeted skin lesion scores differed significantly(P<0.05).The PASI scores of the targeted skin lesions differed significantly beginning at week 6(P<0.05).The treatment group presented better results than those of the control *** one patient had an adverse reaction associated with the *** in skin barrier function differed significantly(P<0.05).CONCLUSION:The flesh-moistening paste demo

关键词： Psoriasis Blood stasis Prepared fleshmoistening paste Randomized controlled trial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Fiber Detection Method for LAMOST Based on the Front-illuminated Method

引用

Research in Astronomy and Astrophysics 2022年第6期22卷 42-51页

作者： Ming zhou Yong Zhang guanru Lv Jian Li Zengxiang zhou Zhigang Liu Jianping Wang Zhongrui Bai Yuan Tian Mengxin Wang Shuqing Wang Hongzhuan Hu Chao Zhai Jiaru Chu Zhijie Han Mingxu Liu Yiqiao Dong Hailong Yuan Yongheng Zhao Yaoquan Chu Haotong Zhang Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China University of Science and Technology of China Hefei 230026China

The double revolving fiber positioning technology is one of the key technologies for the success of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST).The accuracy of fiber positioning will directly affect the observation efficiency of *** achieve higher fiber positioning accuracy,the original open-loop controlled fiber positioning system urgently needs to be upgraded into a closed-loop control *** fiber detection is the most important part of the closed-loop controlled fiber positioning *** back-illuminated detection method is usually used to detect the fiber position by directly detecting the light spot generated at the fiber end in the multi-fiber spectral *** this paper,we introduce a new method to measure the fiber position based on the image of the front-illuminated LAMOST focal *** front-illuminated image does not require lighting devices inside the spectrograph,and it could reduce the instability and light pollution in the spectrograph *** method measures the fiber position by fitting the profile of the fiber pinhole with a 2D Gaussian function.A series of tests show that the relative position measurement precision of the front-illuminated method is about 012,and the method could have the same accuracy as the back-illuminated method once the system bias is calibrated by a simple radial correction *** required fiber positioning accuracy of LAMOST is 04,and the new method satisfies the requirement of LAMOST fiber detection accuracy and could be used in the closed-loop fiber control system.

关键词： techniques image processing-methods data analysis-instrumentation detectors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

青岛沿海站点冬季不同污染条件下气溶胶的来源解析——基于单颗粒质谱分析

引用

中国海洋大学学报（自然科学版） 2023年第12期53卷 127-137页

作者：吴冠儒张艳靖李磊周振姚小红周杨中国海洋大学海洋与大气学院山东青岛266100 暨南大学质谱仪器与大气环境研究所广东广州510632 中国海洋大学海洋环境与生态教育部重点实验室山东青岛266100 青岛海洋科学与技术试点国家实验室海洋生态与环境科学功能实验室山东青岛266237

青岛位于京津冀的下风区,毗邻黄渤海,其大气污染受到陆地和海洋传输的影响,尤其在冬季来源较为复杂。本研究利用单颗粒气溶胶质谱仪于2019年12月在青岛奥帆中心采集913514个大气颗粒,并利用Art-2a算法将其分类,对青岛市大气气溶胶进行... 详细信息

青岛位于京津冀的下风区,毗邻黄渤海,其大气污染受到陆地和海洋传输的影响,尤其在冬季来源较为复杂。本研究利用单颗粒气溶胶质谱仪于2019年12月在青岛奥帆中心采集913514个大气颗粒,并利用Art-2a算法将其分类,对青岛市大气气溶胶进行溯源和分析。其中富钾颗粒(K)、元素碳和有机碳混合颗粒物(ECOC)、有机碳颗粒物(OC)、多环芳烃颗粒物(PAH)、OCEC和富钾颗粒与有机碳元素碳混合颗粒(K_ECOC)等颗粒物多与生物质燃烧有关,其在总颗粒物中的占比高达49.2%;与工业排放有关的元素碳和富钾混合颗粒(EC_K)、富铁颗粒(Fe)和其他重金属(other_HM)颗粒物的占比为29.7%;与海洋排放相关的海盐颗粒和富钠颗粒物(Na_rich)占比为6.8%;另外有机胺(Amine,10.6%)受到了陆源和海洋源的共同影响。根据污染个例分析发现,青岛受到京津冀传输影响时,局地工业源EC_K的贡献从36.0%逐渐降至15.0%,较高的环境湿度促进了Amine在颗粒物上的二次生成;当受到高空输送影响时,以生物质燃烧颗粒为主导(70.5%);在海洋气团影响主导时,青岛受局地排放(EC_K,42.2%)和海洋气溶胶(7.7%)控制。

关键词：沿海城市单颗粒来源解析污染事件

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

新工科教育语境中跨学科课程项目的设计教学法

引用

高等工程教育研究 2023年第6期 16-26页

作者：周鼎吕冠儒郭鹏翔陈龙宝南方科技大学系统设计与智能制造学院

现有工程教育策略需超越科学原理,培养学生创造性思维和行动能力以适应新兴技术和复杂方案。本研究在南方科技大学工业设计专业采用“基于解决方案的设计过程”(Solution-Based Design Process,SBDP)教学法,探究其对新工科教育体系下学... 详细信息

现有工程教育策略需超越科学原理,培养学生创造性思维和行动能力以适应新兴技术和复杂方案。本研究在南方科技大学工业设计专业采用“基于解决方案的设计过程”(Solution-Based Design Process,SBDP)教学法,探究其对新工科教育体系下学生跨学科课程学习的影响。27名本科生参与应用机器人底盘和四门设计工程必修课的“智慧牧场”课程项目,通过反思日志和焦点小组收集质性数据进行主题分析。研究发现,SBDP教学法实现了新工科教育关注的设计、跨学科和解决真实问题的特性。它在设计驱动的跨学科融合和解决真实情境问题方面发挥明显作用,提高学生学习质量和培养创新能力。SBDP通过整合过程性知识、多学科陈述性知识和真实情景的条件性知识,有利于学生通过创造终端产品学习工程知识。此外,它培养了基于技能和意识的高阶思维能力。总结而言,本研究为新工科教育体系下的跨学科课程创新提供了可行方案,揭示了在工业4.0时代工程教育转型中的机遇和挑战,有助于促进管理、教学、学习和产业等多方利益相关者的共同价值。

关键词：新工科教育设计教学法基于解决方案的设计过程跨学科课程项目

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：