Global Pharmacopoeia Genome Database is an integrated and mineable genomic database for traditional medicines derived from eight international pharmacopoeias

作     者：Baosheng Liao Haoyu Hu Shuiming Xiao Guanru Zhou Wei Sun Yang Chu Xiangxiao Meng Jianhe Wei Han Zhang Jiang Xu Shilin Chen Baosheng Liao;Haoyu Hu;Shuiming Xiao;Guanru Zhou;Wei Sun;Yang Chu;Xiangxiao Meng;Jianhe Wei;Han Zhang;Jiang Xu;Shilin Chen

作者机构：Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing100700China Institute of PharmacyHubei University of Chinese MedicineWuhan430065China Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesBeijing100193China Pharmacy CollegeChengdu University of Traditional Chinese MedicineChengdu611137China Institute of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin301617China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2022年第65卷第4期

页      面：809-817页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China (2019YFC1711100) the National Natural Science Foundation of China and Karst Science Research Center of Guizhou Province (U1812403-1) the Special Foundation for National Science and Technology Basic Research Program of China (2018FY100701) the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZXKT17027, ZXKT18014) the Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China (2020GZ2011016) the Funds for Fostering Outstanding Scholars in Science and Technology (Innovation) (ZZ13-YQ-047) Innovation Fund of China Academy of Chinese Medical Sciences 

主　　题：Global Pharmacopoeia Genome Database herb traditional medicine genomics 

摘      要：Genomic data have demonstrated considerable traction in accelerating contemporary studies in traditional medicine. However,the lack of a uniform format and dispersed storage limits the full potential of herb genomic data. In this study, we developed a Global Pharmacopoeia Genome Database(GPGD). The database contains 34,346 records for 903 herb species from eight global pharmacopoeias(Brazilian, Egyptian, European, Indian, Japanese, Korean, the Pharmacopoeia of the People’s Republic of China, and U.S. Pharmacopoeia’s Herbal Medicines Compendium). In particular, the GPGD contains 21,872 DNA barcodes from 867 species, 2,203 organelle genomes from 674 species, 55 whole genomes from 49 species, 534 genomic sequencing datasets from 366 species, and 9,682 transcriptome datasets from 350 species. Among the organelle genomes, 534 genomes from 366 species were newly generated in this study. Whole genomes, organelle genomes, genomic fragments, transcriptomes, and DNA barcodes were uniformly formatted and arranged by species. The GPGD is publicly accessible at http://*** and serves as an essential resource for species identification, decomposition of biosynthetic pathways, and molecular-assisted breeding analysis. Thus, the database is an invaluable resource for future studies on herbal medicine safety, drug discovery, and the protection and rational use of herbal resources.