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Preparation and Characterization of Silica Aerogels Derived from Ambient Pressure

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Journal of Materials Science & Technology 2006年第6期22卷 798-802页

作者： Jun SHEN Zhihua ZHANG guangming WU Bin zhou Xingyuan NI Jue WANG Pohl Institute of Solid State Physics Tongji University Shanghai 200092 China

Silica aerogels were prepared by sol-gel technique from industrial silicon derivatives （polyethoxydisiloxanes, E40）, followed by silylation and drying under ambient pressure. The specific surface area, pore size distribution and thermal conductivity of the silica aerogels were investigated and the results showed that the diameter of the silica particles is about 6 nm and the average pore size of the silica aerogels is 14.7 nm. The specific surface area of which is about 1000 m^2.g^-1 and the thermal conductivity is about 0.014 wm^-l.K^-1 at room temperature and pressure of 1.01×10^5 Pa. The Si-CH3 groups were also detected on the internal surface of the silica aerogels, which show hydrophobic. Silica aerogels derived by this technique is low cost and have wide applications.

关键词： Silica aerogel Sol-gel Nano-structure Ambient pressure drying

Relationship between cellular radio-sensitivity and naked DNA damage in mammalian cells exposed to heavy ions

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Nuclear Science and Techniques 2009年第6期20卷 349-353页

作者： LI Wenjian zhou guangming WANG Zhuanzi LI Qiang DANG Bingrong WANG Jufang Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

The relationship between deoxyribonucleic acid (DNA) damage and the cell death induced by 12C ions irradiation was examined in four kinds of cells, Melanoma B16, cervical squamous carcinoma HeLa, Chinese hamster V79 and hepatoma SMMC-7721. Cell survival was determined by a colonogenic assay, and the sensitivity was described by D50 (the dose of radiation necessary to reduce the survival to 50%). For all cell lines, D50 ranged from 0.74 Gy to 3.85 Gy, among them B16 was the most radiosensitive to 12C ions, and V79 and HeLa cells had almost the same radio-sensitivity, SMMC-7721 was the last. The induction of deproteinized DNA double-strand breaks induced by 12C ions were measured by pulsed-field gel electrophoresis (PFGE), and the initial yield of the deproteinized DNA dsbs per unit dose was expressed as the DNA double break level (L). A linear dose-response curve was seen for initial DNA dsbs for all cell lines (slopes range from 0.40-0.98 (DSBs/100Mbp/Gy)). V79 was the steepest, B16 was the last. There was an inverse relationship between the initial DNA dsb and D50 if the B16 cell line was not considered, but there was no relativity even excludes the B16 cell line. The present results indicate that there is no relationship between cellular sensitivity and initial DNA dsb, even exclude the effects of chromatin structure.

关键词：哺乳动物细胞 DNA损伤放射敏感性重离子 DNA双链断裂脉冲场凝胶电泳无线蜂窝

Space Life Science of China in 2013

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空间科学学报 2014年第5期34卷 747-756页

作者： LEI Runhong zhou guangming MA Hong ZHUANG Fengyuan DENG Yulin School of Life Science Beijing Institute of Technology Department of Space Radiobiology Key Laboratory of Heavy Ion Radiation Biology and MedicineInstitute of Modern Physics Chinese Academy of Sciences

In the past two years, space life science research in China is characterized by a wide area of basic researches for providing foundation for the future China Space Station. The effect of microgravity and radiation was further studied from physiology phenomena to the level of bio-molecule mechanisms. Chinese space life science is maturing in a new era of comprehensive ***, we review and summarize researches on space life sciences which were contributed by Chinese scientists.

关键词： Space life sciences Simulated microgravity Ionizing radiation

Ultra-high dose rate(FLASH)radiotherapy:Revolutionizing tumor targeting and microenvironmental dynamics in cancer treatment

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Chinese Medical Journal 2024年第24期137卷 3148-3150页

作者： Zhiming Wang guangming zhou Yongsheng Zhang Zhifei Cao Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSuzhou Medical College of Soochow UniversitySuzhouJiangsu 215123China

To the Editor:Radiotherapy is an essential component of modern cancer treatment modalities,used by nearly 70%of all individuals diagnosed with ***,conventional radiotherapy(CONV-RT)can damage surrounding healthy tissues,limiting the maximum safe dose and potentially reducing treatment *** studies indicate that ultra-high dose rate radiotherapy(FLASH-RT)spares healthy tissues while maintaining the same tumor control.^([1])

关键词： radiotherapy cancer treatment

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复合材料易碎盖承压和顶破性能研究

复合材料科学与工程 2025年第1期 109-116页

作者：王宇奇徐志明徐澧明苑晓旭姜悦李爽蔡登安周光明南京航空航天大学航空航天结构力学及控制全国重点实验室南京210016 中材科技(阜宁)风电叶片有限公司盐城224431

本文设计了一种通道尺寸为650 mm×650 mm的复合材料薄型易碎式发射箱盖,能够承载极大内压且顶破载荷较小,内压转换为集中力的大小是顶破载荷的7倍,并提出了薄弱区以及加强布的结构设计方案。制作了易碎盖并对其进行承压与顶破试验,试... 详细信息

本文设计了一种通道尺寸为650 mm×650 mm的复合材料薄型易碎式发射箱盖,能够承载极大内压且顶破载荷较小,内压转换为集中力的大小是顶破载荷的7倍,并提出了薄弱区以及加强布的结构设计方案。制作了易碎盖并对其进行承压与顶破试验,试验结果表明,易碎盖的设计结构合理,能够承受0.055 MPa的内压,易碎盖中心点的最大变形为19.83 mm,而顶破易碎盖仅需要3.03 kN的载荷。本文分别建立了易碎盖承压试验和顶破试验的有限元模型,分析结果与试验结果的误差分别为12.7%和8.0%,可以较为准确地预测易碎盖的变形和强度。基于有限元模型,分析了不同位置的加强布层数变化和不同易碎盖厚度对易碎盖变形的影响,Ⅱ,Ⅲ区加强布层数和易碎盖厚度的增加会导致易碎盖变形减少。本文的研究内容可以为薄型易碎式发射箱盖的工程制作提供参考。

关键词：复合材料大尺寸易碎盖薄弱区结构有限元分析

Mechanisms underlying FLASH radiotherapy, a novel way to enlarge the differential responses to ionizing radiation between normal and tumor tissues

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Radiation Medicine and Protection 2020年第1期1卷 35-40页

作者： guangming zhou State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSoochow University199 Renai RoadSuzhou215123China

Different from conventional radiotherapy(CONV-RT),FLASH radiotherapy(FLASH-RT)delivers a single high dose at a mean dose rate40 Gy/s in milliseconds to achieve similar tumor control to CONV-RT while sparing normal tissues from detrimental *** provides an intriguing perspective in improving clinical outcomes for tumor patients as well as a novel way to enhance the differential responses between normal and tumor ***,its mechanisms remain largely *** this paper,we review the currently available publications on FLASH-RT and parse the probable mechanisms of three major aspects including the production of reactive oxygen species,DNA damage response,and *** specifically designed to disclose the intrinsic difference between normal and malignant cells in response to FLASH-RT and CONV-RT are necessary to prove these hypotheses.

关键词： FLASH ROS Radiation quality Immune response

The clinical prospect of FLASH radiotherapy

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Radiation Medicine and Protection 2023年第4期4卷 190-196页

作者： Jiyuan Liu guangming zhou Hailong Pei State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSuzhou Medical College of Soochow UniversitySuzhou 215123China

FLASH radiotherapy(FLASH-RT)is a new strategy for tumor treatment with an ultra-high dose rate of more than 40 Gy/*** with conventional radiotherapy(CONV-RT),FLASH-RT has no different inhibitory effects on tumors but less damage to normal tissues,which is called the“spare”***“spare”effect triggers our exploration of the great prospect of subverting conventional radiotherapy and its intricate *** homeostasis,the immune microenvironment,or DNA integrity may potentially represent the primary breakthrough direction in understanding the ***,it is imperative to advance timely clinical translation *** trials of FLASH-RT have progressed to Phase II in both the United States and Switzerland,with current findings suggesting that FLASH-RT achieves comparable efficacy to CONV-RT while mitigating side effects in select cancer cell *** summarizing the existing FLASH experiments,this paper emphasizes the significance of clinical transformation and the challenges that will be faced and proposes possible solutions.

关键词： Radiotherapy FLASH-RT Oxygen depletion Immune microenvironment Clinical translation

Quadrature Element Vibration Analysis of Arbitrarily Shaped Membranes

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Transactions of Nanjing University of Aeronautics and Astronautics 2022年第1期39卷 1-11页

作者： WANG Xinwei CAI Deng’an zhou guangming State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China

The aim of the present study is to develop an efficient weak form quadrature element for free vibration analysis of arbitrarily shaped *** arbitrarily shaped membrane is firstly mapped into a regular domain using blending functions,and the displacement in the element is assumed as the trigonometric *** formulations are worked out for nodes of any type and a varying number of *** verifications,results are compared with exact solutions and data obtained by other numerical *** is demonstrated that highly accurate frequencies can be obtained with a small number of nodes by present method.

关键词： arbitrarily shaped membrane free vibration quadrature element blending function

Oxygen-driven cuproptosis synergizes with radiotherapy to potentiate tumor immunotherapy

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Aggregate 2024年第3期5卷 219-231页

作者： Pei Pei Yuhong Wang Wenhao Shen Qing He Xiangming Han Chonghai Zhang Yuyuan Xie guangming zhou Ye Zhao Lin Hu Kai Yang Teaching and Research Section of Nuclear Medicine School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection&School for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhouJiangsuChina Department of Pathology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Oncology Taizhou People’s Hospital Affiliated to Nanjing Medical UniversityNanjingJiangsuChina

The immunological implications of cuproptosis,a form of cell death highly sensitive to oxygen presence,remain largely unexplored in the context of tumor ***,we initially investigate the positive correlation between cuproptosis and tumor immunotherapy through bioinformatics ***,an oxygen generator loaded with copper ions(Cu/APH-M)has been constructed,which serves as an effective carrier of copper ions and crucially enhances the oxygenation of the tumor ***,Cu/APH-M-mediated dual strengthening of cuproptosis and radiotherapy could not only trigger a powerful antitumor immunity related to immunogenic cell death by RNA-sequencing analysis,but also effec-tively inhibit the growth of both distal and in situ low rectal tumors after combined immunotherapy,creating a robust immune memory *** work reveals the ben-eficial effects of enhanced cuproptosis in radio-immunotherapy and elucidates its underlying mechanisms,which provides a novel approach for the synergistic inte-gration of cuproptosis with immunotherapy and radiotherapy,broadening the scope of cuproptosis-mediated tumor therapy.

关键词： cuproptosis immune response oxygen generator radio-immunotherapy RNA-seq analysis