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China CDC weekly 2023年第44期5卷 973-977,I0001页

作者： He Jiang Qiuying Zhu Jinghua Huang Xiuling Wu Bo Li Xuanhua Liu Qin Meng Shuai Tang guanghua lan Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Center for Disease Prevention and ControlNanning CityGuangxi Zhuang Autonomous RegionChina Guangxi Key Laboratory for Major Infectious Diseases Prevention and Control and Biosafety Emergency Response Guangxi Center for Disease Prevention and ControlNanning CityGuangxi Zhuang Autonomous RegionChina

Summary What is already known about this topic?The effects of concurrent human immunodeficiency virus(HIV)/hepatitis C virus(HCV)infection on mortality and patient attrition in those undergoing antiretroviral therapy ... 详细信息

关键词： mortality Therapy Impact

SUPER WOMAN 2(SPW2)maintains organ identity in spikelets by inhibiting the expression of floral homeotic genes OsMADS3,OsMADS58,OsMADS13,and DROOPING LEAF

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Journal of Integrative Agriculture 2024年第1期23卷 59-76页

作者： Hui Zhuang Jinsong lan Qiuni Yang Xiaoyu Zhao Yuhuan Li Jingya Zhi Yalin Shen guanghuaHe Yunfeng Li Rice Research Institute Key Laboratory of Application and Safety Control of Genetically Modified CropsAcademy of Agricultural SciencesSouthwest UniversityChongqing 400715China

Flower organ identity in rice is mainly determined by the A-,B-,C-and E-class genes,with the majority encoding MADS-box transcription factors.However,few studies have investigated how the expression of these floral organ identity genes is regulated during flower development.In this study,we identified a gene named SUPER WOMAN 2(SPW2),which is necessary for spikelet/floret development in rice by participating in the regulation of the expression of pistil identity genes such as OsMADS3,OsMADS13,OsMADS58 and DL.In the spw2 mutant,ectopic stigma/ovary-like tissues were observed in the non-pistil organs,including sterile lemma,lemma,palea,lodicule,and stamen,suggesting that the identities of these organs were severely affected by mutations in SPW2.SPW2 was shown to encode a plant-specific EMF1-like protein that is involved in H3K27me3 modification as an important component of the PRC2 complex.Expression analysis showed that the SPW2 mutation led to the ectopic expression of OsMADS3,OsMADS13,OsMADS58,and DL in non-pistil organs of the spikelet.The ChIP-qPCR results showed significant reductions in the levels of H3K27me3 modification on the chromatin of these genes.Thus,we demonstrated that SPW2 can mediate the process of H3K27me3 modification of pistil-related genes to regulate their expression in non-pistil organs of spikelets in rice.The results of this study expand our understanding of the molecular mechanism by which SPW2 regulates floral organ identity genes through epigenetic regulation.

关键词： rice(Oryza sativa) spikelet organ identity H3K27me3

Characteristics of Migration Among HIV-Positive MSM—Guangxi Zhuang Autonomous Region,China,2005–2021

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China CDC weekly 2023年第13期5卷 287-291页

作者： Wenxuan Hou He Jiang Qiuying Zhu Jinghua Huang Jianjun Li Xiuling Wu Xuanhua Liu Nengxiu Liang Shuai Tang Qin Meng Bo Li Dongni Ding Ni Chen guanghua lan Guangxi University of Chinese Medicine Nanning CityGuangxi Zhuang Autonomous RegionChina Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Center for Disease Prevention and ControlNanning CityGuangxi Zhuang Autonomous RegionChina Youjiang Medical University for Nationalities Baise CityGuangxi Zhuang Autonomous RegionChina

Summary What is already known about this topic?Migration has a significant impact on the transmission of human immunodeficiency virus(HIV).To date,there have been few studies examining the characteristics of migration among HIV-positive men who have sex with men(MSM).What is added by this report?The prevalence of migrants among newly reported HIV-positive MSM in Guangxi Zhuang Autonomous Region increased from 2005 to 2021.Yulin Prefecture had the highest proportion of out-migrant MSM(12.6%),while Nanning Prefecture had the highest proportion of in-migrant MSM(55.9%).Risk factors associated with migration among MSM included being in the 18–24 age range,having a college education or higher,and being a student.

关键词： education Region Zhuang

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中等收入群体的规模测度与特征分析

武汉大学学报（哲学社会科学版） 2024年第3期77卷 133-146页

作者：朱兰万广华中国社会科学院数量经济与技术经济研究所、经济大数据与政策评估实验室北京100732 复旦大学世界经济研究所上海200433

中等收入标准的界定是精准施策扩大中等收入群体规模、实现高水平共同富裕的前提。基于共同富裕内涵与“尽力而为量力而行、逐步推进”的原则,提出新的中等收入标准界定方法,可以得到兼具全国统一标准与允许地区差异的中等收入标准。利... 详细信息

中等收入标准的界定是精准施策扩大中等收入群体规模、实现高水平共同富裕的前提。基于共同富裕内涵与“尽力而为量力而行、逐步推进”的原则,提出新的中等收入标准界定方法,可以得到兼具全国统一标准与允许地区差异的中等收入标准。利用1978-2020年全国的收入分组数据,以及1980-2020年31个省级层面的收入分组数据,采用模拟收入分布方法对个体数据进行还原,测算全国和不同省份中等收入群体模型和比重,结果发现:按国家统计局标准,我国中等收入群体规模不断扩大,2020年中等收入群体比重为36.79%;中等收入群体内部收入差距较大,脆弱程度较高;中等收入群体空间分布不均衡,具有东多西少的特征;五类人群是中等收入群体主要组成部分,规模总数为5亿人左右。最后,通过对标准、方法、数据和收入进行四维对比,论证研究结论可信,为进一步制定扩大中等收入群体比重政策提供有效支撑。

关键词：中等收入群体标准界定规模测度特征分析

Treatment outcomes of HIV patients with hepatitis B and C virus co-infections in Southwest China:an observational cohort study

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Infectious Diseases of Poverty 2022年第1期11卷 27-33页

作者： Jingya Jia Qiuying Zhu Luojia Deng guanghua lan Andrew Johnson Huanhuan Chen Zhiyong Shen Jianjun Li Hui Xing Yuhua Ruan Jing Li Hui Lu Sten H.Vermund Jinhui Zhu Han-Zhu Qian SJTU-Yale Joint Center for Biostatistics and Data Science Shanghai Jiao Tong UniversityShanghaiChina Department of Bioinformatics and Biostatistics School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response Guangxi Center for Disease Control and PreventionNanningChina Groton School GrotonMAUSA State Key Laboratory of Infectious Disease Prevention and Control(SKLID) Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina School of Public Health Yale UniversityNew HavenCTUSA

Background:Antiretroviral therapy(ART)has reduced mortality among people living with HIV(PLWH)in China,but co-infections of hepatitis B virus(HBV)and hepatitis C virus(HCV)may individually or jointly reduce the effect of ART.This study aimed to evaluate the impacts of HBV/HCV coinfections on treatment drop-out and mortality among PLWH on ART.Methods:A retrospective cohort study analysis of 58,239 people living with HIV(PLWH)who initiated antiretroviral therapy(ART)during 2010-2018 was conducted in Guangxi Province,China.Data were from the observational database of the National Free Antiretroviral Treatment Program.Cox proportional hazard models were fitted to evaluate the effects of baseline infection of HBV or HCV or both on death and treatment attrition among PLWH.Results:Our study showed high prevalence of HBV(11.5%),HCV(6.6%)and HBV-HCV(1.5%)co-infections.The overall mortality rate and treatment attrition rate was 2.95[95%confidence interval(CI):2.88-3.02]and 5.92(95%CI:5.82-6.01)per 100 person-years,respectively.Compared with HIV-only patients,HBV-co-infected patients had 42%higher mortality[adjusted hazard ratio(a HR)=1.42;95%CI 1.32-1.54],HCV-co-infected patients had 65%higher mortality(a HR=1.65;95%CI:1.47-1.86),and patients with both HCV and HBV co-infections had 123%higher mortality(a HR=2.23;95%CI:1.87-2.66).Conclusions:HBV and HCV coinfection may have an additive effect on increasing the risk of all-cause death among PLWH who are on ART.It is suggested that there is need for primary prevention and access to effective hepatitis treatment for PLWH.

关键词： Hepatitis C virus Hepatitis B virus HIV Antiretroviral therapy Mortality Retrospective cohort

基于地区线性矩法的四川省24 h极值降雨频率分析

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人民长江 2024年第1期55卷 113-119页

作者：胡静王帅人覃光华黎小东兰平四川大学水利水电学院四川成都610042

为探究四川省24 h极值降雨在不同重现期不同频率下的时空分布特征,采用地区线性矩法划分四川省水文气象一致区,确定最优拟合线型,并验证地区线性矩法在站点稀疏地区的适用性,随后估计四川省24 h不同重现期降雨频率值,分析其时空分布特... 详细信息

为探究四川省24 h极值降雨在不同重现期不同频率下的时空分布特征,采用地区线性矩法划分四川省水文气象一致区,确定最优拟合线型,并验证地区线性矩法在站点稀疏地区的适用性,随后估计四川省24 h不同重现期降雨频率值,分析其时空分布特征。研究结果表明:(1)四川省可划分为40个水文气象一致区,经线型拟合优度检验,主要线型为GLO、GEV和GNO,其中川西高原地区的最优线型大多为GLO,盆地区域的最优线型大多为GEV。(2)地区线性矩法在站点相对稀疏的川西高原地区具有良好的适用性。(3)四川省内不同地区24 h极值降雨空间分布十分不均,同一重现期下不同地区降雨频率估计值的最大值可达最小值的10倍。

关键词：极值降雨多重现期降雨频率地区线性矩法四川省

四川省小时极值降水统计参数空间分布特征研究

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四川水力发电 2024年第2期43卷 1-5,27页

作者：王帅人胡静兰平覃光华四川大学水利水电学院四川成都610065

笔者分别采用常规矩法与线性矩法分析了四川省328个站点的1、3小时的极值降水均值、偏差系数、偏态系数和峰度系数的空间分布特征。结果表明:四川省1、3小时极值降水均值、偏差系数、峰度系数分布均具有从川西高原向四川盆地逐渐增高的... 详细信息

笔者分别采用常规矩法与线性矩法分析了四川省328个站点的1、3小时的极值降水均值、偏差系数、偏态系数和峰度系数的空间分布特征。结果表明:四川省1、3小时极值降水均值、偏差系数、峰度系数分布均具有从川西高原向四川盆地逐渐增高的趋势;1、3小时极端降水偏差系数的高值中心分别位于川西高原与川东的德阳市与绵阳市,空间覆盖范围与四川省龙门山暴雨中心一致;极值降水偏态系数分布整体呈现由川西北向川东南递减的趋势,高值中心集中在四川盆地西部;1、3小时峰度系数高值中心分别出现在攀西地区南部和川西高原西部。研究成果在四川省中小流域山洪预报预警的防御工作中具有重要的参考价值。

关键词：线性矩法极值降水统计参数小时雨量

HIV非职业暴露后预防效果的影响因素研究现状

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黑龙江医学 2024年第12期48卷 1525-1527,1531页

作者：吴雨霏陈欢欢蓝光华广西壮族自治区疾病预防控制中心艾滋病防制所广西南宁530028

随着艾滋病防治领域的科技进步,艾滋病预防在生物医学干预方面也取得重大突破,暴露后药物预防技术仍为其中重要组成部分。国际多项研究表明,在特定亚人群中,采取艾滋病病毒暴露后预防用药具有显著预防人类免疫缺陷病毒(HIV)感染的效果... 详细信息

随着艾滋病防治领域的科技进步,艾滋病预防在生物医学干预方面也取得重大突破,暴露后药物预防技术仍为其中重要组成部分。国际多项研究表明,在特定亚人群中,采取艾滋病病毒暴露后预防用药具有显著预防人类免疫缺陷病毒(HIV)感染的效果。文章结合最新国际指南、临床研究数据,探讨影响暴露后药物预防实施效果的因素,为我国推广该策略提供参考。

关键词：人类免疫缺陷疾病非职业暴露后预防影响因素

Treatment for HIV prevention study in southwestern areas of China

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Infectious Disease Modelling 2018年第1期3卷 249-255页

作者： Huanhuan Chen Xiaoyi Yang Qiuying Zhu Xinghua Wu Li Chen Huaxiang Lu Liuhong Luo guanghua lan Xianming Ge Zhenzhu Tang Zhiyong Shen Stephen WPan Hui Xing Yuhua Ruan Yiming Shao Wenmin Yang Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention NanningGuangxiChina The Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital NanningChina Department of Public Health Xi'an Jiaotong Liverpool UniversitySuzhouChina State Key Laboratory of Infectious Disease Prevention and Control Chinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina

Background:China has ambitious to achieve significant reductions in HIV transmission and HIV-related mortality by adopting the World Health Organization's“Treat All”approach.Such a prevention strategy is needed future study on regional scale.Methods:An observational cohort study of HIV epidemiology and treatment databases was used to study the effectiveness of antiretroviral therapy on the transmission of HIV in serodiscordant couples in Guangxi of China.Results:A total of 7713 couples were entered into the cohort study analysis which included 1885 couples in the treatment-naive cohort and 5828 couples in the treated cohort.During the follow-up of 18985.29 person-years from 2003 to 2014,the average incidence of HIV was 2.4 per 100 person-years(95%CI 2.1e2.6).HIV seroincidence rate was significantly higher among the treatment naive group(4.2 per 100 person-years,3.7e4.8)compared with the on treatment group(1.6 per 100 person-years,1.3e1.8).An overall 45%reduction in risk of HIV transmission among serodiscordant couple was associated with ART treatment(adjusted Hazard Ratio[HR]0.55,95%Confidence Interval[CI]0.44e0.69).Treatment prevention had significantly effectiveness for most baseline characteristics of index partners,such as for male,female,age above 25 years,education below high school,farmer,infected by heterosexual intercourse.Conclusion:Treatment-as-prevention can be implemented in the real-world on a national or regional scale,but ART adherence and comprehensive harm reduction while implementing this strategy require further study.

关键词： HIV ART Sero-discordant couples Transmission Cohort study

广西壮族自治区2005-2021年抗病毒治疗男男性行为人群HIV感染者免疫重建及影响因素分析

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中华流行病学杂志 2024年第4期45卷 529-535页

作者：陈妮江河陈欢欢朱秋映吴秀玲李剑军梁能秀孟琴刘玄华黄精华侯文宣王昭荃蓝光华右江民族医学院公共卫生与管理学院百色533000 广西壮族自治区疾病预防控制中心南宁530028 广西中医药大学南宁530028

目的分析广西壮族自治区(广西)抗病毒治疗(ART)的MSM中HIV感染者(MSM感染者)实现免疫重建的比例及影响因素。方法资料来源于中国疾病预防控制信息系统,研究对象为2005-2021年广西首次接受ART≥24周MSM感染者,并维持24个月内HIV RNA低于... 详细信息

目的分析广西壮族自治区(广西)抗病毒治疗(ART)的MSM中HIV感染者(MSM感染者)实现免疫重建的比例及影响因素。方法资料来源于中国疾病预防控制信息系统,研究对象为2005-2021年广西首次接受ART≥24周MSM感染者,并维持24个月内HIV RNA低于检测限。计算其接受ART后免疫重建的比例,采用Cox比例风险回归模型分析其免疫重建的影响因素。采用SPSS 24.0软件进行统计学分析。结果在3200例MSM感染者中,免疫重建不良、中等免疫重建和完全免疫重建的比例分别为15.56%(498/3200)、14.78%(473/3200)和69.66%(2229/3200)。免疫重建的ART时间M(Q_(1),Q3)为12(5,27)个月。多因素Cox比例风险回归模型分析结果显示,相比于开始ART年龄≥30岁、WHO临床分期为Ⅲ期/Ⅳ期、基线BMI<18.50 kg/m^(2)和基线CD4^(+)T淋巴细胞(CD4)计数<200个/μl者,开始ART年龄<30岁、WHO临床分期为Ⅰ期/Ⅱ期、基线BMI≥24.00 kg/m^(2)和基线CD4计数≥200个/μl者更容易实现完全免疫重建。结论2005-2021年广西ART的MSM感染者存在一定比例的免疫重建不良者,应针对年龄较大者和基线CD4计数较低者等重点人群调整和优化ART方案及监测。

关键词：男男性行为人群艾滋病抗病毒治疗免疫重建