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Genes & Diseases 2024年第3期11卷 206-219页

作者： Shuyu Li Zichen Xu Yi Wang Lizhao Chen Xiangxiu Wang Yanghao Zhou Daoxi Lei guangchao zang Guixue Wang Key Laboratory of Biorheological Science and Technology of Ministry of Education National and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China College of Basic Medical Sciences Chongqing Medical UniversityChongqing 400016China Department of Neurosurgery Daping HospitalArmy Medical Center of PLAArmy Medical UniversityChongqing 400042China

Atherosclerotic cardiovascular disease and its complications are a high-incidence disease *** studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells,and it plays an important role in gene regulation of pro-inflammatory,pro-thrombotic,pro-oxidative stress,and cell *** impor-tant endothelial cell mechanosensitive genes have been discovered,including KLK10,CCN gene family,NRP2,YAP,TAZ,HIF-1α,NF-kB,FOS,JUN,TFEB,KLF2/KLF4,NRF2,and *** of them have been intensively studied,whereas the relevant regulatory mechanism of other genes remains *** on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular ***,this article reviews the mechanosensitive genes affecting vascular endothelial cells,including classical pathways and some newly screened genes,and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights foranti-atherosclerosis.

关键词： Atherosclerosis Blood flow Endothelial cell Mechanosensitive gene Therapeutic target

A Novel Poly(3-hexylthiophene) Engineered Interface for Electrochemical Monitoring of Ascorbic Acid During the Occurrence of Glutamate-Induced Brain Cytotoxic Edemas

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Research 2024年第1期2023卷 301-313页

作者： Zexuan Meng Yuchan Zhang Lu Yang Shuang Zhao Qiang Zhou Jiajia Chen Jiuxi Sui Jian Wang Lizhong Guo Luyue Chang Jialing He Guixue Wang guangchao zang Institute of Life Science and Laboratory of Tissue and Cell BiologyLab Teaching and Management CenterChongqing Medical UniversityChongqing 400016China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China Jinfeng Laboratory Chongqing 401329China Department of Pathophysiology Chongqing Medical UniversityChongqingChina

Although neuroelectrochemical sensing technology offers unique benefits for neuroscience research,its application is limited by substantial interference in complex brain environments while ensuring biosafety *** this study,we introduced poly(3-hexylthiophene)(P3HT)and nitrogen-doped multiwalled carbon nanotubes(N-MWCNTs)to construct a composite membrane-modified carbon fiber microelectrode(CFME/P3HT-N-MWCNTs)for ascorbic acid(AA)*** microelectrode presented good linearity,selectivity,stability,antifouling,and biocompatibility and exhibited great performance for application in neuroelectrochemical ***,we applied CFME/P3HT-N-MWCNTs to monitor AA release from in vitro nerve cells,ex vivo brain slices,and in vivo living rat brains and determined that glutamate can induce cell edema and AA *** also found that glutamate activated the N-methyl-d-aspartic acid receptor,which enhanced Na^(+) and Cl^(−) inflow to induce osmotic stress,resulting in cytotoxic edema and ultimately AA *** study is the first to observe the process of glutamate-induced brain cytotoxic edema with AA release and to reveal the *** work can benefit the application of P3HT in in vivo implant microelectrode construction to monitor neurochemicals,understand the molecular basis of nervous system diseases,and discover certain biomarkers of brain diseases.

关键词： release microelectrode Engine

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医学本科生创新能力培养的实践与改革探索

中华医学教育探索杂志 2024年第3期23卷 378-382页

作者：郭利忠臧广超重庆医科大学实验教学管理中心重庆400061

重庆医科大学重视本科生创新能力的培养,并通过加强基础医学理论与实践相结合的方式来培养学生创新能力。近年来,借助"大创项目""大创平台"及卓越医学本科生导师制科研项目深化培养了医学本科生创新能力,医学生在科研论文发表、各类科... 详细信息

重庆医科大学重视本科生创新能力的培养,并通过加强基础医学理论与实践相结合的方式来培养学生创新能力。近年来,借助"大创项目""大创平台"及卓越医学本科生导师制科研项目深化培养了医学本科生创新能力,医学生在科研论文发表、各类科学竞赛及专利申请等方面都取得了较好成绩。但在医学本科生创新能力的培养实践中也发现存在低年级学生医学背景知识薄弱、导师专业单一、平台仪器设备不足等问题,因此需要改革医学本科生创新能力培养方式。基于此,课题组在广泛调查研究后从学生、导师和管理机制3个方面提出针对性的改进对策,以期为医学本科生创新能力培养机制的深化改革提供新线索。

关键词：医学本科生创新能力科研思维人才培养

Shear stress regulation of nanoparticle uptake in vascular endothelial cells

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Regenerative Biomaterials 2023年第1期10卷 1048-1059页

作者： Hongping Zhang Ziqiu Hu Jinxuan Wang Jianxiong Xu Xiangxiu Wang guangchao zang Juhui Qiu Guixue Wang Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China Lab Teaching&Management Center Chongqing Medical UniversityChongqing 400016China JinFeng Laboratory Chongqing 401329China

Nanoparticles(NPs)hold tremendous targeting potential in cardiovascular disease and regenerative medicine,and exciting clinical applications are coming into *** endothelial cells(ECs)exposure to different magnitudes and patterns of shear stress(SS)generated by blood flow could engulf NPs in the ***,an unclear understanding of the role of SS on NP uptake is hindering the progress in improving the targeting of NP ***,the temporal and spatial distribution of SS in vascular ECs and the effect of different SS on NP uptake in ECs are *** mechanism of SS affecting NP uptake through regulating the cellular ROS level,endothelial glycocalyx and membrane fluidity is summarized,and the molecules containing clathrin and caveolin in the engulfment process are *** targeting NPs are expected to overcome the current bottlenecks and change the field of targeting *** assessment on how SS affects the cell uptake of NPs and the marginalization of NPs in blood vessels could guide future research in cell biology and vascular targeting drugs.

关键词： shear stress nanoparticle uptake endothelial cell clathrin caveolin

Cell-derived biomimetic nanoparticles as a novel drug delivery system for atherosclerosis:predecessors and perspectives

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Regenerative Biomaterials 2020年第4期7卷 349-358页

作者： Long Yang guangchao zang Jingwen Li Xinyue Li Yuanzhu Li Yinping Zhao Laboratory of Tissue and Cell Biology Lab Teaching&Management CenterChongqing Medical UniversityNO.1 Medical College RoadYuzhong DistrictChongqing 400016China

Atherosclerosis is a key mechanism underlying the pathogenesis of cardiovascular disease,which is associated with high morbidity and *** the field of precision medicine for the treatment of atherosclerosis,nanoparticle(NP)-mediated drug delivery systems have great potential,owing to their ability to release treatment ***-derived biomimetic NPs have attracted extensive attention at present due to their excellent targeting to atherosclerotic inflammatory sites,low immunogenicity and long blood circulation ***,we review the utility of cell-derived biomimetic NPs,including whole cells,cell membranes and extracellular vesicles,in the treatment of atherosclerosis.

关键词： atherosclerosis nanoparticle cell membrane extracellular vesicle

Particle Size-Controlled Oxygen Reduction and Evolution Reaction Nanocatalysts Regulate Ru(bpy)_(3)^(2+)’s Dual-potential Electrochemiluminescence for Sandwich Immunoassay

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Research 2023年第4期2023卷 701-715页

作者： Shijun Wang Shu Zhu Ziqi Kang Xiangxiu Wang Zixin Deng Kun Hu Jianjun Hu Xiancheng Liu Guixue Wang guangchao zang Yuchan Zhang Institute of Life Science and Laboratory of Tissue and Cell Biology Lab Teaching&Management CenterChongqing Medical UniversityChongqing 400016China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China Jinfeng Laboratory Chongqing 401329China Department of Pathophysiology Chongqing Medical UniversityChongqing 400016China Department of Pathology Guizhou Provincial People’s HospitalGuiyangGuizhou 550002China

Multiple signal strategies remarkably improve the accuracy and efficiency of electrochemiluminescence(ECL)immunoassays,but the lack of potential-resolved luminophore pairs and chemical cross talk hinders their *** this study,we synthesized a series of gold nanoparticles(AuNPs)/reduced graphene oxide(Au/rGO)composites as adjustable oxygen reduction reaction and oxygen evolution reaction catalysts to promote and modulate tris(2,2′-bipyridine)ruthenium(II)(Ru(bpy)_(3)^(2+))’s multisignal *** the increase in the diameter of AuNPs(3 to 30 nm),their ability to promote Ru(bpy)_(3)^(2+)’s anodic ECL was first impaired and then strengthened,and cathodic ECL was first enhanced and then ***/rGOs with medium-small and medium-large AuNP diameters remarkably increased Ru(bpy)_(3)^(2+)’s cathodic and anodic luminescence,***,the stimulation effects of Au/rGOs were superior to those of most existing Ru(bpy)_(3)^(2+)***,we proposed a novel ratiometric immunosensor construction strategy using Ru(bpy)_(3)^(2+)’s luminescence promoter rather than luminophores as tags of antibodies to achieve signal *** method avoids signal cross talk between luminophores and their respective co-reactants,which achieved a good linear range of 10−7 to 10−1 ng/ml and a limit of detection of 0.33 fg/ml for detecting carcinoembryonic *** study addresses the previous scarcity of the macromolecular co-reactants of Ru(bpy)_(3)^(2+),broadening its application in biomaterial ***,the systematic clarification of the detailed mechanisms for converting the potential-resolved luminescence of Ru(bpy)_(3)^(2+)could facilitate an in-depth understanding of the ECL process and should inspire new designs of Ru(bpy)_(3)^(2+)luminescence enhancers or applications of Au/rGOs to other *** work removes some impediments to the development of multisignal ECL biodetection systems and provides vitality into their

关键词： luminescence potential reactant

Sprayed PAA-CaO_(2)nanoparticles combined with calcium ions and reactive oxygen species for antibacterial and wound healing

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Regenerative Biomaterials 2023年第1期10卷 1356-1371页

作者： Hong Yu Jiale Sun Kepeng She Mingqi Lv Yiqiao Zhang Yawen Xiao Yangkun Liu Changhao Han Xinyue Xu Shuqing Yang Guixue Wang guangchao zang Tissue and Cell Biology Lab Teaching&Management CenterChongqing Medical UniversityChongqing 400016China Chongqing University Central Hospital Chongqing Emergency Medical CenterChongqing 400030China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China Jinfeng Laboratory Chongqing 401329China

The most common socioeconomic healthcare issues in clinical are burns,surgical incisions and other skin *** lesion healing can be achieved with nanomedicines and other drug application *** study developed a nano-spray based on cross-linked amorphous calcium peroxide(CaO_(2))nanoparticles of polyacrylic acid(PAA)for treating skin wounds(PAA-CaO_(2)nanoparticles).CaO_(2)serves as a‘drug’precursor,steadily and continuously releasing calcium ions(Ca2+)and hydrogen peroxide(H2O_(2))under mildly acidic conditions,while PAA-CaO_(2)nanoparticles exhibited good spray behavior in aqueous *** demonstrated that PAA-CaO_(2)nanoparticles exhibited low cytotoxicity and allowed L929 cells proliferation and migration in *** effectiveness of PAA-CaO_(2)nanoparticles in promoting wound healing and inhibiting bacterial growth in vivo was assessed in SD rats using full-thickness skin defect and Staphylococcus aureus(***)-infected wound models based *** results revealed that PAA-CaO_(2)nanoparticles demonstrated significant advantages in both ***,the infected rats’skin defects healed in 12 *** benefits are linked to the functional role of Ca^(2+)coalesces with H2O_(2)as known antibacterial and healing-promoted ***,we developed nanoscale PAA-CaO_(2)sprays to prevent bacterial development and heal skin lesions.

关键词： polyacrylic acid calcium peroxide nanomedicines antibacterial wound healing

A novel mechanism of inhibiting in-stent restenosis with arsenic trioxide drug-eluting stent: Enhancing contractile phenotype of vascular smooth muscle cells via YAP pathway

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Bioactive Materials 2021年第2期6卷 375-385页

作者： Yinping Zhao guangchao zang Tieying Yin Xiaoyi Ma Lifeng Zhou Lingjuan Wu Richard Daniel Yunbing Wang Juhui Qiu Guixue Wang Laboratory of Tissue and Cell Biology Lab Teaching&Management CenterChongqing Medical UniversityChongqing400016China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing400030China Beijing Amsinomed Medical Co. LtdBeijing100021China Medical School Newcastle UniversityNewcastle Upon TyneNE24AXUK National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610065China

Objective:Arsenic trioxide(ATO or As2O3)has beneficial effects on suppressing neointimal hyperplasia and restenosis,but the mechanism is still *** goal of this study is to further understand the mechanism of ATO's inhibitory effect on vascular smooth muscle cells(VSMCs).Methods and results:Through in vitro cell culture and in vivo stent implanting into the carotid arteries of rabbit,a synthetic-to-contractile phenotypic transition was induced and the proliferation of VSMCs was inhibited by ATO.F-actin filaments were clustered and the elasticity modulus was increased within the phenotypic modulation of VSMCs induced by ATO in ***,Yes-associated protein(YAP)nuclear translocation was inhibited by ATO both in vivo and in *** was found that ROCK inhibitor or YAP inactivator could partially mask the phenotype modulation of ATO on ***:The interaction of YAP with the ROCK pathway through ATO seems to mediate the contractile phenotype of *** provides an indication of the clinical therapeutic mechanism for the beneficial bioactive effect of ATO-drug eluting stent(AES)on in-stent restenosis(ISR).

关键词： Arsenic trioxide(ATO) Bioactive Yes-associated protein(YAP) In-stent restenosis(ISR)

卓越医学本科生导师制培养中思政教育模式的探索

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医学教育研究与实践 2024年第1期32卷 17-22,31页

作者：张光媛郭利忠陈婷婷刘倩侯毅赵银瓶臧广超刘利舲重庆医科大学实验教学管理中心重庆401334

思政教育是目前高校教育教学改革关注的焦点。重庆医科大学卓越医学本科生导师制(EMTS)是以培养“医学拔尖创新人才”为目标的课外科研创新项目,且在本校医学拔尖创新人才培养方面取得了优异的成绩。分析EMTS项目培养中思政教育的现状... 详细信息

思政教育是目前高校教育教学改革关注的焦点。重庆医科大学卓越医学本科生导师制(EMTS)是以培养“医学拔尖创新人才”为目标的课外科研创新项目,且在本校医学拔尖创新人才培养方面取得了优异的成绩。分析EMTS项目培养中思政教育的现状及存在的问题,探讨了在EMTS全流程培养中导师育人,课程育人,及科研活动育人“三位一体”思政教育模式的实施过程与方法,并总结了该思政教育模式目前的实践成效。该研究进一步拓展并完善了EMTS项目的培养目标,实现了EMTS项目的思政教育功能,为高校医学拔尖创新人才思想政治教育提供参考。

关键词： EMTS项目导师制医学拔尖创新人才思政教育

A novel method for modeling the phase change of iron ore particles in the cohesive zone of a blast furnace

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Particuology 2024年第3期86卷 252-261页

作者： Dianyu E Yingming Wen Jiayun Dan Youyuan Jiang guangchao Wei Jiaxin Cui Jiangxi Provincial Key Laboratory for Simulation and Modelling of Particulate Systems Jiangxi University of Science and TechnologyNanchang330013China International Institute for Innovation Jiangxi University of Science and TechnologyNanchang330013China Ironmaking Plant Xiangtan Iron and Steel Corporation of Hunan HualingXiangtan411101China Schoolof Transportation and Vehicle Enginering Shandong University of TechnologyZibo255000China

Cohesive zone plays a vital role in the stable operation of a blast furnace(BF),yet the complex phase change process of iron ore particles in this zone is still not well *** this study,a novel one-dimensional(1D)unsteady phase change model was developed to elucidate the heat transfer and melting mechanisms of iron ore *** model validation,the effects of several key operating parameters(e.g.,particle diameter,gas velocity,initial temperature)on the phase change behavior of iron ore particles were analyzed,and the joint effect of multiple parameters was *** results show that larger-sized iron ore particles possess lower specific surface areas,which in turn reduces their convective heat absorption ***,the distance from the solid-liquid phase interface to the particle surface increases,thereby slowing down the movement of the phase interface and pro-longing the melting duration of the *** the gas velocity and the initial temperature does not have a significant impact on reducing the duration of the complete melting *** the specified conditions,it is observed that increasing the gas velocity by 3-fold and 9-fold results in a reduction of the melting duration by 2.4%and 8.3%,*** the initial temperature of iron ore particles results in a decrease in the core-to-surface temperature difference,a slower heating rate,and a shorter duration to achieve *** the factors affecting the melting process,the particle diameter is found to be the most significant in terms of the liquid phase precipitation,mushy zone thickness,and core-to-surface temperature difference of iron ore particles.

关键词： Blast furnace Iron ore melting Cohesive zone Heat transfer Phase change