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TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

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Zoological Research 2024年第4期45卷 937-950页

作者： Yi-Fu Zhu Rong-Hua Yu Shuai Zhou Pei-Pei Tang Rui Zhang Yu-Xin Wu Ran Xu Jia-Ming Wei Ying-Ying Wang Jia-Li Zhang Meng-Ke Li Xiao-Jing shi Yu-Wei Zhang guang-Zhi Liu Rick FThorne Xu Dong Zhang Mian Wu Song Chen School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Translational Research Institute of Henan Provincial People’s Hospital and People'’s Hospital of Zhengzhou University Tianjian Laboratory of Advanced Biomedical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450053China Institute of Medicinal Biotechnology Jiangsu College of NursingHuai’anJiangsu 223300China Laboratory Animal Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Henan Key Laboratory of Stem cell Differentiation and Modification Henan Provincial People’s HospitalHenan UniversityZhengzhouHenan 450053China School of Biomedical Sciences and Pharmacy The University of NewcastleNSW 2308Australia

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental *** highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained ***,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in *** deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse ***,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate ***,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this ***,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO ***,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

关键词： Non-canonical autophagy TAX1BP1 FIP200 p62 Aggregates Neural stem cell

不同通气量下双发航行体水下齐射降载增稳特性研究

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工程力学 2024年第10期41卷 247-256页

作者：高山施瑶潘光权晓波西北工业大学航海学院陕西西安710072 无人水下运载技术重点实验室陕西西安710072 北京宇航系统工程研究所北京100076

基于重叠网格技术,VOF(volume of fluid)多相流模型以及改进型分离涡模型相结合方法,建立了基于主动通气下双体水下齐射降载增稳数值方法,分析了通气量对空泡形态、载荷特性及运动稳定性的影响规律。结果表明:在一定范围内,随着通气量... 详细信息

基于重叠网格技术,VOF(volume of fluid)多相流模型以及改进型分离涡模型相结合方法,建立了基于主动通气下双体水下齐射降载增稳数值方法,分析了通气量对空泡形态、载荷特性及运动稳定性的影响规律。结果表明:在一定范围内,随着通气量的增加,当通气空泡完全包裹航行体孔口下方区域后,横向载荷幅值和交变峰值均减小,同时,产生的扶偏力矩能够大幅度减小双发航行体之间狭长流域产生的流动干扰现象。另外,为了避免发生共振现象,设计航行体时应尽量使其固有频率在通气效应产生的低频范围之外。综合分析,主动通气方式对多体水下齐射运动姿态的不稳定性具有较好的改善作用。

关键词：水下齐射通气重叠网格通气量偏转角

Recognition of Blast Furnace Gas Flow Center Distribution Based on Infrared Image Processing

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Journal of Iron and Steel Research International 2016年第3期23卷 203-209页

作者： Lin shi you-bin WEN guang-sheng ZHAO Tao YU School of Mathematics and Physics and Biological Engineering University of Science and Technology of Inner Mongolia School of Materials and Metallurgy University of Science and Technology of Inner Mongolia

To address the problems about the difficulty in accurate recognition of distribution features of gas flow center at blast furnace throat and determine the relationship between gas flow center distribution and gas utilization rate,a method for recognizing distribution features of blast furnace gas flow center was proposed based on infrared image processing,and distribution features of blast furnace gas flow center and corresponding gas utilization rates were categorized by using fuzzy C-means clustering and statistical methods.A concept of gas flow center offset was *** results showed that,when the percentage of gas flow center without offset exceeded 85%,the average blast furnace gas utilization rate was as high as 41%;when the percentage of gas flow center without offset exceeded50%,the gas utilization rate was primarily the center gas utilization rate,and exhibited a positive correlation with no center offset degree;when the percentage of gas flow center without offset was below 50% but the sum of the percentage of gas flow center without offset and that of gas flow center with small offset exceeded 86%,the gas utilization rate depended on both the center and the edges,and was primarily the edge gas utilization *** method proposed was able to accurately and effectively recognize gas flow center distribution state and the relationship between it and gas utilization rate,providing evidence in favor of on-line blast furnace control.

关键词： infrared image processing gas flow center recognition gas utilization rate fuzzy C-means clustering

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膨胀土路堑边坡柔性加固方法及现场监测

中国公路学报 2024年第6期37卷 87-97页

作者：张锐凌时光郑健龙周豫王欢长沙理工大学交通运输工程学院湖南长沙410114 长沙理工大学极端环境绿色长寿道路工程全国重点实验室湖南长沙410114 长沙理工大学道路灾变防治及交通安全教育部工程研究中心湖南长沙410114

为了提出一种用于新开挖膨胀土路堑边坡加固的方法并揭示其作用机理,设计了一种柔性面层+土钉加固结构,并建立了相应设计方法;依托云南某高速公路弱膨胀土路堑边坡加固工程,进行了加固结构设计计算及现场试验;开展了加固结构的受力及变... 详细信息

为了提出一种用于新开挖膨胀土路堑边坡加固的方法并揭示其作用机理,设计了一种柔性面层+土钉加固结构,并建立了相应设计方法;依托云南某高速公路弱膨胀土路堑边坡加固工程,进行了加固结构设计计算及现场试验;开展了加固结构的受力及变形监测,探究了加固结构的作用机理。研究结果表明:当柔性面层允许边坡法向发生3.0%的膨胀变形时,所受到的法向膨胀应力可较不允许发生膨胀变形时下降61.1%,设计的柔性加固结构可满足稳定性的要求。一年内,在雨季土钉中部轴力普遍出现增长,在旱季离坡面较近的土钉端头轴力显著减小;土钉轴力沿土钉长度方向总体呈现“中间大,两端小”分布,与锚杆框架梁相比,受力更为均匀;柔性面层网面的最大拉应变均出现在阶段性停雨后,具有明显的滞后性,且远小于材料极限伸长率;坡面土压力变化与高强加筋三维网应变变化规律基本一致,雨季呈波动增长,旱季缓慢回落,坡面土压力增值与计算所得膨胀力接近;随着土体雨季增湿膨胀、旱季干燥收缩,钢缆绳轴力变化呈现出缓慢增长、持续衰减及逐渐稳定3个阶段;3个监测点位中边坡坡顶水平位移最大,为5.4 mm,边坡整体稳定。监测结果综合反映了柔性加固结构“以柔治胀”的作用机理。所得结论可为新开挖膨胀土边坡的加固设计和施工提供参考。

关键词：路基工程膨胀土边坡现场监测柔性加固膨胀力

Two stages power generation test of the hot dry rock exploration and production demonstration project in the Gonghe Basin,northeastern Qinghai-Tibet plateau,China

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China Geology 2024年第3期7卷 409-421页

作者： Er-yong Zhang Dong-guang Wen Gui-ling Wang Xian-peng Jin Lin-you Zhang Hai-dong Wu Wen-shi Wang Cheng-ming Ye Wei Weng Kuan Li Jin-sheng Wu Xian-chun Tang Chong-yuan Zhang Qing-da Feng Sheng Lian Li-sha Hu Gui-lin Zhu Xing-long Xie Bin Wu Dan Wang Xue Niu Zhao-xuan Niu Dong-lin Liu Hui Zhang Wen-hao Xu Shu-qing Yao Li Yang Center for Hydrogeology and Environmental Geology Survey China Geological SurveyMinistry of Natural ResourcesTianjin 300304China Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesChina Geological SurveyShijiazhuang 050061China Institute of Exploration Techniques Chinese Academy of Geological SciencesChina Geological SurveyLangfang 065000China Institute of Exploration Engineering China Geological SurveyMinistry of Natural ResourcesBeijing 100083China Institute of Exploration Technology Chinese Academy of Geological SciencesChengdu 611734China Chinese Academy of Geological Sciences China Geological SurveyBeijing 100037China Institute of Geomechanics Chinese Academy of Geological SciencesChina Geological SurveyBeijing 100081China Geoscience Documentation Center China Geological SurveyMinistry of Natural ResourcesBeijing 100083China

The Hot Dry Rock(HDR)is considered as a clean and renewable energy,poised to significantly contribute to the global energy decarbonization *** HDR projects worldwide have accumulated valuable experience in efficient drilling and completion,reservoir construction,and fracture *** 2019,China Geological Survey(CGS)initiated a demonstration project of HDR exploration and production in the Gonghe Basin,aiming to overcome the setbacks faced by HDR *** the ensuing four years,the Gonghe HDR project achieved the first power generation in 2021,followed by the second power generation test in *** establishing the primary well group in the initial phase,two directional wells and one branch well were *** progress was made in successfully constructing the targeted reservoir,realizing inter-well connectivity,power generation and grid connection,implementing of the real-time micro-seismic monitoring.A closed-loop technical validation of the HDR exploration and production was ***,many technical challenges remain in the process of HDR industrialization,such as reservoir fracture network characterization,efficient drilling and completion,multiple fracturing treatment,continuous injection and production,as well as mitigation of induced seismicity and numerical simulation technology.

关键词： Power generation Hot dry rock(HDR) Enhanced geothermal system(EGS) Genesis mechanism Gonghe Basin Directional drilling Reservoir construction Circulation test Induced seismicity Clean energy exploration engineering

习近平关于自由贸易试验区建设重要思想的形成逻辑、科学内涵与实践方略

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经济学家 2024年第1期 5-13页

作者：李光辉程仕杰广西大学经济学院

习近平关于自由贸易试验区建设重要思想是党的十八大以来党和国家以自由贸易试验区扩大对外开放、构建开放型经济新体制的理论与实践的结晶,是习近平经济思想的重要内容。这一思想是对马克思主义经典作家关于对外开放观的继承与发展,是... 详细信息

习近平关于自由贸易试验区建设重要思想是党的十八大以来党和国家以自由贸易试验区扩大对外开放、构建开放型经济新体制的理论与实践的结晶,是习近平经济思想的重要内容。这一思想是对马克思主义经典作家关于对外开放观的继承与发展,是以经济现代化全面推进中华民族伟大复兴的重要实践,是对我国经济发展面对的重大问题的解答。其内涵可以概括为“五个坚持”,即坚持创新理念、坚持开放理念、坚持先行先试理念、坚持高标准发展理念、坚持产业优先理念。新时期全面落实习近平关于自由贸易试验区建设的重要思想,需要加强顶层设计、统筹谋划,重点突破、解决好主要问题,探索差异化发展路径,统筹发展与安全。

关键词：自由贸易试验区对外开放建设思想实践方略

习近平总书记关于新质生产力重要论述的整体逻辑

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经济问题 2024年第7期 11-19页

作者：周世露乔光辉东南大学人文学院江苏南京210096

习近平总书记关于新质生产力重要论述内蕴着符合新发展理念的理论逻辑。它以创新动力论揭示了“科技创新是发展新质生产力的核心要素”的发展动力逻辑,以协调跃升论揭示了“劳动者、劳动资料、劳动对象及其优化组合的跃升”的发展平衡逻... 详细信息

习近平总书记关于新质生产力重要论述内蕴着符合新发展理念的理论逻辑。它以创新动力论揭示了“科技创新是发展新质生产力的核心要素”的发展动力逻辑,以协调跃升论揭示了“劳动者、劳动资料、劳动对象及其优化组合的跃升”的发展平衡逻辑,以绿色底色论揭示了“新质生产力本身就是绿色生产力”的发展持续逻辑,以开放环境论揭示了“要扩大高水平对外开放,为发展新质生产力营造良好国际环境”的发展联动逻辑,以共享价值论揭示了“使发展成果更多更公平惠及全体人民”的发展公平逻辑,以实践方法论揭示了“坚持从实际出发,先立后破、因地制宜、分类指导”的发展思路逻辑。总之,深入理解习近平总书记关于新质生产力重要论述的整体逻辑,有助于指导新质生产力实践。

关键词：新质生产力理论新发展理念高质量发展

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颜之推美学思想的双重特质及其辩证关系

南通大学学报（社会科学版） 2024年第2期40卷 32-40页

作者：周世露乔光辉东南大学人文学院

《颜氏家训》是颜之推美学思想的重要文本。通过对其研究,发现颜之推美学思想蕴含着“以典正为本”的依存美和“尚文外之致”的纯粹美双重特质。前者主要强调其美学思想中蕴含的依赖伦理道德规范和注重保存生命等具有功利性的方面,后者... 详细信息

《颜氏家训》是颜之推美学思想的重要文本。通过对其研究,发现颜之推美学思想蕴含着“以典正为本”的依存美和“尚文外之致”的纯粹美双重特质。前者主要强调其美学思想中蕴含的依赖伦理道德规范和注重保存生命等具有功利性的方面,后者主要强调其美学思想中蕴含的鼓励追求心灵自由畅快和审美愉悦的方面。这两种特质虽然彼此独立,但是又相互统一。在文章的形式与内容方面,展现内容正统的依存美与彰显形式个性的纯粹美实现融合。在古今文体方面,依存美与纯粹美均应以古为本、以今为末,不能偏废。在文学艺术的功用方面,重实用的依存美与重审美的纯粹美相互补充。

关键词：颜之推依存美纯粹美《颜氏家训》

Entanglement quantification via weak measurements assisted by deep learning

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Photonics Research 2024年第4期12卷 712-719页

作者： MU YANG YA XIAO ZE-YAN HAO YU-WEI LIAO JIA-HE CAO KAI SUN EN-HUI WANG ZHENG-HAO LIU YUTAKA shiKANO JIN-shi XU CHUAN-FENG LI guang-CAN GUO CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China College of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao 266100China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Electric Power Research Institute State Grid Anhui Electric Power Co.Ltd.Hefei 230601China Institute of Systems and Information Engineering University of TsukubaIbaraki 305-8573Japan Center for Artificial Intelligence Research University of TsukubaIbaraki 305-8577Japan Graduate School of Science and Technology Gunma UniversityGunma 371-8510Japan Institute for Quantum Studies Chapman UniversityOrangeCalifornia 92866USA JST PRESTO Saitama 332-0012Japan

Entanglement has been recognized as being crucial when implementing various quantum information ***, quantifying entanglement for an unknown quantum state requires nonphysical operations or post-processing measurement data. For example, evaluation methods via quantum state tomography require vast amounts of measurement data and likely estimation.

关键词： estimation quantum angle