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Microwave-activated Coupling Reaction on Polyethylene Glycol

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Chinese Chemical Letters 2002年第1期13卷 1-2页

作者： Min XIA yan guang wang Department of Chemistry Zhejiang UniversityHangzhou 310027

The two-step Sonogashira coupling reaction took place rapidly under microwave activation conditions. PEG bound substrates acted as PTC and polymer support as well. Its yields are 80~90% and the products are in high pu... 详细信息

关键词： Microwave-activated coupling and cleavage PEG liquid-phase.

Solid-Phase Total Synthesis of 1-β-Methylcarbapenem

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Chinese Chemical Letters 2003年第1期14卷 6-8页

作者： Ming LEI Cheng MA yan guang wang Department of Chemistry Zhejiang UniversityHangzhou 310027

A 1-b-methylcarbapenem analogue 6 was synthesized on polystyrene-diethylsilane resin (PS-DES) using 2-azetidinone bearing with 2-oxazolidone chiral auxiliary as starting material.

关键词： Solid-phase synthesis of b-lactam carbapenem antibiotics.

4-(Benzylamino)formoyldiphenylammonium Triflate (BDPAT):An Efficient, Recoverable Biphasic Catalyst For Esterification of Carboxylic Acids with Equimolar Amounts of Alcohols

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Chinese Chemical Letters 2002年第6期13卷 487-488页

作者： Ming LEI Cheng MA yan guang wang Department of Chemistry Zhejiang UniversityHangzhou 310027

Esterification of carboxylic acid with equimolar amounts alcohol can be efficiently catalyzed by biphasic 4-(benzylamino)formoyldiphenylammonium triflate (BDPAT, 3) in good yield. The catalyst can be easily recovered... 详细信息

关键词： Benzylamino)formoyldiphenylammonium triflate biphasic catalyst esterification.

Emerging novel targets for nonalcoholic fatty liver disease treatment: Evidence from recent basic studies

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World Journal of Gastroenterology 2023年第1期29卷 75-95页

作者： guang-yan wang Xiao-yan Zhang Chun-Jiong wang You-Fei Guan Department of Physiology and Pathophysiology Tianjin Medical UniversityTianjin 300070China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Tianjin 300070China NHC Key Laboratory of Hormones and Development Chu Hsien-I Memorial Hospital and Tianjin Institute of EndocrinologyTianjin 300070China Health Science Center East China Normal UniversityShanghai 200241China Advanced Institute for Medical Sciences Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Department of Physiology and Pathophysiology School of Basic Medical SciencesDalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Key Laboratory for Nuclear Receptors in Major Metabolic Diseases Dalian 116044Liaoning ProvinceChina

Nonalcoholic fatty liver disease(NAFLD),a leading chronic disease worldwide,affects approximately a quarter of the global *** steatohepatitis(NASH)is an advanced form of NAFLD and is more likely to progress to liver fibrosis than simple *** is also identified as the most rapidly growing cause of hepatocellular *** in the past decade,several phase II/III clinical trials have shown promising results in the use of novel drugs targeting lipid synthase,farnesoid X receptor signaling,peroxisome proliferatoractivated receptor signaling,hepatocellular injury,and inflammatory signaling,proven pharmaceutical agents to treat NASH are still ***,continuous exploration of the mechanism underlying the pathogenesis of NAFLD and the identification of novel therapeutic targets remain urgent tasks in the *** the current review,we summarize studies reported in recent years that not only provide new insights into the mechanisms of NAFLD development but also explore the possibility of treating NAFLD by targeting newly identified signaling *** also discuss evidence focusing on the intrahepatic targets involved in the pathogenesis of NAFLD as well as extrahepatic targets affecting liver metabolism and function.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Pharmaceutical strategies Liver microenvironment Gut-liver axis Adipose tissue-liver axis

Synthesis of Novel Spin Labeled Daunomycin Derivatives

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Chinese Chemical Letters 2001年第6期12卷 483-484页

作者： Shu Jia ZHANG yan guang wang Ju Biao LI Department of Chemistry Zhejiang UniversityHangzhou 310027

Three spin labeled daunomycin derivatives 2-4 were synthesized and their biological activities were tested against mouse leukemia L1210 and human liver cancer BEL-7402 cells in vitro.

关键词： Spin labeled daunomycin derivatives antitumor activity synthesis

A Facile Approach to Regioselective 1-O-Deacylation of Peracylated Glycopyranoses

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Chinese Chemical Letters 2003年第3期14卷 233-234页

作者： Jia Qiang DONG Shu Jia ZHANG yan guang wang Department of Chemistry Zhejiang UniversityHangzhou 310027

The regioselective 1-O-deacylation of peracylated glycopyranoses 1a-d with zinc chloride and zinc oxide in THF/MeOH gave the corresponding tetra-O-acylglycopyranoses 2a-d in good yields.

关键词： Hydroxy sugars oligosaccaride zinc chloride.

Soluble Polymer-supported Synthesis of Indoles via Palladium-mediat-ed Heteroannulation of Terminal Alkynes with o-Iodoanilines

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Chinese Chemical Letters 2002年第8期13卷 705-707页

作者： Xu Feng LIN Cheng MA Ye Wei yanG yan guang wang Department of Chemistry Zhejiang UniversityHangzhou 310027

A soluble polymer-supported synthesis of indoles via palladium-mediated hetero- annulation of terminal alkynes with o-iodoanilines has been described. The protocol provides a useful tool for constructing combinatoria... 详细信息

关键词： Indole polyethylene glycol(PEG) liquid-phase.

A Facile and Efficient Synthesis of Substituted Pyrroles by Three Component Coupling Reaction of Amines, Aldehydes and Nitroalkanes

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Chinese Chemical Letters 2003年第9期14卷 893-896页

作者： Yi Song XIAO, yan guang wang Department of Chemistry, Zhejiang University, Hangzhou 310027 Department of Chemistry Zhejiang University Hangzhou 310027

A facile and efficient synthesis of highly substituted pyrroles has been achieved by a one-pot three-component coupling reaction of aldehyde, amine and nitroalkane by triethyl orthoformate.

关键词： Pyrrole nitroalkane aldehyde.

Total synthesis of glypetelotine

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Chinese Chemical Letters 2009年第6期20卷 643-644页

作者： Xiang Hong Huang Xu Feng Lin Su Qin Chen yan guang wang College of Biology and Environmental Engineering Zhejiang Shuren University Hangzhou 310015 PR China Department of Chemistry Zhejiang University Hangzhou 310027 PR China College of Chemical and Material Engineering Wenzhou University Wenzhou 325027 PR China

A total synthesis of glypetelotine, the first sulphur-containing indole alkaloid from the leaf extracts of Glycosmis petelotii collected in the north of Vietnam, was described from indole through 6 steps. The structure of the glypetelotine was confirmed by IR, 1H NMR, 13C NMR and MS analysis. The spectral data of synthetic compound was identical with those of natural compound.

关键词： Sulphur-containing alkaloid Glypetelotine Total synthesis Indole