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Bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu Zou Ran Liu Mei Huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He min Huang Yi-Li Xu Ling Liu Yu-Chen Sun Mi Yang Qi Guo Yan Huang Tian Su Ye Xiao Wei-Shan Wang Chao Zeng guang-Hua Lei Xiang-Hang Luo Chang-Jun Li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina Hunan Key Laboratory of Joint Degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain *** this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture *** injection of human rGCA in young mice induced SSPC senescence and delayed fracture *** deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC ***,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular *** of Plxnb2 in SSPCs impaired fracture *** of GCA-neutralizing antibody enhanced fracture healing in aged ***,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

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市场准入管制放松与劳动技能溢价

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山西财经大学学报 2024年第8期46卷 99-113页

作者：王光丽马融豆建民上海财经大学财经研究所上海200433 上海财经大学公共经济与管理学院上海200433

采用2011—2021年中国上市企业数据和多期双重差分模型考察放松市场准入管制对企业劳动技能溢价水平的影响。研究发现,放松市场准入管制将显著扩大企业劳动技能溢价水平,而技能偏向型技术进步是其主要渠道,同时,企业高技能劳动力结构和... 详细信息

采用2011—2021年中国上市企业数据和多期双重差分模型考察放松市场准入管制对企业劳动技能溢价水平的影响。研究发现,放松市场准入管制将显著扩大企业劳动技能溢价水平,而技能偏向型技术进步是其主要渠道,同时,企业高技能劳动力结构和盈利能力在二者关系间具有正向调节作用。异质性分析表明,企业劳动密集度、交易成本和产权性质以及宏观市场与制度环境的差异使市场准入负面清单制度的实施效果不同。经济后果检验结果显示,市场准入管制放松将通过扩大劳动技能溢价而推动企业市场竞争力提升。

关键词：市场准入负面清单劳动技能溢价技能偏向型技术进步技能结构盈利能力

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高绩效的代价:员工工作绩效与知识隐藏行为——基于自我知觉理论

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山西财经大学学报 2024年第5期46卷 115-126页

作者：田光迪黄鸣鹏崔敏对外经济贸易大学国际商学院北京100029

现有关于员工工作绩效的研究很大程度上忽视了高工作绩效对员工自身行为的潜在负面影响。因此,本研究从员工视角出发,基于自我知觉理论,探讨员工工作绩效是否、如何以及何时会对员工自身行为产生负面影响,并通过一项情景操纵实验和一项... 详细信息

现有关于员工工作绩效的研究很大程度上忽视了高工作绩效对员工自身行为的潜在负面影响。因此,本研究从员工视角出发,基于自我知觉理论,探讨员工工作绩效是否、如何以及何时会对员工自身行为产生负面影响,并通过一项情景操纵实验和一项多时点、多来源的问卷调查进行验证。研究发现,员工工作绩效正向影响员工资质过剩感,进而导致员工出现知识隐藏行为,并且在领导谦卑程度高时,这一影响更强。

关键词：工作绩效自我知觉理论领导谦卑资质过剩感知识隐藏

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企业资源配置战略与债券信用评级

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财经问题研究 2024年第2期 64-75页

作者：张新民丁璇杨道广对外经济贸易大学国际商学院北京100029 对外经济贸易大学北京企业国际化经营研究基地北京100029

企业战略作为企业全局性、长期性资源配置的重要规划,对企业经营活动具有重要影响,也必然会影响企业的融资行为。本文从企业战略视角出发,以2008—2020年中国A股上市公司为研究对象,运用固定效应模型探究了企业资源配置战略对债券信用... 详细信息

企业战略作为企业全局性、长期性资源配置的重要规划,对企业经营活动具有重要影响,也必然会影响企业的融资行为。本文从企业战略视角出发,以2008—2020年中国A股上市公司为研究对象,运用固定效应模型探究了企业资源配置战略对债券信用评级的影响。研究发现:相对于经营主导型企业,投资主导型企业的债券信用评级更低,并且该结论在处理内生性问题和进行一系列稳健性检验后依然成立。异质性分析发现,企业资源配置战略对债券信用评级的影响在非国有企业和分析师跟踪人数多的企业中更明显。中介效应检验结果表明,企业资源配置战略通过作用于企业违约风险而影响债券信用评级。本文的研究结论对发债企业、信用评级机构和债券市场投资者具有重要启示意义。

关键词：企业资源配置战略债券信用评级企业违约风险投资主导型企业经营主导型企业

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Electroacupuncture activates AMPKa1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer's disease by regulating hippocampal mitochondrial dynamics

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Journal of Integrative Medicine 2024年第05期 588-599页

作者： Wei-wei Jia Hua-wei Lin min-guang Yang Ya-ling Dai Yan-yi Ding Wen-shan Xu Si-nuo Wang Ya-jun Cao Sheng-xiang Liang Zhi-fu Wang Cong Chen Wei-lin Liu College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine The Institute of Rehabilitation Industry Fujian University of Traditional Chinese Medicine National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese Medicine Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese Medicine

Objective: Studies have shown that electroacupuncture(EA) can alleviate cognitive impairments from Alzheimer's disease(AD) by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK), but the specific mechanism involved remains to be elucidated. Therefore, this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial ***: The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKa1-subunit conditional knockout(AMPKa1-cKO) were used for experiments. To evaluate the effects of EA treatment on cognitive function, the T-maze and Morris water maze were used. In addition,chemical exchange saturation transfer, thioflavin staining, transmission electron microscopy, mitochondrial membrane potential, and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 ***: Both APP/PS1 mice and AMPKa1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory impairment. Inactivation of the AMPK/peroxisome proliferatoractivated receptor-γ coactivator-1a(PGC-1a) pathway increased pathological amyloid-β(Aβ) deposition and aggravated the dysfunction in mitochondrial dynamics. In addition, EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1a pathway, specifically by reducing pathological Aβ deposition, normalizing energy metabolism, protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins, and downregulating the expression of fission proteins. However, the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by ***: The regulation of hippocampal mitochondrial dynamics and reduction in Aβ deposition via the AMPK/PGC-1a pathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

关键词：

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吸振器与球平衡器并用控制转子不平衡振动的理论研究

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振动工程学报 2024年第6期37卷 954-963页

作者：朱光远张小龙东亚斌何育民西安建筑科技大学机电工程学院陕西西安710055

球式自动平衡器(Automatic Ball Balancer,简称ABB)可以在临界转速以上区域完全消除转子未知不平衡量,但其缺点是在临界转速附近会引起大振幅的共振响应和不稳定振荡。为此增加动力吸振器(Dynamic Vibration Absorber,简称DVA)来克服其... 详细信息

球式自动平衡器(Automatic Ball Balancer,简称ABB)可以在临界转速以上区域完全消除转子未知不平衡量,但其缺点是在临界转速附近会引起大振幅的共振响应和不稳定振荡。为此增加动力吸振器(Dynamic Vibration Absorber,简称DVA)来克服其缺点,改善其抑振性能。以Jeffcott偏心转子模型为研究对象,根据拉格朗日方程建立了吸振器、球平衡器单独使用以及两者结合使用时控制转子不平衡振动的动力学方程,使用谐波平衡法理论求解新耦合系统的振幅表达式,并分析各参数对稳态幅频曲线的影响规律以获得较合适的参数,采用龙格-库塔数值方法计算得到稳态幅频特性图和瞬态振幅时域变化曲线。对比结果表明,两种手段并用的新方案有效降低了转子经过临界共振区时的振动水平,并使转子在临界转速以上区域衰减为零振幅,达到了融合两者优点的目的,具有更优良的抑振效果。

关键词：振动控制 Jeffcott偏心转子模型动力吸振器球式自动平衡器临界转速

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Impact of task-oriented training based on acupuncture rehabilitation on upper extremity function and quality of life of patients with early stroke

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World Journal of Clinical Cases 2024年第19期12卷 3776-3784页

作者： Hong-guang Liu Jing-Jing Liu Yan-Ping Wang Hong-Ying Wang Ao Sun Yue zhou ming-ming Cai ming-ming Qi Department of Rehabilitation Medicine Ji Xi Ji Mine HospitalJixi 158100Heilongjiang ProvinceChina Department of Neurology Ji Xi Ji Mine HospitalJixi 158100Heilongjiang ProvinceChina Department of Infectious Diseases Jixi Hengshan District People's HospitalJixi 158100Heilongjiang ProvinceChina Department of Medical Care Ji Xi Ji Mine HospitalJixi 158100Heilongjiang ProvinceChina Department of Science and Education Ji Xi Ji Mine HospitalJixi 158100Heilongjiang ProvinceChina

BACKGROUND Eighty percent of stroke patients develop upper limb dysfunction,especially hand dysfunction,which has a very slow recovery,resulting in economic burden to families and *** To investigate the impact of task-oriented training based on acupuncture therapy on upper extremity function in patients with early *** Patients with early stroke hemiplegia who visited our hospital between January 2021 and October 2022 were divided into a control group and an observation group,each with 50 *** control group underwent head acupuncture plus routine upper limb rehabilitation training(acupuncture therapy).In addition to acupuncture and rehabilitation,the observation group underwent upper limb task-oriented training(30 min).Each group underwent treatment 5 d/wk for 4 *** extremity function was assessed in both groups using the Fugl-Meyer Assessment-Upper Extremity(FMA-UE),Wolf Motor Function Rating Scale(WMFT),modified Barthel Index(MBI),and Canadian Occupational Performance Measure(COPM).Quality of life was evaluated using the Short-Form 36-Item Health Survey(SF-36).Clinical efficacy of the interventions was also *** Before intervention,no significant differences were observed in the FMA-UE,MBI,and WMFT scores between the two groups(P>0.05).After intervention,the FMA-UE,WMFT,MBI,COPM-Functional Mobility and Satisfaction,and SF-36 scores increased in both groups(P<0.05),with even higher scores in the observation group(P<0.05).The observation group also obtained a higher total effective rate than the control group(P<0.05).CONCLUSION Task-oriented training based on acupuncture rehabilitation significantly enhanced upper extremity mobility,quality of life,and clinical efficacy in patients with early stroke.

关键词： Stroke Acupuncture rehabilitation Task-oriented training Upper extremity training

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Histone 3 lysine 36 to methionine mutations stably interact with and sequester SDG8 in Arabidopsis thaliana

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Science China(Life Sciences) 2018年第2期61卷 225-234页

作者： guang Lin Ying zhou min Li Yuda Fang National key Laboratory of Plant Molecular Genetics Chinese Academy of Sciences Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and Ecology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai 200032 China

Post-transcriptional modifications of histones play important roles in various biological processes. Here, we report that Arabidopsis plants overexpressing histone H3 lysine to methionine mutations at histone H3.1K36(H3.1K36M) and H3.3K36(H3.3K36M) have serious developmental defects with early-flowering and change in the modifications of endogenous histone H3, including acetylation at lysine 9(H3K9ac), trimethylation at lysine 27(H3K27me3), di-and tri-methylation at lysine 36(H3K36me2 and H3K36me3). In addition, H3K36M mutation alters its subcellular localization and interacts with H3K36 methyltransferase SDG8. Our results support a model in which H3K36M stably interacts with SDG8, and inhibits the activity of SDG8 by sequestering SDG8, resulting in a dominant negative effect to affect the proper expression levels of a variety of genes and plant development.

关键词： histone H3 lysine to methionine mutation SDG8 dominant negative effect Arabidopsis

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Haplotype-resolved and chromosome-scale genomes provide insights into co-adaptation between the Amur tiger and Amur leopard

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Zoological Research 2024年第3期45卷 464-467页

作者： Hai-Meng Li Bo-Yang Liu min-Hui Shi Le Zhang Shang-Chen Yang Sunil Kumar Sahu Liang-Yu Cui Shan-Lin Liu Nicolas Dussex Yue Ma Dan Liu Wei-Yao Kong Hao-Rong Lu Yue Zhao Love Dalén Huan Liu Tian-ming Lan guang-Shun Jiang Yan-Chun Xu College of Wildlife and Protected Area Northeast Forestry UniversityHarbinHeilongjiang 150040China State Key Laboratory of Agricultural Genomics BGI ResearchShenzhenGuangdong 518083China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China BGI Research WuhanHubei 430074China Department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing 100193China Centre for Palaeogenetics Svante Arrhenius väg 20CStockholm 10691Sweden Department of Zoology Stockholm UniversityStockholm 10691Sweden Department of Bioinformatics and Genetics Swedish Museum of Natural HistoryStockholm 10691Sweden Heilongjiang Siberian Tiger Park HarbinHeilongjiang 150000China Jinlin Provincial Academy of Forestry Science ChangchunJilin 130033China China National GeneBank BGI ResearchShenzhenGuangdong 518120China guangdong Provincial Key Laboratory of Genome Read and Write BGI ResearchShenzhenGuangdong 518083China BGI Life Science Joint Research Center Northeast Forestry UniversityHarbinHeilongjiang 150040China Feline Research Center of National Forestry and Grassland Administration College of Wildlife and Protected AreaNortheast Forestry UniversityHarbinHeilongjiang 150040China National Forestry and Grassland Administration Research Center of Engineering Technology for Wildlife Conservation and Utilization HarbinHeilongjiang 150040China

DEAR EDITOR,Big cats,such as Amur tigers(Panthera tigris altaica)and Amur leopards(*** orientalis),are apex predator and have evolved specialized traits for hunting and carnivory(Moya et al.,2022),thus playing a crucial role in maintaining biodiversity and ecosystem integrity by regulating prey-predator ***,human-induced pressures,habitat fragmentation,and environmental alterations have restricted these species in small and isolated ***,all extant big cats are categorized as endangered or threatened according to their conservation *** tigers and Amur leopards share overlapping geographic ranges,habitats,and certain prey species in the forests of Northeast Asia(Jiang et al.,2015).To reduce interspecies conflict,these carnivores exhibit differentiated dietary and temporal *** tigers predominantly prey on large ungulates,while Amur leopards hunt small to medium-sized animals(Sugimoto et al.,2016).Additionally,they occupy different temporal niches,with tigers being active at night and leopards more active during the *** spatial and temporal niche partitioning,interspecific competition between these two species is ***,benefiting from their greater size,have a competitive advantage over leopards,which can manifest in occasional leopard predation by tigers and declines in leopard populations with increasing tiger density(Jiang et al.,2015).Tigers also displace leopards from marginal habitats in nature reserves where they coexist.

关键词： habitat Panthera resolved

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高效液相色谱法同时检测葡萄酒中11种人工合成着色剂

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中国酿造 2024年第7期43卷 246-250页

作者：李广李琪顾敏张锋甘肃省分析测试中心甘肃兰州730000

为快速识别葡萄酒中是否添加人工合成着色剂并准确定量,该实验样品采用乙酸铵溶液稀释、8000 r/min离心后直接过滤法进行前处理,梯度洗脱、Zorbax SB-C_(18)柱分离、多波长检测(288 nm、425 nm、515 nm、620 nm),建立了高效液相色谱法(H... 详细信息

为快速识别葡萄酒中是否添加人工合成着色剂并准确定量,该实验样品采用乙酸铵溶液稀释、8000 r/min离心后直接过滤法进行前处理,梯度洗脱、Zorbax SB-C_(18)柱分离、多波长检测(288 nm、425 nm、515 nm、620 nm),建立了高效液相色谱法(HPLC)同时检测葡萄酒中11种人工合成着色剂的方法。结果表明,该方法前处理简单,各着色剂最大吸收波长检测无杂质干扰、灵敏度高、检出限(0.05 mg/L)、定量限(0.15 mg/L)低,在质量浓度0.20~50 mg/L范围内线性关系良好(R^(2)≥0.9994),方法精密度试验结果的相对标准偏差(RSD)为1.86%~2.61%,加标回收率为93.0%~103.0%。适用于葡萄酒中人工合成着色剂的快速、准确检测。

关键词：人工合成着色剂葡萄酒直接过滤检测高效液相色谱

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