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冠状动脉CTA结合动态心电图夜间ST段趋势图诊断冠状动脉硬化性心脏病的价值研究

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现代生物医学进展 2024年第4期24卷 718-723页

作者：李枝峻殷广吴建林李欢祝家成重庆医科大学附属第一医院南川医院放射科重庆408400 重庆医科大学附属第一医院南川医院心内科重庆408400 重庆医科大学附属第一医院南川医院设备科重庆408400 重庆三峡医药高等专科学校附属人民医院放射科重庆404000

目的:探讨冠状动脉CTA结合动态心电图夜间ST段趋势图对冠状动脉硬化性心脏病(冠心病)的诊断价值。方法:回顾性分析2022年1月-2023年2月在我院疑似冠心病的患者104例,所有患者均行冠状动脉造影、冠状动脉CTA、动态心电图及临床相关实验... 详细信息

目的:探讨冠状动脉CTA结合动态心电图夜间ST段趋势图对冠状动脉硬化性心脏病(冠心病)的诊断价值。方法:回顾性分析2022年1月-2023年2月在我院疑似冠心病的患者104例,所有患者均行冠状动脉造影、冠状动脉CTA、动态心电图及临床相关实验室检查。以冠状动脉造影结果作为诊断冠心病的金标准,分析比较冠状动脉CTA、动态心电图夜间ST段趋势图及两者联合诊断冠心病的诊断效能和一致性。结果:104例疑似冠心病的患者确诊93例(89.42%)。冠状动脉CTA诊断冠心病的敏感性为90.32%,特异性为72.73%,阳性预测值为96.55%,阴性预测值为47.06%,准确率为88.46%,与冠状动脉造影的Kappa值为0.813,一致性好。动态心电图夜间ST段趋势图诊断冠心病的敏感性为84.95%,特异性为63.64%,阳性预测值为95.18%,阴性预测值为33.33%,准确率为82.69%,与冠状动脉造影的Kappa值为0.724,一致性较好。有夜间ST段动态改变的冠心病检出率(84.95%,79/93)明显高于无夜间ST段动态改变的冠心病检出率(15.05%,14/93),差异有统计学意义(P<0.001)。冠状动脉CTA结合动态心电图夜间ST段趋势图诊断冠心病的敏感性为96.77%,特异性为90.91%,阳性预测值为98.90%,阴性预测值为76.92%,准确率为96.15%,与冠状动脉造影的Kappa值为0.923,一致性好。结论:冠状动脉CTA结合动态心电图夜间ST段趋势图诊断冠心病的临床价值优于冠状动脉CTA或动态心电图夜间ST段趋势图单独检查。

关键词：冠状动脉CTA 动态心电图夜间ST段趋势图冠状动脉硬化性心脏病

Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats

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Neuroscience Bulletin 2017年第6期33卷 711-721页

作者： Xiangpeng Kong Jinrong Wei Diyu Wang Xiaoju Zhu Youlang Zhou Shusheng Wang guang-yin Xu Guo-Qin Jiang Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psychiatric Diseases and Institute of Neuroscience The Second Affiliated Hospital Soochow University Center for Translational Medicine Affiliated Zhangjiagang Hospital of Soochow University

Voltage-dependent anion channel 1（VDAC1） is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2–5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4（TLR4）. Intrathecal injection of minocycline, an inhibitor of microglia, also attenuated the pain hypersensitivity of rat models of bone cancer *** results suggest that VDAC1 plays a significant role in the development of complicated cancer pain, possibly by regulating the expression of TLR4.

关键词： Cancer-induced pain Spinal dorsal horn Voltage-dependent anion channel 1 Toll-like receptor 4 Microglia

Adult Stress Promotes Purinergic Signaling to Induce Visceral Pain in Rats with Neonatal Maternal Deprivation

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Neuroscience Bulletin 2020年第11期36卷 1271-1280页

作者： Shufen Hu Qian Sun Wan-Jie Du Jian Song Xin Li Ping-An Zhang Ji-Tian Xu guang-yin Xu Center for Translational Pain Medicine Institute of NeuroscienceSoochow UniversitySuzhou 215123China Department of Physiology and Neurobiology Medical College of Soochow UniversitySuzhou 215123China Department of Physiology and Neurobiology College of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China

Chronic visceral pain is one of the primary symptoms of patients with irritable bowel syndrome(IBS),which affects up to 15%of the population *** detailed mechanisms of visceral pain remain largely *** previous studies have shown that neonatal maternal deprivation(NMD)followed by adult multiple stress(AMS)advances the occurrence of visceral pain,likely due to enhanced norepinephrine(NE)-β2 adrenergic *** study was designed to explore the roles of P2X3 receptors(P2X3Rs)in the chronic visceral pain induced by combined ***,we showed that P2X3 Rs were co-expressed inβ2 adrenergic receptor(β2-AR)-positive dorsal root ganglion neurons and that NE significantly enhanced ATP-induced Ca2+*** and AMS not only significantly increased the protein expression of P2X3Rs,but also greatly enhanced the ATP-evoked current density,number of action potentials,and intracellular Ca2+concentration of colon-related DRG *** injection of the P2X3R inhibitor A317491 greatly attenuated the visceral pain and the ATP-induced Ca2+signals in NMD and AMS ***,theβ2-AR antagonist butoxamine significantly reversed the expression of P2X3Rs,the ATP-induced current density,and the number of action potentials of DRG ***,our data demonstrate that NMD followed by AMS leads to P2X3R activation,which is most likely mediated by upregulation ofβ2 adrenergic signaling in primary sensory neurons,thus contributing to visceral hypersensitivity.

关键词： Irritable bowel syndrome Visceral hypersensitivity β2 adrenergic receptor P2X3 receptor Dorsal root ganglion Stress

Targeting GATA1 and p2x7r Locus Binding in Spinal Astrocytes Suppresses Chronic Visceral Pain by Promoting DNA Demethylation

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Neuroscience Bulletin 2022年第4期38卷 359-372页

作者： Yan-Yan Wu Hai-Long Zhang Xiaomin Lu Han Du Yong-Chang Li Ping-An Zhang guang-yin Xu Jiangsu Key Laboratory of Neuropsychiatric Diseases Institute of NeuroscienceSoochow UniversitySuzhou 215123China Department of Oncology The Affiliated Haian Hospital of Nantong UniversityNantong 226600China Center for Translational Medicine The Affiliated Zhangjiagang Hospital of Soochow UniversitySuzhou 215600China

Irritable bowel syndrome is a gastrointestinal disorder of unknown etiology characterized by widespread,chronic abdominal pain associated with altered bowel *** amounts of evidence indicate that injury and inflammation during the neonatal period have long-term effects on tissue structure and function in the adult that may predispose to gastrointestinal *** this study we aimed to investigate how the epigenetic regulation of DNA demethylation of the p2x7r locus guided by the transcription factor GATA binding protein 1(GATA1)in spinal astrocytes affects chronic visceral pain in adult rats with neonatal colonic inflammation(NCI).The spinal GATA1 targeting to DNA demethylation of p2x7r locus in these rats was assessed by assessing GATA1 function with luciferase assay,chromatin immunoprecipitation,patch clamp,and interference in vitro and in *** addition,a decoy oligodeoxynucleotide was designed and applied to determine the influence of GATA1 on the DNA methylation of a p2x7r CpG *** showed that NCI caused the induction of GATA1,Ten-eleven translocation 3(TET3),and purinergic receptors(P2X7Rs)in astrocytes of the spinal dorsal horn,and demonstrated that inhibiting these molecules markedly increased the pain threshold,inhibited the activation of astrocytes,and decreased the spinal sEPSC *** also markedly demethylated the p2x7r locus in a manner dependent on the enhancement of both a GATA1–TET3 physical interaction and GATA1 binding at the p2x7r ***,we showed that demethylation of the p2x7r locus(and the attendant increase in P2X7R expression)was reversed upon knockdown of GATA1 or TET3 expression,and demonstrated that a decoy oligodeoxynucleotide that selectively blocked the GATA1 binding site increased the methylation of a CpG island in the p2x7r *** results demonstrate that chronic visceral pain is mediated synergistically by GATA1 and TET3 via a DNA-demethylation mechanism that controls p2x7r trans

关键词： Chronic visceral pain GATA binding protein 1 Ten-eleven translocation 3 Purinergic receptor Epigenetic regulation Spinal astrocytes

China's Economy is 'Better than Expected'

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中国周刊 2002年第7期 14-16页

作者： yin guang

For many businessmen ortourists from Europe andother developed countries,China is always a puzzlingcountry, which seems unbe-lievable to them, including its politics,philosophy, culture, history andeconomy.

关键词： China’s Economy is than Better than Expected

Electrochemical properties of LiNi_(0.5)Mn_(1.3)Ti_(0.2)O_4/Li_4Ti_5O_(12)cells

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International Journal of Minerals,Metallurgy and Materials 2012年第5期19卷 457-460页

作者： Guo-qiang Liu Xi Wang Ya-jie Gao Lei Wen guang-yin Liu Jian-jie Zheng Peng Cen ying Li School of Materials and Metallurgy Northeastern University Shenyang 110004 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Spinel compounds LiNi0.5Mn1.3Ti0.2O4（LNMTO） and Li4Ti5O12 （LTO） were synthesized by different methods. The particle sizes of LNMTO and LTO are 0.5-2 and 0.5-0.8 μm, respectively. The LNMTO/LTO cell exhibits better electrochemical properties at both a low current rate of 0.2C and a high current rate of 1C. When the specific capacity was determined based on the mass of the LNMTO cathode, the LNMTO/LTO cell delivered 137 mA.h.g-1 at 0.2C and 118.2 mA-h-g-l at 1C, and the corresponding capacity retentions after 30 cycles are 88.5% and 92.4%, respectively.

关键词： lithium batteries titanium compounds nickel compounds manganese compounds oxides electrochemical properties

Galerkin solution of Winkler foundation-based irregular Kirchhoff plate model and its application in crown pillar optimization

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Journal of Central South University 2016年第5期23卷 1253-1263页

作者：彭康尹旭岩尹光志许江黄滚殷志强 State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing University Chongqing 400044 China State Key Laboratory of Resources and Safe Mining (CUMT) Xuzhou 221116 China College of Resources and Environmental Science Chongqing University Chongqing 400030 China Key Laboratory of Deep Coal Mine Excavation Response & Disaster Prevention and Control of Anhui Province (Anhui University of Science and Technology) Huainan 232001 China

Irregular plates are very common structures in engineering,such as ore structures in *** this work,the Galerkin solution to the problem of a Kirchhoff plate lying on the Winkler foundation with two edges simply supported and the other two clamped supported is *** transformation technique is used during the solving process so that the solution is suitable to irregular shaped *** mechanical model and the solution proposed are then used to model the crown pillars between two adjacent levels in Sanshandao gold mine,which uses backfill method for mining *** that,an objective function,which takes security,economic profits and filling effect into consideration,is built to evaluate design *** optimizations for crown pillars are finally conducted in both conditions that the vertical stiffness of the foundation is known and *** procedure presented in the work provides the guidance in thickness designing of complex shaped crown pillars and the preparation of backfill materials,thus to achieve the best balance between security and profits.

关键词： irregular kirchhoff plate Galerkin method backfill mining crown pillars thickness optimization

Shoot drying and its cause in Calamus simplicifolius at Nanmeiling, Hainan, China

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Journal of Forestry Research 2011年第4期22卷 681-684页

作者： LI Rong-sheng yin guang-tian YANG Jin-chang ZOU Wen-tao LI Jian-guang ZHANG Shuai JIA Rui-feng KOU Liang WANG Dong-guang Research Institute of Tropical Forestry Chinese Academy of ForestryGuangzhou 510520 Gaangdong Province P.R. China

Many stems are subject to shoot drying in the plantations of Calamus simplicifolius Wei at the Nanmeiling Base of the Forestry Bureau of Baisha County, Hainan Province. As a palm, stems of C simplicifolius stop growing and later die if the shoots are dry. Generally, shoot drying means reduced cane production and reduced profit for a rattan plantation. We aimed to quantify the incidence of shoot drying and determine its reason. We sampled eight 20 m × 20 m plots in the C simplicifolius plantations. In each plot, we counted stems and categorized them as drying shoot or normal shoot, and mother stem or sucker stem. We measured stem length and categorized them as drying shoot and normal shoot for mother stems. We cut open each shoot-drying stem to determine the cause of drying from drying part to fresh part. The frequency of mother stems （259 stem·ha^-1）, was significantly lower than sucker stems （588 stem·ha^-1）. The percentage of shoot drying was 33.8% for mother stems, not significantly higher than that for sucker stems （18,9%）. The mother shoot stems were significantly shorter if they were drying than if normal. 80% of stems with a drying shoot were hollow within the leaf sheath, whereas 10% hosted lively mature larvae （one larvae per shoot） and 10% hosted several lively young larvae. Mature larvae were identified as the Red Palm Weevil, Rhynchophorus ferrugineus Oliver. To confirm the present of the weevil, three pheromone traps for the weevil were set up in the plantations and adult weevils were trapped on the next day and identified as the Red Palm Weevil. We conclude that shoot drying of C. simplicifolius is probably caused by the Red Palm Weevil.

关键词： Calamus simpliciJolius rattan shoot drying Red Palm Wee-vil Rhynchophorus ferrugineus

Heterosis and Combining Ability for Major Yield Traits of a New Wheat Germplasm Shannong 0095 Derived from Thinopyrum intermedium

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Agricultural Sciences in China 2009年第6期8卷 753-760页

作者： BAO yin-guang WANG Sen WANG Xiu-qin WANG Yu-hai LI Xing-feng WANG Lin WANG Hong-gang Agronomy College Shandong Agricultural University/Tai＇an Subcentre of National Wheat Improvement Centre Tai＇an 271018 P.R. China State Key Laboratory of Crop Biology Shandong Agricultural University Tai＇an 271018 P.R.China Agronomy College Nanjing Agricultural University Nanjing 210095 P.R. China Jining Institute of Agricultural Sciences Jining 272031 P.R.China Zaozhuang University Zaozhuang 277100 P.R.China

The wheatgrass, Thinopyrum intermedium （Host） Barkworth ＆ DR Dewey, shows many beneficial characteristics, such as big spikes and high resistance to many diseases. To transfer the beneficial genes of this species, many wheat- Thinopyrum intermedium alien chromosome lines were developed. Of them, Shannong 0095 （SN0095）, a disomic substitution, has long spikes and flag-leaves, and thus may be an important genetic resource for wheat yield improvement. In order to realize its heterosis and combining ability on major yield traits, a 7 ×7 complete diallel design was made according to Griffing＇s Method-1. The results showed that heterosis for spike length （SPL）, flag-leaf area （FLA）, number of spikes per plant （NSP）, number of spikelets per spike （NSL）, kernels per spike （KPS）, 1 000-kernel weight （TKW） and grain yield per plant （GYP） existed in all the crosses by SN0095, but heterobeltiosis occurred only for KPS, TKW, and GYP. The relative mid-parent heterosis （RMH） and relative high-parent heterosis （RHH） for GYP, which valued as high as 35.32 and 29.92% respectively, were the highest among all the traits mearsured. Though additive and non-additive gene effects and cytoplasmic effects （or cytoplasmic-nuclear interaction effects） were found in governing all the traits measured above, additive gene action played a predominant role. The results also showed that SN0095 was the best-general combiner for SPL and FLA, and high-general combiner for NSP amongst all the parents. Estimates of specific combining ability （SCA） showed that SN0095 could also make high-SCA combinations for GYP, such as SN0095 × Jimai 19 （JMI9）. SN0095 could be a unique and important parent in hybrid wheat breeding programs.

关键词： Triticum aestivum Thinopyrum intermedium diallel cross combining ability heterosis