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Unveiling expression patterns,mechanisms,and therapeutic opportunities of transmembrane protein 106C:From pan-cancers to hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 144-162页

作者： Jian-Di Li Rong-Quan He Yi-Wu Dang Zhi-guang huang Dan-Dan Xiong Lu Zhang Xiu-Fang Du Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Although transmembrane protein 106C(TMEM106C)has been elucidated to be overexpressed in cancers,its underlying mechanisms have not yet been fully *** To investigate the expression levels and molecular mechanisms of TMEM106C across 34 different cancer types,including liver hepatocellular carcinoma(LIHC).METHODS We analyzed TMEM106C expression patterns in pan-cancers using microenvironment cell populations counter to evaluate its association with the tumor *** set enrichment analysis was conducted to identify molecular pathways related to *** immunoprecipitation followed by sequencing(ChIP-seq)analysis was conducted to identify upstream transcriptional regulators of *** LIHC,we examined mRNA profiles,performed in-house quantitative polymerase chain reaction,immunohistochemistry,and constructed a co-expression gene *** assays,including cell counting kit-8,cell cycle,apoptosis,migration,and invasion,were *** effect of nitidine chloride(NC)on LIHC xenograft was evaluated through RNA sequencing and molecular ***,potential therapeutic agents targeting TMEM106C were *** TMEM106C was significantly overexpressed in 27 different cancer types and presaged poor prognosis in four of these types,including *** pan-cancers,TMEM106C was inversely correlated to the abundances of immune and stromal ***,TMEM106C was significantly linked to cell cycle and DNA replication pathways in ***-seq analysis predicted CCCTC-binding factor as a pivotal transcriptional factor targeting the TMEM106C gene in *** analysis showed that TMEM106C was upregulated in 4657 LIHC compared with 3652 normal liver tissue[combined standardized mean difference=1.31(1.09,1.52)].Inhouse LIHC samples verified the expression status of *** TMEM106C expression signified worse survival conditions in LIHC patients treated with sorafenib,a tyrosin

关键词： Transmembrane protein 106C Pan-cancers Liver hepatocellular carcinoma Molecular biology Nitidine chloride

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New perspectives on DNA methylation modifications in ocular diseases

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 340-350页

作者： Fei-Fei Zong Da-Dong Jia guang-Kun huang Meng Pan Hao Hu Shi-Yi Song Liang Xiao Ru-Weng Wang Liang Liang The First College of Clinical Medical Science China Three Gorges UniversityDepartment of PathologyYichang Central People’s HospitalYichang 443003Hubei ProvinceChina The Second People’s Hospital of China Three Gorges University the Second People’s Hospital of YichangYichang 443000Hubei ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Shaanxi University of Chinese Medicine Basic Medical CollegeXianyang 712046Shaanxi ProvinceChina

The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular *** methylation can regulate gene expression,thereby affecting cell function and signal *** diseases are a kind of complex diseases,and their pathogenesis involves many factors such as genetic,environmental and individual *** addition,inflammation,oxidative stress and lipid metabolism,which abnormal DNA methylation is closely related to,are also considered to be major factors in eye *** current understanding of DNA methylation in eye diseases is becoming more complex and *** addition to the simple suppression of gene expression by hypermethylation,factors such as hypomethylation or demethylation,DNA methylation in non-promoter regions,interactions with other epigenetic modifications,and dynamic changes in DNA methylation must also be ***,although some genes are at abnormal methylation levels,their expression is not significantly changed,which indirectly reflects the complexity of gene *** review aims to summarize and compare some relevant studies,and provide with new ideas and methods for the prevention and treatment of different eye diseases,such as glaucoma,retinoblastoma,and diabetic retinopathy.

关键词： DNA methylation modification epigenetic glaucoma retinoblastoma diabetic retinopathy methylase inhibitors

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雅砻江中下游梯级中长期联合优化调度消落水位分析

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中国农村水利水电 2025年第2期 81-87,96页

作者：黄光伦雅砻江流域水电开发有限公司四川成都610051

梯级水库消落水位是影响梯级水电站发电量的重要因素。随着具有多年调节性能的两河口水库的建成投运,确定两河口水库和下游锦屏一级、二滩水库联合调度的消落水位,提高雅砻江梯级发电量有待进一步研究。以梯级水电站发电量最大为目标,... 详细信息

梯级水库消落水位是影响梯级水电站发电量的重要因素。随着具有多年调节性能的两河口水库的建成投运,确定两河口水库和下游锦屏一级、二滩水库联合调度的消落水位,提高雅砻江梯级发电量有待进一步研究。以梯级水电站发电量最大为目标,构建了雅砻江中下游梯级水电站联合优化调度模型,采用动态规划—逐步优化算法(DPPOA)进行求解,统计两河口、锦屏一级和二滩水电站消落水位、径流量和发电量信息,并采用K-means聚类算法开展梯级水电站中长期优化调度下消落水位与径流量、发电量之间的相关关系分析。研究结果表明:(1)相较梯级水电站常规调度多年平均发电量,联合优化调度可增加91.08亿kWh发电量(对应增幅为9.36%),且锦屏二级水电站作为高水头的水电站,增发电量更为明显;(2)对于大部分来水年份下,联合优化调度下两河口、锦屏一级和二滩水电站消落水位分别为2 800,1 825和1 175 m,相较常规调度,可增加40.43亿kWh发电量,对应发电量增幅为4.16%;(3)梯级水电站发电量与径流量呈现正相关关系,上游两河口水电站消落水位与入库径流量呈现负相关关系,而受上游电站径流调节影响,下游二滩水电站消落水位与径流量相关关系较弱。研究成果可为雅砻江中下游梯级联合调度和消落水位控制提供参考依据。

关键词：雅砻江中下游梯级联合优化调度动态规划—逐步优化算法 K-means聚类算法

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Quantifying the strength of magnetic fields using baryon electric charge correlation

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Nuclear Science and Techniques 2024年第8期35卷 5-8页

作者： Xu‑guang huang Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics National Natural Science Foundation of China and Fudan UniversityShanghai 200438China

Although heavy-ion collisions generate strong magnetic fields,their direct measurement is a challenging task.A new observable,the baryon electric charge correlation,was recently found to be sensitive to the magnetic field strength and thus could be used as a magnetometer for heavy-ion ***,this observable may shed light on the equation of state and phase structure of quantum chromodynamics(QCD)under magnetic *** and understanding the phase structure of quantum chromodynamics(QCD)is important in contemporary physics[1].

关键词： charge observable magnetic

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Novel quantum phenomena induced by strong magnetic fields in heavy-ion collisions

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Nuclear Science and Techniques 2017年第2期28卷 70-98页

作者： Koichi Hattori Xu-guang huang Physics Department and Center for Particle Physics and Field Theory Fudan University Shanghai 200433 China RIKEN-BNL Research Center Brookhaven National Laboratory Upton NY 11973-5000 USA Department of Physics Brookhaven National LaboratoryUpton NY 11973-5000 USA

The relativistic heavy-ion collisions create both hot quark–gluon matter and strong magnetic fields, and provide an arena to study the interplay between quantum chromodynamics and quantum electrodynamics. In recent years, it has been shown that such an interplay can generate a number of interesting quantum phenomena in hadronic and quark–gluon matter. In this short review, we first discuss some properties of the magnetic fields in heavy-ion collisions and then give an overview of the magnetic fieldinduced novel quantum effects. In particular, we focus on the magnetic effect on the heavy flavor mesons, the heavyquark transports, and the phenomena closely related to chiral anomaly.

关键词： Relativistic heavy-ion collisions Strong magnetic fields Anomalous transports Quarkonium Heavy quark diffusion dynamics

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Spin polarization formula for Dirac fermions at local equilibrium

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Science China(Physics,Mechanics & Astronomy) 2022年第7期65卷 121-128页

作者： Yu-Chen Liu Xu-guang huang Physics Department and Center for Field Theory and Particle Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China

We derive a Cooper-Frye type spin polarization formula for Dirac fermions at local thermal equilibrium described by a grand canonical ensemble specified by temperature, fluid velocity, chemical potential, and spin potential. We discuss the physical meaning of different contributions to spin polarization and compare them with previous work. The present formula provides machinery to convert the spin potential computed in, e.g., relativistic spin hydrodynamics to the spin polarization observable in,e.g., heavy-ion collisions.

关键词： spin polarization local equilibrium spin kinetic theory

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Revisions of Convolution Model of Reflected Seismic Wave

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Chinese Physics Letters 1998年第11期15卷 851-853页

作者： huang guang-yuan Institute of Mathematics Shandong UniversityJi’nan 250100

The convolution model of reflected wave used in exploration physics has no serious physical concept and mathematical *** phenomena should be characterized by instantaneous spectrum in physics and a complex function of three real variables(*** frequency)in *** coefficient is also a complex function of place and *** new formulas instead of convolution model are *** on wavelet transform and a method of“3 basis colors”,new color sectional image is obtained from practical data.

关键词： convolution sectional Wave

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RELAXED ASYNCHRONOUS ITERATIONS FOR THE LINEAR COMPLEMENTARITY PROBLEM

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Journal of Computational Mathematics 2002年第1期20卷 97-112页

作者： Zhong-zhi Bai Yu-guang huang LSEC ICMSECAcademy of Mathematics and Systems SciencesChinese Academy of SciencesBeijing 100080China Oxford University Computing Laboratory Wolfson BuildingParks RoadOxford OX1 3QDU.K.

Presents a class of relaxed asynchronous parallel multisplitting iterative methods for solving the linear complementarity problem on multiprocessor systems. Establishment of the methods; Convergence theories; Numerica... 详细信息

关键词： linear complementarity problem matrix multisplitting relaxation method asynchronous iteration convergence theory

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3D analysis for pit evolution and pit-to-crack transition during corrosion fatigue

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第4期14卷 292-299页

作者： Xiao-guang huang Jin-quan XU Department of Engineering Mechanics China University of Petroleum Department of Engineering Mechanics Shanghai Jiao Tong University

This paper presents a deterministic model to predict the pit evolving morphology and crack initiation life of corrosion *** on the semi-ellipsoidal pit assumption,the thermodynamic potential including elastic energy,surface energy and electrochemical energy of the cyclically stressed solid with an evolving pit is established,from which specific parameters that control the pit evolution are introduced and their influence on the pit evolution are *** critical pit size for crack nucleation is obtained from stress intensity factor criterion and the crack nucleation life is evaluated by Faraday's ***,this paper presents a numerical example to verify the proposed model and investigate the influence of cyclic load on the corrosion fatigue crack nucleation *** corrosion pit appears approximately as a hemisphere in its early formation,and it gradually transits from semicircle to *** strain energy accelerates the morphology evolution of the pit,while the surface energy decelerates *** higher the stress amplitude is,the smaller the critical pit size is and the shorter the crack initiation life is.

关键词： Pit Evolving morphology Thermodynamic potential Critical pit size Crack nucleation

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NUMERICAL SIMULATIONS OF A CENTERED CONDUCTING BODY ON NATURAL CONVECTION AND HEAT TRANSFER IN AN ENCLOSURE

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Journal of Hydrodynamics 2005年第5期17卷 539-545页

作者： LI guang-zheng huang Jian-chun College of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan430074 China

Numerical simulations are performed for laminar natural convection heat transfer from a centered conducting body enclosed in a square cavity. A high accuracy un steady numerical method is used, combining the unique condition of the pressure, the convergent solutions and the streamfunction value of the inside heat conducting body are given simultaneously. Two examples are simulated with this numerical method and compared with the experimental results. The results of the numerical solutions are consistent with the experimental results. It shows that the numerical method is valid and feasible.

关键词： natural convection in an enclosure inside heat conducting body stream value of solid walls unsteady numerical method

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