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Recognition of HBV antigens and HBV DNA by dendritic cells

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Hepatobiliary & Pancreatic Diseases International 2010年第6期9卷 584-592页

作者： cui, guang-Ying Diao, Hong-Yan Zhejiang Univ Sch Med Affiliated Hosp 1 State Key Lab Diag & Treatment Infect Dis Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: Hepatitis B virus (HBV) is a hepatotropic, noncytopathic, DNA virus which can cause acute and chronic infection. Viral persistence is associated with a weak or absent specific immune responses to HBV, particularly the cellular immune response. Dendritic cells (DCs) are professional antigen-presenting cells with a unique T cell stimulatory aptitude that play a crucial role in the instruction of adaptive immune responses upon infection. An impaired function of DCs was suggested by recent studies to account for the T and B cell hyporesponsiveness in chronic HBV infection. This review summarizes recent insights into the recognition of HBV antigens by DCs. DATA SOURCES: Studies were identified by searching MEDLINE and/or PubMed for articles using the key words 'hepatitis B virus (HBV)', 'dendritic cells', 'C-type lectins', 'mannose receptor', 'toll-like receptor', and 'dendritic cell-specific intercellular-adhesion-molecule-3 grabbing nonintegrin (DC-SIGN)' up to December 2009. Additional papers were identified by a manual search of the references from the key articles. RESULTS: DCs play an important role in the progress of hepatitis B, especially in the recognition of HBV. There are three main ways of recognition of HBV antigens by DCs. First, HBV DNA can be recognized by DCs through toll-like receptor 9 (TLR9) which activates the NF-kappa B signal pathway and p38 MAPK to up-regulate the expression of interferon (IFN) regulatory factor 7 (IRF-7) in a manner independent of type I IFN signaling, resulting in secretion of type I IFN and inflammatory cytokines, and induction of DC maturation and the adaptive immune response. Second, HBc/HBeAg cannot be recognized by DCs, but DNA or ssRNA encapsulated within HBcAg can be internalized by DCs through TLRs. Third, HBsAg can be internalized by DCs through the mannose receptor, which lacks the ability to induce DC maturation without the assistance of DC-SIGN. Meanwhile, there is some cross-talk among the three mechani

关键词： dendritic cells hepatitis B virus antigen HBV DNA toll-like receptor mannose receptor

Study of Viscoelastic Properties of White Carbon Black Reinforced Synthetic Polyisoprene

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Chinese Journal of Polymer Science 2016年第4期34卷 457-465页

作者： guang-jun cui Shi-wei Wang Peng-gang Yin 郭林 Key Laboratory of Bio-Inspired-Smart Interfacial Science and Technology of Ministry of Education School of Chemistry and EnvironmentBeihang UniversityBeijing 100191China

The viscoelastic properties of synthetic polyisoprenes （PI） reinforced by white carbon black （WCB） have been investigated and compared with WCB reinforced natural rubber （NR）, including cure characteristics, physio-mechanical and dynamic mechanical properties. Compared with NR, PI loaded with the same amount of WCB （PI/WCB） exhibited shorter scorch time and optimal cure time, indicating that WCB fillers are comparatively easier to conjugate with PI. The tensile strength and elongation at break decreased with WCB filling in both PI and NR vulcanizates. The hardness of the rubber vulcanizates increased with the WCB filling in the rubber matrix. PI/WCB blends exhibited smaller hardness data, lower tensile strength, as well as lower elongation at break and tensile stress. Increasing the amount of WCB in rubber matrix induced the Payne effect. However, the Payne effect is much more obvious for the PI/WCB system, and PI/WCB also displayed higher storage modulus whereas lower loss modulus and loss tangent than NR/WCB, which could all be attributed to the poor dispersibilities of WCB in the PI matrix.

关键词： Reinforcement White carbon black Synthetic polyisoprene Natural rubber Viscoelastic properties Payne effect.

WAPN:a distributed wormhole attack detection approach for wireless sensor networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第2期10卷 279-289页

作者： Fan-rui KONG Chun-wen LI Qing-qing DING guang-zhao cui Bing-yi cui Department of Automation. Tsinghua University Beijing 100084. China State Key Lab of Power Systems Departmet of Electrical Engineering Tsinghua University Beijing 100084 China State Key Lab of Informational Electric Apparatus in Henan Zhengzhou 450002 China Department of Phvsics Nanjing University Nanjing 210093 China

As the applications of wireless sensor networks(WSNs) diversify,providing secure communication is emerging as a critical requirement. In this paper,we investigate the detection of wormhole attack,a serious security issue for WSNs. Wormhole attack is difficult to detect and prevent,as it can work without compromising sensor nodes or breaching the encryption key. We present a wormhole attack detection approach based on the probability distribution of the neighboring-node-number,WAPN,which helps the sensor nodes to judge distributively whether a wormhole attack is taking place and whether they are in the in-fluencing area of the attack. WAPN can be easily implemented in resource-constrained WSNs without any additional requirements,such as node localization,tight synchronization,or directional antennas. WAPN uses the neighboring-node-number as the judging criterion,since a wormhole usually results in a significant increase of the neighboring-node-number due to the extra attacking link. Firstly,we model the distribution of the neighboring-node-number in the form of a Bernoulli distribution. Then the model is simplified to meet the sensor nodes' constraints in computing and memory capacity. Finally,we propose a simple method to obtain the threshold number,which is used to detect the existence of a wormhole. Simulation results show that WAPN is effective under the conditions of different network topologies and wormhole parameters.

关键词： Wireless sensor networks (WSNs) Security Wormhole detection

Inversion Solidification Cladding of H90-Steel

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Journal of Iron and Steel Research International 2008年第4期15卷 51-56页

作者： LI Bao-mian XU guang-ming cui Jian-zhong Key Laboratory of Electromagnetic Processing of Materials Northeastern University Shenyang 110004 Liaoning China

The variation law of cladding thickness as well as the structures and properties of H90-steel clad strip produced by inversion solidification was studied. The interface bonding mechanisms were approached. It is found that the thickness of H90 cladding goes sequentially through the solidification growth stage, holding stage, and remelting stage, with an increase in immersion time. The higher the preheating temperature of the steel coil, the thicker is the maximum cladding thickness. Observation by using optical microscopy （OM） and the electron probe microanalyzer （EPMA） shows that the microstructure of H90 cladding is composed of equiaxed grains, and that interdiffusion between Cu and Fe at interface occurs but obvious diffusion of Zn and the intermetallic layer are not observed. The diffusion layer is thin and about 4 μm. Multipass small reduction cold rolling and repeated bending tests show that the interface is firmly bonded. Tensile test shows that the mechanical properties of the as-clad strips can meet the requirements of GB5213-2001 for the F-grade deep-drawing steel plate though there is a slight difference in the mechanical properties among the clad strips with different cladding thickness.

关键词： inversion solidification clad coil clad layer interface bond strength

Effects and complications of placement of motility coupling post in porous polyethylene orbital implants

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 464-469页

作者： Hong-guang cui Rong-rong HU Hui-yan LI Wei HAN Department of Ophthalmology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To investigate the effects and complications of primary and secondary placements of motility coupling post （MCP） in the unwrapped porous polyethylene orbital implant （PPOI） following enucleation. Methods： We investigated 198 patients who received PPOI implantation following the standard enucleation procedure in the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, from 2002 to 2004. These patients were subgrouped into PPOI-only patients （112 cases, received PPOI following enucleation）, primary MCP patients （46 cases, received primary placement of MCP during PPOI operation）, and secondary MCP patients （40 cases, received secondary placement ofMCP 6 months after the initial surgery）. Effects and complications among these three groups were compared. Results： The PPOI-only patients took shorter treatment course when compared with other two MCP groups （P〈0.001）, without significant difference noted between the two MCP groups. However, the two MCP groups had better prosthetic motility than PPOI-only group （P〈0.001）, without significant difference between the two MCP groups. In the early stage, 2 eyes in the PPOI-only group and l eye in the primary MCP group had PPOI infection. In PPOI-only group, 3 （2.68%） eyes had PPOI exposure, which occurred after fitting the prostheses; 4 eyes （8.70%） in primary MCP group and 1 eye （2.50%） in secondary MCP had PPOI exposure, which occurred before fitting the prostheses. After prosthesis was fit successfully, the excessive discharge and granuloma were 33.9% and 1.79% in PPOI group-only, 53.3% and 8.9% in primary MCP group, and 52.5% and 7.5% in secondary MCP group, respectively. Conclusion： Both primary and secondary placements of MCP into the PPOI following enucleation can help patients to obtain desirable prosthetic motility, but may be associated with more complications. The primary placement of MCP with skilled operation in selected patients is more recommendable than secondary placemen

关键词： Porous polyethylene orbital implant (PPOI) Motility coupling post (MCP)

A novel sort of porous ceramic foam ball with modified surface for arsenic removal from aqueous solution

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Journal of Iron and Steel Research International 2017年第6期24卷 661-668页

作者： Pei-sheng Liu guang cui Yi-jiao Guo Jing-he Chen Zi-xuan Yang College of Nuclear Science and Technology Beijing Normal University Beijing 100875 China

A sort of lightwerght porous ceramic foam ball that can float on the water was recently made from the nat- ural zeolite. The diameters of porous hall and its macroscopic pores are around 5 and 1 mm, respectively. Such ball surface could be modified to activate in different ways, i. e. loading the active alumina or desili- cating the ball. Both of modified products have been investigated to adsorb the toxic ion of arsenic （As） in water effectively. This kind of porous ceramic hall was prepared by powder sintering, using natural clinop- tilolite powder as the primary raw material. An active-alumina loaded porous ceramic product was genera- ted by sol-gel method with pseudoboehmite （A1OOH） as the main composition. The active AI atom on the porous ball surface could also be achieved by desilicating the ceramic ball in the NaOH solution. Such a desilicated product exhibited a good activity to adsorb the arsenic ion although carrying no ac- tive alumina. With this effective porous structure, the present products can be expected to become practically advantageous.

关键词： Porous materialCeramic foamPorous ceramic ballSurface modificationArsenic removal

Correlation of plasma miR-21 and miR-93 with radiotherapy and chemotherapy efficacy and prognosis in patients with esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2019年第37期25卷 5604-5618页

作者： Wen-Tao Wang Chang-Qing Guo guang-Hui cui Song Zhao Department of Thoracic Surgery First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Digestive Department First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is one of the main causes of human *** is usually already in middle or advanced stage when diagnosed due to its hidden symptoms in early ***,patients have already lost the best surgical timing when *** and chemotherapy are standard treatment methods for ESCC clinically,but the efficacy and prognosis of patients from them are still ***,it is of great clinical significance to seek for biomarkers that can predict the radiotherapy and chemotherapy response and prognosis of ESCC *** To explore the clinical value of plasma miR-21 and miR-93 in *** A total of 128 ESCC patients admitted to the First Affiliated Hospital of Zhenzhou University were enrolled as a study group and treated with concurrent radiotherapy and chemotherapy,and other 45 healthy people during the same period were enrolled as a control *** expression of plasma miR-21 and miR-93 was determined using quantitative real-time polymerase chain reaction,and the correlation of expression of plasma miR-21 and miR-93 with clinical pathological parameters about the patients was *** receiver operating characteristic(ROC)curve was adopted to assess the diagnostic value of plasma miR-21 and miR-93 for clinical pathological features of ESCC patients,the Logistic regression analysis adopted to analyze the risk factors for radiotherapy and chemotherapy efficacy in ESCC patients,and the Cox regression analysis to identify the prognostic factors for ESCC *** The study group showed significantly higher relative expression of plasma miR-21 and miR-93 than the control group(P<0.01).The area under the ROC curve(AUC)of plasma miR-21 for diagnosing T stage,N stage,M stage,and pathological differentiation of ESCC was 0.819,0.758,0.824,and 0.725,respectively,and that of plasma miR-93 for diagnosing T stage,N stage,and M stage of ESCC was 0.827,0.815,and 0.814,*** AUC

关键词： MiR-21 MiR-93 Esophageal squamous cell carcinoma Radiotherapy and chemotherapy Prognosis Diagnosis

Associate factors for endoscopic submucosal dissection operation time and postoperative delayed hemorrhage of early gastric cancer

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 94-104页

作者： Ren-Song Cai Wei-Zhong Yang guang-Rui cui Digestive Endoscopy Department the Second Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina

BACKGROUND Endoscopic submucosal dissection(ESD)is a treatment for early gastric cancer with the advantages of small invasion,fewer complications,and a low local recurrence ***,there is a high risk of complications such as bleeding and perforation,and the operation time is also *** operation time is closely related to bleeding and *** To investigate the influencing factors associated with ESD operation time and postoperative delayed hemorrhage to provide a reference for early planning,early identification,and prevention of *** We conducted a retrospective study based on the clinical data of 520 patients with early gastric cancer in the Second Affiliated Hospital of Hainan Medical University from January 2019 to December *** baseline data,clinical features,and endoscopic and pathological characteristics of patients were *** multivariate linear regression model was used to investigate the influencing factors of ESD operation *** regression analysis was carried out to evaluate the influencing factors of postoperative delayed *** The multivariate analysis of ESD operation time showed that the maximum lesion diameter could affect 8.815%of ESD operation time when other influencing factors remained *** operation time increased by 3.766%or 10.247%if the lesion was mixed or *** operation time increased by 4.417%if combined with an ulcer or *** operation time increased by 3.692%if combined with *** infiltrated into the submucosa,it increased by 2.536%.Multivariate analysis of delayed hemorrhage after ESD showed that the maximum diameter of the lesion,lesion morphology,and ESD operation time were independent influencing factors for delayed hemorrhage after *** with lesion≥3.0 cm(OR=3.785,95%CI:1.165-4.277),lesion morphology-concave(OR=10.985,95%CI:2.133-35.381),and ESD operation time≥60 min(OR=2.958,95%CI:1.117-3.526)were prone to delayed hemorrhage

关键词： Early gastric cancer Endoscopic submucosal dissection Operation time Delayed hemorrhage

Ionic conductivity of infiltrated Ln (Ln = Gd, Sm, Y)-doped ceria

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Rare Metals 2018年第9期37卷 734-742页

作者： Jiang-Wei Ju Dao-Ming Huan Yan-Xiang Zhang Chang-Rong Xia guang-Lei cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bio-energy and Bio-process Technology Chinese Academy of Sciences Qingdao 266101 China Qingdao Key Laboratory of Solar Energy Utilization and Energy Storage Technology Qingdao Institute of Bio-energy and Bio- process Technology Chinese Academy of Sciences Qingdao 266101 China CAS Key Laboratory of Materials for Energy Conversion Department of Materials Science and Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology University of Science and Technology of China Hefei 230026 China National Key Laboratory for Precision Hot Pressing of Metals School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

This work studies the ionic conductivity of nanosized Gd-, Sm-, and Y-doped ceria prepared by the infiltration/impregnation method. The nanoparticles were deposited onto porous pure ceria substrates via infiltration- heating processes, and the conductivity was determined with the electrochemical impedance spectroscopy （EIS） using the conductive model for infiltrated phases. The conductivity of the infiltrated doped ceria changes with the doping amount, and Gd0.25Ce0.75O2-δ, Sm0.2Ce0.8O2-δ, and Y0.15Ce0.85O2-δ show the highest values of 2.56, 3.01, and 2.07 × 10-3 ***-1 at 600 ℃, respectively. Overall, Sin-doped samples show the highest conductivity, whileY-doped samples show the lowest conductivity. In con- sideration of the Bruggeman factor, the intrinsic conduc- tivity of the infiltrated doped ceria was calculated. Compared with the bulk doped ceria, the intrinsic con- ductivity is higher while the activation energy is lower, which may suggest different conduction mechanisms. Besides, co-doping effects on the conductivity of the infiltrated sample are less obvious than those of the bulk sample.

关键词： Doped ceria Infiltration Ionic conductivity Solid oxide fuel cell Nanoparticle