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Polymorphisms of GSTM1 and CYP1A1 genes and their genetic susceptibility to prostate cancer in Chinese men

Chinese Medical Journal 2008年第4期121卷 305-308页

作者： LIMing guan Tong-yu LI Yao NA Yan-qun Department of Urology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100036 China Department of Urology First Hospital Peking University Beijing 100034 China State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Science Fudan University Shanghai 200433 China

Background Variation in prostate cancer incidence between different racial groups has been well documented, for which genetic polymorphisms are hypothesized to be an explanation. We evaluated the association between polymorphisms in the cytochrome P-450 CYP1A1 （CYP1A1） and glutathione S-transferase M1 （GSTM1） genes and genetic susceptibility to prostate cancer in Chinese men.Methods TWO hundred and eight prostate cancer patients and 230 age matched controls were enrolled in this study. All DNA samples from peripheral blood lymphocytes were genotyped for common genetic polymorphisms of the CYP1A1 and GSTM1 genes using the oligonucleotide microarray （DNA chip） technique and the polymorphism results confirmed by sequencing. The different polymorphisms in prostate cancer patients were also analyzed according to age at diagnosis, prostate specific antigen level, cancer stage and grade （Gleason score）.Results The prevalence of the GSTM1 （0/0） genotype was significantly higher in prostate cancer patients （58.2%） than in controls （41.7%, P〈0.05）. Further analysis demonstrated that the prostate cancer patients with a GSTM1 （0/0） genotype were younger than those with the GSTM1 （＋/＋） genotype （P=-0.024）. No significant differences in the frequency distributions of CYP1A1 polymorphisms were observed between prostate cancer patients and controls.Conclusion GSTM1 （0/0）-gene polymorphism may be linked to prostate cancer risk and early age of Onset in Chinese.

关键词： cytochrome P-450 CYP1A1 glutathione S-transferase M1 oligonucleotide array sequence analysis prostatic neoplasms

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具身认知观对语言理解的新诠释——心理模拟:语言理解的一种手段

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心理科学 2007年第5期30卷 1252-1256页

作者：官群美国佛罗里达州立大学教育学院语言学习与认知专业

具身认知观(Embodied Cognition)试图对心-身-世界之间的交互方式给予系统的理论说明,主张:"认知是一种高度具身的、情景化的活动"(Micheal ***,2004);认知是从身体与环境的相互作用中产生的,依赖于某种类型的经验。从具身认知观来看,... 详细信息

具身认知观(Embodied Cognition)试图对心-身-世界之间的交互方式给予系统的理论说明,主张:"认知是一种高度具身的、情景化的活动"(Micheal ***,2004);认知是从身体与环境的相互作用中产生的,依赖于某种类型的经验。从具身认知观来看,心理模拟是语言理解的一种手段,通过再入情景(re-situating)来实现。本文根据上述逻辑考察了词、句、语篇不同信息加工层面的实验研究进展,证实了人们在语言加工过程中感知、肌肉运动以及其他的经验印痕被激活,支持了语言理解是运动感觉以及其他相关经验的心理模拟过程。这种语言理解的心理模拟需要人们再入情景,与已有的听读说写的语言经验发生共鸣,从而为语言理解提供了新的诠释,丰富和发展了认知语言学的理论与实践。

关键词：具身认知观再入情景语言理解心理模拟预发声

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重复经颅磁刺激对首发抑郁症患者执行功能的影响研究

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联勤军事医学 2024年第3期38卷 222-227页

作者：马竹静孙科伟关慕桢汪国强陈晨张良谷亚男杨群空军军医大学军事医学心理学系陕西西安710032 空军军医大学基础医学院陕西西安710032 西安医学院精神卫生学教研室

目的通过采集行为学和脑电数据,考察重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对首发抑郁症患者的疗效及对执行功能的影响,初步探讨rTMS治疗抑郁症患者潜在的认知神经影响的机制。方法采用随机数字表法将首... 详细信息

目的通过采集行为学和脑电数据,考察重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对首发抑郁症患者的疗效及对执行功能的影响,初步探讨rTMS治疗抑郁症患者潜在的认知神经影响的机制。方法采用随机数字表法将首发抑郁症患者分为试验组(n=26)和对照组(n=25),试验组患者进行8周的rTMS联合药物治疗,对照组患者仅进行单纯药物治疗。于干预前和干预后采用汉密尔顿抑郁量表24(24-item Hamilton depression rating scale,HAMD-24)、汉密尔顿焦虑量表14(14-item Hamilton anxiety rating scale,HAMA-14)以及行为学工具和事件相关电位(event-related potential,ERP)评估患者的抑郁焦虑状态和执行功能的变化。结果两组抑郁症患者治疗后的HAMD-24评分和HAMA-14评分较干预前均显著下降(P均<0.001),且试验组患者HAMD-24评分显著低于对照组(P<0.05)。Go/Nogo任务中,两组抑郁症患者Nogo条件正确应答数较干预前均明显提升(P均<0.05);Stroop任务中,试验组抑郁症患者不一致条件的正确应答数较干预前明显提升,不一致条件反应时较干预前明显变短,且试验组抑郁症患者不一致条件的正确应答数较对照组明显提升、不一致条件反应时明显变短(P均<0.05)。脑电指标中,试验组抑郁症患者干预后较干预前诱发了更大的Nogo N2波幅和P3波幅(P均<0.05);试验组抑郁症患者的N2差异波波幅和P3差异波波幅显著大于对照组(P均<0.05)。结论rTMS可以加强抑郁症患者的认知神经活动水平,提升执行功能,对抑郁症患者抑郁症状的治疗效果更好。

关键词：抑郁症重复经颅磁刺激药物治疗执行功能

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Venous thromboembolism in children with acute lymphoblastic leukemia in China:a report from the Chinese Children’s Cancer Group-ALL-2015

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Frontiers of Medicine 2023年第3期17卷 518-526页

作者： Mengmeng Yin Hongsheng Wang Xianmin guan Ju Gao Minghua Yang Ningling Wang Tianfeng Liu Jingyan Tang Alex WK Leung Fen zhou Xuedong Wu Jie Huang Hong Li Shaoyan Hu Xin Tian Hua Jiang Jiaoyang Cai Xiaowen Zhai Shuhong Shen qun Hu Department of Pediatrics Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology/Oncology Children’s Hospital of Fudan UniversityShanghai 201100China Department of Hematology/Oncology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityKey Laboratory of Pediatric Hematology&Oncology of China Ministry of HealthShanghai 200120China Department of Hematology/Oncology Chongqing Medical University Affiliated Children’s HospitalChongqing 400015China Department of Pediatrics Key Laboratory of Birth Defects and Related Disease of Women and ChildrenMinistry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Xiangya Hospital Central South UniversityChangsha 410008China Department of Pediatrics Anhui Medical University Second Affiliated HospitalHefei 230601China State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases Center Institute of Hematology and Blood Diseases HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesTianjin 300020China Department of Pediatrics Hong Kong Children’s HospitalThe Chinese University of Hong KongHong Kong SAR 999077China Department of Pediatrics Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Pediatrics Nanfang HospitalSouthern Medical UniversityGuangzhou 516006China Department of Hematology/Oncology Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Shanghai Children’s HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Hematology/Oncology Children’s Hospital of Soochow UniversitySuzhou 215002China Department of Hematology/Oncology Kunming Children’s HospitalKunming 650103China Department of Hematology/Oncology Guangzhou Women and Children’s Medical CenterGuangzhou 510620China

Venous thromboembolism(VTE)is a complication in children with acute lymphoblastic leukemia(ALL).The Chinese Children’s Cancer Group-ALL-2015 protocol was carried out in China,and epidemiology,clinical characteristics,and risk factors associated with VTE were *** collected data on VTE in a multiinstitutional clinical study of 7640 patients with ALL diagnosed in 20 hospitals from January 2015 to December ***,VTE occurred in 159(2.08%)patients,including 90(56.6%)during induction therapy and 108(67.92%)in the upper extremities.T-ALL had a 1.74-fold increased risk of VTE(95%CI 1.08–2.8,P=0.022).Septicemia,as an adverse event of ALL treatment,can significantly promote the occurrence of VTE(P<0.001).Catheter-related thrombosis(CRT)accounted for 75.47%(n=120);and,symptomatic VTE,58.49%(n=93),which was more common in patients aged 12–18 years(P=0.023),non-CRT patients(P<0.001),or patients with cerebral thrombosis(P<0.001).Of the patients with VTE treated with anticoagulation therapy(n=147),4.08%(n=6)had *** VTE recurrence rate was 5.03%(n=8).Patients with VTE treated by non-ultrasoundguided venous cannulation(P=0.02),with residual thrombus(P=0.006),or with short anticoagulation period(P=0.026)had high recurrence ***,preventing repeated venous puncture and appropriately prolonged anticoagulation time can reduce the risk of VTE recurrence.

关键词： acute lymphoblastic leukemia child venous thromboembolism epidemiology clinical characteristic risk factor

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Progress and prospects of horizontal well fracturing technology for shale oil and gas reservoirs

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Petroleum Exploration and Development 2022年第1期49卷 191-199页

作者： LEI qun XU Yun CAI Bo guan Baoshan WANG Xin BI Guoqiang LI Hui LI Shuai DING Bin FU Haifeng TONG Zheng LI Tao ZHANG Haoyu Research Institute of Petroleum Exploration&Development PetroChinaBeijing 100083China CNPC Key Laboratory of Oil&Gas Reservoir Stimulation Langfang 065007China

By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D development of stacked shale reservoirs, small well spacing and dense well pattern, horizontal well re-fracturing, fracturing parameters optimization and cost control. In light of requirements on horizontal well fracturing technology in China, we have summarized the technological progress in simulation of multi-fracture propagation, horizontal well frac-design, electric-drive fracturing equipment, soluble tools and low-cost downhole materials and factory-like operation. On this basis, combined with the demand analysis of horizontal well fracturing technology in the “14th Five-Year Plan” for unconventional shale oil and gas, we suggest strengthening the research and development in the following 7 aspects:(1) geology-engineering integration;(2) basic theory and design optimization of fracturing for shale oil and gas reservoirs;(3) development of high-power electric-drive fracturing equipment;(4) fracturing tool and supporting equipment for long horizontal section;(5) horizontal well flexible-sidetracking drilling technology for tapping remaining oil;(6) post-frac workover technology for long horizontal well;(7) intelligent fracturing technology.

关键词： shale oil and gas horizontal well fracturing fracturing equipment fracturing parameter three-dimensional development intelligent fracturing

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Hg^0 absorption in potassium persulfate solution

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第5期7卷 404-410页

作者： YE qun-feng WANG Cheng-yun WANG Da-hui SUN guan XU Xin-hua Department of Environmental Engineering Zhejiang University Hangzhou 310027 China

The aqueous phase oxidation of gaseous elemental mercury (Hg0) by potassium persulfate (KPS) catalyzed by Ag+ was investigated using a glass bubble column reactor. Concentration of gaseous mercury and potassium persulfate were measured by cold vapor atom absorption (CVAA) and ion chromatograph (IC), respectively. The effects of pH value, concentration of potassium persulfate and silver nitrate (SN), temperature, Hg0 concentration in the reactor inlet and tertiary butanol (TBA), free radical scavenger, on the removal efficiency of Hg0 were studied. The results showed that the removal efficiency of Hg0 increased with increasing concentration of potassium persulfate and silver nitrate, while temperature and TBA were negatively effective. Furthermore, the removal efficiency of Hg0 was much better in neutral solution than in both acidic and alkaline solution. But the influence of pH was almost eliminated by adding AgNO3. High Hg0 concentration has positive effect. The possible reaction mechanism of gaseous mercury was also discussed.

关键词： Potassium persulfate Gaseous elemental mercury Absorption Reaction mechanism

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A novel approach of tight oil reservoirs stimulation based on fracture controlling optimization and design

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Petroleum Exploration and Development 2020年第3期47卷 632-641页

作者： LEI qun WENG Dingwei guan Baoshan MU Lijun XU Yun WANG Zhen GUO Ying LI Shuai Research Institute of Petroleum Exploration&Development PetroChinaBeijing 100083China Stimulation Department of National Energy Tight Oil and Gas R&D Center Langfang 065007China First Oil Factory of Changqing Oilfield Company PetroChinaYan’an 716000China

To deal with the stress interference caused by simultaneous propagation of multiple fractures and the wettability reversal and physical property changes of the reservoir caused by fracturing fluid getting in during large-volume fracturing of tight oil reservoirs through a horizontal well, a non-planar 3D fracture growth model was built, wettability reversal characterizing parameters and change of relative permeability curve were introduced to correct the production prediction model of fractured horizontal well, a fracturing design optimization software(Fr Smart) by integrating geological and engineering data was developed, and a fracturing design optimization approach for tight oil reservoirs based on fracture control was worked out. The adaptability of the method was analyzed and the fracture parameters of horizontal wells in tight oil reservoirs were optimized. The simulation results show that fracturing technology based on fracture control is suitable for tight oil reservoirs, and by optimizing fracture parameters, this technology makes it possible to produce the maximum amount of reserves in the well-controlled unit of unconventional reservoirs. The key points of fracturing design optimization based on fracture control include increasing lateral length of and reducing the row spacing between horizontal wells, increasing perforation clusters in one stage to decrease the spacing of neighboring fractures, and also avoiding interference of old and new fracturing wells. Field tests show that this technology can increase single well production and ultimate recovery. Using this technology in developing unconventional resources such as tight oil reservoirs in China will enhance the economics significantly.

关键词： tight oil reservoir stimulation horizontal well fracture controlling fracturing multi-stage and multi-cluster fracturing fracture parameter

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V形尾缘分开排气喷管喷流流场的数值模拟

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航空动力学报 2011年第1期26卷 154-160页

作者：康冠群王强北京航空航天大学能源与动力工程学院北京100191

采用二阶迎风离散格式并选用RNG(renormalization group)k-ε湍流模型,对轴对称分开排气喷管和核心喷管上采用V形尾缘的分开排气喷管的喷流流场进行三维数值模拟.结果表明,相对基准轴对称分开排气喷管,V形尾缘一方面引入了流向涡,另一... 详细信息

采用二阶迎风离散格式并选用RNG(renormalization group)k-ε湍流模型,对轴对称分开排气喷管和核心喷管上采用V形尾缘的分开排气喷管的喷流流场进行三维数值模拟.结果表明,相对基准轴对称分开排气喷管,V形尾缘一方面引入了流向涡,另一方面增加了核心喷流与风扇喷流之间的混合层长度,强化了喷流的混合,有效地缩短了热核心区的长度,降低了喷流中心线附近的最大速度.此外,V形尾缘随着偏转角度的增加在一定的轴向范围内显著地减小了喷流速度和总温,相对而言,V形尾缘长度的增加对喷流混合的加强作用并不明显.

关键词：分开排气 V形尾缘喷流流场数值模拟强化混合

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认知神经科学证据:何时开始学习二语效果最好?

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中国特殊教育 2010年第5期 79-84页

作者：官群美国匹兹堡大学学习科学中心匹兹堡15260

从我国新课程改革推行"小学开设英语"的举措入手,系统介绍了认知神经科学运用fMRI,PET和ERP等技术研究获得的关于二语学习关键期及其效应的研究证据,立足二语习得年龄与最终成绩、年龄与二语习得和加工、二语习得的年龄效应特点诸方面... 详细信息

从我国新课程改革推行"小学开设英语"的举措入手,系统介绍了认知神经科学运用fMRI,PET和ERP等技术研究获得的关于二语学习关键期及其效应的研究证据,立足二语习得年龄与最终成绩、年龄与二语习得和加工、二语习得的年龄效应特点诸方面展开探讨,对"何时开始学习二语效果最好"的问题有了深刻全面的理解。基本结论是:(1)二语习得存在关键期;(2)二语习得的效果受关键期效应影响;(3)6、7岁之前学习二语有望达到纯正语音效果;(4)12岁之前学习二语整体效果优于之后迟学的效果;(5)二语迟学者尽管失去二语学习"关键期",足够的训练也能达到一定的熟练效果;(6)新课程改革小学三年级开设英语,有条件的学校小学一年级开设英语,符合二语习得的认知神经科学特点和规律。

关键词：认知神经科学PET fMRI ERP二语习得关键期

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儿童早期语言天赋:来自国际研究前沿的证据

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学前教育研究 2016年第8期 32-40页

作者：官群北京科技大学外国语学院北京100083

语言是人类特有的一种高级神经活动,是儿童阅读、学习、智力及社会适应能力等多方面发展的重要工具。孩子出生就有语言天赋源于先天论的理论假说。最近美国纽约大学脑神经科学家的研究为此理论假设提供了实证依据。对单卵和双卵双胞胎... 详细信息

语言是人类特有的一种高级神经活动,是儿童阅读、学习、智力及社会适应能力等多方面发展的重要工具。孩子出生就有语言天赋源于先天论的理论假说。最近美国纽约大学脑神经科学家的研究为此理论假设提供了实证依据。对单卵和双卵双胞胎的研究也发现,人类的语言获得是受基因决定的。正是语言基因决定了语言中枢的神经元数量以及神经联结的复杂程度和可塑性。这从生物遗传学角度说明,在某种程度上语言可被视为人类独有的天赋。当然后天环境和学习对幼童语言天赋集中爆发的作用也不可忽视。已有研究还揭示了跨语言的幼儿更容易区分人类几乎所有的语音。这是婴幼儿语言天赋爆发的第一"引爆点"。随着词汇量的快速增长,幼童开始语言创造。科学开发幼童语言天赋的主要策略包括从关键内容入手、多开展指认—命名或交谈等活动、尊重儿童语言习得的规律、善用母婴语言、让儿童从错误中学习、正视多语学习等。

关键词：语言天赋语言发展儿童早期教育

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