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18β-Glycyrrhetinic Acid Improves Cardiac Diastolic Function by Attenuating Intracellular Calcium Overload

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Current Medical Science 2020年第4期40卷 654-661页

作者： Jun HAN guan-hua su Yu-hui WANG Yong-xin LU Hong-liang ZHAO Xin-xin ShuaI Department of Cardiology Wuhan Fourth HospitalPuai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430033China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

summary:Ranolazine,a late sodium current inhibitor,has been demonstrated to be effective on heart failure.18B-glycyrrhetinic acid(18β-GA)has the similar inhibitory effect on late sodium ***,its effect on diastolic function is still *** study aimed to determine whether 18β-GA can improve the diastolic function and to explore the underlying *** male Sprague Dawley(SD)rats of Langendorff model were randomly divided into the following groups:group A,normal cardiac perfusion group;group B,ischemia-reperfusion group;group C,ischemia-reperfusion with anemoniasulcata toxinⅡ(ATX-Ⅱ);group D,ranolazine group;and group E,18β-GA group with four different ***,a pressure-overloaded rat model induced by trans-aortic constriction(TAC)was *** and hemodynamics were used to evaluate diastolic function at 14th day after *** of free intracellular calcium(Ca27)concentration was indirectly detected by laser scanning confocal microscope to confirm the inhibition of late sodium *** the intervention of ATX-Ⅱon ischemia reperfusion injury group,5 umol/L ranolazine,and 5,10,20,40μmol/L 18β-GA could improve ATX-I-induced cardiac diastolic dysfunction.630 mg/kg glycyrrhizin tablets could improve cardiac diastolic function in the pressure-overloaded rats.18B-GA and ranolazine had similar effects on reducing the free calcium in *** study demonstrates that 18B-GA and glycyrrhizin could improve diastolic dysfunction induced by ischemia-reperfusion injury in Langendorff-perfused rat hearts and pressure-overloaded *** mechanism may be attributed to the inhibition of enhanced late sodium currents.

关键词： glycyrrhetinic acid diastolic function calcium overload

Inhibitory effect of Gardenblue blueberry (Vaccinium ashei Reade) anthocyanin extracts on lipopolysaccharide-stimulated inflammatory response in RAW 264.7 cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第6期17卷 425-436页

作者： Wei XU Qing ZHOU Yong YAO Xing LI Jiu-liang ZHANG guan-hua su Ai-ping DENG College of Food Science and Technology Huazhong Agricultural University Research Center for Food Safety and Nutrition Key Lab of Urban Agriculture (South) Bor S.Luh Food Safety Research CenterSchool of Agriculture & Biology Shanghai Jiao Tong University Department of Pharmacy Wuhan City Central Hospital Tongji Medical CollegeHuazhong University of Science and Technology Key Laboratory of Environment Correlative Dietology (huazhong Agricultural University) Ministry of Education Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology

Blueberries are a rich source of anthocyanins, which are associated with health benefits contributing to a reduced risk for many diseases. The present study identified the functional Gardenblue blueberry （Vaccinium ashei Reade） anthocyanin extracts （GBBAEs） and evaluated their capacity and underlying mechanisms in protecting murine RAW 264.7 cells from lipopolysaccharide （LPS）-stimulated inflammation in vitro. Enzyme-linked immunosorbent assay （ELISA） kit results showed that GBBAEs significantly inhibited the production of nitric oxide （NO）, prostaglandin E2 （PGE2）, interleukin-6 （IL-6）, IL-113, and interferon-y （INF-y）. Real-time polymerase chain reaction （PCR） analysis in- dicated that the mRNA expression levels of IL-6, IL-113, tumor necrosis factor-α （TNF-α）, monocyte chemoattractant protein-1 （MCP-1）, and cyclooxygenase 2 （COX-2） were suppressed in LPS-stimulated RAW 264.7 cells. Additionally, Western blot analysis was used to evaluate the relative protein expression levels of COX-2 and nuclear factor-κB p65 （NF-κBp65）. All these results suggested the potential use of GBBAEs as a functional food for the treatment of in- flammatory diseases.

关键词： Gardenblue blueberry (Vaccinium ashei Reade) anthocyanin extracts (GBBAEs) Anti-inflammatory RAW 264.7 Cyclooxygenase 2 (COX-2) Nuclear factor-κB p65 (NF-κBp65)

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王安石人性论新探

南昌大学学报（人文社会科学版） 2018年第1期49卷 14-23页

作者：关素华复旦大学哲学学院上海200433

王安石对儒家人性论的思考,经历了性善论、性有善有恶论、性无善无恶论三个阶段,虽几经变化,但终究没有形成一套完整的理论体系。王安石对人性的研究只是承袭先秦告子、荀子和汉代以来的"顺气而言性"的道路,他的人性只是"才性""气性""... 详细信息

王安石对儒家人性论的思考,经历了性善论、性有善有恶论、性无善无恶论三个阶段,虽几经变化,但终究没有形成一套完整的理论体系。王安石对人性的研究只是承袭先秦告子、荀子和汉代以来的"顺气而言性"的道路,他的人性只是"才性""气性""气质之性",而非"天命之性""义理之性"。这既体现了王安石人性研究强调后天"习"养"作用、重视人为力量的特点,也反映了其人性研究的不彻底性。王安石主张自然的天道观,把天道与人道区分为二,从而没有构建起儒家的道德形而上学,这一任务只有在二程等理学家那里才得以完成。

关键词：王安石人性论性归于善性有善有恶性不可善恶言气性

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先王之道:王安石法思想探析

东华理工大学学报（社会科学版） 2020年第5期39卷 412-418页

作者：关素华南京中医药大学医学人文学院江苏南京210046

“法”在王安石变法中具有独特地位,它是王安石政治哲学的核心观念,也是理解王安石思想的一把钥匙。在北宋重建秩序的时代背景之下,王安石强调回向“三代”,效法“先王之道”。他从现实出发,把北宋政治失序的原因归结为“不知法度”,因... 详细信息

“法”在王安石变法中具有独特地位,它是王安石政治哲学的核心观念,也是理解王安石思想的一把钥匙。在北宋重建秩序的时代背景之下,王安石强调回向“三代”,效法“先王之道”。他从现实出发,把北宋政治失序的原因归结为“不知法度”,因而提出“大明法度,众建贤才”的口号。王安石的“法”有三层内涵:“先王之法度”、具体的政治制度和刑法。“法”的三层内涵既体现了王安石对“孔孟之道”和“孔荀之制”的融合,也反映了他对儒道思想的融合,这正是王安石思想的特色。

关键词：王安石法重建秩序儒道融合道与法

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Brownfield Redevelopment Toward sustainable Urban Land Use in China

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Chinese Geographical Science 2007年第2期17卷 127-134页

作者： CAO Kang guan hua School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210093 China

Brownfield redevelopment is a new urban land use strategy to pursue the ideal of sustainable development. It relieves environmental pressure and resolves the glaring contradiction between urban land idleness and urban sprawl. It addresses issues of urban land use and farmland protection in China. This paper compares brownfield with greenfield, and defines brownfield and its redevelopment. It elaborates general and special government policies for this sustainable land use strategy in the context of China. General policies contain two aspects: clarifying brownfield redevelopment's priority in Chinese urban planning and land use and setting a general quantitative redevelopment target. The extent of the government's special policies, which aim at coordinating three factors in the redevelopment process, namely govern- ments, developers and users, are divided into five areas: statistics and categorization, assessment and remediation, fi- nancial supports and tax incentives, environmental and legal liability, and publicity and guidance. The paper concludes the major functions of different levels of Chinese government in the redevelopment process, i.e. making general strategy, formulating legislation, spectifying regulations and technical standards, estimating and categorizing brownfield sites, drawing up brownfield planning, providing information and financial support, guiding developers, publicizing the strategy to the public, and checking reuse results.

关键词： brownfield redevelopment sustainable development land use

A Conceptual Model of Service Customization and Its Implementation

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Journal of Computer Science & Technology 2004年第2期19卷 138-149页

作者： su-BinShen guan-QunGu Shun-YiZhang ResearchCenterofNetworkTechnology NanjingUniversityofPostsandTelecommunicationsNanjing210003P.R.China DepartmentofComputerScienceandEngineering SoutheastUniversityNanjing210096P.R.China

With the development of Internet and next generation networks in telecommunications, more and more new services are required to be introduced into networks. Introducing new services into traditional network is always associated with standardizing new protocols. The progress of protocol standardization usually takes several years, which cannot meet the increasing demands of the applications in Internet and next generation networks. Service customization in network systems may be one possible solution to cope with this problem. Based on the principle that network service is provided by interactions among protocol entities, this paper proposes a conceptual model of service customization (SECUM) by separating the service logic from protocol interactive logic within existing network architecture. The theory of Communicating Sequential Processes (CSP) is used to formalize the SECUM in order to locate exactly the service logic and to define precisely the SECUM. For validating the SECUM's usability in practical network systems, this paper also proposes an implementation model for SECUM: a component-based protocol implementation model (CPIM). CPIM discomposes protocol entity into application component, service component, message component and communication component. Service component associates application component with message component. Users or network managers can customize network services by configuring service component. The paper shows respectively the applications of SECUM and CPIM by proposing a customizable IP service model based on SECUM and describing an implementation of Session Initiation Protocol (SIP) based on CPIM. Compared with the existing service-customization techniques, SECUM is a service customization model internal to network system and may provide more powerful capabilities of service customization.

关键词： service customization protocol implementation network service CSP IP service SIP

Synthesis of Pb(OH)2/rGO Catalyst for Conversion of sugar to Lactic Acid in Water

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Chinese Journal of Chemical Physics 2015年第4期28卷 -页

作者： guan-hua Hou Li-feng Yan Department of Chemical Physics Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) University of Science and Technology of China Hefei 230026 China

Conversion of sugars from biomass to platform chemicals or fuels is an attracting topic for the utilization of biomass. Pb2+ ion is an efficient catalyst for the degradation of sugar to lactic acid, and it will be better to fix lead on a solid catalyst to reduce the risk of exposure of Pb2+ to environment. Here, a simple method has been developed to prepare a composite catalyst of Pb(OH)2/rGO, where the nanoparticles of Pb(OH)2 in size of 2–5 nm were prepared and fixed over the as-prepared reduced graphene oxide (rGO) nanosheets. The as-obtained catalyst showed an efficient catalytic activity to degrade glucose, fructose, and cellulose in aqueous solution, and the major product is lactic acid. The yield of lactic acid reached 58.7% when fructose was used as the feedstock (433 K and 2.5 MPa N2), and the catalyst can be recycled with high activity. Cellulose can also be directly converted into lactic acid in aqueous solution over the catalyst without extra acid or alkali, and the maximum yield of lactic acid is 31.7%.

关键词： Graphene Lead hydroxide Nanoparticles Composite Catalyst Lactic acid

Dynamic Behavior Analysis of Finger Seal Based on Equivalent Dynamic Model

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Chinese Journal of Mechanical Engineering 2010年第5期23卷 590-599页

作者： su hua CHEN Guoding School of Mechatronics Northwestern Polytechnical University Xi ＇an 710072 China

Finger seal is a new technology developed for gas path sealing in gas turbine *** has been paid attention to its good sealing performance and lower manufacture *** vibration behavior of finger seal is not be considered in performance analysis for the contact finger seal with compliant geometric configuration,then this will influence the reliability of the performance analysis and the parametric design of a finger *** to the dynamic character of finger seal,the harmonic vibration and free vibration models of a repetitive section of a two-layer finger seal that contains one high and one low finger seal are established *** dynamic behavior of finger seal in different working conditions is obtained based on the dynamic response analysis of finger＇s *** dynamic low hysteresis and low wear terms based on the equivalent dynamic model of finger seal are put forward,which can be used to predict the dynamic behavior of finger *** an example,the dynamic behaviors of an 8-layer finger seal and a 10-layer finger seal were predicted,and the validity of the prediction was demonstrated by the leakage test results of these two finger *** work presented here not only could make the dynamic analysis of finger seal with complicated structure simple and easy especially for multi-layer finger seal system,but also suggest a useful method for designing the finger seal with good dynamic behavior by means of different seal layers assembly.

关键词： finger seal dynamic behavior vibration