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Reduning plus ribavirin display synergistic activity against severe pneumonia induced by H1N1 influenza A virus in mice

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Journal of Traditional Chinese Medicine 2020年第5期40卷 803-811页

作者： Chen Weitao Ma Yuexia Zhang Hong Guo Yali guan mengyue Wang Yuguang Department of Respiratory Medicine Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Department of Respiratory Medicine Fangshan HospitalBeijing University of Chinese MedicineBeijing 102400China Department of Internal Medicine Fangshan HospitalBeijing University of Chinese MedicineBeijing 102400China

OBJECTIVE:To investigate synergistic effect of Reduning(RDN)injection plus ribavirin against severe pneumonia induced by H1 N1 influenza A virus in ***:We established a mouse model of severe pneumonia induced by influenza A virus by infecting Balb/c mice with CA07 *** randomly assigned the infected mice into four groups,and treated them with normal saline(NS group),RDN(injection,86.6 mg/kg),ribavirin(injection,66.6 mg/kg)or double Ribavirin plus RDN group,the same dosage as used in the single treatments)for 5 *** index and lung pathology were recorded or calculated in terms of the curative ***,NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome related protein including caspase-associated recruitment domain(CARD)domain Apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),caspase-1 and NOD-like receptor family,pyrin domain containing 3(NLRP3),and reactive oxygen species were simultaneously ***:RDN plus ribavirin treatment,not RDN or ribavirin alone,provided a significant survival benefit to the influenza A virus-infected *** combination treatment protected the mice against severe influenza infection by attenuating the severe lung *** combined treatment also reduced the viral titers in mouse lungs and lung index,downregulated their immunocytokine levels,including IL-1βand IL-18,and down regulated the NLRP3,especially the transcription and translation of *** NS group had significantly higher reactive oxygen species(ROS)expression which could was dramatically reduced by the treatment of RDN plus ***:Our study showed that RDN combined with ribavirin could protect the mice,and reduce the lung immunopathologic damage caused by severe influenza *** mechanism could be that it reduced ROS produce and inhibited NLRP3 inflammasome activation so that mainly lower the downstream inflammatory cytokines IL-1βand IL-18.

关键词： Influenza A Virus,H1N1 Subtype Pneumonia NLR Family,Pyrin domain-containing 3 protein Inflammasomes Ribavirin Reduning

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从“肺肠相关”论通腑法在肺系疾病治疗中的应用

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长春中医药大学学报 2017年第4期33卷 571-574页

作者：管梦月张伟山东中医药大学济南250014 山东中医药大学附属医院济南250011

近年来,由于空气污染日益加重、抽烟人群数不断上升等原因,肺系疾病的发病率日益增高,严重危害人们的身体健康。在中医学理论体系中有"肺与大肠相表里"的说法,即二者在生理与病理方面相互影响,故临床在肺系病的治疗中,常加入通腑之剂,... 详细信息

近年来,由于空气污染日益加重、抽烟人群数不断上升等原因,肺系疾病的发病率日益增高,严重危害人们的身体健康。在中医学理论体系中有"肺与大肠相表里"的说法,即二者在生理与病理方面相互影响,故临床在肺系病的治疗中,常加入通腑之剂,调畅腑气,从而"通腑以调肺",使肺部气机通畅。从"肺与大肠相表里"的理论入手,探究其中西医学理论依据、临床应用效果,探讨分析通腑法在肺系疾病治疗中的应用,以期为临床治疗开拓思路。

关键词：肺肠相关通腑法肺系疾病中医药疗法

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从“正气内虚,痰瘀并存”论治肺间质纤维化

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长春中医药大学学报 2016年第5期32卷 941-943页

作者：王英管梦月张伟山东中医药大学济南250014 山东中医药大学附属医院济南250011

中医认为,肺间质纤维化的病因病机特点为本虚标实,本虚为肺、脾、肾三脏虚损,标实为痰、瘀、热、毒,痰、热、毒均在虚和瘀基础上形成。正虚和邪实可以相互影响,并互为因果,形成因虚致实、因实致虚、虚者更虚、实者更实的病理特点。中医... 详细信息

中医认为,肺间质纤维化的病因病机特点为本虚标实,本虚为肺、脾、肾三脏虚损,标实为痰、瘀、热、毒,痰、热、毒均在虚和瘀基础上形成。正虚和邪实可以相互影响,并互为因果,形成因虚致实、因实致虚、虚者更虚、实者更实的病理特点。中医药治疗该病有其独特优势,可外感与内伤并重,扶正与祛邪并调。从"正气内虚,痰瘀并存"的病机观点论治肺间质纤维化,可为该病的治疗提供理论依据。

关键词：肺间质纤维化正气内虚,痰瘀并存病机

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氯喹类药物治疗病毒感染性疾病作用相关研究综述

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国际病毒学杂志 2020年第4期27卷 344-347页

作者：管梦月闫世艳王玉光首都医科大学附属北京中医医院呼吸科 100700 中国中医科学院中医临床基础医学研究所北京100700

基于氯喹类药物具有广泛抗病毒作用,在细胞水平对新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)、严重急性呼吸道综合征冠状病毒(severe acute respiratory syndrome coronavirus,SARS-CoV)有抑制作用,且可以调节机体免疫应答、自噬,氯喹类药物被认为具有治疗新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)的潜力。本研究对氯喹类药物治疗病毒感染性疾病的相关研究进行综述,以期为氯喹类药物的进一步研究提供依据。

关键词：氯喹病毒感染性疾病新型冠状病毒肺炎抗病毒免疫反应

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基于科研诚信承诺备案系统的论文诚信管理模式构建与实践

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中国医药导报 2024年第21期21卷 147-150页

作者：魏晓艺闵力吕晓飞管梦月郭水龙首都医科大学附属北京友谊医院科技处北京100050 首都医科大学附属北京友谊医院医院办公室北京100050

随着论文撤稿事件愈发频繁,医疗机构声誉与学术生态逐渐受到威胁,强化论文投稿的监管迫在眉睫。针对论文投稿管理的现状及存在风险,首都医科大学附属北京友谊医院开发了一套科研诚信承诺备案系统,将投稿过程监管流程化、信息化,并基于... 详细信息

随着论文撤稿事件愈发频繁,医疗机构声誉与学术生态逐渐受到威胁,强化论文投稿的监管迫在眉睫。针对论文投稿管理的现状及存在风险,首都医科大学附属北京友谊医院开发了一套科研诚信承诺备案系统,将投稿过程监管流程化、信息化,并基于该信息系统形成院内论文诚信管理模式,以信息为溯源之本、制度为奖惩之度,贯穿科学研究-论文成果单位管理全流程,推动学术作风规范管理长效化。该模式的实施提升了管理部门的工作效率及监管效能,有助于规范论文投稿的流程,防止学术不端行为的发生,为本单位科研诚信体系的建设奠定坚实基础。

关键词：科研诚信论文投稿论文监管

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen Yu Han Jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan Zhang Xiaomin Cheng Qinghua guan Jing Dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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