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Journal of Traditional Chinese Medicine 2016年第4期36卷 450-455页

作者： Hou Lili Xu Lei Shi Yan gu fen Department of Nursing Shanghai Pulmonary Hospital Department of Nursing Putuo HospitalShanghai University of Traditional Chinese Medicine Department of Nursing Tenth People's Hospital of Tongji University Respiratory Department Shanghai Pulmonary Hospital

OBJECTIVE:To evaluate the effects of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors,and to explore an efficient and noninvasive method for postoperative recovery of bowel ***:Forty patients were randomly and evenly assigned into a regular nursing care group(RNC) and an acupoint electric stimulation group(AES).Patients in the RNC group received regular nursing care and patients in the AES group received regular nursing care plus electric stimulation of *** serum levels of gastrin(GAS),motilin(MOT),and cholecystokinin(CCK),and an electrogastrogram(EGG) of all the patients were evaluated on the first,third,and fifth day after *** time to first flatus after surgery and the number of patients with side effects such as abdominal pain,abdominal distention,and diarrhea were ***:There were significant differences between the two groups in GAS,MOT,EGG,time to first flatus,abdominal pain,abdominal distention,and diarrhea(P < 0.05).CONCLUSION:Electric stimulation on acupoints could increase levels of GAS and MOT,promote the recovery of gastrointestinal functions,and decrease complications among postoperative senile patients with gastrointestinal tumors.

关键词： Electric stimulation therapy Aged Gas trointestinal stromal tumors Gastrointestinal hor mones Gastrointestinal motility Point ST36(Zusan li) Point ST37(Shangjuxu)

Thermodynamic assessment of Mg-Ni-Y system focusing on long-period stacking ordered phases in the Mg-rich corner

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Journal of Magnesium and Alloys 2022年第11期10卷 3250-3266页

作者： Cheng Liu Qun Luo Qin-fen gu Qian Li Kuo-Chih Chou State Key Laboratory of Advanced Special Steels&Shanghai Key Laboratory of Advanced Ferrometallurgy School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Australian Synchrotron Clayton 3168Australia

The long-period stacking ordered phases(LPSOs) in Mg-Ni-Y system have been attracting great interest as effective strengthening components because of their unique structural characteristics and deformation ***,the phase relationships in LPSOs are complicated and unclear,which restricts the design of advanced magnesium-based *** aim of the present work is to experimentally determine the phase equilibria relationships focusing on LPSOs and establish the thermodynamic description for Mg-Ni-Y *** types of LPSOs,that is,14H,12R,18R and 10H,are confirmed through equilibrated alloys and high-resolution transmission electron microscopy(HR-TEM).The formation enthalpies of LPSOs(14H,12R,18R and 10H) are calculated based on density functional theories(DFT) calculations.A new ternary compound,termed as τ phase,is observed for the first time which is likely to be the distorted structure of 12R as determined from the TEM image which shows a 12-layer closed packing plane distance of 3.252nm and a shear angle of 83.2°between(0002) and(10■0) *** on the determined phase equilibria relationship,the Mg-Ni-Y system is assessed and a selfconsistent description is obtained where the LPSOs are modeled as the stoichiometric *** comparison between the calculation result and experimental data suggests the accuracy of the present thermodynamic database in the Mg-rich corner.

关键词： LPSO phases Crystal structures Phase equilibria Thermodynamics

A molding method to fabricate the waveguide multilayer card

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Optoelectronics Letters 2008年第2期4卷 153-154页

作者： ZHOU Wang-ren LIANG Zhong-cheng gu Min-fen College of Mathematics ＆ Physics Nanjing University of Posts ＆Telecommunications Nanjing 210003 China Jiangsu Key Lab. of Optoelectronic Technology Nanjing Normal University Nanjing 210097 China

Waveguide multilayer optical card (WMOC) is a new kind of three-dimensional storage device. A method of fabricating the WMOC using the molding technique is introduced in this paper. The fabrication of WMOC mainly includes data writing with hot embossing method and multilayer bonding with PDMS material. The structure of the WMOC is consisted with Polycarbonate (PC) as the core layer material and Polydimethylsiloxane (PDMS) as cladding layer. The experimental results demonstrate that the molding fabrication method is feasible and effective.

关键词：波导多层卡制模方法结构

Functionalized magnetic nanoparticles for drug delivery in tumor therapy

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Chinese Physics B 2021年第1期30卷 87-93页

作者： Ruo-Nan Li Xian-Hong Da Xiang Li Yun-Shu Lu fen-fen gu Yan Liu School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of General Surgery Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pharmacy Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

The side effects of chemotherapy are mainly the poor control of drug release. Magnetic nanoparticles(MNPs) have super-paramagnetic behaviors which are preferred for biomedical applications such as in targeted drug delivery, besides, in magnetic recording, catalysis, and others. MNPs, due to high magnetization response, can be manipulated by the external magnetic fields to penetrate directly into the tumor, thus they can act as ideal drug carriers. MNPs also play a crucial role in drug delivery system because of their high surface-to-volume ratio and porosity. The drug delivery in tumor therapy is related to the sizes, shapes, and surface coatings of MNPs as carriers. Therefore, in this review, we first summarize the effects of the sizes, shapes, and surface coatings of MNPs on drug delivery, then discuss three types of drug release systems, i.e., p H-controlled, temperature-controlled, and magnetic-controlled drug release systems, and finally compare the principle of passive drug release with that of active drug release in tumor therapy.

关键词： magnetic nanoparticles tumor drug carriers targeted therapy

Magnetoelectric coupling effect of polarization regulation in BiFeO_(3)/LaTiO_(3)heterostructures

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Chinese Physics B 2021年第7期30卷 387-393页

作者： Chao Jin feng-Zhu Ren Wei Sun Jing-Yu Li Bing Wang Qin-fen gu Institute for Computational Materials Science School of Physics and ElectronicsInternational Joint Research Laboratory of New Energy Materials and Devices of Henan ProvinceHenan UniversityKaifeng 475004China Australian Synchrotron ANSTO800 Blackburn RdClaytonVIC3168Australia

An effective regulation of the magnetism and interface of ferromagnetic materials is not only of great scientific significance,but also has an urgent need in modern *** this work,by using the first-principles calculations,we demonstrate an effective approach to achieve non-volatile electrical control of ferromagnets,which proves this idea in multiferroic heterostructures of ferromagnetic La TiO_(3)and ferroelectric Bi FeO_(3).The results show that the magnetic properties and two-dimensional electron gas concentrations of La TiO_(3)films can be controlled by changing the polarization directions of Bi FeO_(3).The destroyed symmetry being introduced by ferroelectric polarization of the system leads to the transfer and reconstruction of the Ti-3 d electrons,which is the fundamental reason for the changing of magnetic *** multiferroic heterostructures will pave the way for non-volatile electrical control of ferromagnets and have potential applications.

关键词： first-principles calculations BiFeO_(3)/LaTiO_(3)heterostructures magnetoelectric coupling effect polarization regulation

Development of the readout system for waveguide multilayer optical card

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Optoelectronics Letters 2008年第2期4卷 150-152页

作者： gu Min-fen LIANG Zhong-cheng WANG Ren-zhou DONG Xiang-mei ZHANG Pei-ming CHEN Jia-bi College of Mathematics ＆ Physics Nanjing University of Posts ＆ Telecommunications Nanjing 210003 China Jiangsu Key Lab. of Optoelectronic Technology Nanjing Normal University Nanjing 210097 China College of Optics and Electronics Information Engineering Shanghai University for Science and Technology Shanghai 200093 China

Waveguide multilayer optical card (WMOC) is a novel storage device of three-dimensional optical information. An advanced readout system fitting for the WMOC is introduced in this paper. The hardware mainly consists of the light source for reading, WMOC, motorized stages addressing unit, microscope imaging unit, CCD detecting unit and PC controlling & processing unit. The movement of the precision motorized stage is controlled by the computer through Visual Basic (VB) language in software. A control panel is also designed to get the layer address and the page address through which the position of the motorized stages can be changed. The WMOC readout system is easy to manage and the readout result is directly displayed on computer monitor.

关键词：读出系统波导光学卡存贮器

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新型冠状病毒肺炎临床治疗药物最新研究进展

中国新药杂志 2021年第2期30卷 154-161页

作者：顾觉奋中国药科大学生命与科学学院南京210009

新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)正在世界范围内流行。作为冠状病毒,新型冠状病毒(SARS-Co V-2)和严重急性呼吸综合征冠状病毒(SARS-Co V)都通过人血管紧张素转化酶2(ACE2)受体侵入宿主细胞。面对疫情异常严峻的现... 详细信息

新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)正在世界范围内流行。作为冠状病毒,新型冠状病毒(SARS-Co V-2)和严重急性呼吸综合征冠状病毒(SARS-Co V)都通过人血管紧张素转化酶2(ACE2)受体侵入宿主细胞。面对疫情异常严峻的现状,目前尚缺乏疫苗和尚无特异性针对该病毒的抗病毒药物,临床上仍以支持治疗和对症治疗为主。本文简单介绍了新型冠状病毒和ACE2的关系及作用机制,总结了潜在抗新型冠状病毒治疗药物的最新临床疗效,及其相关药物可能的作用机制,以便充分了解COVID-19的发展过程和药物研究方向,为后续探讨COVID-19药物治疗和疫苗研发提供思路。

关键词：新型冠状病毒肺炎新型冠状病毒最新临床研究进展治疗药物作用机制

Analysis of the Clinical Interventions for Falls in Elderly Patients in the Community From 2002 To 2022:A Bibliometric Analysis

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Journal of Clinical and Nursing Research 2024年第3期8卷 32-49页

作者： Xiaoxiao Zhu Yue Zhang fen gu Shanghai Jiao Tong University School of Medicine Shanghai 200011China Department of General Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Objective:To analyze and provide a comprehensive overview of the knowledge structure and research hotspots of clinical interventions for falls in elderly patients in the ***:The search for publications related to clinical interventions for falls in elderly patients in the community from 2002 to 2022 was conducted on the Web of Science Core Collection(WoSCC)***,CiteSpace,and the R package“bibliometrix”were used to conduct this bibliometric ***:2091 articles from 70 countries,primarily the United States and Australia,were *** number of publications related to clinical interventions for falls in elderly patients is increasing *** main research institutions in this field were the University of Sydney,Harvard University,and the University of *** Central(BMC)Geriatrics was the most popular journal in this field and Journals of the American Geriatrics Society was the most co-cited *** publications came from 8984 authors among which author Lord SR had published the most papers and author Tinetti Me had the most *** main keywords in this research field were“balance,”“exercise,”and“risk factor.”Conclusion:This was the first bibliometric study that comprehensively summarized the research hot spots and development of clinical interventions for falls in elderly patients in the *** paper aims to provide a reference for scholars and researchers in this particular field.

关键词： Bibliometrics Vosviewer Clinical intervention Falls Community

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COPD病人症状负担对生活质量的影响

护理研究 2024年第11期38卷 2039-2042页

作者：郑肖霞顾芬吴奕帆朱晓筱同济大学医学院上海200333 上海交通大学医学院附属第九人民医院

目的:调查慢性阻塞性肺疾病(COPD)病人症状负担,分析症状负担对生活质量的影响,并进一步探讨相关机制。方法:采用便利抽样方法选取宁波市某三级甲等医院232例COPD病人为研究对象,采用一般资料调查表、记忆症状评估量表、医学应对方式问... 详细信息

目的:调查慢性阻塞性肺疾病(COPD)病人症状负担,分析症状负担对生活质量的影响,并进一步探讨相关机制。方法:采用便利抽样方法选取宁波市某三级甲等医院232例COPD病人为研究对象,采用一般资料调查表、记忆症状评估量表、医学应对方式问卷和慢性阻塞性肺疾病评估测试量表进行调查。结果:COPD病人生理症状负担、心理症状负担、总负担指数、症状负担、屈服均与生活质量呈正相关(P<0.05),面对与生活质量呈负相关(P<0.05);屈服在症状负担各维度与生活质量间均存在部分中介作用,且屈服参与调节中介。结论:面对应对方式在COPD病人症状负担对生活质量影响中存在部分中介作用,且屈服参与调节中介。提示医护人员应当动态评估病人在疾病治疗过程中症状负担及应对方式,实施个性化干预来优化疾病管理模式。

关键词：慢性阻塞性肺疾病症状负担生活质量应对方式中介作用护理

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艾滋病疫苗的研究进展:挑战和曙光

中国新药杂志 2014年第20期23卷 2399-2405页

作者：顾觉奋中国药科大学生命科学与技术学院南京210009

虽然安全有效的艾滋病疫苗至今仍未问世,但近年来艾滋病疫苗的研发不断有新的突破,一系列的候选疫苗走上了临床试验阶段,一系列的新型疫苗处于不断的研究中,新免疫策略和HIV致病机制的研究发现为HIV的疫苗带来了曙光,本文综述了近年来HI... 详细信息

虽然安全有效的艾滋病疫苗至今仍未问世,但近年来艾滋病疫苗的研发不断有新的突破,一系列的候选疫苗走上了临床试验阶段,一系列的新型疫苗处于不断的研究中,新免疫策略和HIV致病机制的研究发现为HIV的疫苗带来了曙光,本文综述了近年来HIV疫苗的进展,希望为HIV疫苗的后续研究提供思路。

关键词： HIV疫苗广谱中和抗体新免疫策略免疫逃避机制