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Transcriptomic and epigenomic landscapes of muscle growth during the postnatal period of broilers

Journal of Animal Science and Biotechnology 2024年第5期15卷 1851-1865页

作者： Shuang gu Qiang Huang Yuchen Jie Congjiao Sun Chaoliang Wen Ning Yang State Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding China Agricultural UniversityBeijing 100193China National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsDepartment of Animal Genetics and BreedingCollege of Animal Science and Technology China Agricultural UniversityBeijing 100193China. Sanya Institute of China Agricultural University Hainan 572025China

Background Broilers stand out as one of the fastest-growing livestock globally,making a substantial contribution to animal meat ***,the molecular and epigenetic mechanisms underlying the rapid growth and development of broiler chickens are still *** study aims to explore muscle development patterns and regulatory networks during the postnatal rapid growth phase of fast-growing *** measured the growth performance of Cornish(CC)and White Plymouth Rock(RR)over a 42-d *** muscle samples from both CC and RR were randomly collected at day 21 after hatching(D21)and D42 for RNA-seq and ATAC-seq library *** The consistent increase in body weight and pectoral muscle weight across both breeds was observed as they matured,with CC outpacing RR in terms of weight at each stage of *** expression analysis identified 398 and 1,129 genes in the two dimensions of breeds and ages,respectively.A total of 75,149 ATAC-seq peaks were annotated in promoter,exon,intron and intergenic regions,with a higher number of peaks in the promoter and intronic *** age-biased genes and breed-biased genes of RNA-seq were combined with the ATAC-seq data for subsequent *** results spotlighted the upregulation of ACTC1 and FDPS at D21,which were primarily associated with muscle structure development by gene cluster ***,a noteworthy upregulation of MUSTN1,FOS and TGFB3 was spotted in broiler chickens at D42,which were involved in cell differentiation and muscle regeneration after injury,suggesting a regulatory role of muscle growth and *** This work provided a regulatory network of postnatal broiler chickens and revealed ACTC1 and MUSTN1 as the key responsible for muscle development and *** findings highlight that rapid growth in broiler chickens triggers ongoing muscle damage and subsequent *** findings provide a foundation for future research to i

关键词： ATAC-seq Broiler Pectoral muscle development Rapid growth RNA-seq

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OpBench: an operator-level GPU benchmark for deep learning

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Science China(Information Sciences) 2024年第9期67卷 76-87页

作者： Qingwen gu Bo FAN Zhengning LIU Kaicheng CAO Songhai ZHANG Shimin HU Department of Computer Science and Technology Tsinghua University National Innovation Institute of Defense Technology Academy of Military Science Beijing Fitten Technology Co. Ltd.

Operators(such as Conv and ReLU) play an important role in deep neural networks. Every neural network is composed of a series of differentiable operators. However, existing AI benchmarks mainly focus on accessing model training and inference performance of deep learning systems on specific models. To help GPU hardware find computing bottlenecks and intuitively evaluate GPU performance on specific deep learning tasks, this paper focuses on evaluating GPU performance at the operator level. We statistically analyze the information of operators on 12 representative deep learning models from six prominent AI tasks and provide an operator dataset to show the different importance of various types of operators in different networks. An operator-level benchmark, OpBench, is proposed on the basis of this dataset, allowing users to choose from a given range of models and set the input sizes according to their demands. This benchmark offers a detailed operator-level performance report for AI and hardware developers. We also evaluate four GPU models on OpBench and find that their performances differ on various types of operators and are not fully consistent with the performance metric FLOPS(floating point operations per second).

关键词： deep learning operator benchmark model benchmark GPU performance analysis deep neural networks

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Ordovician reservoirs in Fuxian area:Gas accumulation patterns and their implications for the exploration of lower Paleozoic carbonates in the southern Ordos Basin

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Energy Geoscience 2024年第1期5卷 63-71页

作者： Ning gu Juntao Zhang Xiaohui Jin Fei Yang Lu Liu Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Huabei Oil&Gas Branch SINOPECZhengzhouHenan450000China

In recent years,the Fuxian area in the southeastern Ordos Basin has undergone significant exploration,with industrial gas flow tested in wells drilled into the Ordovician marine *** this,the gas accumulation patterns of this area are not fully understood,posing challenges for further *** analysis of geological conditions indicates that the Ordovician Majiagou Formation in this area hosts two gas plays:one found in weathering crusts and the other found in interior of the *** investigated various typical gas reservoirs in the area,focusing on differentiating the geological conditions and factors controlling gas accumulation in the weathering-crust and interior gas *** results suggest three primary gas accumulation patterns in the Majiagou Formation in the Fuxian area:(1)upper gas accumulation in weathering crusts,present in the high parts of landforms such as residual paleo-hills or buried paleo-platform(Pattern I);(2)the stereoscopic pattern with gas accumulation in both weathering crusts and strata interior,arising in high parts of landforms such as residual paleo-hills or buried paleo-platforms(Pattern II);(3)lower gas accumulation in strata interior,occurring in the upper reaches and on both sides of paleo-trenches(Pattern III).This study will serve as a geological basis for future exploration deployment in the Fuxian area.

关键词： Gas accumulation Ordovician Weathering crust play Interior play Fuxian area The ordos basin

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Unveiling the intrinsic properties of single NiZnFeO_x entity for promoting electrocatalytic oxygen evolution

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Chinese Chemical Letters 2024年第4期35卷 181-186页

作者： Zhihao gu Jiabo Le Hehe Wei Zehui Sun Mahmoud Elsayed Hafez Wei Ma Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Department of Chemistry Faculty of ScienceBeni-Suef UniversityBeni-Suef 62511Egypt

Although considerable research efforts have been devoted to the design and development of non-noble electrocatalysts for oxygen evolution reaction(OER), substantial enhancement of OER performance with commercial-scale water electrolysis remains a big challenge. This could result from the difficulties in detecting the intrinsic properties and overlooking the assembly process for electrochemical OER process. Here, we employ a microjet collision method to investigate the intrinsic OER activities of individual NiZnFeO_x entities with and without a moderate magnetic field. Our results demonstrate that single NiZnFeO_x nanoparticles(NPs) show the excellent OER performance with a lowest onset potential(~1.35 V vs. RHE) and a greatest magnetic enhancement(~118%) among bulk materials, single agglomerations and NPs. Furthermore, we explore the utility of theoretical investigation by density functional theory(DFT)calculations for studying OER process on NiZnFeO_x surfaces without and with spin alignment, indicating monodispersed NiZnFeO_xNPs with totally spin alignment facilitates the OER process under the external magnetic field. It is found that the well-dispersion of NiZnFeO_x NPs would increase the electrical conductivity and the surface spin state, resulting in promoting their OER activities. This work provides a test for uncovering the essential roles of NPs assembly to a significant promotion of their magnet-assisted OER.

关键词： Single entity OER Magnetic enhancement Electrocatalysis Well-dispersion

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Introducing on-chain graph data to consortium blockchain for commercial transactions

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Frontiers of Computer Science 2024年第2期18卷 255-257页

作者： Pengyi ZHANG Yuchen YUAN Jie SONG Yu gu Qiang QU Yongjie BAI Software College Northeastern UniversityShenyang 110819China School of Computer Science and Engineering Northeastern UniversityShenyang 110819China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Blockchain Lab Huawei Cloud Computing Technologies Co.Ltd.Shenzhen 518101China

1 Introduction A blockchain can be referred to as a distributed ledger[1].Nowadays,according to our previous work[2],the graphrelated blockchain grows efficiently in both academic studies and commercial *** data,algor... 详细信息

关键词： transactions ledge commercial

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Development and validation of a nomogram to predict allograft survival after pediatric liver transplantation

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World Journal of Pediatrics 2024年第3期20卷 239-249页

作者： guang-Xiang gu Shu-Ting Pan Yi-Chen Fan Chen Chen Qiang Xia Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineNo.160 Pujian RoadPudong New DistrictShanghai 200128China Department of Liver Transplantation Sun Yet-Sen Memorial HospitalSun Yat-Sen UniversityNo.107 Yanjiang West RoadGuangzhou 510080China Clinical Center for Investigation Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Background Liver transplantation is the main treatment for cholestatic liver disease and some metabolic liver diseases in ***,no accurate prediction model to determine the survival probability of grafts prior to surgery *** study aimed to develop an effective prognostic model for allograft survival after pediatric liver *** This retrospective cohort study included 2032 patients who underwent pediatric liver transplantation between January 1,2006,and January 1,2020.A nomogram was developed using Cox regression and validated based on bootstrap *** and discriminatory accuracies were determined using the concordance index and visualized using calibration curves;net benefits were calculated for model *** online Shiny application was developed for easy access to the *** Multivariable analysis demonstrated that preoperative diagnosis,recipient age,body weight,graft type,preoperative total bilirubin,interleukin-1β,portal venous blood flow direction,spleen thickness,and the presence of heart disease and cholangitis were independent factors for survival,all of which were selected in the *** of the nomogram indicated that the 1-,3-,and 5-year predicted survival rates agreed with the actual survival *** concordance indices for graft survival at 1,3,and 5 years were 0.776,0.757,and 0.753,respectively,which were significantly higher than those of the Pediatric End-Stage Liver Disease and Child-Pugh scoring *** allograft dysfunction risk of a recipient could be easily predicted using the following URL:https://***/ASPELT/l Conclusion The allograft survival after pediatric liver transplantation(ASPELT)score model can effectively predict the graft survival rate after liver transplantation in children,providing a simple and convenient evaluation method for clinicians and patients.

关键词： Allograft survival Nomogram Pediatric liver transplantation

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中国电梯行业安全技术的再造与升级探讨——“功能安全在中国电梯行业的应用与推广研讨会·2015·苏州”之成果综述

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中国电梯 2015年第12期26卷 28-30页

作者：赵勇原维晨顾德仁南德认证检测(中国)有限公司(T(U)V南德) 苏州远志科技有限公司

近期，电梯行业协会、机构、企业、学院等，围绕电梯中的功能安全、EMC技术，在中国电梯集中产业地区之一的江苏省，开展了一系列多层次的技术讨论。

关键词：电梯行业功能安全安全技术中国综述苏州应用 EMC技术

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Retinal Vessel Segmentation via Adversarial Learning and Iterative Refinement

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Journal of Shanghai Jiaotong university(Science) 2024年第1期29卷 73-80页

作者：顾闻徐奕 School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Retinal vessel segmentation is a challenging medical task owing to small size of dataset,micro blood vessels and low image *** address these issues,we introduce a novel convolutional neural network in this paper,which takes the advantage of both adversarial learning and recurrent neural *** iterative design of network with recurrent unit is performed to refine the segmentation results from input retinal image *** unit preserves high-level semantic information for feature reuse,so as to output a sufficiently refined segmentation map instead of a coarse ***,an adversarial loss is imposing the integrity and connectivity constraints on the segmented vessel regions,thus greatly reducing topology errors of *** experimental results on the DRIVE dataset show that our method achieves area under curve and sensitivity of 98.17%and 80.64%,*** method achieves superior performance in retinal vessel segmentation compared with other existing state-of-the-art methods.

关键词： medical image processing retinal image segmentation adversarial learning iterative refinement

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Waldenström macroglobulinemia:a challenging case treated with anti-CD19 CAR-T cell therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 719-722页

作者： Yang YANG Xiaolin gu Jingsong HE Yongxian HU Zhen CAI Bone Marrow Transplantation Center Department of Hematologythe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310006China Department of Hematology Putuo People’s HospitalZhoushan 316100China

Waldenström macroglobulinemia(WM)is characterized by lymphoplasmacytic lymphoma associated with large amounts of monoclonal immunoglobulin M(IgM)protein(Owen et al.,2003).Common signs and symptoms include fatigue due to anemia,lymph node enlargement,hepatosplenomegaly,thrombocytopenia,symptoms related to high viscosity,and peripheral neuropathy,among *** significant advances in WM treatment,this type of indolent lymphoma remains incurable,with a wide array of patient outcomes(Ruan et al.,2020).In recent years,chimeric antigen receptor T(CAR-T)cell therapy targeting cluster of differentiation 19(CD19)has shown unprecedented response rates and durability in the treatment of B-cell *** this report,we describe a challenging case of WM that involved multiple extramedullary sites,relapsed,and was refractory to chemotherapy,immunotherapy,and targeted *** anti-CD19 CAR-T cell therapy,the tumor burden significantly decreased and the patient’s condition remained stable at the writing of this report.

关键词： CD19 globulin durability

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Three-dimensional structural models,evolution and petroleum geological significances of transtensional faults in the Ziyang area,central Sichuan Basin,SW China

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Petroleum Exploration and Development 2024年第3期51卷 604-620页

作者： TIAN Fanglei guO Tonglou HE Dengfa gu Zhanyu MENG Xianwu WANG Renfu WANG Ying ZHANG Weikang LU guo School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism Ministry of EducationBeijing 100083China Sinopec Southwest Oil and Gas Company Chengdu 610031China

With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,fault throw analyzing,and balanced profile restoration,it is pointed out that the transtensional fault system in the Ziyang 3-D seismic survey consists of the northeast-trending F_(I)19 and F_(I)20 fault zones dominated by extensional deformation,as well as 3 sets of northwest-trending en echelon normal faults experienced dextral shear *** them,the F_(I)19 and F_(I)20 fault zones cut through the Neoproterozoic to Lower Triassic Jialingjiang Formation,presenting a 3-D structure of an“S”-shaped *** before Permian and during the Early Triassic,the F_(I)19 and F_(I)20 fault zones underwent at least two periods of structural ***,the 3 sets of northwest-trending en echelon normal faults are composed of small normal faults arranged in pairs,with opposite dip directions and partially left-stepped *** before Permian,they had formed almost,restricting the eastward growth and propagation of the F_(I)19 fault *** F_(I)19 and F_(I)20 fault zones communicate multiple sets of source rocks and reservoirs from deep to shallow,and the timing of fault activity matches well with oil and gas generation *** there were favorable Cambrian-Triassic sedimentary facies and reservoirs developing on the local anticlinal belts of both sides of the F_(I)19 and F_(I)20 fault zones,the major reservoirs in this area are expected to achieve breakthroughs in oil and gas exploration.

关键词： transtensional(strike-slip)fault three-dimensional structural model structural evolution petroleum geological significance Ziyang area Sichuan Basin

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