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手术切除的黄斑下脉络膜新生血管之组织病理学及超微结构特点:黄斑下手术试验系列报道之7

世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 16-17页

作者： grossniklaus h.e. Miskala P.h. Green W.R. 黎黎 L. F. Montgomery Ophthalmic Pathology Laboratory BT428 Emory Eye Center 1365 Clifton Rd NE Atlanta GA 30322 United States

Objectives: To identify the histologic and ultrastructural features of surgica lly excised subfoveal choroidal neovascular lesions from patients enrolled in th.e.Submacular Surgery Trials and to compare them with clinical data. Methods: Sur gically excised subfoveal choroidal neovascular lesions from patients enrolled i n the Submacular Surgery Trials group N trial (lesion predominantly choroidal ne ovascularization [CNV] with.e.idence of classic CNV from age-related macular de generation), group B trial (lesion predominantly hemorrhagic from age-relatedma cular degeneration), and grouphtrial (idiopathic subfoveal CNV or subfoveal CNV from ocular histoplasmosis syndrome) between October 1, 1999, and September 1, 2 001, were submitted to the pathology center. The lesion growth pattern (subretin al pigment epithelial [sub-RPe], subretinal, combined, or indeterminate) and th.e.cellular and extracellular constituents were classified independently. Demogra phic, clinical, and fluorescein angiographic characteristics of patients, eyes, and lesions, respectively, were compared with the pathologic features. Results: Of 269 patients assigned to surgery during the 24 months that pathologic specime nswere collected, surgical specimens from study eyes of 199 were submitted to th.e.pathology center. Of the 199 routine histologie specimens processed, 144 (72% ) were classified as CNV, 51 (26%) as fibrocellular tissue, and 4 (2%) as hemo rrhage. The median specimen size was smaller in group h (932 X 208 μm) than in groups N (1980 X 325 μm) and B (1800 X 395 μm). The CNV growth pattern was det ermined in 91 (46%) of 199 specimens. Of 159 group N and group B lesions, 76 (4 8%) had an indeterminate growth pattern, 28 (18%) had a sub-RPe growth patter n, and 33 (21%) had sub-RPe and subretinal growth patterns. Of 40 group h lesi ons, 32 (80%) had an indeterminate growth pattern, 7 (18%) had a subretinal gr owth pattern, and 1 (2%) had a combined sub-RPe and subretinal pattern. Based o

关键词：超微结构试验系列组织病理学老年黄斑变性老年性黄斑变性眼组织眼底荧光造影胶原纤维组织纤维化上皮型

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原发性眼内淋巴瘤的临床表现、细胞学检查及流式细胞仪分析

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 58-59页

作者： Zaldivar R.A. Martin D.F. holden J.T. grossniklaus h.e. 黎黎 Department of Ophthalmology Emory University Atlanta GA United States Dr.

Purpose To compare cytologic with flow cytom etric results of vitreous biopsy specimens obtained to rule out primary intraocu lar lymphoma (PIOL). Study design Prospective noncomparative case series. Partic ipants Patients suspected of having PIOL who underwent vitreous biopsy were eval uated. Methods Patients underwent a standard 3-port vitrectomy and vitreous bio psy to rule out PIOL. each undiluted specimen was split, and half was prepared f or cytologic evaluation with the collodion bag method; the other half was submit ted for flow cytometric immunophenotyping (FCI). The diluted specimen was proces sed as a cell block for cytology. Main outcome measures Final diagnosis based on cytology and FCI. Results Ten of 14 patients had sufficient specimens for both cytologic and FCI evaluation. Th.e. patients had chronic inflammation confirmed by both methods. Six patients had large cell lymphoma identified by both cytolog y and FCI. Two of those 6 patients initially had insufficient specimen for FCI. One patient had large cell lymphoma diagnosed cytologically that was initially n egative for a clonal population by FCI. All lymphomas were B-cell type. Conclus ions Cytologic evaluation is an accurate diagnostic technique to evaluate for PI OL. FCI is useful for immunophenotyping PIOL. Multiple biopsies may be required to ach.e.e a diagnosis.

关键词：流式细胞仪淋巴瘤免疫分型火棉胶病例研究慢性炎症

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视网膜新生血管并发视网膜母细胞瘤

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 16-16页

作者： Shuler Jr. R.K. hubbard Ⅲ G.B. grossniklaus h.e. 司冰心

To report retinal neovascularization associated with retinoblastoma in a 14- month-old infant. Observational case report. Review of clinical and pathologic findings. A large frond of retinal neovascularization was present posterior to the lens in the right eye, which also contained a retinoblastoma. Retinal neovascularization is an unusual association with retinoblastoma.

关键词：视网膜母细胞瘤视网膜新生血管眼晶状体观察性

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Nanomedicine in the application of uveal melanoma

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International Journal of Ophthalmology(english.e.ition) 2016年第8期9卷 1215-1225页

作者： Shuo You Jing Luo hans e.grossniklaus Ma-Ling Gou Ke Meng Qing Zhang Department of endocrinology the Second Xiangya HospitalCentral South University Winship Cancer Institute School of Medicine Emory University Department of Ophthalmology the Second Xiangya Hospital Central South University Department of Ophthalmology School of Medicine Emory University Department of Pathology School of Medicine Emory University State Key Laboratory of Biotherapy Sichuan University

Rapid advances in nanomedicine have significantly changed many aspects of nanoparticle application to the eye including areas of diagnosis, imaging and more importantly drug delivery. The nanoparticle-based drug delivery systems has provided a solution to various drug solubility-related problems in ophthalmology treatment. Nanostructured compounds could be used to ach.e.e local ocular delivery with minimal unwanted systematic side effects produced by taking advantage of the phagocyte system. In addition, the in vivo control release by nanomaterials encapsulated drugs provides prolong exposure of the compound in the body. Furthermore, certain nanoparticles can overcome important body barriers including the blood-retinal barrier as well as the corneal-retinal barrier of the eye for effective delivery of the drug. In summary, the nanotechnology based drug delivery system may serve as an important tool for uveal melanoma treatment.

关键词： nanomedicine nanoparticles gene delivery drug delivery uveal melanoma

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Animal models of uveal melanoma

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Annals of eye Science 2022年第1期7卷 66-85页

作者： Ogul e.Uner Nikhila Gandrakota Corrina P.Azarcon hans e.grossniklaus Department of Ophthalmology Emory University School of MedicineAtlantaGAUSA Department of Family Medicine Emory University School of MedicineAtlantaGAUSA Rollins School of Public health Emory UniversityAtlantaGAUSA Department of Pathology Emory University School of MedicineAtlantaGAUSA

Animal models are crucial for the study of tumorigenesis and therapies in oncology *** rare,uveal melanoma(UM)is the most common intraocular tumor and remains one of the most lethal *** the limitations of studying human UM cells in vitro,animal models have emerged as excellent platforms to investigate disease onset,progression,and *** Greene’s initial studies on hamster UM,researchers have dramatically improved the array of animal *** with spontaneous tumors have largely been replaced by engrafted and genetically engineered *** techniques continue to be refined and *** methods for directed mutagenesis have formed transgenic models to reliably study primary *** UM cell lines have been used to generate rapidly growing *** recently,patient-derived xenografts have emerged as models that closely mimic the behavior of human *** animal models to study metastatic UM have also been *** the advancements,the prognosis has only recently improved for UM patients,especially in patients with *** is a need to identify and evaluate new preclinical *** accomplish this goal,it is important to understand the origin,methods,advantages,and disadvantages of current animal *** this review,the authors present current and historic animal models for the experimental study of *** strengths and shortcomings of each model are discussed and potential future directions are explored.

关键词： Uveal melanoma(UM) ocular melanoma animal model xenograft transgenic mice

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抗CXCR4多肽对小鼠脉络膜黑色素瘤模型肝脏微转移的抑制作用

抗CXCR4多肽对小鼠脉络膜黑色素瘤模型肝脏微转移的抑制作用

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中华医学会第十二届全国眼科学术大会

作者：刘可杨桦 hans e grossniklaus 唐罗生中南大学湘雅二医院眼科

目的：分析抗 CXCR4多肽对小鼠脉络膜黑色素瘤肝脏微转移的抑制作用。方法：1．采用 Western blot 方法及 RT— PCR 检测 CXCR4在 B16SL9细胞内的表达。2．将 B16LS9 分为加 SDF—1及抗 CXCR4多肽培养液组、加 SDF—1培养

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手术祛除黄斑下脉络膜新生血管后2D重建与荧光血管造影表现的对照研究:15号SST报道

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 50-51页

作者： grossniklaus h. e. Bressler S. B. Miskala P. h. 安胜(译) 不详 L. F. Montgomery Ophthalmic Pathology Laboratory BT428 Emory Eye Center1365 Clifton Road Atlanta GA 30322 United States

Objectives: To compare topographic features of surgically excised subfoveal choroidal neovascularization with preoperative and postoperative fluorescein angiographic features from Submacular Surgery Trials (SST) patients,and to compare histological and angiographic features with preoperative and postoperative visual acuities (VAs). Methods: Patients enrolled in the SST GroupsN,B,and h trials between October 1999 and September 2001 and assigned to the surgery arm had surgically removed choroidal neovascularization sent to the SST Pathology Center. Grossly intact specimens were sectioned serially for 2-dimensional reconstruction and were assigned to growth pattern groups based on topographic mapping of the location of cellular components relative to the retinal pigment epithelium (RPe): sub-RPe,subretinal,combined,or indeterminate. These features were compared with preoperative fluorescein angiographic features. The histological choroidal neovascularization growth pattern was compared with preoperative VAs. Results: Two-dimensional reconstructions of surgically excised choroidal neovascularization could not be matched point for point to fluorescein angiographic features. Among the 52 specimens selected,the growth pattern could be determined by 2-dimensional reconstruction in 34 instances (65% ),including 28 (80% ) of 35 Group N specimens,2 (40% ) of 5 Group B specimens,and 4 (33% ) of 12 Group h specimens. Among the choroidal neovascularization growth patterns that could be determined from specimens submitted,the majority of GroupN specimens were combined,and the majority of Group h specimenswere subretinal. In most instances for GroupBspecimens,the growth pattern was indeterminate. The postoperative abnormalities on fluorescein angiography were generally larger than measurements of excised specimens. The subretinal growth pattern was associated with the smallest decrease in 3-month postoperative average VA. Conclusions: Among the 52 specimens from the SST with adequa

关键词：黄斑下脉络膜新生血管荧光血管造影血管造影表现对照研究 SST 手术隐匿性脉络膜新生血管祛除血管组织学生长模型

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拉坦前列腺素与非拉坦前列腺素治疗患者虹膜切除标本的组织病理学特征研究

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美国医学会眼科杂志（中文版） 2005年第3期17卷 131-136页

作者： Daniel M. Albert Ronald e. Gangnon Michele L. Zimbric Christine M. Damico Marian R. Fisher Joel Gleiser hans e. grossniklaus W. Richard Green 尚庆丽（译）马景学（校） Department of Ophthalmology and Visual Sciences University of Wisconsin Medical School Madison Department of Biostatistics and Medical Informaties University of Wisconsin Medical School Madison Department of Ophthalmology Emory University Adan-ta Ga Department of Ophthalmology The Johns Hopkins University Baltimore Md 不详

目的：观察青光眼手术患者虹膜切除标本的组织病理学特征。比较拉坦前列腺素治疗组与非拉坦前列腺素治疗组（对照组）组织学差异。方法：虹膜切除标本及患者病史资料呈送拉坦前列腺素病理学中心。标本由3位眼科病理学家以盲法分别观察... 详细信息

目的：观察青光眼手术患者虹膜切除标本的组织病理学特征。比较拉坦前列腺素治疗组与非拉坦前列腺素治疗组（对照组）组织学差异。方法：虹膜切除标本及患者病史资料呈送拉坦前列腺素病理学中心。标本由3位眼科病理学家以盲法分别观察。评估内容包括：癌变。癌前改变及其他病变：色素沉着水平差异，细胞构成差异。炎症，血管异常情况及虹膜色素上皮改变。结果：所收集标本中，449例曾接受拉坦前列腺素治疗，142例无拉坦前列腺素或其衍生物治疗史。所有标本均未发现癌或癌前病变。拉坦前列腺素治疗组，虹膜痣发生率显著高于对照组（P=0．001）。基质成纤维细胞和黑色素细胞数为对照组2倍（P〈0．001）。采用免疫组化染色技术分析2002年6月收集的各亚组标本，结果显示：拉坦前列腺素治疗组与非拉坦前列腺素治疗组黑色素细胞均数无显著差异（P=0．35）。结论：本研究结果支持已有观点，即：拉坦前列腺素诱发的眼部颜色的改变是由于虹膜基质黑色素细胞内黑色素数量增多而引起，虹膜痣数量增加可能是此效应的局部表现。

关键词：拉坦前列腺素组织病理学特征虹膜色素上皮切除标本治疗患者基质成纤维细胞黑色素细胞免疫组化染色技术癌前病变

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人角膜激光原位磨镶术后角膜切口的组织学、超微结构及免疫荧光评估

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 23-23页

作者： Dawson D.G Kramer T.R grossniklaus h.e.h.F. edelhauser 曹绪胜 emory eye Center 1365- B Clifton Rd NE Atlanta GA 30322 United States.Dr

Objective: To evaluate human corneas after laser-assisted in situ keratomileusis at different postoperative intervals. Methods: Thirty-eight postmortem corneas from 20 patients with postoperative intervals from 2 months to 6.5 years after laserassisted in situ keratomileusis surgery were collected from eye banks. The corneas were trisected and processed for conventional histologic analysis, transmission electron microscopy, and immunofluorescence. Results: Light microscopy and transmission electron microscopy showed focal undulations in Bowman layer, focal epithelial hypertrophicmodifications, and a variably thick (range, 0.4- 16.4- μ m) lamellar stromal interface scar in all specimens. The flap wound margin, which was adjacent to the epithelium, healed by producing an approximately 8- μ m-thick hypercellular fibrotic stromal scar, whereas the central and paracentral wound regions healed differently because a thinner (approximately 5- μ m) hypocellular primitive stromal scar was present in all the corneas examined. Immunofluorescence identified increased type 3 collagen and myofibroblasts in the hypercellular fibrotic scar regions and decreased or absent levels of all corneal stromal components other than type 1 collagen in the hypocellular primitive scar regions. Conclusions: After laser-assisted in situ keratomileusis surgery, the keratocyte-mediated production of a variably thick lamellar corneal stromal scar occurs, resulting in 2 regional types of scarring. The hypercellular fibrotic scar at the wound margin is usually visible clinically and functions to hold the flap in place, while the more central hypocellular primitive scar is not visible clinically and allows easy lifting of the flap postoperatively.

关键词：角膜切口免疫荧光人角膜超微结构角膜瓣角膜基质角膜上皮角膜组织 Ⅰ型胶原纤维纤维瘢痕组织

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