手术切除的黄斑下脉络膜新生血管之组织病理学及超微结构特点:黄斑下手术试验系列报道之7

作     者：Grossniklaus H.E. Miskala P.H. Green W.R. 黎黎 

作者机构：L. F. Montgomery Ophthalmic Pathology Laboratory BT428 Emory Eye Center 1365 Clifton Rd NE Atlanta GA 30322 United States 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2005年第1卷第11期

页      面：16-17页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：超微结构 试验系列 组织病理学 老年黄斑变性 老年性黄斑变性 眼组织 眼底荧光造影 胶原纤维 组织纤维化 上皮型 

摘      要：Objectives: To identify the histologic and ultrastructural features of surgica lly excised subfoveal choroidal neovascular lesions from patients enrolled in th e Submacular Surgery Trials and to compare them with clinical data. Methods: Sur gically excised subfoveal choroidal neovascular lesions from patients enrolled i n the Submacular Surgery Trials group N trial (lesion predominantly choroidal ne ovascularization [CNV] with evidence of classic CNV from age-related macular de generation), group B trial (lesion predominantly hemorrhagic from age-relatedma cular degeneration), and groupHtrial (idiopathic subfoveal CNV or subfoveal CNV from ocular histoplasmosis syndrome) between October 1, 1999, and September 1, 2 001, were submitted to the pathology center. The lesion growth pattern (subretin al pigment epithelial [sub-RPE], subretinal, combined, or indeterminate) and th e cellular and extracellular constituents were classified independently. Demogra phic, clinical, and fluorescein angiographic characteristics of patients, eyes, and lesions, respectively, were compared with the pathologic features. Results: Of 269 patients assigned to surgery during the 24 months that pathologic specime nswere collected, surgical specimens from study eyes of 199 were submitted to th e pathology center. Of the 199 routine histologie specimens processed, 144 (72% ) were classified as CNV, 51 (26%) as fibrocellular tissue, and 4 (2%) as hemo rrhage. The median specimen size was smaller in group H (932 X 208 μm) than in groups N (1980 X 325 μm) and B (1800 X 395 μm). The CNV growth pattern was det ermined in 91 (46%) of 199 specimens. Of 159 group N and group B lesions, 76 (4 8%) had an indeterminate growth pattern, 28 (18%) had a sub-RPE growth patter n, and 33 (21%) had sub-RPE and subretinal growth patterns. Of 40 group H lesi ons, 32 (80%) had an indeterminate growth pattern, 7 (18%) had a subretinal gr owth pattern, and 1 (2%) had a combined sub-RPE and subretinal pattern. Based o